This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
erbB-3/HER-3 Antibody, clone 2F12
目录 :
05-390
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 牛
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片
文章摘录数: 16
出版应用/物种/样本/稀释 | 参考文献 |
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| Momeny M, Saunus J, Marturana F, McCart Reed A, Black D, Sala G, et al. Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget. 2015;6:3932-46 pubmed
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Xiao Z, Sperl B, Ullrich A, Knyazev P. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. Oncotarget. 2014;5:12877-90 pubmed
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产品信息
目录代码 :
05-390
亚类别 :
Cell Signaling
产品名称 :
Anti-erbB-3/HER-3 Antibody, clone 2F12
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P21860
宿主名称 :
小鼠
抗原 :
erbB-3/HER-3
克隆 :
2F12
共轭标签 :
纯化
抗体亚型 :
IgG2aκ
产品描述 :
Anti-erbB-3/HER-3 Antibody, clone 2F12
交叉活性 :
人类;大鼠;小鼠;牛
背景 :
The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.
别名 :
Tyrosine kinase-type cell surface receptor HER3;lethal congenital contracture syndrome 2;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
免疫原 :
Recombinant rat erbB-3/HER-3 oncoprotein expressed in insect cells and purified by metal chelating chromatography. The epitope maps between amino acid residues 1295-1323 of human erbB-3. Clone 2F12.
特异性 :
This antibody recognizes erbB-3/HER-3, Mr 185 kDa. Does not cross-react with erbB-1 (EGFR) and erbB-2/HER-2.
包装尺寸 :
200微克
用途 :
免疫细胞化学;免疫组化;免疫沉淀;免疫印迹
储存 :
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations:
Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany
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