Huang G, Liu L, Wang H, Gou M, Gong P, Tian C, et al. Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation. iScience. 2020;23:100908 pubmed 出版商

Nagaoka S, Nakaki F, Miyauchi H, Nosaka Y, Ohta H, Yabuta Y, et al. ZGLP1 is a determinant for the oogenic fate in mice. Science. 2020;: pubmed 出版商

Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, et al. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature. 2020;578:296-300 pubmed 出版商

Sarek G, Kotsantis P, Ruis P, Van Ly D, Margalef P, Borel V, et al. CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle. Nature. 2019;: pubmed 出版商

Perera O, Sobinoff A, Teber E, Harman A, Maritz M, Yang S, et al. Telomerase promotes formation of a telomere protective complex in cancer cells. Sci Adv. 2019;5:eaav4409 pubmed 出版商

Chaves Pérez A, Yilmaz M, Perna C, de la Rosa S, Djouder N. URI is required to maintain intestinal architecture during ionizing radiation. Science. 2019;364: pubmed 出版商

Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, et al. Restriction of AID activity and somatic hypermutation by PARP-1. Nucleic Acids Res. 2019;47:7418-7429 pubmed 出版商

Pfeifer M, Brem R, Lippert T, Boulianne B, Ho H, Robinson M, et al. SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. J Immunol. 2019;202:3423-3433 pubmed 出版商

Li S, Lavagnino Z, Lemaçon D, Kong L, Ustione A, Ng X, et al. Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019;74:1123-1137.e6 pubmed 出版商

Chan E, Shibue T, McFarland J, Gaeta B, Ghandi M, Dumont N, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568:551-556 pubmed 出版商

Liu H, Huang T, Li M, Li M, Zhang C, Jiang J, et al. SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Res. 2019;47:5670-5683 pubmed 出版商

Ao Y, Zhang J, Liu Z, Qian M, Li Y, Wu Z, et al. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv. 2019;5:eaav5078 pubmed 出版商

Pillay N, Tighe A, Nelson L, Littler S, Coulson Gilmer C, Bah N, et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 2019;35:519-533.e8 pubmed 出版商

Anglada T, Repullès J, Espinal A, Labarge M, Stampfer M, Genesca A, et al. Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect. Aging (Albany NY). 2019;11:1510-1523 pubmed 出版商

Poondla N, Chandrasekaran A, Heese K, Kim K, Ramakrishna S. CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis. Biochem Biophys Res Commun. 2019;: pubmed 出版商

Kojima M, de Rooij D, Page D. Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice. elife. 2019;8: pubmed 出版商

So C, Ramachandran S, Martin A. E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair. Mol Cell Biol. 2019;39: pubmed 出版商

Jachimowicz R, Beleggia F, Isensee J, Velpula B, Goergens J, Bustos M, et al. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 2019;176:505-519.e22 pubmed 出版商

Meisenberg C, Pinder S, Hopkins S, Wooller S, Benstead Hume G, Pearl F, et al. Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol Cell. 2019;73:212-223.e7 pubmed 出版商

Delgado Benito V, Rosen D, Wang Q, Gazumyan A, Pai J, Oliveira T, et al. The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell. 2018;72:636-649.e8 pubmed 出版商

Slyskova J, Sabatella M, Ribeiro Silva C, Stok C, Theil A, Vermeulen W, et al. Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage. Nucleic Acids Res. 2018;46:9537-9549 pubmed 出版商

Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. 2018;560:112-116 pubmed 出版商

Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, et al. ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. Nat Commun. 2018;9:2736 pubmed 出版商

Zimmermann M, Murina O, Reijns M, Agathanggelou A, Challis R, Tarnauskaitė Ž, et al. CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Nature. 2018;559:285-289 pubmed 出版商

Schrank B, Aparicio T, Li Y, Chang W, Chait B, Gundersen G, et al. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature. 2018;559:61-66 pubmed 出版商

Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed 出版商

Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed 出版商

Li M, Yang X, LU X, Dai N, Zhang S, Cheng Y, et al. APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res. 2018;46:5664-5677 pubmed 出版商

Parisotto M, Grelet E, El Bizri R, Dai Y, Terzic J, Eckert D, et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo. J Exp Med. 2018;215:1749-1763 pubmed 出版商

Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed 出版商

Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, et al. Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018;46:3468-3486 pubmed 出版商

Zhao Y, Tan M, Liu X, Xiong X, Sun Y. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death Dis. 2018;9:145 pubmed 出版商

Welty S, Teng Y, Liang Z, Zhao W, Sanders L, Greenamyre J, et al. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem. 2018;293:1353-1362 pubmed 出版商

Hu J, Sun F, Handel M. Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biol Reprod. 2018;98:102-114 pubmed 出版商

Schellenberg M, Lieberman J, Herrero Ruíz A, Butler L, Williams J, Muñoz Cabello A, et al. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Science. 2017;357:1412-1416 pubmed 出版商

Daddacha W, Koyen A, Bastien A, Head P, Dhere V, Nabeta G, et al. SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell Rep. 2017;20:1921-1935 pubmed 出版商

Song C, Hotz Wagenblatt A, Voit R, Grummt I. SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. Genes Dev. 2017;31:1370-1381 pubmed 出版商

