| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
- 免疫印迹; 人类; 1:1000; 图 4b, 6s1c
- 免疫印迹; 小鼠; 1:1000; 图 2c
| Diaz Osterman C, Ozmadenci D, Kleinschmidt E, Taylor K, Barrie A, Jiang S, et al. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. elife. 2019;8: pubmed 出版商 |
- 免疫组化-石蜡切片; 人类; 1:500; 图 1a
- 免疫印迹; 人类; 图 2a
| Waters A, Stafman L, Garner E, Mruthyunjayappa S, Stewart J, Mroczek Musulman E, et al. Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells. Transl Oncol. 2016;9:263-73 pubmed 出版商 |
| Barcus C, Keely P, Eliceiri K, Schuler L. Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells. Oncotarget. 2016;7:48093-48106 pubmed 出版商 |
- 免疫沉淀; 人类; 图 2
- 免疫印迹; 人类; 图 2
| Budina Kolomets A, Webster M, Leu J, Jennis M, Krepler C, Guerrini A, et al. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016;76:2720-30 pubmed 出版商 |
| Petridou N, Skourides P. A ligand-independent integrin β1 mechanosensory complex guides spindle orientation. Nat Commun. 2016;7:10899 pubmed 出版商 |
| Waters A, Stewart J, Atigadda V, Mroczek Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies. Mol Cancer Ther. 2016;15:911-21 pubmed 出版商 |
- 免疫细胞化学; 人类; 1:50; 图 4
- 免疫印迹; 人类; 1:800; 图 6
| Swaminathan V, Fischer R, Waterman C. The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin. Mol Biol Cell. 2016;27:1085-100 pubmed 出版商 |
| Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed 出版商 |
| Dave J, Abbey C, Duran C, Seo H, Johnson G, Bayless K. Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase. J Cell Sci. 2016;129:743-56 pubmed 出版商 |
| Picot N, Guerrette R, Beauregard A, Jean S, Michaud P, Harquail J, et al. Mammaglobin 1 promotes breast cancer malignancy and confers sensitivity to anticancer drugs. Mol Carcinog. 2016;55:1150-62 pubmed 出版商 |
| Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2016;35:1926-42 pubmed 出版商 |
| Trerotola M, Ganguly K, Fazli L, Fedele C, Lu H, Dutta A, et al. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget. 2015;6:14318-28 pubmed |
| Tancioni I, Miller N, Uryu S, Lawson C, Jean C, Chen X, et al. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res. 2015;17:47 pubmed 出版商 |
| Gillory L, Stewart J, Megison M, Waters A, Beierle E. Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival. J Surg Res. 2015;196:339-49 pubmed 出版商 |
| Morris E, Assi K, Salh B, Dedhar S. Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum. Sci Rep. 2015;5:8389 pubmed 出版商 |
| Curran C, Carrillo E, Ponik S, Keely P. Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells. Environ Toxicol Pharmacol. 2015;39:114-24 pubmed 出版商 |
| Golubovskaya V, Ylagan L, Miller A, Hughes M, Wilson J, Wang D, et al. High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer. 2014;14:769 pubmed 出版商 |
| Bjerke M, Dzamba B, Wang C, DeSimone D. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. Dev Biol. 2014;394:340-56 pubmed 出版商 |
| Dy G, Ylagan L, Pokharel S, Miller A, Brese E, Bshara W, et al. The prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancer. J Thorac Oncol. 2014;9:1278-84 pubmed 出版商 |
| Son J, Jeong H, Kim H, Kim Y, Lee E, Lee H, et al. Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase. Biochem Pharmacol. 2014;89:236-45 pubmed 出版商 |
| Yoon H, Choi Y, Song J, Do I, Kang S, Ko Y, et al. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PLoS ONE. 2014;9:e88587 pubmed 出版商 |
- 免疫印迹基因敲除验证; 小鼠; 图 1c
- 免疫组化-石蜡切片; 人类; 1:100; 图 1a
- 免疫印迹; 人类; 图 2a
