This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Fas Antibody (human, activating), clone CH11
目录 :
05-201
规格 :
50微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CH11

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠,
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 抑制或激活实验
文章摘录数: 104
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类; 图 4a
Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, et al. Phosphatidylserine exposure is required for ADAM17 sheddase function. Nat Commun. 2016;7:11523 pubmed 出版商
  • 流式细胞仪; 人类; 图 2b
Trisdale S, Schwab N, Hou X, Davis J, Townson D. Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells. J Ovarian Res. 2016;9:8 pubmed 出版商
  • 抑制或激活实验; 人类
Gill R, Lanni L, Jen K, McCabe M, ROSENSPIRE A. Docosahexaenoic acid counteracts attenuation of CD95-induced cell death by inorganic mercury. Toxicol Appl Pharmacol. 2015;282:61-7 pubmed 出版商
  • 流式细胞仪; 人类
Park S, Park J, Kim Y, Song S, Kwon H, Lee Y. Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells. Cell Stress Chaperones. 2015;20:149-57 pubmed 出版商
  • 抑制或激活实验; 人类
Boyd Tressler A, Penuela S, Laird D, Dubyak G. Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism. J Biol Chem. 2014;289:27246-63 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, et al. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049 pubmed 出版商
  • 免疫印迹; 人类
Potu H, Peterson L, Pal A, Verhaegen M, Cao J, Talpaz M, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 2014;5:5559-69 pubmed
  • 流式细胞仪; 人类
Gao B, Moore C, Porcheray F, Rong C, Abidoglu C, DeVito J, et al. Pretransplant IgG reactivity to apoptotic cells correlates with late kidney allograft loss. Am J Transplant. 2014;14:1581-91 pubmed 出版商
  • 免疫沉淀; 人类; 1 ug/ml
  • 免疫印迹; 人类
Li C, Egloff A, Sen M, Grandis J, Johnson D. Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. Mol Oncol. 2014;8:1220-30 pubmed 出版商
  • 抑制或激活实验; 人类; 15 ug/ml
Noviello M, Tedesco F, Bondanza A, Tonlorenzi R, Rosaria Carbone M, Gerli M, et al. Inflammation converts human mesoangioblasts into targets of alloreactive immune responses: implications for allogeneic cell therapy of DMD. Mol Ther. 2014;22:1342-1352 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫印迹; 人类
Villa Morales M, Cobos M, González Gugel E, Alvarez Iglesias V, Martinez B, Piris M, et al. FAS system deregulation in T-cell lymphoblastic lymphoma. Cell Death Dis. 2014;5:e1110 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000
Li H, Zhou Y, Zhao A, Qiu Y, Xie G, Jiang Q, et al. Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. Cell Death Dis. 2013;4:e830 pubmed 出版商
  • 抑制或激活实验; 人类; 200 ng/ml
Porcheray F, Fraser J, Gao B, McColl A, DeVito J, Dargon I, et al. Polyreactive antibodies developing amidst humoral rejection of human kidney grafts bind apoptotic cells and activate complement. Am J Transplant. 2013;13:2590-600 pubmed 出版商
  • 免疫细胞化学; 人类; 500 ng/mL
Lolli F, Martini H, Citro A, Franceschini D, Portaccio E, Amato M, et al. Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis. J Neuroinflammation. 2013;10:94 pubmed 出版商
  • 抑制或激活实验; 人类
Li H, Pauza C. Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells. Retrovirology. 2013;10:60 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200
Brinkmann K, Hombach A, Seeger J, Wagner Stippich D, Klubertz D, Kronke M, et al. Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing. Leuk Lymphoma. 2014;55:645-51 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Huang S, Scruggs A, Donaghy J, Horowitz J, Zaslona Z, Przybranowski S, et al. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. Cell Death Dis. 2013;4:e621 pubmed 出版商