Takaki T, Montagner M, Serres M, Le Berre M, Russell M, Collinson L, et al. Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Nat Commun. 2017;8:16013 pubmed 出版商

Parajuli S, Teasley D, Murali B, Jackson J, Vindigni A, Stewart S. Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork. J Biol Chem. 2017;292:15216-15224 pubmed 出版商

Senturk J, Bohlman S, Manfredi J. Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53. Oncogene. 2017;36:6085-6096 pubmed 出版商

Bleuyard J, Fournier M, Nakato R, Couturier A, Katou Y, Ralf C, et al. MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress. Proc Natl Acad Sci U S A. 2017;114:7671-7676 pubmed 出版商

Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed 出版商

Rivera B, Di Iorio M, Frankum J, Nadaf J, Fahiminiya S, Arcand S, et al. Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma. Cancer Res. 2017;77:4517-4529 pubmed 出版商

Van T, Polykratis A, Straub B, Kondylis V, Papadopoulou N, Pasparakis M. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017;127:2662-2677 pubmed 出版商

Nozawa R, Boteva L, Soares D, Naughton C, Dun A, Buckle A, et al. SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs. Cell. 2017;169:1214-1227.e18 pubmed 出版商

Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, et al. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature. 2017;546:549-553 pubmed 出版商

Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, et al. Identification of the elementary structural units of the DNA damage response. Nat Commun. 2017;8:15760 pubmed 出版商

Horn A, Celic I, Dong C, Martirosyan I, Han J. A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. PLoS Genet. 2017;13:e1006837 pubmed 出版商

Tan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed 出版商

Marks D, Thomas R, Chin Y, Shah R, Khoo C, Benezra R. Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit. Cell Rep. 2017;19:1832-1845 pubmed 出版商

Jiang L, Li T, Zhang X, Zhang B, Yu C, Li Y, et al. RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Curr Biol. 2017;27:1498-1505.e6 pubmed 出版商

Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson I, Kanemaki M. Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis. Genes Dev. 2017;31:816-829 pubmed 出版商

Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed 出版商

Singh V, Connelly Z, Shen X, De Benedetti A. Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity. Cell Cycle. 2017;16:915-926 pubmed 出版商

Singh S, Vaughan C, Frum R, Grossman S, Deb S, Palit Deb S. Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication. J Clin Invest. 2017;127:1839-1855 pubmed 出版商

Timashev L, Babcock H, Zhuang X, de Lange T. The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev. 2017;31:578-589 pubmed 出版商

Vancevska A, Douglass K, Pfeiffer V, Manley S, Lingner J. The telomeric DNA damage response occurs in the absence of chromatin decompaction. Genes Dev. 2017;31:567-577 pubmed 出版商

Filipescu D, Naughtin M, Podsypanina K, Lejour V, Wilson L, Gurard Levin Z, et al. Essential role for centromeric factors following p53 loss and oncogenic transformation. Genes Dev. 2017;31:463-480 pubmed 出版商

Feng X, Hsu S, Kasbek C, Chaiken M, Price C. CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance. Nucleic Acids Res. 2017;45:4281-4293 pubmed 出版商

Smith E, Gole B, Willis N, Soria R, Starnes L, Krumpelbeck E, et al. DEK is required for homologous recombination repair of DNA breaks. Sci Rep. 2017;7:44662 pubmed 出版商

Nagano T, Nakashima A, Onishi K, Kawai K, Awai Y, Kinugasa M, et al. Proline dehydrogenase promotes senescence through the generation of reactive oxygen species. J Cell Sci. 2017;130:1413-1420 pubmed 出版商

Xu P, Zhou Z, Xiong M, Zou W, Deng X, Ganaie S, et al. Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. PLoS Pathog. 2017;13:e1006266 pubmed 出版商

Leung J, Makharashvili N, Agarwal P, Chiu L, Pourpre R, Cammarata M, et al. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes Dev. 2017;31:260-274 pubmed 出版商

Ho T, Warr M, Adelman E, Lansinger O, Flach J, Verovskaya E, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543:205-210 pubmed 出版商

Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed 出版商

Liu Y, Cussiol J, Dibitetto D, Sims J, Twayana S, Weiss R, et al. TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol. 2017;216:623-639 pubmed 出版商

Williams P, Harder J, Foxworth N, Cochran K, Philip V, Porciatti V, et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 2017;355:756-760 pubmed 出版商

Spriggs C, Laimins L. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. MBio. 2017;8: pubmed 出版商

Pajalunga D, Franzolin E, Stevanoni M, Zribi S, Passaro N, Gurtner A, et al. A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells. Cell Death Differ. 2017;24:774-784 pubmed 出版商

Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed 出版商

Bot C, Pfeiffer A, Giordano F, Manjeera D, Dantuma N, Ström L. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. J Cell Sci. 2017;130:1134-1146 pubmed 出版商

JI J, Zhang Y, Redon C, Reinhold W, Chen A, Fogli L, et al. Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay. PLoS ONE. 2017;12:e0171582 pubmed 出版商

Sagie S, Toubiana S, Hartono S, Katzir H, Tzur Gilat A, Havazelet S, et al. Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids. Nat Commun. 2017;8:14015 pubmed 出版商

Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed 出版商

Igarashi K, Kobayashi J, Katsumura T, Urushihara Y, Hida K, Watanabe Asaka T, et al. An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations. PLoS ONE. 2017;12:e0170006 pubmed 出版商

