Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

磷酸化地图Kinase1/2抗体

05-481

100微克

单克隆

小鼠

未共轭

磷酸化

12D4

同一抗体克隆可从以下厂商购到:

• 北京傲锐东源: AM00084BT-N, AM00084PU-N, AM00084FC-N
• 圣克鲁斯生物技术: sc-81492

Cell Signaling

抗磷酸化地图Kinase1/2抗体

抗体

单克隆抗体

P27361

小鼠

磷酸化地图Kinase1/2

克隆12D4

纯化

IgG1κ

抗磷酸化地图Kinase1/2抗体

Human;Mouse;Rat;Avian;Canine

The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called p44 and p42 MAP kinases, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. Because the 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade, the two proteins are often referred to collectively as ERK1/2 or p44/p42 MAP kinase. The ERK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of ERK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand. Extracellular signal/mitogen activated protein kinases (erk/MAPK) are a group of proline-directed serine/threonine kinases that are activated by dual phosphorylation of conserved threonine and tyrosine residues within a characteristic T X Y peptide motif. The mitogen-activated kinases erk1 (MAPK1) and erk2 (MAPK2) acquire full enzymatic activity upon phosphorylation of both threonine and tyrosine residues within the sequence motif T E Y.

Extracellular signal-regulated kinase;Insulin-stimulated MAP2 kinase;MAP kinase 1;MAPK 1;Microtubule-associated protein 2 kinase;extracellular signal-related kinase 1;mitogen-activated protein kinase 3

KLH-conjugated phosphopeptide containing the pTEpY motif of Erk1 and Erk2. Clone: 12D4

Specific for phosphorylated (activated) Erk1 and Erk2. Antibody recognition requires phosphorylation of both the threonine and tyrosine residues of Erk1/Erk2 and will not interact with the non-phosphorylated form of the proteins. Does not cross react with activated SAP Kinase 1 or 2.

100微克

免疫印迹;免疫沉淀;酶联免疫吸附测定;免疫细胞化学

Stable for 1 year at from date of receipt.