Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

血管内皮生长因子抗体, 克隆JH

05-443

100微克

单克隆

小鼠

未共轭

JH

人类, 小鼠

Cell Signaling

抗血管内皮生长因子抗体, 克隆JH

抗体

单克隆抗体

P15692

小鼠

血管内皮生长因子

克隆JH

纯化

IgG1κ

抗血管内皮生长因子抗体, 克隆JH

人类;小鼠;大鼠;兔

The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines. Flt3 is also expressed the placenta, testis, spleen, thymus, bone marrow, brain and in cerebellar Purkinje cells. The VEGF receptors stimulate the Ras-MAP kinase pathway, suggesting that it signals as a conventional receptor tyrosine kinase.

Vascular permeability factor;vascular endothelial growth factor;vascular endothelial growth factor A;vascular endothelial growth factor isoform VEGF165

重组人类VEGF121。 克隆JH121

Recognizes 34-54 kDa isoforms of Vascular Endothelial Growth Factor/Vascular Permeability Factor (VEGF/VPF).

100微克

免疫组化(石蜡)

Stable for 1 year at from date of receipt.