Chang V, Tsai Y, Tsai Y, Peng S, Chen S, Chang T, et al. Krüpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene. Radiother Oncol. 2017;122:476-484 pubmed 出版商

Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed 出版商

Macia M, Halbritter J, Delous M, Bredrup C, Gutter A, Filhol E, et al. Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. Am J Hum Genet. 2017;100:323-333 pubmed 出版商

Li J, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017;355:638-641 pubmed 出版商

Herold N, Rudd S, Ljungblad L, Sanjiv K, Myrberg I, Paulin C, et al. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nat Med. 2017;23:256-263 pubmed 出版商

Zanini I, Soneson C, Lorenzi L, Azzalin C. Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion. J Cell Sci. 2017;130:767-778 pubmed 出版商

Hoch N, Hanzlikova H, Rulten S, Tetreault M, Komulainen E, Ju L, et al. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. 2017;541:87-91 pubmed 出版商

Graveline R, Marcinkiewicz K, Choi S, Paquet M, Wurst W, Floss T, et al. The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence. Mol Cell Biol. 2017;37: pubmed 出版商

Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D Angelo C, et al. SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. Nucleic Acids Res. 2017;45:1820-1834 pubmed 出版商

Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed 出版商

Redko B, Tuchinsky H, Segal T, Tobi D, Luboshits G, Ashur Fabian O, et al. Toward the development of a novel non-RGD cyclic peptide drug conjugate for treatment of human metastatic melanoma. Oncotarget. 2017;8:757-768 pubmed 出版商

Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, et al. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017;31:132-147 pubmed 出版商

Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed 出版商

Couturier A, Fleury H, Patenaude A, Bentley V, Rodrigue A, Coulombe Y, et al. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic Acids Res. 2016;44:10879-10897 pubmed

Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed 出版商

Mosteiro L, Pantoja C, Alcazar N, Marion R, Chondronasiou D, Rovira M, et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science. 2016;354: pubmed

Gong L, Pan X, Chen H, Rao L, Zeng Y, Hang H, et al. p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming. Sci Rep. 2016;6:37281 pubmed 出版商

Poncelet L, Garigliany M, Ando K, Franssen M, Desmecht D, Brion J. Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus. Cell Cycle. 2016;15:3482-3489 pubmed 出版商

Hansen R, Mund A, Poulsen S, Sandoval M, Klement K, Tsouroula K, et al. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016;18:1357-1366 pubmed 出版商

Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed 出版商

Balmus G, Barros A, Wijnhoven P, Lescale C, Hasse H, Boroviak K, et al. Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016;30:2152-2157 pubmed

Biswas U, Hempel K, Llano E, Pendas A, Jessberger R. Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis. PLoS Genet. 2016;12:e1006389 pubmed 出版商

Smith C, Mont S, Traver G, Sekhar K, Crooks P, Freeman M. Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Oncotarget. 2016;7:77926-77936 pubmed 出版商

Konstantinidou C, Taraviras S, Pachnis V. Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis. BMC Biol. 2016;14:94 pubmed

Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, et al. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016;126:4417-4429 pubmed 出版商

Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet Robinet E, Salles B, et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep. 2016;6:36022 pubmed 出版商

Maachani U, Shankavaram U, Kramp T, Tofilon P, Camphausen K, Tandle A. FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells. Oncotarget. 2016;7:77365-77377 pubmed 出版商

Dilley R, Verma P, Cho N, Winters H, Wondisford A, Greenberg R. Break-induced telomere synthesis underlies alternative telomere maintenance. Nature. 2016;539:54-58 pubmed 出版商

Andriani G, Almeida V, Faggioli F, Mauro M, Tsai W, Santambrogio L, et al. Whole Chromosome Instability induces senescence and promotes SASP. Sci Rep. 2016;6:35218 pubmed 出版商

Kotsantis P, Silva L, Irmscher S, Jones R, Folkes L, Gromak N, et al. Increased global transcription activity as a mechanism of replication stress in cancer. Nat Commun. 2016;7:13087 pubmed 出版商

Murai J, Feng Y, Yu G, Ru Y, Tang S, Shen Y, et al. Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. Oncotarget. 2016;7:76534-76550 pubmed 出版商

Kanakkanthara A, Jeganathan K, Limzerwala J, Baker D, Hamada M, Nam H, et al. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science. 2016;353:1549-1552 pubmed

Bridges K, Chen X, Liu H, Rock C, Buchholz T, Shumway S, et al. MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Oncotarget. 2016;7:71660-71672 pubmed 出版商

Kehrli K, Phelps M, Lazarchuk P, Chen E, Monnat R, Sidorova J. Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest. J Biol Chem. 2016;291:24487-24503 pubmed

Li M, Cole F, Patel D, Misenko S, Her J, Malhowski A, et al. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. EMBO Rep. 2016;17:1532-1541 pubmed

Mansuroglu Z, Benhelli Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, et al. Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Sci Rep. 2016;6:33047 pubmed 出版商

Hu Y, Shi G, Zhang L, Li F, Jiang Y, Jiang S, et al. Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX. Sci Rep. 2016;6:32280 pubmed 出版商

Feringa F, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, et al. Hypersensitivity to DNA damage in antephase as a safeguard for genome stability. Nat Commun. 2016;7:12618 pubmed 出版商

Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016;6:31895 pubmed 出版商

Cunningham C, Li S, Vizeacoumar F, Bhanumathy K, Lee J, Parameswaran S, et al. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget. 2016;7:61544-61561 pubmed 出版商

Vermeij W, Dollé M, Reiling E, Jaarsma D, Payan Gomez C, Bombardieri C, et al. Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature. 2016;537:427-431 pubmed 出版商

Oza J, Ganguly B, Kulkarni A, Ginjala V, Yao M, Ganesan S. A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response. J Biol Chem. 2016;291:22881-22893 pubmed

Murakami Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed 出版商

Maynard J, Emmas S, Blé F, Barjat H, Lawrie E, Hancox U, et al. The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3K?/? inhibitor. EJNMMI Res. 2016;6:62 pubmed 出版商

Nelson D, Jaber Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016;17:158 pubmed 出版商

Lesina M, Wörmann S, Morton J, Diakopoulos K, Korneeva O, Wimmer M, et al. RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. J Clin Invest. 2016;126:2919-32 pubmed 出版商

Grinshtein N, Rioseco C, Marcellus R, UEHLING D, Aman A, Lun X, et al. Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Oncotarget. 2016;7:59360-59376 pubmed 出版商

Sloan E, Orr A, Everett R. MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus. J Virol. 2016;90:8621-33 pubmed 出版商

Li L, Shi L, Yang S, Yan R, Zhang D, Yang J, et al. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun. 2016;7:12235 pubmed 出版商

Gygli P, Chang J, Gokozan H, Catacutan F, Schmidt T, Kaya B, et al. Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (Albany NY). 2016;8:1540-70 pubmed 出版商

Yuan Y, Ren Y, Yuan P, Yan L, Qiao J. TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis. Sci Rep. 2016;6:29735 pubmed 出版商

He M, Lin Y, Tang Y, Liu Y, Zhou W, Li C, et al. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging (Albany NY). 2016;8:1442-56 pubmed 出版商

Gao Y, Mutter Rottmayer E, Greenwalt A, Goldfarb D, Yan F, Yang Y, et al. A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis. Nat Commun. 2016;7:12105 pubmed 出版商

Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, et al. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med. 2016;22:861-8 pubmed 出版商

Fong C, Mazo G, Das T, Goodman J, Kim M, O Rourke B, et al. 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. elife. 2016;5: pubmed 出版商

Michl J, Zimmer J, Buffa F, McDermott U, Tarsounas M. FANCD2 limits replication stress and genome instability in cells lacking BRCA2. Nat Struct Mol Biol. 2016;23:755-757 pubmed 出版商

Eymery A, Liu Z, Ozonov E, Stadler M, Peters A. The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos. Development. 2016;143:2767-79 pubmed 出版商

Kargaran P, Yasaei H, Anjomani Virmouni S, Mangiapane G, Slijepcevic P. Analysis of alternative lengthening of telomere markers in BRCA1 defective cells. Genes Chromosomes Cancer. 2016;55:864-76 pubmed 出版商

Li Y, Zhang W, Chang L, Han Y, Sun L, Gong X, et al. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016;7:478-88 pubmed 出版商

Beck D, Zobel J, Barber R, Evans S, Lezina L, Allchin R, et al. Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. J Biol Chem. 2016;291:16686-98 pubmed 出版商

Kais Z, Rondinelli B, Holmes A, O Leary C, Kozono D, D Andrea A, et al. FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair. Cell Rep. 2016;15:2488-99 pubmed 出版商

Penterling C, Drexler G, Böhland C, Stamp R, Wilke C, Braselmann H, et al. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS ONE. 2016;11:e0156599 pubmed 出版商

Minakawa Y, Atsumi Y, Shinohara A, Murakami Y, Yoshioka K. Gamma-irradiated quiescent cells repair directly induced double-strand breaks but accumulate persistent double-strand breaks during subsequent DNA replication. Genes Cells. 2016;21:789-97 pubmed 出版商

Romanello M, Schiavone D, Frey A, Sale J. Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J. 2016;35:1452-64 pubmed 出版商

Lin K, Cheng S, Tsai S, Tsai J, Lin C, Cheung C. Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Onco Targets Ther. 2016;9:2601-13 pubmed 出版商

Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed 出版商

Agostoni E, Michelazzi S, Maurutto M, Carnemolla A, Ciani Y, Vatta P, et al. Effects of Pin1 Loss in Hdh(Q111) Knock-in Mice. Front Cell Neurosci. 2016;10:110 pubmed 出版商

Maure J, Moser S, Jaffray E, F Alpi A, Hay R. Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage. Sci Rep. 2016;6:26178 pubmed 出版商

Manchon J, DABAGHIAN Y, Uzor N, Kesler S, Wefel J, Tsvetkov A. Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons. Sci Rep. 2016;6:25705 pubmed 出版商

Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed 出版商

Cao N, Li J, Rao Y, Liu H, Wu J, Li B, et al. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. BMC Mol Biol. 2016;17:12 pubmed 出版商

Ho T, Guilbaud G, Blow J, Sale J, Watson C. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Rep. 2016;15:724-734 pubmed 出版商

Avila A, Illing A, Becker F, Maerz L, Morita Y, Philipp M, et al. Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation. Nucleic Acids Res. 2016;44:6252-61 pubmed 出版商

Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, et al. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol. 2016;23:522-30 pubmed 出版商

Mata Garrido J, Casafont I, Tapia O, Berciano M, Lafarga M. Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization. Acta Neuropathol Commun. 2016;4:41 pubmed 出版商

Burridge P, Li Y, Matsa E, Wu H, Ong S, Sharma A, et al. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med. 2016;22:547-56 pubmed 出版商

Chatterjee G, Jiménez Sáinz J, Presti T, Nguyen T, Jensen R. Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity. Nucleic Acids Res. 2016;44:5256-70 pubmed 出版商

Chiang T, le Sage C, Larrieu D, Demir M, Jackson S. CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing. Sci Rep. 2016;6:24356 pubmed 出版商

Jain V, Kumar P, Koya P, Jaikrishan G, Das B. Lack of increased DNA double-strand breaks in peripheral blood mononuclear cells of individuals from high level natural radiation areas of Kerala coast in India. Mutat Res. 2016;788:50-7 pubmed 出版商

Kaur A, Webster M, Marchbank K, Behera R, Ndoye A, Kugel C, et al. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016;532:250-4 pubmed 出版商

Liu J, Sun X, Zhu H, Qin Q, Yang X, Sun X. Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma. J Biochem. 2016;160:195-204 pubmed

Valle García D, Qadeer Z, McHugh D, Ghiraldini F, Chowdhury A, Hasson D, et al. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Epigenetics. 2016;11:398-414 pubmed 出版商

Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja J, et al. Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope. Nat Commun. 2016;7:11084 pubmed 出版商

Gruosso T, Mieulet V, Cardon M, Bourachot B, Kieffer Y, Devun F, et al. Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med. 2016;8:527-49 pubmed 出版商

Sears C, Cooney S, Chin Sinex H, Mendonca M, Turchi J. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 2016;40:35-46 pubmed 出版商

Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed 出版商

Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, et al. Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. PLoS Genet. 2016;12:e1005894 pubmed 出版商

Daly O, Gaboriau D, Karakaya K, King S, Dantas T, Lalor P, et al. CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity. J Cell Sci. 2016;129:1769-74 pubmed 出版商

Chen S, FORRESTER W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016;351:1204-8 pubmed 出版商

Rai R, Chen Y, Lei M, Chang S. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nat Commun. 2016;7:10881 pubmed 出版商

Ercilla A, Llopis A, Feu S, Aranda S, Ernfors P, Freire R, et al. New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. Nucleic Acids Res. 2016;44:4745-62 pubmed 出版商

Wu J, Chi L, Chen Z, Lu X, Xiao S, Zhang G, et al. Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death. Mol Med Rep. 2016;13:3173-80 pubmed 出版商

O Hagan Wong K, Nadeau S, Carrier Leclerc A, Apablaza F, Hamdy R, Shum Tim D, et al. Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis. Oncotarget. 2016;7:13285-96 pubmed 出版商

Köhler C, Koalick D, Fabricius A, Parplys A, Borgmann K, Pospiech H, et al. Cdc45 is limiting for replication initiation in humans. Cell Cycle. 2016;15:974-85 pubmed 出版商

Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon H, et al. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. 2016;351:943-9 pubmed 出版商

McLaughlin D, Coey C, Yang W, Drohat A, Matunis M. Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo. J Biol Chem. 2016;291:9014-24 pubmed 出版商

Francia S, Cabrini M, Matti V, Oldani A, d Adda di Fagagna F. DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. J Cell Sci. 2016;129:1468-76 pubmed 出版商

Keuss M, Thomas Y, Mcarthur R, Wood N, Knebel A, Kurz T. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016;129:1441-54 pubmed 出版商

Pecháčková S, Burdova K, Benada J, Kleiblova P, Jenikova G, Macurek L. Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3. Oncotarget. 2016;7:14458-75 pubmed 出版商

Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, et al. Knockout of BRD7 results in impaired spermatogenesis and male infertility. Sci Rep. 2016;6:21776 pubmed 出版商

Weyemi U, Redon C, Choudhuri R, Aziz T, Maeda D, Boufraqech M, et al. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016;7:10711 pubmed 出版商

Ahuja A, Jodkowska K, Teloni F, Bizard A, Zellweger R, Herrador R, et al. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016;7:10660 pubmed 出版商

Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen J, et al. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell. 2016;27:1346-57 pubmed 出版商

Awate S, De Benedetti A. TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint. BMC Mol Biol. 2016;17:3 pubmed 出版商

Wu Y, Hu X, Li Z, Wang M, Li S, Wang X, et al. Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis. Sci Rep. 2016;6:20435 pubmed 出版商

Davies B, Hatton E, Altemose N, Hussin J, Pratto F, Zhang G, et al. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016;530:171-176 pubmed 出版商

Heeren A, He N, de Souza A, Goercharn Ramlal A, van Iperen L, Roost M, et al. On the development of extragonadal and gonadal human germ cells. Biol Open. 2016;5:185-94 pubmed 出版商

Wang Y, Xu Q, Sack L, Kang C, Elledge S. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016;30:293-306 pubmed 出版商

Thornton T, Delgado P, Chen L, Salas B, Krementsov D, Fernández M, et al. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nat Commun. 2016;7:10553 pubmed 出版商

