This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Ras相关C3肉毒杆菌毒素底物1抗体, 克隆23A8
目录 :
05-389
规格 :
250微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
23A8

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫印迹基因敲除验证
文章摘录数: 162
出版应用/物种/样本/稀释参考文献
  • 免疫沉淀; 人类; 图 s3c
  • 免疫印迹; 人类; 1:500; 图 s3c
Kennedy S, Jarboui M, Srihari S, Raso C, Bryan K, Dernayka L, et al. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 2020;11:499 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6c
Ommer A, Figlia G, Pereira J, Datwyler A, Gerber J, Degeer J, et al. Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system. J Cell Biol. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s1a
Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed 出版商
  • 免疫印迹; 人类; 图 4h
Huang L, Chambliss K, Gao X, Yuhanna I, Behling Kelly E, Bergaya S, et al. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature. 2019;569:565-569 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1c
Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed 出版商
  • 免疫印迹; 人类; 1:4000; 图 2c
Yue X, Zhang C, Zhao Y, Liu J, Lin A, Tan V, et al. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017;31:1641-1654 pubmed 出版商
  • 免疫印迹; 人类; 图 7e
Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017;36:6850-6862 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3b
Lavall D, Schuster P, Jacobs N, Kazakov A, Böhm M, Laufs U. Rac1 GTPase regulates 11β hydroxysteroid dehydrogenase type 2 and fibrotic remodeling. J Biol Chem. 2017;292:7542-7553 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 7b
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed 出版商
  • 免疫印迹; 人类; 图 1h
Li L, Baxter S, Gu N, Ji M, Zhan X. Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci. 2017;130:1475-1485 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3d
He Y, Northey J, Pelletier A, Kos Z, Meunier L, Haibe Kains B, et al. The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer. Oncogene. 2017;36:3490-3503 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1e
Ahn B, Coblentz P, Beharry A, Patel N, Judge A, Moylan J, et al. Diaphragm Abnormalities in Patients with End-Stage Heart Failure: NADPH Oxidase Upregulation and Protein Oxidation. Front Physiol. 2016;7:686 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s5c
Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, et al. A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. J Cell Biol. 2017;216:199-215 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Campa C, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, et al. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Sci Signal. 2016;9:ra124 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
  • 免疫印迹; 人类; 图 2
Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 6c
Ubba V, Soni U, Chadchan S, Maurya V, Kumar V, Maurya R, et al. RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model. Reprod Sci. 2017;24:738-752 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300; 图 4a
Priya R, Wee K, Budnar S, Gomez G, Yap A, Michael M. Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II. Cell Cycle. 2016;15:3033-3041 pubmed
  • 免疫印迹; 小鼠; 图 s10b
Hodgson L, Spiering D, Sabouri Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, et al. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nat Chem Biol. 2016;12:802-809 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2b
Desrochers L, Bordeleau F, Reinhart King C, Cerione R, Antonyak M. Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation. Nat Commun. 2016;7:11958 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 5
Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Hein A, Post C, Sheinin Y, Lakshmanan I, Natarajan A, Enke C, et al. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016;35:6319-6329 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:2000; 图 1
