This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
RNA polymerase II Antibody, clone CTD4H8, Ascites Free
目录 :
05-623-Z
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CTD4H8

同一抗体克隆可从以下厂商购到:
反应物种 :
酵母菌目, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq
文章摘录数: 59
出版应用/物种/样本/稀释参考文献
  • 免疫沉淀; 人类; 图 6d
Fujimoto M, Takii R, Katiyar A, Srivastava P, Nakai A. Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA. Mol Cell Biol. 2018;38: pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4c
Audet Walsh E, Yee T, Tam I, Giguere V. Inverse Regulation of DHT Synthesis Enzymes 5?-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer. Endocrinology. 2017;158:1015-1021 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4b
Hu T, Zhu X, Pi W, Yu M, Shi H, Tuan D. Hypermethylated LTR retrotransposon exhibits enhancer activity. Epigenetics. 2017;12:226-237 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5b
  • 染色质免疫沉淀 ; 小鼠; 图 5a
Vispute S, Bu P, Le Y, Cheng X. Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction. Toxicology. 2017;378:95-106 pubmed 出版商
  • ChIP-Seq; 人类; 图 4
Gilan O, Lam E, Becher I, Lugo D, Cannizzaro E, Joberty G, et al. Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nat Struct Mol Biol. 2016;23:673-81 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 7e
Yamashita D, Moriuchi T, Osumi T, Hirose F. Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α. J Biol Chem. 2016;291:11619-34 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 6g
Shao Z, Zhang R, Khodadadi Jamayran A, Chen B, Crowley M, Festok M, et al. The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun. 2016;7:10869 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:100; 图 5b
Wang X, Jung Y, Jun S, Lee S, Wang W, Schneider A, et al. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun. 2016;7:10633 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Madsen A, Bozickovic O, Bjune J, Mellgren G, Sagen J. Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Sci Rep. 2015;5:16430 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 6
Tan K, Fujimoto M, Takii R, Takaki E, Hayashida N, Nakai A. Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity. Nat Commun. 2015;6:6580 pubmed 出版商
  • 免疫印迹; 人类; 图 4
García Carmona Y, Cols M, Ting A, Radigan L, Yuk F, Zhang L, et al. Differential induction of plasma cells by isoforms of human TACI. Blood. 2015;125:1749-58 pubmed 出版商
  • 免疫印迹; 酵母菌目
Allepuz Fuster P, Martínez Fernández V, Garrido Godino A, Alonso Aguado S, Hanes S, Navarro F, et al. Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation. Nucleic Acids Res. 2014;42:13674-88 pubmed
  • 染色质免疫沉淀 ; 人类; 图 1
Maruyama A, Mimura J, Itoh K. Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding. Nucleic Acids Res. 2014;42:13599-614 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Wright R, Slemmons K, Vaughan A. Estradiol induces gene proximity and MLL-MLLT3 fusion in an activation-induced cytidine deaminase-mediated pathway. Leuk Lymphoma. 2015;56:1460-5 pubmed 出版商
  • 免疫沉淀; 酵母菌目
Mirón García M, Garrido Godino A, Martínez Fernández V, Fernández Pévida A, Cuevas Bermúdez A, Martín Expósito M, et al. The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription. Nucleic Acids Res. 2014;42:9666-76 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Maruyama A, Mimura J, Harada N, Itoh K. Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter. Nucleic Acids Res. 2013;41:5223-34 pubmed 出版商
Chappidi N, Nascakova Z, Boleslavska B, Zellweger R, Isik E, Andrs M, et al. Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Mol Cell. 2019;: pubmed 出版商
Baquero Perez B, Antanaviciute A, Yonchev I, Carr I, Wilson S, Whitehouse A. The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus. elife. 2019;8: pubmed 出版商
Rossi M, Bucci G, Rizzotto D, Bordo D, Marzi M, Puppo M, et al. LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β. Nat Commun. 2019;10:1969 pubmed 出版商