  • 抑制或激活实验; 人类
Li Y, Shively J. CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with ?-catenin. Exp Cell Res. 2013;319:1061-72 pubmed 出版商
  • 抑制或激活实验; 人类
Ajayi I, Sisson T, Higgins P, Booth A, Sagana R, Huang S, et al. X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis. Am J Respir Cell Mol Biol. 2013;49:86-95 pubmed 出版商
  • 流式细胞仪; 人类; 1:25
  • 流式细胞仪; 牛; 1:25
Duncan A, Forcina J, Birt A, Townson D. Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines. Reprod Biol Endocrinol. 2012;10:90 pubmed 出版商
  • 抑制或激活实验; 人类; 100 ng/ml
Inoue S, Browne G, Melino G, Cohen G. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ. 2009;16:1053-61 pubmed 出版商
Dakic A, DiVito K, Fang S, Suprynowicz F, Gaur A, Li X, et al. ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes. Oncotarget. 2016;7:66740-66753 pubmed 出版商
Chen C, Wu M, Huang Y, Lin P, Shih C, Lin F, et al. Iridovirus CARD Protein Inhibits Apoptosis through Intrinsic and Extrinsic Pathways. PLoS ONE. 2015;10:e0129071 pubmed 出版商
Honjo K, Kubagawa Y, Kearney J, Kubagawa H. Unique ligand-binding property of the human IgM Fc receptor. J Immunol. 2015;194:1975-82 pubmed 出版商
Kubagawa Y, Honjo K, Kang D, Kubagawa H. Monoclonal antibodies specific for human IgM Fc receptor inhibit ligand-binding activity. Monoclon Antib Immunodiagn Immunother. 2014;33:393-400 pubmed 出版商
Benard A, Janssen C, van den Elsen P, van Eggermond M, Hoon D, Van De Velde C, et al. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis. 2014;19:1769-78 pubmed 出版商
Popescu I, Drummond M, Gama L, Coon T, Merlo C, Wise R, et al. Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190:744-55 pubmed 出版商
Mace P, Riedl S, Salvesen G. Caspase enzymology and activation mechanisms. Methods Enzymol. 2014;544:161-78 pubmed 出版商
Al Ejeh F, Staudacher A, Smyth D, Darby J, Denoyer D, Tsopelas C, et al. Postchemotherapy and tumor-selective targeting with the La-specific DAB4 monoclonal antibody relates to apoptotic cell clearance. J Nucl Med. 2014;55:772-9 pubmed 出版商
Jia S, Parodo J, Charbonney E, Tsang J, Jia S, Rotstein O, et al. Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8. Am J Pathol. 2014;184:1030-1040 pubmed 出版商
Das A, Ganesh K, Khanna S, Sen C, Roy S. Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation. J Immunol. 2014;192:1120-9 pubmed 出版商
Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014;289:2978-91 pubmed 出版商
Geering B, Stoeckle C, Rozman S, Oberson K, Benarafa C, Simon H. DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. J Leukoc Biol. 2014;95:293-303 pubmed 出版商
Gao J, Sana R, Calder V, Calonge M, Lee W, Wheeler L, et al. Mitochondrial permeability transition pore in inflammatory apoptosis of human conjunctival epithelial cells and T cells: effect of cyclosporin A. Invest Ophthalmol Vis Sci. 2013;54:4717-33 pubmed 出版商
Wise J, Berkova Z, Mathur R, Zhu H, Braun F, Tao R, et al. Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex. Blood. 2013;121:4729-39 pubmed 出版商
Rippo M, Babini L, Prattichizzo F, Graciotti L, Fulgenzi G, Tomassoni Ardori F, et al. Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes. Cell Death Dis. 2013;4:e594 pubmed 出版商
Nho R, Peterson M, Hergert P, Henke C. FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas. PLoS ONE. 2013;8:e61017 pubmed 出版商
