产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Akt/PKB Antibody, PH Domain, clone SKB1
目录 :
05-591
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
SKB1
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 22
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:500; 图 7a
Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, et al. The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. Nat Commun. 2017;8:15663 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s1b
Kuo W, Hwu L, Wu C, Lee J, Chang C, Liu R. STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer. Theranostics. 2017;7:647-663 pubmed 出版商
  • 免疫印迹; 大鼠; 图 7e
Houddane A, Bultot L, Novellasdemunt L, Johanns M, Gueuning M, Vertommen D, et al. Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes. Cell Signal. 2017;34:23-37 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, et al. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. J Neuroinflammation. 2017;14:9 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed 出版商
  • 免疫印迹; 人类
Bawadekar M, de Andrea M, Lo Cigno I, Baldanzi G, Caneparo V, Graziani A, et al. The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation. J Interferon Cytokine Res. 2015;35:441-53 pubmed 出版商
  • 免疫印迹; 小鼠
Young M, Brewer R, Peliciari Garcia R, Collins H, He L, Birky T, et al. Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart. J Biol Rhythms. 2014;29:257-76 pubmed 出版商
  • 免疫印迹; 人类
Glorieux C, Auquier J, Dejeans N, Sid B, Demoulin J, Bertrand L, et al. Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway. Biochem Pharmacol. 2014;89:217-23 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Pulinilkunnil T, Kienesberger P, Nagendran J, Sharma N, Young M, Dyck J. Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity. Int J Obes (Lond). 2014;38:205-15 pubmed 出版商
Dong C, Rovnaghi C, Anand K. Ketamine affects the neurogenesis of rat fetal neural stem progenitor cells via the PI3K/Akt-p27 signaling pathway. Birth Defects Res B Dev Reprod Toxicol. 2014;101:355-63 pubmed 出版商
Zhang W, Xiao H, Parkin K. Apoptosis in MCF-7 breast cancer cells induced by S-alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite. Food Chem Toxicol. 2014;68:1-10 pubmed 出版商
Yue M, Li Q, Zhang Y, Zhao Y, Zhang Z, Bao S. Histone H4R3 methylation catalyzed by SKB1/PRMT5 is required for maintaining shoot apical meristem. PLoS ONE. 2013;8:e83258 pubmed 出版商
Tsai S, Lu C, Lee C, Lin Y, Chung J, Kuo S, et al. AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells. Int J Oncol. 2012;41:1683-92 pubmed 出版商
Lin H, Chen Y, Hsu W, Yang C, Kao C, Tsai T. Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse model. Cancer Prev Res (Phila). 2012;5:952-62 pubmed 出版商
Jones L, Antonelli J, Masko E, Broadwater G, Lascola C, Fels D, et al. Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. J Appl Physiol (1985). 2012;113:263-72 pubmed 出版商
Stains C, Tedford N, Walkup T, Luković E, Goguen B, Griffith L, et al. Interrogating signaling nodes involved in cellular transformations using kinase activity probes. Chem Biol. 2012;19:210-7 pubmed 出版商
Gannon J, Ohlendieck K. Subproteomic analysis of basic proteins in aged skeletal muscle following offgel pre-fractionation. Mol Med Rep. 2012;5:993-1000 pubmed 出版商
Pulinilkunnil T, He H, Kong D, Asakura K, Peroni O, Lee A, et al. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011;286:8798-809 pubmed 出版商
Lapchak P, SCHUBERT D, Maher P. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. J Neurochem. 2011;116:122-31 pubmed 出版商
Treebak J, Taylor E, Witczak C, An D, Toyoda T, Koh H, et al. Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. Am J Physiol Cell Physiol. 2010;298:C377-85 pubmed 出版商
Gannon J, Doran P, Kirwan A, Ohlendieck K. Drastic increase of myosin light chain MLC-2 in senescent skeletal muscle indicates fast-to-slow fibre transition in sarcopenia of old age. Eur J Cell Biol. 2009;88:685-700 pubmed 出版商
Lin H, Chiou S, Wu C, Lin W, Chen L, Yang Y, et al. Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J Pharmacol Exp Ther. 2007;323:365-73 pubmed
产品信息
目录代码 :
05-591
亚类别 :
Cell Signaling
产品名称 :
Anti-Akt/PKB Antibody, PH Domain, clone SKB1
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P31749
宿主名称 :
小鼠
抗原 :
Akt/PKB
克隆 :
SKB1
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
Anti-Akt/PKB Antibody, PH Domain, clone SKB1
交叉活性 :
人类;小鼠;大鼠
背景 :
Akt (protein kinase B), a serine/threonine kinase, has emerged as a critical enzyme in signal transduction pathways involved in cell proliferation, apoptosis, angiogenesis, and diabetes. In mammals three isoforms of Akt (α, β, γ or Akt 1, 2, 3) are reported that exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt α is the predominant isoform in most tissues, whereas the highest expression of Akt β is observed in the insulin-responsive tissues, and Akt γ is abundant in brain tissue. Each Akt isoform is composed of three functionally distinct regions: an N-terminal pleckstrin homology (PH) domain that provides a lipid-binding module to direct Akt to PIP2 and PIP3, a central catalytic domain, and a C-terminal hydrophobic motif.
免疫原 :
GST-fusion protein corresponding to residues 1-149 of human Akt1
特异性 :
识别Akt1/PKBα
包装尺寸 :
100微克
用途 :
流式细胞仪;免疫细胞化学;免疫沉淀;免疫印迹
储存 :
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.