Nagase M, Kurihara H, Aiba A, Young M, Sakai T. Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS ONE. 2016;11:e0150886 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Tao Y, Hu K, Tan F, Zhang S, Zhou M, Luo J, et al. SH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathway. Oncotarget. 2016;7:18356-70 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Cho C, Lee K, Chen W, Wang C, Chang Y, Huang H, et al. MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer. Oncotarget. 2016;7:14586-604 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Pan D, Barber M, Hornigold K, Baker M, Toth J, Oxley D, et al. Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1. J Biol Chem. 2016;291:6359-75 pubmed 出版商
  • 免疫印迹; 牛; 图 4
Lampi M, Faber C, Huynh J, Bordeleau F, Zanotelli M, Reinhart King C. Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption. PLoS ONE. 2016;11:e0147033 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 2
Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, et al. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. elife. 2016;5:e10727 pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 6
  • 免疫印迹; 大鼠; 图 6
Fan S, Numata Y, Numata M. Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration. Mol Biol Cell. 2016;27:702-15 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Nagy Z, Wynne K, von Kriegsheim A, Gambaryan S, Smolenski A. Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets. J Biol Chem. 2015;290:29974-83 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015;35:14327-40 pubmed 出版商
  • 免疫印迹; 人类; 图 2
  • 免疫印迹; 大鼠; 图 4
  • 免疫印迹; 小鼠; 图 7
Yu D, Makkar G, Strickland D, Blanpied T, Stumpo D, Blackshear P, et al. Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation. J Am Heart Assoc. 2015;4:e002255 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 7
Yuzugullu H, Baitsch L, Von T, Steiner A, Tong H, Ni J, et al. A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis. Nat Commun. 2015;6:8501 pubmed 出版商
  • 免疫印迹; 大鼠; 1:200; 图 1i
Poitelon Y, Bogni S, Matafora V, Della Flora Nunes G, Hurley E, Ghidinelli M, et al. Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nat Commun. 2015;6:8303 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 s2h
  • 免疫印迹; 人类; 1:200; 图 s2j
Priya R, Gomez G, Budnar S, Verma S, Cox H, Hamilton N, et al. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol. 2015;17:1282-93 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Suárez Causado A, Caballero Díaz D, Bertrán E, Roncero C, Addante A, García Álvaro M, et al. HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model. Biochim Biophys Acta. 2015;1853:2453-63 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Razidlo G, Magnine C, Sletten A, Hurley R, Almada L, Fernandez Zapico M, et al. Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion. Cancer Res. 2015;75:2907-15 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
  • 免疫印迹; 人类; 图 5
D Hulst G, Sylow L, Hespel P, Deldicque L. Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle. Eur J Appl Physiol. 2015;115:1219-31 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, et al. Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res. 2015;25:157-68 pubmed 出版商
  • 免疫印迹; 小鼠; 图 8
Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood D, Schwartz M, et al. Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem. 2015;290:409-22 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Menhofer M, Bartel D, Liebl J, Kubisch R, Busse J, Wagner E, et al. In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor. Cardiovasc Res. 2014;104:303-14 pubmed 出版商
  • 免疫印迹; 人类
Zuo Y, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells. J Cell Biochem. 2015;116:124-32 pubmed 出版商
  • 免疫印迹; 人类
Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, et al. VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res. 2014;16:R53 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Romanov V, Brichkina A, Morrison H, Pospelova T, Pospelov V, Herrlich P. Novel mechanism of JNK pathway activation by adenoviral E1A. Oncotarget. 2014;5:2176-86 pubmed
  • 免疫印迹; 小鼠
Moissoglu K, Kiessling V, Wan C, Hoffman B, Norambuena A, Tamm L, et al. Regulation of Rac1 translocation and activation by membrane domains and their boundaries. J Cell Sci. 2014;127:2565-76 pubmed 出版商