Backman L, Danielson P. Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes. J Cell Mol Med. 2013;17:723-33 pubmed 出版商
Bryce S, Avlasevich S, Bemis J, Tate M, Walmsley R, Saad F, et al. Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment. Environ Mol Mutagen. 2013;54:180-94 pubmed 出版商
Kastamoulas M, Chondrogiannis G, Kanavaros P, Vartholomatos G, Bai M, Briasoulis E, et al. Cytokine effects on cell survival and death of A549 lung carcinoma cells. Cytokine. 2013;61:816-25 pubmed 出版商
Seidelin J, Coskun M, Vainer B, Riis L, Soendergaard C, Nielsen O. ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis. J Mol Med (Berl). 2013;91:839-49 pubmed 出版商
Faccenda D, Tan C, Seraphim A, Duchen M, Campanella M. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ. 2013;20:686-97 pubmed 出版商
De Miguel D, Basañez G, Sanchez D, Malo P, Marzo I, Larrad L, et al. Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells. Mol Pharm. 2013;10:893-904 pubmed 出版商
Stenberg A, Sehlin J, Oldenborg P. Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRP?) from the cell surface. J Leukoc Biol. 2013;93:403-12 pubmed 出版商
Pettigrew C, Clerkin J, Cotter T. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer Res. 2012;32:5175-81 pubmed
Perinpanayagam M, Beauchamp E, Martin D, Sim J, Yap M, Berthiaume L. Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases. FASEB J. 2013;27:811-21 pubmed 出版商
Förster A, Falcone F, Gibbs B, Preussner L, Fiebig B, Altunok H, et al. Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils. Leuk Lymphoma. 2013;54:835-42 pubmed 出版商
Soto P, Karris M, Spina C, Richman D, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl). 2013;91:261-70 pubmed 出版商
Qian H, Xia L, Ling P, Waxman S, Jing Y. CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts. Cancer Biol Ther. 2012;13:1276-83 pubmed 出版商
Markwick L, Clements D, Roberts M, Ceresa C, Knox A, Johnson S. CCR3 induced-p42/44 MAPK activation protects against staurosporine induced-DNA fragmentation but not apoptosis in airway smooth muscle cells. Clin Exp Allergy. 2012;42:1040-50 pubmed 出版商
Izawa T, Zou W, Chappel J, Ashley J, Feng X, Teitelbaum S. c-Src links a RANK/?v?3 integrin complex to the osteoclast cytoskeleton. Mol Cell Biol. 2012;32:2943-53 pubmed 出版商
Steiert A, Reimers K, Burke W, Zapf A, Vogt P. Covalent vectored binding of functional proteins by bifunctional crosslinking at silicone interfaces. J Biomed Mater Res A. 2012;100:1248-55 pubmed 出版商
Honjo K, Kubagawa Y, Kubagawa H. Is Toso an antiapoptotic protein or an Fc receptor for IgM?. Blood. 2012;119:1789-90 pubmed 出版商
Chodorge M, Zuger S, Stirnimann C, Briand C, Jermutus L, Grutter M, et al. A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Differ. 2012;19:1187-95 pubmed 出版商
Iglesias Guimarais V, Gil Guiñón E, Gabernet G, García Belinchón M, Sánchez Osuna M, Casanelles E, et al. Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease. J Biol Chem. 2012;287:7766-79 pubmed 出版商
Hsu A, Dowdell K, Davis J, Niemela J, Anderson S, Shaw P, et al. Autoimmune lymphoproliferative syndrome due to FAS mutations outside the signal-transducing death domain: molecular mechanisms and clinical penetrance. Genet Med. 2012;14:81-9 pubmed 出版商
Arabanian L, Kujawski S, Habermann I, Ehninger G, Kiani A. Regulation of fas/fas ligand-mediated apoptosis by nuclear factor of activated T cells in megakaryocytes. Br J Haematol. 2012;156:523-34 pubmed 出版商
