This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Src Antibody, clone GD11
目录 :
05-184
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
GD11
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫沉淀, reverse phase protein lysate microarray, 其他
文章摘录数: 73
出版应用/物种/样本/稀释参考文献
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed 出版商
  • 免疫印迹; 人类
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Janjanam J, Rao G. Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1. Sci Rep. 2016;6:28687 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 1
Ikeuchi M, Fukumoto Y, Honda T, Kuga T, Saito Y, Yamaguchi N, et al. v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage. Int J Mol Sci. 2016;17: pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 2
Chojnacka K, Bilinska B, Mruk D. Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication. Cell Signal. 2016;28:469-480 pubmed 出版商
  • 其他; 人类; 图 st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed 出版商
  • 免疫印迹; 人类; 0.4 ug/ml; 图 1
  • 免疫印迹; 小鼠; 0.4 ug/ml; 图 1
Tabariès S, Annis M, Hsu B, Tam C, Savage P, Park M, et al. Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis. Oncotarget. 2015;6:9476-87 pubmed
  • 免疫印迹; 小鼠; 图 3
  • 免疫印迹; 人类; 图 3
Sun J, Lu F, He H, Shen J, Messina J, Mathew R, et al. STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion. J Cell Biol. 2014;207:535-48 pubmed 出版商
  • 免疫印迹; 人类
Son J, Jeong H, Kim H, Kim Y, Lee E, Lee H, et al. Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase. Biochem Pharmacol. 2014;89:236-45 pubmed 出版商
  • 免疫印迹; 人类
Bijian K, Lougheed C, Su J, Xu B, Yu H, Wu J, et al. Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine. Br J Cancer. 2013;109:2810-8 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Thapa N, Choi S, Hedman A, Tan X, Anderson R. Phosphatidylinositol phosphate 5-kinase I?i2 in association with Src controls anchorage-independent growth of tumor cells. J Biol Chem. 2013;288:34707-18 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kubota S, Fukumoto Y, Aoyama K, Ishibashi K, Yuki R, Morinaga T, et al. Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1? (HP1?) with heterochromatin. J Biol Chem. 2013;288:17871-83 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 5a
Zhong J, Baquiran J, Bonakdar N, Lees J, Ching Y, Pugacheva E, et al. NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration. PLoS ONE. 2012;7:e35058 pubmed 出版商
Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed 出版商
Benzina S, Harquail J, Guerrette R, O Brien P, Jean S, Crapoulet N, et al. Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. J Cancer. 2016;7:2035-2044 pubmed 出版商
Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, et al. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. J Biol Chem. 2017;292:1648-1665 pubmed 出版商
Shigeno Nakazawa Y, Kasai T, Ki S, Kostyanovskaya E, Pawlak J, Yamagishi J, et al. A pre-metazoan origin of the CRK gene family and co-opted signaling network. Sci Rep. 2016;6:34349 pubmed 出版商
Hodgson L, Spiering D, Sabouri Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, et al. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nat Chem Biol. 2016;12:802-809 pubmed 出版商
Flierl U, Nero T, Lim B, Arthur J, Yao Y, Jung S, et al. Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. J Exp Med. 2015;212:129-37 pubmed 出版商
Bach C, Murray R, Owen D, Gaus K, O Neill G. Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking. Mol Cell Biol. 2014;34:4436-46 pubmed 出版商
Fan P, Agboke F, Cunliffe H, Ramos P, Jordan V. A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer. Eur J Cancer. 2014;50:2866-76 pubmed 出版商
Morinaga T, Abe K, Nakayama Y, Yamaguchi N, Yamaguchi N. Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment. J Biol Chem. 2014;289:26327-43 pubmed 出版商
Bradbury P, Bach C, Paul A, O Neill G. Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions. J Biol Chem. 2014;289:24792-800 pubmed 出版商
Fukumoto Y, Miura T, Morii M, Kubota S, Honda T, Kubota S, et al. v-Src inhibits the interaction between Rad17 and Rad9 and induces replication fork collapse. Biochem Biophys Res Commun. 2014;450:885-90 pubmed 出版商
Hughes A, Spelke D, Xu Z, Kang C, Schaffer D, Herr A. Single-cell western blotting. Nat Methods. 2014;11:749-55 pubmed 出版商
Wallez Y, Riedl S, Pasquale E. Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. J Biol Chem. 2014;289:10431-44 pubmed 出版商