  • 免疫印迹; 小鼠
Khan O, Akula M, Skålén K, Karlsson C, Ståhlman M, Young S, et al. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation. 2013;127:782-90 pubmed 出版商
  • 免疫印迹; 人类
Mayeenuddin L, Garrison J. Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. J Biol Chem. 2006;281:1921-8 pubmed
Akula M, Ibrahim M, Ivarsson E, Khan O, Kumar I, Erlandsson M, et al. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. Nat Commun. 2019;10:3975 pubmed 出版商
Shcherbakova D, Cox Cammer N, Huisman T, Verkhusha V, Hodgson L. Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET. Nat Chem Biol. 2018;14:591-600 pubmed 出版商
Bonfim Melo A, Ferreira d, Mortara R. Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. Front Microbiol. 2018;9:360 pubmed 出版商
Dendo K, Yugawa T, Nakahara T, Ohno S, Goshima N, Arakawa H, et al. Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression. Carcinogenesis. 2018;39:202-213 pubmed 出版商
Umezawa Y, Akiyama H, Okada K, Ishida S, Nogami A, Oshikawa G, et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). J Biol Chem. 2017;292:19639-19655 pubmed 出版商
He R, Peng J, Yuan P, Yang J, Wu X, Wang Y, et al. Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. Sci Rep. 2017;7:10532 pubmed 出版商
Leduc C, Etienne Manneville S. Regulation of microtubule-associated motors drives intermediate filament network polarization. J Cell Biol. 2017;216:1689-1703 pubmed 出版商
Choo M, Sano Y, Kim C, Yasuda K, Li X, Lin X, et al. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017;214:1297-1311 pubmed 出版商
Priya R, Liang X, Teo J, Duszyc K, Yap A, Gomez G. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Mol Biol Cell. 2017;28:12-20 pubmed 出版商
Schelle I, Bruening J, Buetepage M, Genth H. Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B. Toxins (Basel). 2016;9: pubmed 出版商
Deshmukh J, Pofahl R, Pfister H, Haase I. Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis. Oncotarget. 2016;7:57841-57850 pubmed 出版商
Gueguinou M, Harnois T, Crottès D, Uguen A, Déliot N, Gambade A, et al. SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline. Oncotarget. 2016;7:36168-36184 pubmed 出版商
Barrows D, Schoenfeld S, Hodakoski C, Silkov A, Honig B, Couvillon A, et al. p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. J Biol Chem. 2015;290:28915-31 pubmed 出版商
Jamieson C, Lui C, Brocardo M, Martino Echarri E, Henderson B. Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import. J Cell Sci. 2015;128:3933-46 pubmed 出版商
Yang Y, Park S, Nguyen T, Yu Y, Nguyen T, Sun E, et al. Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility. PLoS ONE. 2015;10:e0137889 pubmed 出版商
Liu W, Yue F, Zheng M, Merlot A, Bae D, Huang M, et al. The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget. 2015;6:8851-74 pubmed
Goka E, Lippman M. Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression. Oncogene. 2015;34:5395-405 pubmed 出版商
Ferraro A, Boni T, Pintzas A. EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene. PLoS ONE. 2014;9:e115276 pubmed 出版商
Menhofer M, Kubisch R, Schreiner L, Zorn M, Foerster F, Mueller R, et al. The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility. PLoS ONE. 2014;9:e112542 pubmed 出版商
Larson Casey J, Murthy S, Ryan A, Carter A. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. J Biol Chem. 2014;289:36204-19 pubmed 出版商
Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, et al. DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. J Immunol. 2014;193:5660-7 pubmed 出版商
Gray E, Petsalaki E, James D, Bagshaw R, Stacey M, Rocks O, et al. Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. J Biol Chem. 2014;289:35397-408 pubmed 出版商
Köster M, Dell Orco D, Koch K. The interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes. FEBS J. 2014;281:5175-85 pubmed 出版商
Ishii H, Saitoh M, Sakamoto K, Kondo T, Katoh R, Tanaka S, et al. Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. J Biol Chem. 2014;289:27386-99 pubmed 出版商
Bagci H, Laurin M, Huber J, Muller W, Côté J. Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling. Cell Death Dis. 2014;5:e1375 pubmed 出版商
