This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301, Alexa Fluor系列荧光染料®647
目录 :
05-636-AF647
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AF647
抗原修饰 :
磷酸化
克隆名称 :
JBW301
文章摘录数: 5
参考文献
Abe H, Alavattam K, Hu Y, Pang Q, Andreassen P, Hegde R, et al. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Curr Biol. 2019;: pubmed 出版商
Aubrey B, Janic A, Chen Y, Chang C, Lieschke E, Diepstraten S, et al. Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development. Genes Dev. 2018;32:1420-1429 pubmed 出版商
Mancini A, Xavier Magalhães A, Woods W, Nguyen K, Amen A, Hayes J, et al. Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. Cancer Cell. 2018;34:513-528.e8 pubmed 出版商
Davies B, Hatton E, Altemose N, Hussin J, Pratto F, Zhang G, et al. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016;530:171-176 pubmed 出版商
Cohen I, Idan C, Rider P, Peleg R, Vornov E, Elena V, et al. IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2015;5:14756 pubmed 出版商
产品信息
目录代码 :
05-636-AF647
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301, Alexa Fluor系列荧光染料®647
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P16104
宿主名称 :
小鼠
抗原 :
H2A组蛋白家族成员X
克隆 :
JBW301
共轭标签 :
AlexaFluor®647
纯化方法 :
蛋白质G纯化
抗体亚型 :
IgG1
产品描述 :
抗磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301, Alexa Fluor系列荧光染料®647
交叉活性 :
人类
背景 :
As a member of the histone H2A family, histone H2A.x (H2A.x) is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. H2A.x is involved in the DNA repair of double-strand breakage (DSB) damage on nuclear DNA. After a double strand DNA break, H2A.x is rapidly phosphorylated at serine 139 by ATM kinase and becomes gamma-H2AFX. This phosphorylation step can extend up to several thousand nucleosomes from the actual site of the DSB and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. As a part of posttranslational modifications during apoptosis caused by severe DNA damage, high expression of phosphorylated H2A.x is considered as an accurate indicator of apoptosis.
别名 :
组蛋白H2A组蛋白家族成员X, H2a/x, 组蛋白H2A.X
免疫原 :
Linear peptide corresponding to phospho Histone H2A.X (Ser139).
包装尺寸 :
100微升
用途 :
免疫细胞化学
储存 :
收到之日起在2-8℃稳定1年
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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