This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Fas Antibody (human, neutralizing), clone ZB4
目录 :
05-338
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ZB4

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 中和反应, 流式细胞仪, 抑制或激活实验
文章摘录数: 23
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 7e
Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, et al. Kras Is Critical for B Cell Lymphopoiesis. J Immunol. 2016;196:1678-85 pubmed 出版商
  • 抑制或激活实验; 人类
Lim D, Yawata N, Selva K, Li N, Tsai C, Yeong L, et al. The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. J Immunol. 2014;193:5065-75 pubmed 出版商
  • 抑制或激活实验; 人类
Li H, Pauza C. Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells. Retrovirology. 2013;10:60 pubmed 出版商
Shi L, Wang H, Wang F, Feng M, Wang M, Guan W. Effects of gastrokine‑2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways. Mol Med Rep. 2014;10:2898-904 pubmed 出版商
Saxena N, Yadav P, Kumar O. The Fas/Fas ligand apoptotic pathway is involved in abrin-induced apoptosis. Toxicol Sci. 2013;135:103-18 pubmed 出版商
Praveen K, Saxena N. Crosstalk between Fas and JNK determines lymphocyte apoptosis after ionizing radiation. Radiat Res. 2013;179:725-36 pubmed 出版商
Su C, Lin H, Lin Y, Shan Y, Yang B. Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1- and Stat3-dependent pathway. Cell Immunol. 2013;281:101-10 pubmed 出版商
Mizrahi K, Stein J, Yaniv I, Kaplan O, Askenasy N. TNF-? has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8. Stem Cells. 2013;31:156-66 pubmed 出版商
Cheng S, Wu L, Hsieh Y, Wu C, Chan Y, Chang L, et al. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. J Agric Food Chem. 2012;60:9620-30 pubmed
García Santos G, Martin V, Rodriguez Blanco J, Herrera F, Casado Zapico S, Sánchez Sánchez A, et al. Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin. Br J Cancer. 2012;106:1288-96 pubmed 出版商
Li H, Pauza C. HIV envelope-mediated, CCR5/?4?7-dependent killing of CD4-negative ?? T cells which are lost during progression to AIDS. Blood. 2011;118:5824-31 pubmed 出版商
Hsieh Y, Rao Y, Whang Peng J, Huang C, Shyue S, Hsu S, et al. Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. J Agric Food Chem. 2011;59:10943-54 pubmed 出版商
Martínez Serra J, Maffiotte E, Martin J, Bex T, Navarro Palou M, Ros T, et al. Yondelis® (ET-743, Trabectedin) sensitizes cancer cell lines to CD95-mediated cell death: new molecular insight into the mechanism of action. Eur J Pharmacol. 2011;658:57-64 pubmed 出版商
Mavroudi I, Papadaki V, Pyrovolaki K, Katonis P, Eliopoulos A, Papadaki H. The CD40/CD40 ligand interactions exert pleiotropic effects on bone marrow granulopoiesis. J Leukoc Biol. 2011;89:771-83 pubmed 出版商
Buddingh E, Schilham M, Ruslan S, Berghuis D, Szuhai K, Suurmond J, et al. Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells. Cancer Immunol Immunother. 2011;60:575-86 pubmed 出版商
Paunel Görgülü A, Flohe S, Scholz M, Windolf J, Lögters T. Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis. Crit Care. 2011;15:R20 pubmed 出版商
Shin M, Shim J, Lee J, Chae W, Lee H, Morio T, et al. Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. Int J Hematol. 2010;92:262-70 pubmed 出版商
Xu Z, Ding T, Haridas V, Connolly F, Gutterman J. Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts. PLoS ONE. 2009;4:e8532 pubmed 出版商
Rubio S, Quintana J, Eiroa J, Triana J, Estevez F. Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells. Mol Carcinog. 2010;49:32-43 pubmed 出版商
Hestvik A, Skorstad G, Vartdal F, Holmøy T. Idiotope-specific CD4(+) T cells induce apoptosis of human oligodendrocytes. J Autoimmun. 2009;32:125-32 pubmed 出版商
Larrosa M, Tomas Barberan F, Espín J. The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem. 2006;17:611-25 pubmed
Clarke M, Savill J, Jones D, Noble B, Brown S. Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. J Cell Biol. 2003;160:577-87 pubmed
Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med. 2002;195:1303-16 pubmed
产品信息
目录代码 :
05-338
亚类别 :
Apoptosis & Cancer
产品名称 :
Anti-Fas Antibody (human, neutralizing), clone ZB4
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P25445
宿主名称 :
小鼠
抗原 :
Fas (human
克隆 :
克隆ZB4
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
Anti-Fas Antibody (human, neutralizing), clone ZB4
交叉活性 :
人类
背景 :
Fas (also known as Apo-1 and CD95) is a 40-50 kDa cell surface glycoprotein and a member of the TNF receptor family. Fas is an apotosis signalling molecule that forms the death inducing signalling complex (DISC) upon binding by the Fas ligand trimer on an adjacent cell. The Fas receptor also trimerizes, after which it is internalized and can then bind to the adaptor molecule FADD. FADD facilitates binding of caspase-8. which is activated to induce caspase-8 mediated apoptosis. Fas also plays a role in T cell mediated cytotoxicity and T cell development. Fas is found in the thymus, liver, heart, and ovary, where it is expressed on a minority of resting T and B cells and monocytes. The antagonistic ZB4 clone anti-Fas monoclonal has been used to block the apoptosis-inducing activity of the Anti-Fas CH-11 clone in multiple publications.
别名 :
APO-1 cell surface antigen;Apo-1 antigen;Apoptosis-mediating surface antigen FAS;CD95 antigen;FASLG receptor;Fas (TNF receptor superfamily, member 6);Fas AMA;Fas antigen;apoptosis antigen 1;tumor necrosis factor receptor superfamily member 6;tumor necrosis factor receptor superfamily, member 6
免疫原 :
Recombinant human Fas.
特异性 :
This antibody recognizes the human cell surface antigen Fas expressed in various human cells, including myeloid cells, T lympho-blastoid cells and diploid fibroblasts. It does not induce apoptosis in cell culture.
包装尺寸 :
100微克
用途 :
Western Blotting;Flow Cytometry;Neutralizing
储存 :
Stable for 1 year at from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
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  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.