| Megison M, Gillory L, Stewart J, Nabers H, Mrozcek Musulman E, Beierle E. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res. 2014;12:514-26 pubmed 出版商 |
| Thapa N, Choi S, Hedman A, Tan X, Anderson R. Phosphatidylinositol phosphate 5-kinase I?i2 in association with Src controls anchorage-independent growth of tumor cells. J Biol Chem. 2013;288:34707-18 pubmed 出版商 |
| Dave J, Kang H, Abbey C, Maxwell S, Bayless K. Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). J Biol Chem. 2013;288:30720-33 pubmed 出版商 |
- 免疫组化-石蜡切片; 人类; 1:100
- 免疫细胞化学; 人类; 1:1000
- 免疫印迹; 人类
| Stewart J, Ma X, Megison M, Nabers H, Cance W, Kurenova E, et al. Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Mol Carcinog. 2015;54:9-23 pubmed 出版商 |
| Henderson Y, Toro Serra R, Chen Y, Ryu J, Frederick M, Zhou G, et al. Src inhibitors in suppression of papillary thyroid carcinoma growth. Head Neck. 2014;36:375-84 pubmed 出版商 |
| Barcus C, Keely P, Eliceiri K, Schuler L. Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells. J Biol Chem. 2013;288:12722-32 pubmed 出版商 |
- 免疫组化-石蜡切片; 小鼠; 1:200
- 免疫印迹; 人类
| Megison M, Stewart J, Nabers H, Gillory L, Beierle E. FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastoma. Clin Exp Metastasis. 2013;30:555-68 pubmed 出版商 |
- 免疫细胞化学; 人类; 1:1000
- 免疫印迹; 人类; 图 s10
| Beierle E, Ma X, Stewart J, Megison M, Cance W, Kurenova E. Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Mol Carcinog. 2014;53:230-42 pubmed 出版商 |
| Vickerman V, Kamm R. Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions. Integr Biol (Camb). 2012;4:863-74 pubmed 出版商 |
- 免疫细胞化学基因敲除验证; 小鼠; 图 1c
- 免疫组化基因敲除验证; 小鼠; 图 2c
- 免疫印迹基因敲除验证; 小鼠; 图 1b
- 免疫组化-石蜡切片; 小鼠; 图 2c
| van Miltenburg M, Lalai R, de Bont H, van Waaij E, Beggs H, Danen E, et al. Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility. FASEB J. 2009;23:3482-93 pubmed 出版商 |
| Kim Y, Kim H, Kim H, Gawk H, Bae S, Sim H, et al. FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer. Cancers (Basel). 2019;11: pubmed 出版商 |
| Zhao W, Liu D, Wei J, Miao Z, Zhang K, Su Z, et al. Caspr1 is a host receptor for meningitis-causing Escherichia coli. Nat Commun. 2018;9:2296 pubmed 出版商 |
| Benzina S, Harquail J, Guerrette R, O Brien P, Jean S, Crapoulet N, et al. Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. J Cancer. 2016;7:2035-2044 pubmed 出版商 |
| Kir D, Saluja M, Modi S, Venkatachalam A, Schnettler E, Roy S, et al. Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis. Oncotarget. 2016;7:65348-65363 pubmed 出版商 |
| Harizanova J, Fermin Y, Malik Sheriff R, Wieczorek J, Ickstadt K, Grecco H, et al. Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions. PLoS ONE. 2016;11:e0160591 pubmed 出版商 |
| Huynh N, Everts V, Leethanakul C, Pavasant P, Ampornaramveth R. Rinsing with Saline Promotes Human Gingival Fibroblast Wound Healing In Vitro. PLoS ONE. 2016;11:e0159843 pubmed 出版商 |
| Gao C, Chen G, Kuan S, Zhang D, Schlaepfer D, Hu J. FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. elife. 2015;4: pubmed 出版商 |
| Williams K, Bundred N, Landberg G, Clarke R, Farnie G. Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem Cells. 2015;33:327-41 pubmed 出版商 |
| van Miltenburg M, van Nimwegen M, Tijdens I, Lalai R, Kuiper R, Klarenbeek S, et al. Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation. Br J Cancer. 2014;110:2747-55 pubmed 出版商 |
