Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

erbB-3/HER-3 Antibody, clone H3.105.5

05-471

100微克

单克隆

小鼠

未共轭

H3.105.5

Cell Signaling

Anti-erbB-3/HER-3 Antibody, clone H3.105.5

抗体

单克隆抗体

P21860

小鼠

erbB-3/HER-3

H3.105.5

纯化

IgG1

Anti-erbB-3/HER-3 Antibody, clone H3.105.5

人类;小鼠

erbB3 (HER3, c-erbB3) is a receptor tyrosine kinase (RTK). erbB3 is one of four members of the EGFR/ErbB family of receptor tyrosine kinases. The ErbB family of receptors are a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Though erbB3 is membrane bound and can bind its ligand, it does not have an active kinase domain so it can not transmit this signal without first forming a heterodimer with other EGFR family members. This heterodimerization then leads to proliferation and differentiation. erbB3 is also known to bind Phosphoinositide 3-kinase (PI3 Kinase, PI3K) though six tyrosine phosphorylation sites that PI3K can bind to, which results in the activation of Akt/PKB. erbB3 is known to be amplified in numerous cancers including breast and prostate.

Tyrosine kinase-type cell surface receptor HER3;lethal congenital contracture syndrome 2;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Extracellular domain of recombinant human erbB-3/HER-3 oncoprotein. Clone H3.105.5 Antibody Class IgG1, antibody produced by P3X63Ag8U1 (P3U1) x Balb/c spleen cells. Purified by ammonium sulfate precipitation, Sephacryl S-300 gel filtration and DEAE-52 chromatography.

This antibody recognizes erbB-3, Mr 185 kDa, but not EGF receptor, erbB-2/HER-2, or erbB-4/HER-4 Antibody Class IgG1, antibody produced by P3X63Ag8U1 (P3U1) x Balb/c spleen cells. Purified by ammonium sulfate precipitation, Sephacryl S-300 gel filtration and DEAE-52 chromatography.

100微克

Immunoprecipitation;Neutralizing

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.