Zhang Q, Dan J, Wang H, Guo R, Mao J, Fu H, et al. Tcstv1 and Tcstv3 elongate telomeres of mouse ES cells. Sci Rep. 2016;6:19852 pubmed 出版商

Moudry P, Watanabe K, Wolanin K, Bartkova J, Wassing I, Watanabe S, et al. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J Cell Biol. 2016;212:281-8 pubmed 出版商

Hasvold G, Lund Andersen C, Lando M, Patzke S, Hauge S, Suo Z, et al. Hypoxia-induced alterations of G2 checkpoint regulators. Mol Oncol. 2016;10:764-73 pubmed 出版商

Du Y, Yamaguchi H, Wei Y, Hsu J, Wang H, Hsu Y, et al. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016;22:194-201 pubmed 出版商

Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, et al. Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A. 2016;113:1273-8 pubmed 出版商

Kuo C, Li X, Stark J, Shih H, Ann D. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016;15:787-98 pubmed 出版商

Murakami K, Günesdogan U, Zylicz J, Tang W, Sengupta R, Kobayashi T, et al. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature. 2016;529:403-407 pubmed 出版商

Rassoolzadeh H, Coucoravas C, Farnebo M. The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1. Nucleus. 2015;6:417-24 pubmed 出版商

Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun. 2016;7:10201 pubmed 出版商

Chatalic K, Konijnenberg M, Nonnekens J, De Blois E, Hoeben S, de Ridder C, et al. In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies. Theranostics. 2016;6:104-17 pubmed 出版商

Hoffmann S, Smedegaard S, Nakamura K, Mortuza G, Räschle M, Ibañez de Opakua A, et al. TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J Cell Biol. 2016;212:63-75 pubmed 出版商

Zahavi T, Lanton T, Divon M, Salmon A, Peretz T, Galun E, et al. Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model. Oncotarget. 2016;7:4860-70 pubmed 出版商

Huang R, Langdon S, Tse M, Mullen P, Um I, Faratian D, et al. The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer. Oncotarget. 2016;7:4695-711 pubmed 出版商

Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed 出版商

Zhang H, Zheng T, Chua C, Shen M, Gelmann E. Nkx3.1 controls the DNA repair response in the mouse prostate. Prostate. 2016;76:402-8 pubmed 出版商

Obermeier K, Sachsenweger J, Friedl T, Pospiech H, Winqvist R, Wiesmüller L. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2016;35:3796-806 pubmed 出版商

Li M, Huang R, Jiang X, Chen Y, Zhang Z, Zhang X, et al. CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo. PLoS ONE. 2015;10:e0143148 pubmed 出版商

Harley M, Murina O, Leitch A, Higgs M, Bicknell L, Yigit G, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet. 2016;48:36-43 pubmed 出版商

Wanzel M, Vischedyk J, Gittler M, Gremke N, Seiz J, Hefter M, et al. CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol. 2016;12:22-8 pubmed 出版商

García Rubio M, Pérez Calero C, Barroso S, Tumini E, Herrera Moyano E, Rosado I, et al. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 2015;11:e1005674 pubmed 出版商

Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed 出版商

Bélanger F, Angers J, Fortier Ã, Hammond Martel I, Costantino S, Drobetsky E, et al. Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair. J Biol Chem. 2016;291:522-37 pubmed 出版商

Kanu N, Zhang T, Burrell R, Chakraborty A, Cronshaw J, DaCosta C, et al. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene. 2016;35:4009-19 pubmed 出版商

Herriott A, Tudhope S, Junge G, Rodrigues N, Patterson M, Woodhouse L, et al. PARP1 expression, activity and ex vivo sensitivity to the PARP inhibitor, talazoparib (BMN 673), in chronic lymphocytic leukaemia. Oncotarget. 2015;6:43978-91 pubmed 出版商

Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, et al. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. 2015;527:389-93 pubmed 出版商

Ramcharan R, Aleksic T, Kamdoum W, Gao S, Pfister S, Tanner J, et al. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. Oncotarget. 2015;6:39877-90 pubmed 出版商

Hausmann C, Temme A, Cordes N, Eke I. ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation. Oncotarget. 2015;6:34592-605 pubmed 出版商

Young L, Marzio A, Pérez Durán P, Reid D, Meredith D, Roberti D, et al. TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response. Cell Rep. 2015;13:451-459 pubmed 出版商

Alvarez S, Diaz M, Flach J, Rodriguez Acebes S, López Contreras A, Martinez D, et al. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 2015;6:8548 pubmed 出版商

Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed 出版商

Cohen I, Idan C, Rider P, Peleg R, Vornov E, Elena V, et al. IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2015;5:14756 pubmed 出版商

Castella M, Jacquemont C, Thompson E, Yeo J, Cheung R, Huang J, et al. FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet. 2015;11:e1005563 pubmed 出版商

Hedstrom E, Pederiva C, Farnebo J, Nodin B, Jirstrom K, Brennan D, et al. Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome. Cell Death Dis. 2015;6:e1892 pubmed 出版商

Saquilabon Cruz G, Kong X, Silva B, Khatibzadeh N, Thai R, Berns M, et al. Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res. 2016;44:e27 pubmed 出版商

Ortega Atienza S, Wong V, Deloughery Z, Luczak M, Zhitkovich A. ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic Acids Res. 2016;44:198-209 pubmed 出版商