Gomathinayagam R, Muralidharan J, Ha J, Varadarajalu L, Dhanasekaran D. Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes Cancer. 2014;5:84-99 pubmed
Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, et al. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol. 2014;205:97-111 pubmed 出版商
Song H, Bush R, Vijayasarathy C, Fariss R, Kjellstrom S, Sieving P. Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis. Invest Ophthalmol Vis Sci. 2014;55:2659-68 pubmed 出版商
Moon S, Han D, Kim Y, Jin J, Ho W, Kim Y. Interactome analysis of AMP-activated protein kinase (AMPK)-?1 and -?1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Sci Rep. 2014;4:4376 pubmed 出版商
Gungor B, Gombos I, Crul T, Ayaydin F, Szabo L, Torok Z, et al. Rac1 participates in thermally induced alterations of the cytoskeleton, cell morphology and lipid rafts, and regulates the expression of heat shock proteins in B16F10 melanoma cells. PLoS ONE. 2014;9:e89136 pubmed 出版商
Bachmann V, Bister K, Stefan E. Interplay of PKA and Rac: fine-tuning of Rac localization and signaling. Small Gtpases. 2013;4:247-51 pubmed 出版商
Rahman A, Davis B, Lövdahl C, Hanumaiah V, Feil R, Brakebusch C, et al. The small GTPase Rac1 is required for smooth muscle contraction. J Physiol. 2014;592:915-26 pubmed 出版商
de Kreuk B, Schaefer A, Anthony E, Tol S, Fernandez Borja M, Geerts D, et al. The human minor histocompatibility antigen 1 is a RhoGAP. PLoS ONE. 2013;8:e73962 pubmed 出版商
Cheung H, Dunbar C, Mórotz G, Cheng W, Chan H, Miller C, et al. FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J. 2014;28:337-49 pubmed 出版商
Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem. 2013;288:30815-31 pubmed 出版商
Itakura A, Aslan J, Kusanto B, Phillips K, Porter J, Newton P, et al. p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS ONE. 2013;8:e73063 pubmed 出版商
Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z, et al. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the G?q-p63RhoGEF-Rho GTPase pathway. Cancer Res. 2013;73:6206-18 pubmed 出版商
Yamazaki D, Itoh T, Miki H, Takenawa T. srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity. Mol Biol Cell. 2013;24:3393-405 pubmed 出版商
Chen Y, Chu H, Ze Shiang Lin -, Shiah W, Chou C, Klimstra D, et al. p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. PLoS ONE. 2013;8:e69389 pubmed 出版商
Favaro P, Traina F, Machado Neto J, Lazarini M, Lopes M, Pereira J, et al. FMNL1 promotes proliferation and migration of leukemia cells. J Leukoc Biol. 2013;94:503-12 pubmed 出版商
Aslan J, Baker S, Loren C, Haley K, Itakura A, Pang J, et al. The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol. 2013;305:C519-28 pubmed 出版商
Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, et al. The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation. Blood. 2013;122:386-93 pubmed 出版商
Ahn J, Truesdell P, Meens J, Kadish C, Yang X, Boag A, et al. Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis. Mol Cancer Res. 2013;11:952-63 pubmed 出版商
Herder C, Swiercz J, Müller C, Peravali R, Quiring R, Offermanns S, et al. ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation. Development. 2013;140:2787-97 pubmed 出版商
Ljubimova J, Kleinman M, Karabalin N, Inoue S, Konda B, Gangalum P, et al. Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors. Exp Toxicol Pathol. 2013;65:1063-71 pubmed 出版商
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产品信息
目录代码 :
05-389
亚类别 :
Cell Signaling
产品名称 :
抗Ras相关C3肉毒杆菌毒素底物1抗体, 克隆23A8
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P63000
宿主名称 :
小鼠
抗原 :
Ras相关C3肉毒杆菌毒素底物1
克隆 :
23A8
共轭标签 :
纯化
抗体亚型 :
IgG2b
产品描述 :
抗Ras相关C3肉毒杆菌毒素底物1抗体, 克隆23A8
交叉活性 :
人类;小鼠;大鼠
背景 :
Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.
免疫原 :
Recombinant protein containing the full length human Rac
特异性 :
Recognizes Rac1; Strong Rac1 preference with slight Rac2 cross-reactivity.
包装尺寸 :
250微克
用途 :
免疫组化;免疫沉淀;免疫印迹
储存 :
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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