Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

磷脂酰肌醇(-3)激酶抗体, p85, N-SH2

05-217

200微升

单克隆

小鼠

未共轭

UB93-3

Cell Signaling

抗磷脂酰肌醇(-3)激酶抗体, p85, N-SH2

抗体

单克隆抗体

P27986

小鼠

磷脂酰肌醇(-3)激酶

克隆UB93-3

Culture Supernatant

IgG

抗磷脂酰肌醇(-3)激酶抗体, p85, N-SH2

人类;小鼠;大鼠

The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that is thought to phosphorylate second messengers in growth signalling pathways. PI3K exists as a heterodimer of catalytic 110 kDa (p110) and regulatory 85 kDa (p85, p50 or p55) subunits. The p85 unit consists of two closely related proteins: p85 alpha, which binds tightly to the catalytic subunit and p85 beta, a protein of unknown function. They share 62% amino acid sequence identity. p85 alpha lacks PI3 kinase activity, but may serve as regulator of the catalytic subunit, p110, by acting as the link between PI3K and the ligand activated receptor. Both isoforms bind to activated receptors and serve as tyrosine kinase substrates.

PI3-kinase p110 subunit alpha;PtdIns-3-kinase p110;phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha;phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic;subunit, alpha isoform;phosphoinositide-3-kinase, catalytic, alpha polypeptide

GST fusion protein corresponding to N-Terminal SH2 region (amino acid residues 327-434) of rat phosphoinositide 3-Kinase.

Recognizes N-SH2 region of p85 alpha subunit of PI3 Kinase.

200微升

免疫印迹;免疫沉淀

Stable for 1 year at from date of receipt.