Sharma P, Lioutas A, Fernandez Fuentes N, Quilez J, Carbonell Caballero J, Wright R, et al. Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription. Mol Cell. 2019;73:84-96.e7 pubmed 出版商
Bornelöv S, Reynolds N, Xenophontos M, Gharbi S, Johnstone E, Floyd R, et al. The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression. Mol Cell. 2018;71:56-72.e4 pubmed 出版商
Cannizzaro E, Bannister A, Han N, Alendar A, Kouzarides T. DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4. FEBS Lett. 2018;592:2308-2322 pubmed 出版商
Kim M, Xia B, Suh H, Lee S, Jun S, Lien E, et al. PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis. Dev Cell. 2018;44:582-596.e4 pubmed 出版商
Tan X, Banerjee P, Liu X, Yu J, Gibbons D, Wu P, et al. The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest. 2018;128:1267-1282 pubmed 出版商
Chen J, Teo B, Cai Y, Wee S, Lu J. The linker histone H1.2 is a novel component of the nucleolar organizer regions. J Biol Chem. 2018;293:2358-2369 pubmed 出版商
Bugge M, Bergstrom B, Eide O, Solli H, Kjønstad I, Stenvik J, et al. Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness. J Biol Chem. 2017;292:15408-15425 pubmed 出版商
Lu W, Katzenellenbogen B. Estrogen Receptor-? Modulation of the ER?-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer. Horm Cancer. 2017;8:230-242 pubmed 出版商
Ono R, Masuya M, Ishii S, Katayama N, Nosaka T. Eya2, a Target Activated by Plzf, Is Critical for PLZF-RARA-Induced Leukemogenesis. Mol Cell Biol. 2017;37: pubmed 出版商
Slobodin B, Han R, Calderone V, Vrielink J, Loayza Puch F, Elkon R, et al. Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation. Cell. 2017;169:326-337.e12 pubmed 出版商
Ma J, Sanchez B, Hall D, Tremblay A, Di Marco S, Gallouzi I. STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner. EMBO Mol Med. 2017;9:622-637 pubmed 出版商
Martínez Alonso M, Hengrung N, Fodor E. RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II. J Virol. 2016;90:6014-6021 pubmed 出版商
Hsu C, Liu J, Wu P, Guan H, Chen Y, Lin A, et al. Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol. 2014;8:1575-87 pubmed 出版商
Khurana J, Wang X, Chen X, Perlman D, Landweber L. Transcription-independent functions of an RNA polymerase II subunit, Rpb2, during genome rearrangement in the ciliate, Oxytricha trifallax. Genetics. 2014;197:839-49 pubmed 出版商
Sonzogni S, Ogara M, Belluscio L, Castillo D, Scassa M, Cánepa E. p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation. Biochim Biophys Acta. 2014;1840:2171-83 pubmed 出版商
Angulo Rojo C, Manning Cela R, Aguirre A, Ortega A, Lopez Bayghen E. Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA. ASN Neuro. 2013;5:e00130 pubmed 出版商
Tanaka Nakanishi A, Yasunaga J, Takai K, Matsuoka M. HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization. Cancer Res. 2014;74:188-200 pubmed 出版商
Lim H, Dimova N, Tan M, Sigoillot F, King R, Shi Y. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Mol Cell Biol. 2013;33:4166-80 pubmed 出版商
Garrido Godino A, García López M, Navarro F. Correct assembly of RNA polymerase II depends on the foot domain and is required for multiple steps of transcription in Saccharomyces cerevisiae. Mol Cell Biol. 2013;33:3611-26 pubmed 出版商
Chen W, Jia W, Wang K, Si X, Zhu S, Duan T, et al. Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells. PLoS ONE. 2013;8:e66076 pubmed 出版商
Udofa E, Stringer B, Gade P, Mahony D, Buzza M, Kalvakolanu D, et al. The transcription factor C/EBP-? mediates constitutive and LPS-inducible transcription of murine SerpinB2. PLoS ONE. 2013;8:e57855 pubmed 出版商
Wong J, Mehta V, Voronova A, Coutu J, Ryan T, Shelton M, et al. ?-catenin is essential for efficient in vitro premyogenic mesoderm formation but can be partially compensated by retinoic acid signalling. PLoS ONE. 2013;8:e57501 pubmed 出版商
Tashiro S, Asano T, Kanoh J, Ishikawa F. Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast. Genes Cells. 2013;18:327-39 pubmed 出版商
