This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301
目录 :
05-636-I
规格 :
200微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
JBW301
反应物种 :
仓鼠, 嗜热四膜虫, 人类, 小鼠, 大鼠, , ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
文章摘录数: 549
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 5a
de Jong M, Langendonk M, Reitsma B, Herbers P, Lodewijk M, Nijland M, et al. WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma. Ther Adv Hematol. 2020;11:2040620719898373 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3s1a
Hayes M, Ward S, Crawford G, Seoane R, Jackson W, Kipling D, et al. Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 1j
Pfeifer M, Brem R, Lippert T, Boulianne B, Ho H, Robinson M, et al. SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. J Immunol. 2019;202:3423-3433 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1d
Anglada T, Repullès J, Espinal A, Labarge M, Stampfer M, Genesca A, et al. Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect. Aging (Albany NY). 2019;11:1510-1523 pubmed 出版商
  • 免疫细胞化学; 人类; 图 e1f, e6a
Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 s3a
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4c
Zhao Y, Tan M, Liu X, Xiong X, Sun Y. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death Dis. 2018;9:145 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:2000; 图 1d
  • 免疫细胞化学; 人类; 1:2000; 图 1d
Welty S, Teng Y, Liang Z, Zhao W, Sanders L, Greenamyre J, et al. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem. 2018;293:1353-1362 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 1b
  • 免疫印迹; 人类; 1:5000; 图 s1b
Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, et al. Identification of the elementary structural units of the DNA damage response. Nat Commun. 2017;8:15760 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Horn A, Celic I, Dong C, Martirosyan I, Han J. A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. PLoS Genet. 2017;13:e1006837 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Marks D, Thomas R, Chin Y, Shah R, Khoo C, Benezra R. Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit. Cell Rep. 2017;19:1832-1845 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6
Cottineau J, Kottemann M, Lach F, Kang Y, Vély F, Deenick E, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991-2006 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6e
Li X, Eberhardt A, Hansen J, Bohmann D, Li H, Schor N. Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies. FASEB J. 2017;31:2327-2339 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2d
Pajalunga D, Franzolin E, Stevanoni M, Zribi S, Passaro N, Gurtner A, et al. A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells. Cell Death Differ. 2017;24:774-784 pubmed 出版商
  • 免疫组化; 人类; 1:800; 图 4e
  • 免疫印迹; 人类; 图 4b
Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2d
Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 2a
Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed 出版商
  • 免疫组化; 人类; 图 3d
Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D Angelo C, et al. SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. Nucleic Acids Res. 2017;45:1820-1834 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed 出版商
  • 免疫组化-石蜡切片; 猫; 1:50; 图 3d
Poncelet L, Garigliany M, Ando K, Franssen M, Desmecht D, Brion J. Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus. Cell Cycle. 2016;15:3482-3489 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4b
Balmus G, Barros A, Wijnhoven P, Lescale C, Hasse H, Boroviak K, et al. Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016;30:2152-2157 pubmed
  • 免疫组化-冰冻切片; 小鼠; 图 6b
  • 免疫细胞化学; 小鼠; 1:100; 图 4b
  • 免疫印迹; 小鼠; 1:1000; 图 5d
Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, et al. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016;126:4417-4429 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 3f
Kotsantis P, Silva L, Irmscher S, Jones R, Folkes L, Gromak N, et al. Increased global transcription activity as a mechanism of replication stress in cancer. Nat Commun. 2016;7:13087 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:10,000; 图 5
Li M, Cole F, Patel D, Misenko S, Her J, Malhowski A, et al. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. EMBO Rep. 2016;17:1532-1541 pubmed
  • 免疫印迹; 小鼠; 1:3000; 图 5g
Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016;6:31895 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Murakami Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6b
Sloan E, Orr A, Everett R. MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus. J Virol. 2016;90:8621-33 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 8b
  • 免疫印迹; 人类; 1:2000; 图 8a
He M, Lin Y, Tang Y, Liu Y, Zhou W, Li C, et al. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging (Albany NY). 2016;8:1442-56 pubmed 出版商
