This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
p21/WAF1/Cip1抗体
目录 :
05-345
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CP36, CP74
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀
文章摘录数: 31
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:4000; 图 10a
Kalita B, Ranjan R, Singh A, Yashavarddhan M, Bajaj S, Gupta M. A Combination of Podophyllotoxin and Rutin Attenuates Radiation Induced Gastrointestinal Injury by Negatively Regulating NF-?B/p53 Signaling in Lethally Irradiated Mice. PLoS ONE. 2016;11:e0168525 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Funauchi Y, Tanikawa C, Yi Lo P, Mori J, Daigo Y, Takano A, et al. Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep. 2015;5:16497 pubmed 出版商
  • 免疫印迹; 人类
Yang C, Chiang C, Chen C, Lee Y, Wu M, Tsou Y, et al. Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58). J Biomed Sci. 2015;22:33 pubmed 出版商
  • 免疫印迹; 人类
Sokka M, Rilla K, Miinalainen I, Pospiech H, Syväoja J. High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation. Nucleic Acids Res. 2015;43:4975-89 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Zeng L, Holly J, Perks C. Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells. Front Endocrinol (Lausanne). 2014;5:61 pubmed 出版商
  • 免疫印迹; 人类
Anderson V, Walton M, Eve P, Boxall K, Antoni L, Caldwell J, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011;71:463-72 pubmed 出版商
Calışkan B, Sinoplu E, İbiş K, Akhan Güzelcan E, Cetin Atalay R, Banoglu E. Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents. J Enzyme Inhib Med Chem. 2018;33:1352-1361 pubmed 出版商
Noh J, Kim K, Idda M, Martindale J, Yang X, Abdelmohsen K, et al. GRSF1 suppresses cell senescence. Aging (Albany NY). 2018;10:1856-1866 pubmed 出版商
Shih C, Chang Y, Chen Y, Ma C, Chen H, Yang C, et al. The PPARγ-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence. Aging Cell. 2017;16:797-813 pubmed 出版商
Benatti P, Basile V, Dolfini D, Belluti S, Tomei M, Imbriano C. NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription. Oncotarget. 2016;7:45901-45915 pubmed 出版商
Trino S, Iacobucci I, Erriquez D, Laurenzana I, De Luca L, Ferrari A, et al. Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients. Oncotarget. 2016;7:12951-61 pubmed 出版商
Kim M, Min D, Wright G, Goldlust I, Annunziata C. Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21. Oncotarget. 2014;5:12788-802 pubmed
Shi H, Fu C, Wang W, Li Y, Du S, Cao R, et al. The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. J Cell Mol Med. 2014;18:2061-70 pubmed 出版商
Colciago A, Ruscica M, Mornati O, Piccolella M, Montagnani Marelli M, Eberini I, et al. In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells. Biomed Res Int. 2014;2014:801473 pubmed 出版商
Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell S, Doxaki C, et al. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. PLoS Pathog. 2014;10:e1004136 pubmed 出版商
Chen Y, Lin H, Chen J, Tsai M, Hsieh H, Chang J, et al. CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. Int J Cancer. 2014;135:751-62 pubmed 出版商
Chuang M, Wu S, Tang S, Lai X, Lai H, Hsu K, et al. The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation. PLoS ONE. 2013;8:e73401 pubmed 出版商
Lin Y, Huang A, Kuo C, Yang J, Lan Y, Yu C, et al. Induction of cell cycle arrest and apoptosis in human osteosarcoma U-2 OS cells by Solanum lyratum extracts. Nutr Cancer. 2013;65:469-79 pubmed 出版商
Gonon G, Groetz J, De Toledo S, Howell R, Fromm M, Azzam E. Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations. Radiat Res. 2013;179:444-57 pubmed 出版商
Wang Y, Sun Y, Qiao S. ADAM23 knockdown promotes neuronal differentiation of P19 embryonal carcinoma cells by up-regulating P27KIP1 expression. Cell Biol Int. 2012;36:1275-9 pubmed 出版商