Spring K, Lapointe L, Caron C, Langlois S, Royal I. Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor. Cell Signal. 2014;26:1283-93 pubmed 出版商
Stutz E, Gautschi O, Fey M, Gugger M, Tschan M, Rothschild S. Crizotinib inhibits migration and expression of ID1 in MET-positive lung cancer cells: implications for MET targeting in oncology. Future Oncol. 2014;10:211-7 pubmed 出版商
Ambati S, Lopes E, Kosugi K, Mony U, Zehir A, Shah S, et al. Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma. Mol Oncol. 2014;8:323-36 pubmed 出版商
Destaing O, Ferguson S, Grichine A, Oddou C, De Camilli P, Albiges Rizo C, et al. Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes. PLoS ONE. 2013;8:e77956 pubmed 出版商
Kim K, Kim N, Kim J, Park J, Yi J, Lee J, et al. Magnolol suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways. Nutr Cancer. 2013;65:1245-53 pubmed 出版商
Kundumani Sridharan V, Dyukova E, Hansen D, Rao G. 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J Biol Chem. 2013;288:15830-42 pubmed 出版商
Soeda S, Nakayama Y, Honda T, Aoki A, Tamura N, Abe K, et al. v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure. Exp Cell Res. 2013;319:1382-97 pubmed 出版商
Miekus K, Lukasiewicz E, Jarocha D, Sekula M, Drabik G, Majka M. The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation. Cell Death Dis. 2013;4:e459 pubmed 出版商
Chuang Y, Xu X, Kwiatkowska A, Tsapraillis G, Hwang H, Petritis K, et al. Regulation of synaptojanin 2 5'-phosphatase activity by Src. Cell Adh Migr. 2012;6:518-25 pubmed 出版商
Hukkelhoven E, Liu Y, Yeh N, Ciznadija D, Blain S, Koff A. Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. J Biol Chem. 2012;287:38523-30 pubmed 出版商
Wiedemann A, Rosselin M, Mijouin L, Bottreau E, Velge P. Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion. J Biol Chem. 2012;287:31148-54 pubmed 出版商
Chaufty J, Sullivan S, Ho A. Intracellular amyloid precursor protein sorting and amyloid-? secretion are regulated by Src-mediated phosphorylation of Mint2. J Neurosci. 2012;32:9613-25 pubmed 出版商
Nakayama Y, Matsui Y, Takeda Y, Okamoto M, Abe K, Fukumoto Y, et al. c-Src but not Fyn promotes proper spindle orientation in early prometaphase. J Biol Chem. 2012;287:24905-15 pubmed 出版商
Fan P, McDaniel R, Kim H, Clagett D, Haddad B, Jordan V. Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines. Eur J Cancer. 2012;48:3488-98 pubmed 出版商
Lau S, Shields D, Murphy E, Desgrosellier J, Anand S, Huang M, et al. EGFR-mediated carcinoma cell metastasis mediated by integrin ?v?5 depends on activation of c-Src and cleavage of MUC1. PLoS ONE. 2012;7:e36753 pubmed 出版商
Willard M, Lajiness M, Wulur I, Feng B, Swearingen M, Uhlik M, et al. Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Mol Cancer Res. 2012;10:739-49 pubmed 出版商
Meiler E, Nieto Pelegrin E, Martinez Quiles N. Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading. PLoS ONE. 2012;7:e33662 pubmed 出版商
Lahlou H, Sanguin Gendreau V, Frame M, Muller W. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res. 2012;14:R36 pubmed
Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y, Yamaguchi N. Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: a novel method suitable for examining dynamic changes in proteins during mitotic progression. Eur J Cell Biol. 2012;91:413-9 pubmed 出版商
Rothschild S, Tschan M, Federzoni E, Jaggi R, Fey M, Gugger M, et al. MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma. Oncogene. 2012;31:4221-32 pubmed 出版商
Prinetti A, Cao T, Illuzzi G, Prioni S, Aureli M, Gagliano N, et al. A glycosphingolipid/caveolin-1 signaling complex inhibits motility of human ovarian carcinoma cells. J Biol Chem. 2011;286:40900-10 pubmed 出版商
Guilluy C, Zhang Z, Bhende P, Sharek L, Wang L, Burridge K, et al. Latent KSHV infection increases the vascular permeability of human endothelial cells. Blood. 2011;118:5344-54 pubmed 出版商
Mandal A, Shahidullah M, Beimgraben C, Delamere N. The effect of endothelin-1 on Src-family tyrosine kinases and Na,K-ATPase activity in porcine lens epithelium. J Cell Physiol. 2011;226:2555-61 pubmed 出版商
Hennessy B, Lu Y, Gonzalez Angulo A, Carey M, Myhre S, Ju Z, et al. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin Proteomics. 2010;6:129-51 pubmed 出版商
Curtiss M, Hostager B, Stepniak E, Singh M, Manhica N, Knisz J, et al. Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1). Mol Immunol. 2011;48:1424-31 pubmed 出版商