He S, Khan D, Winter S, Seiser C, Davie J. Dynamic distribution of HDAC1 and HDAC2 during mitosis: association with F-actin. J Cell Physiol. 2013;228:1525-35 pubmed 出版商
Wier E, Neighoff J, Sun X, Fu K, Wan F. Identification of an N-terminal truncation of the NF-?B p65 subunit that specifically modulates ribosomal protein S3-dependent NF-?B gene expression. J Biol Chem. 2012;287:43019-29 pubmed 出版商
Cherian M, Wilson E, Shapiro D. A competitive inhibitor that reduces recruitment of androgen receptor to androgen-responsive genes. J Biol Chem. 2012;287:23368-80 pubmed 出版商
Jani D, Lutz S, Hurt E, Laskey R, Stewart M, Wickramasinghe V. Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res. 2012;40:4562-73 pubmed 出版商
Ianculescu I, Wu D, Siegmund K, Stallcup M. Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. J Biol Chem. 2012;287:4000-13 pubmed 出版商
Lee Y, Lee J, Ho C, Hong Q, Yu S, Tzeng C, et al. miRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells. Breast Cancer Res. 2011;13:R116 pubmed 出版商
Grbic D, Degagné E, Larrivée J, Bilodeau M, Vinette V, Arguin G, et al. P2Y6 receptor contributes to neutrophil recruitment to inflamed intestinal mucosa by increasing CXC chemokine ligand 8 expression in an AP-1-dependent manner in epithelial cells. Inflamm Bowel Dis. 2012;18:1456-69 pubmed 出版商
Purcell D, Jeong K, Bittencourt D, Gerke D, Stallcup M. A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulation. J Biol Chem. 2011;286:41963-71 pubmed 出版商
Garcia Lopez M, Pelechano V, Mirón García M, Garrido Godino A, Garcia A, Calvo O, et al. The conserved foot domain of RNA pol II associates with proteins involved in transcriptional initiation and/or early elongation. Genetics. 2011;189:1235-48 pubmed 出版商
Gorski J, Savage K, Mulligan J, McDade S, Blayney J, Ge Z, et al. Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis. Nucleic Acids Res. 2011;39:9536-48 pubmed 出版商
Furumai R, Ito A, Ogawa K, Maeda S, Saito A, Nishino N, et al. Histone deacetylase inhibitors block nuclear factor-?B-dependent transcription by interfering with RNA polymerase II recruitment. Cancer Sci. 2011;102:1081-7 pubmed 出版商
Garcia A, Rosonina E, Manley J, Calvo O. Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. Mol Cell Biol. 2010;30:5180-93 pubmed 出版商
Pfenning A, Kim T, Spotts J, Hemberg M, Su D, West A. Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PLoS ONE. 2010;5:e10870 pubmed 出版商
Bitler B, Goverdhan A, Schroeder J. MUC1 regulates nuclear localization and function of the epidermal growth factor receptor. J Cell Sci. 2010;123:1716-23 pubmed 出版商
Harte M, O Brien G, Ryan N, Gorski J, Savage K, Crawford N, et al. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. Cancer Res. 2010;70:2538-47 pubmed 出版商
Torres Padilla M, Zernicka Goetz M. Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J Cell Biol. 2006;174:329-38 pubmed
Shopland L, Lynch C, Peterson K, Thornton K, Kepper N, Hase J, et al. Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence. J Cell Biol. 2006;174:27-38 pubmed
产品信息
目录代码 :
05-623-Z
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
Anti-RNA polymerase II Antibody, clone CTD4H8, Ascites Free
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P24928
宿主名称 :
小鼠
抗原 :
RNA聚合酶II
克隆 :
CTD4H8
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-RNA polymerase II Antibody, clone CTD4H8, Ascites Free
交叉活性 :
人类;小鼠;大鼠;酵母
背景 :
RNA polymerase II (Pol II) is a multi-subunit enzyme responsible for the transcription of protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. Pol II can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription.
别名 :
DNA-directed RNA polymerase II subunit RPB1;RNA polymerase II subunit B1;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA-directed RNA polymerase II subunit RPB1
免疫原 :
Linear peptide corresponding to human RNA polymerase II.
包装尺寸 :
200微克
用途 :
Western Blotting;Immunocytochemistry;ChIP-seq
储存 :
收到之日起在2-8℃稳定1年
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.