This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
p21/WAF1/Cip1抗体
目录 :
05-345
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CP36, CP74
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀
文章摘录数: 31
出版应用/物种/样本/稀释 | 参考文献 |
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Trino S, Iacobucci I, Erriquez D, Laurenzana I, De Luca L, Ferrari A, et al. Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients. Oncotarget. 2016;7:12951-61 pubmed 出版商
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Kim M, Min D, Wright G, Goldlust I, Annunziata C. Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21. Oncotarget. 2014;5:12788-802 pubmed
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Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell S, Doxaki C, et al. The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. PLoS Pathog. 2014;10:e1004136 pubmed 出版商
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Gonon G, Groetz J, De Toledo S, Howell R, Fromm M, Azzam E. Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations. Radiat Res. 2013;179:444-57 pubmed 出版商
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产品信息
目录代码 :
05-345
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗p21/WAF1/Cip1抗体
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P38936
宿主名称 :
小鼠
抗原 :
p21/WAF1/Cip1
克隆 :
CP36, CP74
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
抗p21/WAF1/Cip1抗体
交叉活性 :
人类;小鼠
背景 :
Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically. The biochemical activities and patterns of expression of CKIs during development implicate these proteins as the primary effectors of signaling pathways that control cell cycle exit, an event that is critical for differentiation. Studies have shown that p21WAF1/Cip1 binds tightly to the G1 and S phase kinases, cyclin E/Cdk2, cyclin D/Cdk4, and cyclin A/Cdk2, and effectively inhibits their activity, whereas p21WAF1/Cip1 is a relatively poor inhibitor of the G2/M phase kinase cyclin B/Cdc2. In addition, p21WAF1/Cip1 inhibits proliferating cell nuclear antigen (PCNA), binds to and inhibits inactivation of Rb, which is essential for cell cycle progression, and may also interact with E2F and protect cells against p53-mediated apoptosis.
别名 :
CDK-interacting protein;CDK-interaction protein;DNA synthesis inhibitor;Melanoma differentiation-associated protein 6;cyclin-dependent kinase inhibitor 1A;melanoma differentiation associated protein 6;wild-type p53-activated fragment 1
免疫原 :
Recombinant full-length human Cip1 with a histidine tag.
特异性 :
Recognizes Cip1, MW 21 kDa
包装尺寸 :
200微克
用途 :
免疫印迹;免疫沉淀
储存 :
Stable for 1 year at from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany
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