Baker A, Cox T, Bird D, Lang G, Murray G, Sun X, et al. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst. 2011;103:407-24 pubmed 出版商
Srirangam A, Milani M, Mitra R, Guo Z, RODRIGUEZ M, Kathuria H, et al. The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin. J Thorac Oncol. 2011;6:661-70 pubmed 出版商
Chao J, Gui P, Zamponi G, Davis G, Davis M. Spatial association of the Cav1.2 calcium channel with ?5?1-integrin. Am J Physiol Cell Physiol. 2011;300:C477-89 pubmed 出版商
Yang H, Yang X, Cao J, Li S, Liu Y, Suo Z, et al. cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain. J Neurochem. 2011;116:93-104 pubmed 出版商
Destaing O, Planus E, Bouvard D, Oddou C, Badowski C, Bossy V, et al. ?1A integrin is a master regulator of invadosome organization and function. Mol Biol Cell. 2010;21:4108-19 pubmed 出版商
Patwardhan P, Resh M. Myristoylation and membrane binding regulate c-Src stability and kinase activity. Mol Cell Biol. 2010;30:4094-107 pubmed 出版商
Singh J, Aaronson S, Mlodzik M. Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene. 2010;29:4033-45 pubmed 出版商
Zhang Q, Wang D, Kundumani Sridharan V, Gadiparthi L, Johnson D, Tigyi G, et al. PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization. Blood. 2010;116:1377-85 pubmed 出版商
Schrage Y, Briaire de Bruijn I, de Miranda N, van Oosterwijk J, Taminiau A, van Wezel T, et al. Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. Cancer Res. 2009;69:6216-22 pubmed 出版商
Cayer M, Proulx M, Ma X, Sakac D, Giguere J, Drouin M, et al. c-Src tyrosine kinase co-associates with and phosphorylates signal transducer and activator of transcription 5b which mediates the proliferation of normal human B lymphocytes. Clin Exp Immunol. 2009;156:419-27 pubmed 出版商
Caron C, Spring K, Laramée M, Chabot C, Cloutier M, Gu H, et al. Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells. Cell Signal. 2009;21:943-53 pubmed 出版商
Zimmerman B, Simaan M, Lee M, Luttrell L, Laporte S. c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cell Signal. 2009;21:103-10 pubmed 出版商
Chabot C, Spring K, Gratton J, Elchebly M, Royal I. New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol Cell Biol. 2009;29:241-53 pubmed 出版商
Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N. TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. Cancer Sci. 2008;99:1827-34 pubmed 出版商
Yu M, Pisitkun T, Wang G, Aranda J, Gonzales P, Tchapyjnikov D, et al. Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct. Am J Physiol Cell Physiol. 2008;295:C661-78 pubmed 出版商
Perrone L, Peluso G, Melone M. RAGE recycles at the plasma membrane in S100B secretory vesicles and promotes Schwann cells morphological changes. J Cell Physiol. 2008;217:60-71 pubmed 出版商
Balbis A, Parmar A, Wang Y, Baquiran G, Posner B. Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology. 2007;148:2944-54 pubmed
Inoue O, Suzuki Inoue K, Dean W, Frampton J, Watson S. Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. J Cell Biol. 2003;160:769-80 pubmed
产品信息
目录代码 :
05-184
亚类别 :
Cell Signaling
产品名称 :
Anti-Src Antibody, clone GD11
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P12931
宿主名称 :
小鼠
抗原 :
Src
克隆 :
GD11
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
Anti-Src Antibody, clone GD11
交叉活性 :
Avian;Human;Mouse;Mink;Rat
背景 :
Src is a family of proto-oncogenic tyrosine kinases originally discovered by J. Michael Bishop and Harold E. Varmus. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry. Some tumor-inducing retroviruses (such as Rous sarcoma virus (RSV)), contain a gene called v-src (viral-sarcoma). It was found that the v-src gene in RSV is required for the formation of cancer. Src tyrosine kinases transmit integrin-dependent signals central to cell movement and proliferation. Hallmarks of v-src induced transformation are rounding of the cell and the formation of actin rich podosomes on the basal surface of the cell. These structures are correlated with increased invasiveness, a process thought to be essential for metastasis. v-src lacks the C-terminal inhibitory phosphorylation site, and is therefore constitutively active as opposed to normal src (c-src) which is only activated under certain circumstances where it is required (e.g. growth factor signaling). v-src is therefore an instructive example of an oncogene whereas c-src is a proto-oncogene.
免疫原 :
Recombinant chicken pp60src; v-src
特异性 :
识别pp60src
包装尺寸 :
200微克
用途 :
免疫沉淀;免疫印迹
储存 :
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.