This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
GSK3抗体, 克隆4G-1E
目录 :
05-412
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
反应物种 :
人类, 小鼠, fruit fly
文章摘录数: 17
参考文献 |
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Reintsch W, Habring Mueller A, Wang R, Schohl A, Fagotto F. beta-Catenin controls cell sorting at the notochord-somite boundary independently of cadherin-mediated adhesion. J Cell Biol. 2005;170:675-86 pubmed
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Eickholt B, Walsh F, Doherty P. An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J Cell Biol. 2002;157:211-7 pubmed
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产品信息
目录代码 :
05-412
亚类别 :
Cell Signaling
产品名称 :
抗GSK3抗体, 克隆4G-1E
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P49840
宿主名称 :
小鼠
抗原 :
GSK3
克隆 :
4G-1E
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
抗GSK3抗体, 克隆4G-1E
交叉活性 :
Vertebrates;Mouse;Rat;Human;Dictyostelium;Yeast ( S. pombe )
背景 :
Glycogen synthase kinase-3 (GSK-3), a multifunctional serine/threonine kinase, is a key regulator of numerous signaling pathways. Two isoforms of GSK-3 are reported in mammals: a 51 kDa GSK-3a and a 47 kDa GSK-3b. These two isoforms exhibit about 98% homology in their kinase domains, but share only about 36% identity in the last 76 C-terminal amino acid residues. GSK-3a contains a glycine-rich extension at its N-terminus. A minor (~15% of total) splice variant of GSK-3b, GSK-3b2, has also been identified, which contains a 13-residue insert within the kinase domain. It exhibits reduced kinase activity towards tau protein compared with ‘unspliced’ GSK-3b. GSK-3b2 is localized primarily to neuronal cell bodies, unlike unspliced GSK-3b that is also found in neuronal processes. GSK-3b plays a key inhibitory role in the Wnt signaling pathway. Wnt genes encode a large family of secreted, cysteine-rich proteins that are important in development and in maintenance of adult tissues. Abnormalities in Wnt signaling are reported to promote both human dgenerative diseases and cancer.
别名 :
GSK-3甲;糖原合酶激酶3甲
免疫原 :
18 residue synthetic peptide (C-KQLLHGEP NVSYICSRY) corresponding to amino acids 203-219 derived from a region of the catalytic domain (between subdomain VII and VIII) of the Drosophila GSK3/shaggy enzyme, coupled to ovalbumin. Clone 4G-1E.
特异性 :
GSK3, α and β isoforms
包装尺寸 :
100微克
用途 :
免疫细胞化学;免疫印迹
储存 :
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany
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View all the new antibodies at www.emdmillipore.com.
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