Horowitz J, Ajayi I, Kulasekaran P, Rogers D, White J, Townsend S, et al. Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. Int J Biochem Cell Biol. 2012;44:158-69 pubmed 出版商
Martin D, Ahpin C, Heit R, Perinpanayagam M, Yap M, Veldhoen R, et al. Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKC?, a case study. FASEB J. 2012;26:13-28 pubmed 出版商
Steiert A, Sendler D, Burke W, Choi C, Reimers K, Vogt P. Attack the tumor counterattack-c-FLIP expression in Jurkat-T-cells protects against apoptosis induced by coculture with SW620 colorectal adenocarcinoma cells. J Surg Res. 2012;176:133-40 pubmed 出版商
Cummins N, Klicpera A, Sainski A, Bren G, Khosla S, Westendorf J, et al. Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations. PLoS ONE. 2011;6:e24876 pubmed 出版商
Li H, Pauza C. HIV envelope-mediated, CCR5/?4?7-dependent killing of CD4-negative ?? T cells which are lost during progression to AIDS. Blood. 2011;118:5824-31 pubmed 出版商
Tsai C, Huang W, Chen C, Hsieh C, Lin Y, Chen S, et al. Glycogen synthase kinase-3 facilitates con a-induced IFN-?-- mediated immune hepatic injury. J Immunol. 2011;187:3867-77 pubmed 出版商
Cerella C, Sobolewski C, Chateauvieux S, Henry E, Schnekenburger M, Ghelfi J, et al. COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells. Biochem Pharmacol. 2011;82:1277-90 pubmed 出版商
Zhou Y, Adolfs Y, Pijnappel W, Fuller S, van der Schors R, Li K, et al. MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 2011;31:3603-15 pubmed 出版商
Jeon H, Zheng L, Lee S, Lee W, Park N, Park J, et al. Comparative analysis of the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA. Exp Cell Res. 2011;317:2007-18 pubmed 出版商
Swindall A, Bellis S. Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells. J Biol Chem. 2011;286:22982-90 pubmed 出版商
Geng L, Zhu B, Dai B, Sui C, Xu F, Kan T, et al. A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis. Biochem Biophys Res Commun. 2011;408:494-9 pubmed 出版商
Sancho Martínez S, Piedrafita F, Cannata Andia J, Lopez Novoa J, Lopez Hernandez F. Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis. Toxicol Sci. 2011;122:73-85 pubmed 出版商
Hofmann Bowman M, Heydemann A, Gawdzik J, Shilling R, Camoretti Mercado B. Transgenic expression of human S100A12 induces structural airway abnormalities and limited lung inflammation in a mouse model of allergic inflammation. Clin Exp Allergy. 2011;41:878-89 pubmed 出版商
Martínez Serra J, Maffiotte E, Martin J, Bex T, Navarro Palou M, Ros T, et al. Yondelis® (ET-743, Trabectedin) sensitizes cancer cell lines to CD95-mediated cell death: new molecular insight into the mechanism of action. Eur J Pharmacol. 2011;658:57-64 pubmed 出版商
Muhlethaler Mottet A, Flahaut M, Bourloud K, Nardou K, Coulon A, Liberman J, et al. Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis. Cell Death Dis. 2011;2:e125 pubmed 出版商
Crescenzi E, Pacifico F, Lavorgna A, De Palma R, D Aiuto E, Palumbo G, et al. NF-?B-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells. Oncogene. 2011;30:2707-17 pubmed 出版商
Li Z, Xu Q, Peng H, Cheng R, Sun Z, Ye Z. IFN-? enhances HOS and U2OS cell lines susceptibility to ?? T cell-mediated killing through the Fas/Fas ligand pathway. Int Immunopharmacol. 2011;11:496-503 pubmed 出版商
Croft D, Crighton D, Samuel M, Lourenco F, Munro J, Wood J, et al. p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res. 2011;21:666-82 pubmed 出版商