  • 免疫印迹; 鸡; 图 s4
Romanello M, Schiavone D, Frey A, Sale J. Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J. 2016;35:1452-64 pubmed 出版商
  • 免疫细胞化学; 人类; 1:3000; 图 5
Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed 出版商
  • 免疫组化; 大鼠; 1:50; 图 2a
Manchon J, DABAGHIAN Y, Uzor N, Kesler S, Wefel J, Tsvetkov A. Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons. Sci Rep. 2016;6:25705 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
  • 免疫印迹; 人类; 1:500; 图 3d
Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Huang C, Cheng J, Bawa Khalfe T, Yao X, Chin Y, Yeh E. SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 2016;15:147-157 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Liu J, Sun X, Zhu H, Qin Q, Yang X, Sun X. Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma. J Biochem. 2016;160:195-204 pubmed
  • 免疫细胞化学; 嗜热四膜虫; 1:100; 图 5
Xu Q, Wang R, Ghanam A, Yan G, Miao W, Song X. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein Cell. 2016;7:236-249 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Sears C, Cooney S, Chin Sinex H, Mendonca M, Turchi J. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 2016;40:35-46 pubmed 出版商
  • 免疫细胞化学; 鸡; 1:1000; 图 1b
Daly O, Gaboriau D, Karakaya K, King S, Dantas T, Lalor P, et al. CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity. J Cell Sci. 2016;129:1769-74 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1n
Chen S, FORRESTER W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016;351:1204-8 pubmed 出版商
  • 免疫印迹; 人类; 图 s1
Köhler C, Koalick D, Fabricius A, Parplys A, Borgmann K, Pospiech H, et al. Cdc45 is limiting for replication initiation in humans. Cell Cycle. 2016;15:974-85 pubmed 出版商
  • 免疫组化; 小鼠
Davies B, Hatton E, Altemose N, Hussin J, Pratto F, Zhang G, et al. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016;530:171-176 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1d
Sun Y, Zhu D, Chen F, Qian M, Wei H, Chen W, et al. SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment. Oncogene. 2016;35:4321-34 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5c
  • 免疫细胞化学; 人类; 图 4a
García Rubio M, Pérez Calero C, Barroso S, Tumini E, Herrera Moyano E, Rosado I, et al. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 2015;11:e1005674 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Bélanger F, Angers J, Fortier Ã, Hammond Martel I, Costantino S, Drobetsky E, et al. Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair. J Biol Chem. 2016;291:522-37 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5b
Herriott A, Tudhope S, Junge G, Rodrigues N, Patterson M, Woodhouse L, et al. PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia. Oncotarget. 2015;6:43978-91 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s1
Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1
Cohen I, Idan C, Rider P, Peleg R, Vornov E, Elena V, et al. IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2015;5:14756 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
Castella M, Jacquemont C, Thompson E, Yeo J, Cheung R, Huang J, et al. FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet. 2015;11:e1005563 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 6a
Kleiner R, Verma P, Molloy K, Chait B, Kapoor T. Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response. Nat Chem Biol. 2015;11:807-14 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2000; 图 3
  • 免疫细胞化学; 小鼠; 1:2000; 图 1
  • 免疫印迹; 小鼠; 1:1000; 图 s7
Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, et al. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes Dev. 2015;29:1955-68 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:1000
Lohse I, Borgida A, Cao P, Cheung M, Pintilie M, Bianco T, et al. BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. Br J Cancer. 2015;113:425-32 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Schraivogel D, Schindler S, Danner J, Kremmer E, Pfaff J, Hannus S, et al. Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels. Nucleic Acids Res. 2015;43:7447-61 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Wang J, Chen S, Sun C, Chien T, Chern Y. A central role of TRAX in the ATM-mediated DNA repair. Oncogene. 2016;35:1657-70 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Neumann J, Yang Y, Köhler R, Giaisi M, Witzens Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 6
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s12
Pang B, de Jong J, Qiao X, Wessels L, Neefjes J. Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat Chem Biol. 2015;11:472-80 pubmed 出版商
  • 免疫细胞化学; 牛; 图 3
Koike M, Yutoku Y, Koike A. Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation. J Vet Med Sci. 2015;77:1109-14 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 7
