This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Eck/EphA2 Antibody, clone D7
目录 :
05-480
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
D7

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠, 犬, 牛
文章摘录数: 9
参考文献
Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, et al. Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nat Commun. 2017;8:14646 pubmed 出版商
Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, et al. EphA2 is a functional receptor for the growth factor progranulin. J Cell Biol. 2016;215:687-703 pubmed
Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed 出版商
Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed 出版商
Sato M, Kadota M, Tang B, Yang H, Yang Y, Shan M, et al. An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-? in human breast cancer. Breast Cancer Res. 2014;16:R57 pubmed 出版商
Amato K, Wang S, Hastings A, Youngblood V, Santapuram P, Chen H, et al. Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC. J Clin Invest. 2014;124:2037-49 pubmed 出版商
Sáinz Jaspeado M, Huertas Martínez J, Lagares Tena L, Martín Liberal J, Mateo Lozano S, de Alava E, et al. EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1. PLoS ONE. 2013;8:e71449 pubmed 出版商
Tiwari A, Schneider M, Fiorino A, Haider R, Okoniewski M, Roschitzki B, et al. Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PLoS ONE. 2013;8:e69473 pubmed 出版商
Nair P, Salaita K, Petit R, Groves J. Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling. Nat Protoc. 2011;6:523-39 pubmed 出版商
产品信息
目录代码 :
05-480
亚类别 :
神经科学
产品名称 :
Anti-Eck/EphA2 Antibody, clone D7
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P29317
宿主名称 :
小鼠
抗原 :
Eck/EphA2
克隆 :
D7
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
Anti-Eck/EphA2 Antibody, clone D7
交叉活性 :
人类;大鼠;小鼠;牛;狗
背景 :
EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
别名 :
EPH receptor A2;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK;ephrin receptor EphA2;epithelial cell receptor protein tyrosine kinase;protein tyrosine kinase;receptor protein tyrosine kinase regulated by p53 and E2F-1
免疫原 :
Native protein isolated by purification of phosphotyrosine-containing proteins. Clone D7.
特异性 :
This antibody recognizes Epithelial Cell Kinase (Eck/EphA2), Mr 140 kDa
包装尺寸 :
200微克
用途 :
Immunocytochemistry;Immunoprecipitation;Enzyme Assay;Western Blotting
储存 :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. NOTE: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.