This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
NFκB p52抗体
目录 :
05-361
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫沉淀, EMSA
文章摘录数: 25
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2
Schirmer M, Trentin L, Queudeville M, Seyfried F, Demir S, Tausch E, et al. Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death Dis. 2016;7:e2052 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Baydoun H, Cherian M, Green P, Ratner L. Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma. Retrovirology. 2015;12:71 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Moniz S, Bandarra D, Biddlestone J, Campbell K, Komander D, Bremm A, et al. Cezanne regulates E2F1-dependent HIF2α expression. J Cell Sci. 2015;128:3082-93 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Urban B, Collard T, Eagle C, Southern S, Greenhough A, Hamdollah Zadeh M, et al. BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. Gut. 2016;65:1151-64 pubmed 出版商
  • 免疫印迹; 人类
Greenfeld H, Takasaki K, Walsh M, Ersing I, Bernhardt K, Ma Y, et al. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015;11:e1004890 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed 出版商
  • 免疫印迹; 人类
Ledoux A, Sellier H, Gillies K, Iannetti A, James J, Perkins N. NF?B regulates expression of Polo-like kinase 4. Cell Cycle. 2013;12:3052-62 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Rauert Wunderlich H, Siegmund D, Maier E, Giner T, Bargou R, Wajant H, et al. The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NF?B transcription factors. PLoS ONE. 2013;8:e59292 pubmed 出版商
  • 免疫印迹; 人类
Fernandez G, Zaikos T, Khan S, Jacobi A, Behlke M, Zeichner S. Targeting I?B proteins for HIV latency activation: the role of individual I?B and NF-?B proteins. J Virol. 2013;87:3966-78 pubmed 出版商
D Ignazio L, Shakir D, Batie M, Müller H, Rocha S. HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6. Int J Mol Sci. 2020;21: pubmed 出版商
Kreckel J, Anany M, Siegmund D, Wajant H. TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling. Front Immunol. 2019;10:2024 pubmed 出版商
D Ignazio L, Batie M, Rocha S. TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway. Cells. 2018;7: pubmed 出版商
House C, Jordan E, Hernandez L, Ozaki M, James J, Kim M, et al. NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells. Cancer Res. 2017;77:6927-6940 pubmed 出版商
Vazquez Santillan K, Melendez Zajgla J, Jimenez Hernandez L, Gaytan Cervantes J, Muñoz Galindo L, Pina Sanchez P, et al. NF-kappa?-inducing kinase regulates stem cell phenotype in breast cancer. Sci Rep. 2016;6:37340 pubmed 出版商
Labouba I, Poisson A, Lafontaine J, Delvoye N, Gannon P, Le Page C, et al. The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo. Cancer Cell Int. 2014;14:67 pubmed 出版商
Carmona Arana J, Seher A, Neumann M, Lang I, Siegmund D, Wajant H. TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK. Front Immunol. 2014;5:63 pubmed 出版商
Vaque J, Gomez Lopez G, Monsálvez V, Varela I, Martinez N, Perez C, et al. PLCG1 mutations in cutaneous T-cell lymphomas. Blood. 2014;123:2034-43 pubmed 出版商
Kenneth N, Mudie S, Naron S, Rocha S. TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling. Biochem J. 2013;449:275-84 pubmed 出版商
Vaughan C, Singh S, Windle B, Sankala H, Graves P, Andrew Yeudall W, et al. p53 mutants induce transcription of NF-?B2 in H1299 cells through CBP and STAT binding on the NF-?B2 promoter and gain of function activity. Arch Biochem Biophys. 2012;518:79-88 pubmed 出版商
Ganeff C, Remouchamps C, Boutaffala L, Bénézech C, Galopin G, Vandepaer S, et al. Induction of the alternative NF-?B pathway by lymphotoxin ?? (LT??) relies on internalization of LT? receptor. Mol Cell Biol. 2011;31:4319-34 pubmed 出版商
Rauert H, Stühmer T, Bargou R, Wajant H, Siegmund D. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell Death Dis. 2011;2:e194 pubmed 出版商
Hildebrand J, Luo Z, Manske M, Price Troska T, Ziesmer S, Lin W, et al. A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling. J Exp Med. 2010;207:2569-79 pubmed 出版商
Li T, Morgan M, Choksi S, Zhang Y, Kim Y, Liu Z. MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol. 2010;11:799-805 pubmed 出版商
Arima K, Watanabe N, Hanabuchi S, Chang M, Sun S, Liu Y. Distinct signal codes generate dendritic cell functional plasticity. Sci Signal. 2010;3:ra4 pubmed 出版商
Wu L, Nakano H, Wu Z. The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1. J Biol Chem. 2006;281:2162-9 pubmed
产品信息
目录代码 :
05-361
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗NFκB p52抗体
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
Q00653
宿主名称 :
小鼠
抗原 :
NFκB p52
共轭标签 :
纯化
抗体亚型 :
IgG2a
产品描述 :
抗NFκB p52抗体
交叉活性 :
人类
背景 :
The NFκB transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The DNA binding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino terminus of a precursor designated p105. A cDNA has been isolated that encodes an alternative DNA binding subunit of NFκB. It is synthesized as a protein that is expressed in a variety of cell types and, like p105, undergoes cleavage to generate its NFκB subunit, in this case a protein designated p52 (previously referred to as p49). In contrast to p50 derived from p105, p52 acts in synergy with p65 to stimulate the HIV enhancer in transiently transfected Jurkat cells.
别名 :
DNA-binding factor KBF2;Lymphocyte translocation chromosome 10;Oncogene Lyt-10;nuclear factor of kappa light chain gene enhancer in B-cells 2;nuclear factor of kappa light polypeptide gene enhancer in B-cells 2;nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
免疫原 :
GST-fusion protein corresponding to amino acids 1-444 of human NFκB p52 subunit (Schmidt, R., 1991;Bours, V., 1992).
特异性 :
This antibody recognizes the p52 subunit of NFκB and its p100 precursor.
包装尺寸 :
200微克
用途 :
电泳迁移率变动分析 ;免疫沉淀;免疫印迹
储存 :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.