Ashley J, McCoy E, Clements D, Shi Z, Chen T, Feng X. Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. Assay Drug Dev Technol. 2011;9:40-9 pubmed 出版商
Salvetti N, Stangaferro M, Palomar M, Alfaro N, Rey F, Gimeno E, et al. Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Anim Reprod Sci. 2010;122:98-110 pubmed 出版商
Akimzhanov A, Wang X, Sun J, Boehning D. T-cell receptor complex is essential for Fas signal transduction. Proc Natl Acad Sci U S A. 2010;107:15105-10 pubmed 出版商
Sagan D, Jermnim N, Tangvarasittichai O. CD95 is not functional in human erythrocytes. Int J Lab Hematol. 2010;32:e244-7 pubmed 出版商
Um H, Kwon T. Protective effect of melatonin on oxaliplatin-induced apoptosis through sustained Mcl-1 expression and anti-oxidant action in renal carcinoma Caki cells. J Pineal Res. 2010;49:283-90 pubmed 出版商
Kohler R, Schmitz D, Cornils H, Hemmings B, Hergovich A. Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Mol Cell Biol. 2010;30:4507-20 pubmed 出版商
Cho H, Park S, Hwang E, Baek K, Kim I, Nam I, et al. Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor. J Biol Chem. 2010;285:25500-5 pubmed 出版商
Wen K, Damania B. Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1. Oncogene. 2010;29:3532-44 pubmed 出版商
Woodcock J, Ma Y, Coolen C, Pham D, Jones C, Lopez A, et al. Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cell Signal. 2010;22:1291-9 pubmed 出版商
Kim Y, Lee H, Jang C, Kim H, Cho Y. Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression. Korean J Physiol Pharmacol. 2009;13:483-9 pubmed 出版商
Xu Z, Ding T, Haridas V, Connolly F, Gutterman J. Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts. PLoS ONE. 2009;4:e8532 pubmed 出版商
Yap M, Kostiuk M, Martin D, Perinpanayagam M, Hak P, Siddam A, et al. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res. 2010;51:1566-80 pubmed 出版商
Eeva J, Nuutinen U, Ropponen A, Mättö M, Eray M, Pellinen R, et al. The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells. Apoptosis. 2009;14:687-98 pubmed 出版商
Engedal N, Auberger P, Blomhoff H. Retinoic acid regulates Fas-induced apoptosis in Jurkat T cells: reversal of mitogen-mediated repression of Fas DISC assembly. J Leukoc Biol. 2009;85:469-80 pubmed 出版商
Wedemeyer I, Bechmann L, Odenthal M, Jochum C, Marquitan G, Drebber U, et al. Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: therapeutic implications for hepatitis C. J Hepatol. 2009;50:140-9 pubmed 出版商
Pop C, Salvesen G, Scott F. Caspase assays: identifying caspase activity and substrates in vitro and in vivo. Methods Enzymol. 2008;446:351-67 pubmed 出版商
Ruan W, Lee C, Desbarats J. A novel juxtamembrane domain in tumor necrosis factor receptor superfamily molecules activates Rac1 and controls neurite growth. Mol Biol Cell. 2008;19:3192-202 pubmed 出版商
Izquierdo J. Fas splicing regulation during early apoptosis is linked to caspase-mediated cleavage of U2AF65. Mol Biol Cell. 2008;19:3299-307 pubmed 出版商
De Zio D, Ferraro E, D Amelio M, Simoni V, Bordi M, Soroldoni D, et al. Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells. Cell Mol Life Sci. 2008;65:1780-90 pubmed 出版商
Dash P, McCormick J, Thomson M, Johnstone A, Cartwright J, Whitley G. Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase Cepsilon. Exp Cell Res. 2007;313:3421-31 pubmed
Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol. 2007;178:93-105 pubmed
Obermeier F, Hausmann M, Kellermeier S, Kiessling S, Strauch U, Duitman E, et al. IL-15 protects intestinal epithelial cells. Eur J Immunol. 2006;36:2691-9 pubmed