| Wan H, Mruk D, Wong C, Cheng C. Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study. Endocrinology. 2014;155:249-62 pubmed 出版商 |
| Chen Y, Lu H, Hsu S, Kuo C, Chang S, Lin J, et al. Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways. Environ Toxicol. 2015;30:74-82 pubmed 出版商 |
| Kawada I, Hasina R, Lennon F, Bindokas V, Usatyuk P, Tan Y, et al. Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer. Cancer Biol Ther. 2013;14:679-91 pubmed 出版商 |
| Lai W, Hsu S, Chueh F, Chen Y, Yang J, Lin J, et al. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013;33:1941-50 pubmed |
| Fromont G, Godet J, Peyret A, Irani J, Celhay O, Rozet F, et al. 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. Hum Pathol. 2013;44:1617-23 pubmed 出版商 |
| Lu C, Yang J, Chiang J, Hour M, Amagaya S, Lu K, et al. Inhibition of invasion and migration by newly synthesized quinazolinone MJ-29 in human oral cancer CAL 27 cells through suppression of MMP-2/9 expression and combined down-regulation of MAPK and AKT signaling. Anticancer Res. 2012;32:2895-903 pubmed |
| Bougault C, Aubert Foucher E, Paumier A, Perrier Groult E, Huot L, Hot D, et al. Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes. PLoS ONE. 2012;7:e36964 pubmed 出版商 |
| Welman A, Sproul D, Mullen P, Muir M, Kinnaird A, Harrison D, et al. Diversity of matriptase expression level and function in breast cancer. PLoS ONE. 2012;7:e34182 pubmed 出版商 |
| Lahlou H, Sanguin Gendreau V, Frame M, Muller W. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res. 2012;14:R36 pubmed |
| Shaw C, Grobmyer S, Ucar D, Cance W, Reith J, Hochwald S. Elevated expression of IRS2 in the progression from neurofibroma to malignant peripheral nerve sheath tumor. Anticancer Res. 2012;32:439-43 pubmed |
| Huang C, Fu X, Liu J, Qi Y, Li S, Wang H. The involvement of integrin ?1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers. Biomaterials. 2012;33:1791-800 pubmed 出版商 |
| Wortmann A, He Y, Christensen M, Linn M, Lumley J, Pollock P, et al. Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. J Biol Chem. 2011;286:42303-15 pubmed 出版商 |
| Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol Cancer. 2011;10:118 pubmed 出版商 |
| Eke I, Cordes N. Dual targeting of EGFR and focal adhesion kinase in 3D grown HNSCC cell cultures. Radiother Oncol. 2011;99:279-86 pubmed 出版商 |
| Tall E, Bernstein A, Oliver N, Gray J, Masur S. TGF-?-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2010;51:5002-11 pubmed 出版商 |
| Sun Y, Ling K, Wagoner M, Anderson R. Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J Cell Biol. 2007;178:297-308 pubmed |
| Kornberg L, Grant M. Adenoviruses increase endothelial cell proliferation, migration, and tube formation: partial reversal by the focal adhesion kinase inhibitor, FRNK. Microvasc Res. 2007;73:157-62 pubmed |
| Banu N, Teichman J, Dunlap Brown M, Villegas G, Tufro A. Semaphorin 3C regulates endothelial cell function by increasing integrin activity. FASEB J. 2006;20:2150-2 pubmed |
| Guan F, Villegas G, Teichman J, Mundel P, Tufro A. Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP. Am J Physiol Renal Physiol. 2006;291:F422-8 pubmed |
| Hoffman L, Jensen C, Kloeker S, Wang C, Yoshigi M, Beckerle M. Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol. 2006;172:771-82 pubmed |
| Ling K, Doughman R, Iyer V, Firestone A, Bairstow S, Mosher D, et al. Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. J Cell Biol. 2003;163:1339-49 pubmed |
