Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

IGF-I抗体, 克隆Sm1.2

05-172

200微克

单克隆

小鼠

未共轭

Sm1.2

同一抗体克隆可从以下厂商购到:

• LifeSpan Biosciences: LS-C85204

人类, 小鼠, 鸡

Cell Signaling

抗IGF-I抗体, 克隆Sm1.2

抗体

单克隆抗体

P05019

小鼠

IGF-I

Sm1.2

纯化

IgG1κ

抗IGF-I抗体, 克隆Sm1.2

Human;Mouse;Rat;Chicken;Avian

Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 is produced primarily by the liver as an endocrine hormone and targets tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5b. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. Its primary action is mediated by binding to specific IGF receptors present on many cell types in many tissues. The signal is transduced by intracellular events. IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

Mechano growth factor;insulin-like growth factor 1;insulin-like growth factor 1 (somatomedin C);somatomedin C

Human insulin-like growth factor I (IGF-I) purified from human plasma. (van Wyk, J.J., 1986).

IGF-I. (Russel, W.E., 1984). 40% cross reactivity to IGF-II. (van Wyk, J.J., 1997).

200微克

Immunohistochemistry;Immunoprecipitation;Neutralizing;Western Blotting

Stable for 1 year at -20ºC from date of receipt.