Petrovas C, Casazza J, Brenchley J, Price D, Gostick E, Adams W, et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med. 2006;203:2281-92 pubmed
Krispin A, Bledi Y, Atallah M, Trahtemberg U, Verbovetski I, Nahari E, et al. Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states. Blood. 2006;108:3580-9 pubmed
Li H, Wang A, Zhang R, Wei Y, Chen H, She Z, et al. A20 inhibits oxidized low-density lipoprotein-induced apoptosis through negative Fas/Fas ligand-dependent activation of caspase-8 and mitochondrial pathways in murine RAW264.7 macrophages. J Cell Physiol. 2006;208:307-18 pubmed
de Groot D, Timmer T, Spierings D, Le T, de Jong S, de Vries E. Indomethacin-induced activation of the death receptor-mediated apoptosis pathway circumvents acquired doxorubicin resistance in SCLC cells. Br J Cancer. 2005;92:1459-66 pubmed
Iordanov M, Kirsch J, Ryabinina O, Wong J, Spitz P, Korcheva V, et al. Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs). Apoptosis. 2005;10:167-76 pubmed
Iordanov M, Ryabinina O, Schneider P, Magun B. Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis. Apoptosis. 2005;10:153-66 pubmed
Ricci Vitiani L, Pedini F, Mollinari C, Condorelli G, Bonci D, Bez A, et al. Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death. J Exp Med. 2004;200:1257-66 pubmed
产品信息
目录代码 :
05-201
亚类别 :
Apoptosis & Cancer
产品名称 :
Anti-Fas Antibody (human, activating), clone CH11
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P25445
宿主名称 :
小鼠
抗原 :
Fas (human
克隆 :
CH11
共轭标签 :
亲和纯化
抗体亚型 :
IgM
产品描述 :
Anti-Fas Antibody (human, activating), clone CH11
交叉活性 :
人类
背景 :
Fas/APO-1/CD95 (36 kDa) is a member of the tumor necrosis factor (TNF) receptor superfamily, a family of transmembrane receptors. Fas has been shown to be an important mediator of apoptotic cell death, as well as being involved in inflammation. Binding of the Fas ligand (Fas-L) induces trimerization of Fas in the target cell membrane. Activation of Fas causes the recruitment of Fas-associated protein with death domain (FADD) via interactions between the death domains of Fas and FADD. Procaspase 8 binds to Fas-bound FADD via interactions between the death effector domains (DED) of FADD and pro-caspase 8 leading to the activation of caspase 8. Activated caspase 8 cleaves (activates) other procaspases, in effect beginning a caspase cascade that ultimately leads to apoptosis. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure. Fas-induced apoptosis can be effectively blocked at several stages by either FLICE-inhibitory protein (FLIP), by Bcl-2, or by the cytokine response modifier A (CrmA). Biological Activity The antibody demonstrates cytolytic activity on human cells that express Fas. Murine WR19L cells and L929 cells transfected with cDNA encoding human Fas undergo apoptosis in response to this antibody.
别名 :
APO-1 cell surface antigen;CD95 antigen;Fas (TNF receptor superfamily, member 6);Fas AMA;Fas antigen;apoptosis antigen 1;tumor necrosis factor receptor superfamily, member 6
免疫原 :
FS-7(人类二倍体成纤维细胞细胞株)。 克隆CH-11
特异性 :
This antibody recognizes the human cell surface antigen Fas, Mr 43 kDa expressed in various human cells, including myeloid cells, T lympho-blastoid cells, and diploid fibroblasts.
包装尺寸 :
50微克
用途 :
流式细胞仪;免疫细胞化学;免疫印迹
储存 :
Stable for 1 year at -20°C from date of receipt. For maximum recovery of the product, centrifuge the original vial prior to removing the cap.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.