Neault M, Mallette F, Vogel G, Michaud Levesque J, Richard S. Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 2012;40:9513-21 pubmed 出版商
Parolin C, Calonghi N, Presta E, Boga C, Caruana P, Naldi M, et al. Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer. Biochim Biophys Acta. 2012;1821:1334-40 pubmed 出版商
Lu H, Tung W, Yang J, Huang F, Lee C, Huang Y, et al. In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol. J Agric Food Chem. 2012;60:7634-43 pubmed 出版商
Yu C, Ko F, Yu C, Lin C, Huang Y, Yang J, et al. Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells. Int J Oncol. 2012;41:1050-60 pubmed 出版商
Hayashi M, Cesare A, Fitzpatrick J, Lazzerini Denchi E, Karlseder J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Biol. 2012;19:387-94 pubmed 出版商
Bouchet B, Fauvet F, Grelier G, Galmarini C, Puisieux A. p21(Cip1) regulates cell-substrate adhesion and interphase microtubule dynamics in untransformed human mammary epithelial cells. Eur J Cell Biol. 2011;90:631-41 pubmed 出版商
Autsavapromporn N, De Toledo S, Little J, Jay Gerin J, Harris A, Azzam E. The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose ?-particle-irradiated human cells. Radiat Res. 2011;175:347-57 pubmed 出版商
Ruiz Miró M, Colomina N, Fernández R, Garí E, Gallego C, Aldea M. Translokin (Cep57) interacts with cyclin D1 and prevents its nuclear accumulation in quiescent fibroblasts. Traffic. 2011;12:549-62 pubmed 出版商
Napper J, Sollars V. 17-N-Allylamino-17-demethoxygeldanamycin induces a diverse response in human acute myelogenous cells. Leuk Res. 2010;34:1493-500 pubmed 出版商
Redmond K, Crawford N, Farmer H, D Costa Z, O Brien G, Buckley N, et al. T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells. Oncogene. 2010;29:3252-62 pubmed 出版商
Yao C, Yang C, Chuang S, Yan J, Liu C, Chen S, et al. Targeting PML-RAR? and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evid Based Complement Alternat Med. 2011;2011:984154 pubmed 出版商
产品信息
目录代码 :
05-345
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗p21/WAF1/Cip1抗体
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P38936
宿主名称 :
小鼠
抗原 :
p21/WAF1/Cip1
克隆 :
CP36, CP74
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
抗p21/WAF1/Cip1抗体
交叉活性 :
人类;小鼠
背景 :
Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically. The biochemical activities and patterns of expression of CKIs during development implicate these proteins as the primary effectors of signaling pathways that control cell cycle exit, an event that is critical for differentiation. Studies have shown that p21WAF1/Cip1 binds tightly to the G1 and S phase kinases, cyclin E/Cdk2, cyclin D/Cdk4, and cyclin A/Cdk2, and effectively inhibits their activity, whereas p21WAF1/Cip1 is a relatively poor inhibitor of the G2/M phase kinase cyclin B/Cdc2. In addition, p21WAF1/Cip1 inhibits proliferating cell nuclear antigen (PCNA), binds to and inhibits inactivation of Rb, which is essential for cell cycle progression, and may also interact with E2F and protect cells against p53-mediated apoptosis.
别名 :
CDK-interacting protein;CDK-interaction protein;DNA synthesis inhibitor;Melanoma differentiation-associated protein 6;cyclin-dependent kinase inhibitor 1A;melanoma differentiation associated protein 6;wild-type p53-activated fragment 1
免疫原 :
Recombinant full-length human Cip1 with a histidine tag.
特异性 :
Recognizes Cip1, MW 21 kDa
包装尺寸 :
200微克
用途 :
免疫印迹;免疫沉淀
储存 :
Stable for 1 year at from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
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  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.