This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1
目录 :
05-117
规格 :
500微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
bFM-1
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
中和反应, 免疫沉淀, 放射免疫分析法, 抑制或激活实验
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类; 图 6
Zhao C, Zhang W, Zhao Y, Yang Y, Luo H, Ji G, et al. Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism. Sci Rep. 2016;6:19404 pubmed 出版商
  • 抑制或激活实验; 人类; 5 ug/ml
Azuma K, Kawahara A, Sonoda K, Nakashima K, Tashiro K, Watari K, et al. FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor. Oncotarget. 2014;5:5908-19 pubmed
  • 抑制或激活实验; 人类
  • 抑制或激活实验; 小鼠; 1:200
Santiago J, McNaughton L, Koleini N, Ma X, Bestvater B, Nickel B, et al. High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling. PLoS ONE. 2014;9:e97281 pubmed 出版商
  • 抑制或激活实验; 大鼠
Higginson J, Thompson S, Santos Silva A, Guimond S, Turnbull J, Barnett S. Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. J Neurosci. 2012;32:15902-12 pubmed 出版商
Fessler E, Borovski T, Medema J. Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF. Mol Cancer. 2015;14:157 pubmed 出版商
Guerrouahen B, Pasquier J, Kaoud N, Maleki M, Beauchamp M, Yasmeen A, et al. Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer. Mol Cancer Ther. 2014;13:3123-36 pubmed 出版商
Traer E, Javidi Sharifi N, Agarwal A, Dunlap J, English I, Martinez J, et al. Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations. Blood. 2014;123:1516-24 pubmed 出版商
Ladewig J, Koch P, Brüstle O. Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration. Nat Neurosci. 2014;17:24-6 pubmed 出版商
Knelson E, Gaviglio A, Tewari A, Armstrong M, Mythreye K, Blobe G. Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. J Clin Invest. 2013;123:4786-98 pubmed
Sáinz Jaspeado M, Huertas Martínez J, Lagares Tena L, Martín Liberal J, Mateo Lozano S, de Alava E, et al. EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1. PLoS ONE. 2013;8:e71449 pubmed 出版商
Chang Y, Lin L, Lou C, Chou C, Ch ang H. Bone marrow transplantation rescues intestinal mucosa after whole body radiation via paracrine mechanisms. Radiother Oncol. 2012;105:371-7 pubmed 出版商
Fan Y, Lv Z, Yao X, Wang W, Huang K, Meng Q, et al. Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA. Clin Exp Allergy. 2012;42:1604-14 pubmed 出版商
Voulgari Kokota A, Fairless R, Karamita M, Kyrargyri V, Tseveleki V, Evangelidou M, et al. Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function. Exp Neurol. 2012;236:161-70 pubmed 出版商
Wang L, Park H, Chhim S, Ding Y, Jiang W, Queen C, et al. A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Mol Cancer Ther. 2012;11:864-72 pubmed 出版商
Shiota M, Hikita Y, Kawamoto Y, Kusakabe H, Tanaka M, Izumi Y, et al. Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2. J Cell Mol Med. 2012;16:2001-9 pubmed 出版商
Santiago J, Ma X, McNaughton L, Nickel B, Bestvater B, Yu L, et al. Preferential accumulation and export of high molecular weight FGF-2 by rat cardiac non-myocytes. Cardiovasc Res. 2011;89:139-47 pubmed 出版商
Gutierrez J, Brandan E. A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation. Mol Cell Biol. 2010;30:1634-49 pubmed 出版商
Einstein O, Friedman Levi Y, Grigoriadis N, Ben Hur T. Transplanted neural precursors enhance host brain-derived myelin regeneration. J Neurosci. 2009;29:15694-702 pubmed 出版商
Lefevre G, Babchia N, Calipel A, Mouriaux F, Faussat A, Mrzyk S, et al. Activation of the FGF2/FGFR1 autocrine loop for cell proliferation and survival in uveal melanoma cells. Invest Ophthalmol Vis Sci. 2009;50:1047-57 pubmed 出版商
Begum S, Zhang Y, Shintani T, Toratani S, Sato J, Okamoto T. Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis. Oncol Rep. 2007;17:591-6 pubmed
Watanabe Y, Matsumoto N, Dezawa M, Itokazu Y, Yoshihara T, Ide C. Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neurons. Neurosci Lett. 2005;379:158-63 pubmed
产品信息
目录代码 :
05-117
亚类别 :
Cell Signaling
产品名称 :
Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P09038
宿主名称 :
小鼠
抗原 :
FGF-2/basic FGF (neutralizing)
克隆 :
bFM-1
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1
交叉活性 :
牛;人类;小鼠;大鼠
背景 :
Basic fibroblast growth factor, also known as bFGF or FGF2, is a member of the fibroblast growth factor family. In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide. It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate-degrading enzymes activates bFGF, thus mediating the formation of new blood vessels, a process known as angiogenesis. Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined.
别名 :
Basic fibroblast growth factor;basic fibroblast growth factor bFGF;fibroblast growth factor 2;fibroblast growth factor 2 (basic);heparin-binding growth factor 2.
免疫原 :
Purified bovine brain basic FGF (HBGF-2). Clone bFM-1.
特异性 :
This antibody recognizes the non-denatured form of FGF-2/basic FGF; does not cross-react with bovine acidic FGF.
包装尺寸 :
500微克
用途 :
Neutralizing;Radioimmunoassay
储存 :
Stable for 1 year at -20ºC from date of receipt. Aliquot to avoid repeated freezing and thawing. For maximum recovery of the product, centrifuge the original vial after thawing and prior to removing the cap.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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