Zhao Y, Xiao Z, Chen W, Yang J, Li T, Fan B. Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression. Mol Med Rep. 2015;12:2313-22 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Prickaerts P, Niessen H, Dahlmans V, Spaapen F, Salvaing J, Vanhove J, et al. MK3 modulation affects BMI1-dependent and independent cell cycle check-points. PLoS ONE. 2015;10:e0118840 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 s8
  • 免疫印迹; 小鼠; 1:1000; 图 3
Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed 出版商
  • 免疫印迹; 人类; 图 s6a
Sato M, Rodríguez Barrueco R, Yu J, Do C, Silva J, Gautier J. MYC is a critical target of FBXW7. Oncotarget. 2015;6:3292-305 pubmed
  • 免疫组化; 人类; 图 s3
Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 3
La Sala G, Marazziti D, Di Pietro C, Golini E, Matteoni R, Tocchini Valentini G. Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015;29:2059-69 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
Newman E, Lu F, Bashllari D, Wang L, Opipari A, Castle V. Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma. Mol Cancer Res. 2015;13:470-82 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 6
Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
Ciccia A, Huang J, Izhar L, Sowa M, Harper J, Elledge S. Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proc Natl Acad Sci U S A. 2014;111:18631-6 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 5
Gabriel D, Roedl D, Gordon L, Djabali K. Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. Aging Cell. 2015;14:78-91 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Brownlow N, Pike T, Zicha D, Collinson L, Parker P. Mitotic catenation is monitored and resolved by a PKCε-regulated pathway. Nat Commun. 2014;5:5685 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 4a
Alagpulinsa D, Ayyadevara S, SHMOOKLER REIS R. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014;4:289 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000
Harada A, Matsuzaki K, Takeiri A, Mishima M. The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens. Mutat Res Genet Toxicol Environ Mutagen. 2014;771:23-9 pubmed 出版商
  • 免疫沉淀; 仓鼠
  • 免疫细胞化学; 仓鼠
  • 免疫印迹; 仓鼠
  • 免疫印迹; 人类
Kononenko A, Bansal R, Lee N, Grimes B, Masumoto H, Earnshaw W, et al. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. 2014;42: pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Carlessi L, Fusar Poli E, Bechi G, Mantegazza M, Pascucci B, Narciso L, et al. Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency. Cell Death Dis. 2014;5:e1342 pubmed 出版商
  • 免疫细胞化学; 鸡
Gao C, Bourke E, Scobie M, Famme M, Koolmeister T, Helleday T, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014;4:5372 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 4a
Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Vidi P, Liu J, Salles D, Jayaraman S, Dorfman G, Gray M, et al. NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks. Nucleic Acids Res. 2014;42:6365-79 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Storm M, Kumpfmueller B, Bone H, Buchholz M, Sanchez Ripoll Y, Chaudhuri J, et al. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE. 2014;9:e89821 pubmed 出版商
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Morales J, Richard P, Rommel A, Fattah F, Motea E, Patidar P, et al. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res. 2014;42:4996-5006 pubmed 出版商
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产品信息
目录代码 :
05-636-I
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P16104
宿主名称 :
小鼠
抗原 :
磷酸化组蛋白H2A.X(Ser139)
克隆 :
JBW301
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
抗磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301
交叉活性 :
人类;小鼠;大鼠
背景 :
The histone H2A.X protein is a variant member of the H2A family of histones that is distinguished from other H2A histones by a unique carboxy-terminal sequence. This unique sequence is highly conserved throughout eukaryotic evolution and is rapidly phosphorylated by ATM or ATR at the fourth residue from the carboxy-terminus (Serine 139 in mammalian H2A.X) in response to DNA double-strand breaks (DSBs). Phosphorylation of H2A.X is important in the formation of a stable repair complex at the site of DNA damage. H2A.X phosphorylation is a very rapid response to DNA damage, occurring within as little as one minute after exposure to ionizing radiation. Phosphorylation of H2A.X occurs irrespective of the cause of the DNA DSBs and phospho-H2A.X has been observed in response to environmental stresses that result in DSBs as well as programmed cellular events, including DNA rearrangement and apoptosis.
别名 :
组蛋白H2A.x;H2a/x;H2A.XS139p;H2AXS139p
免疫原 :
KLH-conjugated linear peptide corresponding to human phospho-Histone H2A. X (Ser139).
包装尺寸 :
200微克
用途 :
免疫印迹;免疫细胞化学;染色质免疫沉淀 (ChIP);免疫荧光
储存 :
收到之日起在2-8℃稳定1年
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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