Birch J, Anderson R, Correia Melo C, Jurk D, Hewitt G, Marques F, et al. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1124-37 pubmed 出版商

Baker C, Petkova P, Walker M, Flachs P, Mihola O, Trachtulec Z, et al. Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots. PLoS Genet. 2015;11:e1005512 pubmed 出版商

Kubben N, Brimacombe K, Donegan M, Li Z, Misteli T. A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds. Methods. 2016;96:46-58 pubmed 出版商

Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, et al. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes Dev. 2015;29:1955-68 pubmed 出版商

Neuschäfer Rube F, Schraplau A, Schewe B, Lieske S, Krützfeldt J, Ringel S, et al. Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes. Toxicology. 2015;337:1-9 pubmed 出版商

Barazzuol L, Rickett N, Ju L, Jeggo P. Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells. J Cell Sci. 2015;128:3597-606 pubmed 出版商

Chang C, Zhang M, Rajapakshe K, Coarfa C, Edwards D, Huang S, et al. Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage. Stem Cell Reports. 2015;5:378-91 pubmed 出版商

Shimada M, Dumitrache L, Russell H, McKinnon P. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015;34:2465-80 pubmed 出版商

Lin H, Ha K, Lu G, Fang X, Cheng R, Zuo Q, et al. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol. 2015;35:3657-68 pubmed 出版商

Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed 出版商

González Loyola A, Fernández Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, et al. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol. 2015;35:3566-78 pubmed 出版商

Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed 出版商

Lohse I, Borgida A, Cao P, Cheung M, Pintilie M, Bianco T, et al. BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts. Br J Cancer. 2015;113:425-32 pubmed 出版商

Schraivogel D, Schindler S, Danner J, Kremmer E, Pfaff J, Hannus S, et al. Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels. Nucleic Acids Res. 2015;43:7447-61 pubmed 出版商

King C, Diaz H, McNeely S, Barnard D, Dempsey J, Blosser W, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015;14:2004-13 pubmed 出版商

Marchesini M, Matocci R, Tasselli L, Cambiaghi V, Orleth A, Furia L, et al. PML is required for telomere stability in non-neoplastic human cells. Oncogene. 2016;35:1811-21 pubmed 出版商

Chen S, Chou W, Hu L, Hsiung C, Chu H, Huang Y, et al. The Effect of MicroRNA-124 Overexpression on Anti-Tumor Drug Sensitivity. PLoS ONE. 2015;10:e0128472 pubmed 出版商

Huang P, Yang J, Ning J, Wang M, Song Q. Atrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells. Int J Mol Sci. 2015;16:14353-68 pubmed 出版商

Sun L, Tan R, Xu J, LaFace J, Gao Y, Xiao Y, et al. Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death. Nucleic Acids Res. 2015;43:6334-47 pubmed 出版商

Specks J, Lecona E, Lopez Contreras A, Fernandez Capetillo O. A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development. Mol Cell Biol. 2015;35:2910-7 pubmed 出版商

Wang Y, Zhu T, Li Q, Liu C, Han F, Chen M, et al. Prmt5 is required for germ cell survival during spermatogenesis in mice. Sci Rep. 2015;5:11031 pubmed 出版商

Ahn J, Kim S, Na W, Baek S, Kim J, Min K, et al. SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase. Nucleic Acids Res. 2015;43:6321-33 pubmed 出版商

Tomas Roca L, Tsaalbi Shtylik A, Jansen J, Singh M, Epstein J, Altunoglu U, et al. De novo mutations in PLXND1 and REV3L cause Möbius syndrome. Nat Commun. 2015;6:7199 pubmed 出版商

Neumann J, Yang Y, Köhler R, Giaisi M, Witzens Harig M, Liu D, et al. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest. Int J Cancer. 2015;137:2739-48 pubmed 出版商

Hollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses. 2015;7:2908-27 pubmed 出版商

Xu Y, Wu X, Her C. hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J Biol Chem. 2015;290:18545-58 pubmed 出版商

Sachweh M, Stafford W, Drummond C, McCarthy A, Higgins M, Campbell J, et al. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. Oncotarget. 2015;6:16488-506 pubmed

Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed 出版商

Van Sluis M, McStay B. A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 2015;29:1151-63 pubmed 出版商

Abbasi A, Khalaj M, Akiyama K, Mukai Y, Matsumoto H, Acosta T, et al. Lack of Rev7 function results in development of tubulostromal adenomas in mouse ovary. Mol Cell Endocrinol. 2015;412:19-25 pubmed 出版商

Izhar L, Adamson B, Ciccia A, Lewis J, Pontano Vaites L, Leng Y, et al. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep. 2015;11:1486-500 pubmed 出版商

Saini P, Li Y, Dobbelstein M. Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress. Oncotarget. 2015;6:13072-87 pubmed

Mortusewicz O, Evers B, Helleday T. PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites. Oncogene. 2016;35:761-70 pubmed 出版商

Pang B, de Jong J, Qiao X, Wessels L, Neefjes J. Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat Chem Biol. 2015;11:472-80 pubmed 出版商

Koike M, Yutoku Y, Koike A. Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation. J Vet Med Sci. 2015;77:1109-14 pubmed 出版商

Goldstein M, Kastan M. Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res. 2015;75:2699-707 pubmed 出版商

Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, et al. Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice. Nat Commun. 2015;6:7035 pubmed 出版商

Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed 出版商

Annovazzi L, Caldera V, Mellai M, Riganti C, Battaglia L, Chirio D, et al. The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment. Int J Oncol. 2015;46:2299-308 pubmed 出版商

Mehta K, Gunasekharan V, Satsuka A, Laimins L. Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators. PLoS Pathog. 2015;11:e1004763 pubmed 出版商

Prickaerts P, Niessen H, Dahlmans V, Spaapen F, Salvaing J, Vanhove J, et al. MK3 modulation affects BMI1-dependent and independent cell cycle check-points. PLoS ONE. 2015;10:e0118840 pubmed 出版商

Scialpi F, Mellis D, Ditzel M. EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole. J Biol Chem. 2015;290:12585-94 pubmed 出版商

Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS ONE. 2015;10:e0122582 pubmed 出版商

Ortega Atienza S, Green S, Zhitkovich A. Proteasome activity is important for replication recovery, CHK1 phosphorylation and prevention of G2 arrest after low-dose formaldehyde. Toxicol Appl Pharmacol. 2015;286:135-41 pubmed 出版商

Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed 出版商

Augello M, Berman Booty L, Carr R, Yoshida A, Dean J, Schiewer M, et al. Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med. 2015;7:628-47 pubmed 出版商

Kumari A, Owen N, Juarez E, McCullough A. BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst). 2015;28:73-82 pubmed 出版商

Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed 出版商

Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed 出版商

Kanu N, Grönroos E, Martinez P, Burrell R, Yi Goh X, Bartkova J, et al. SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene. 2015;34:5699-708 pubmed 出版商

Yang H, Luo J, Liu Z, Zhou R, Luo H. MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX. Cancer Invest. 2015;33:126-36 pubmed 出版商

KocyÅ‚owski M, Rey A, Stewart G, Halazonetis T. Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle. 2015;14:1748-58 pubmed 出版商

Nakagawa Y, Sedukhina A, Okamoto N, Nagasawa S, Suzuki N, Ohta T, et al. NF-κB signaling mediates acquired resistance after PARP inhibition. Oncotarget. 2015;6:3825-39 pubmed

Sato M, Rodríguez Barrueco R, Yu J, Do C, Silva J, Gautier J. MYC is a critical target of FBXW7. Oncotarget. 2015;6:3292-305 pubmed

Diner B, Li T, Greco T, Crow M, Fuesler J, Wang J, et al. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015;11:787 pubmed 出版商

Parameswaran B, Chiang H, Lu Y, Coates J, Deng C, Baer R, et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14:437-48 pubmed 出版商

Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, et al. The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell. 2015;14:274-83 pubmed 出版商

Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed 出版商

Ceccaldi R, Liu J, Amunugama R, Hajdu I, Primack B, Petalcorin M, et al. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 2015;518:258-62 pubmed 出版商

Jiang X, Ma T, Zhang Y, Zhang H, Yin S, Zheng W, et al. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice. Biol Reprod. 2015;92:79 pubmed 出版商

Lin Z, Hirano T, Shibata S, Seki N, Kitajima R, Sedohara A, et al. Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development. Dev Biol. 2015;400:43-58 pubmed 出版商

Ho J, Bassi C, Stambolic V. Characterization of nuclear PTEN and its post translational modifications. Methods. 2015;77-78:104-11 pubmed 出版商

La Sala G, Marazziti D, Di Pietro C, Golini E, Matteoni R, Tocchini Valentini G. Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015;29:2059-69 pubmed 出版商

Kehrli K, Sidorova J. Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells. Oncoscience. 2014;1:540-555 pubmed

Majuelos Melguizo J, Rodríguez M, López Jiménez L, Rodríguez Vargas J, Martí Martín Consuegra J, Serrano Sáenz S, et al. PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma. Oncotarget. 2015;6:4790-803 pubmed

Ochi T, Blackford A, Coates J, Jhujh S, Mehmood S, Tamura N, et al. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science. 2015;347:185-188 pubmed 出版商

Liu E, Xu N, O Prey J, Lao L, Joshi S, Long J, et al. Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proc Natl Acad Sci U S A. 2015;112:773-8 pubmed 出版商

Newman E, Lu F, Bashllari D, Wang L, Opipari A, Castle V. Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma. Mol Cancer Res. 2015;13:470-82 pubmed 出版商

Bhattacharjee V, Zhou Y, Yen T. A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell Cycle. 2014;13:3839-56 pubmed 出版商

Smith Roe S, Nakamura J, Holley D, Chastain P, Rosson G, Simpson D, et al. SWI/SNF complexes are required for full activation of the DNA-damage response. Oncotarget. 2015;6:732-45 pubmed

Abdou I, Poirier G, Hendzel M, Weinfeld M. DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair. Nucleic Acids Res. 2015;43:875-92 pubmed 出版商

Zhukova N, Ramaswamy V, Remke M, Martin D, Castelo Branco P, Zhang C, et al. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. Acta Neuropathol Commun. 2014;2:174 pubmed 出版商

Ray Chaudhuri A, Ahuja A, Herrador R, Lopes M. Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase. Mol Cell Biol. 2015;35:856-65 pubmed 出版商

Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed 出版商

Ciccia A, Huang J, Izhar L, Sowa M, Harper J, Elledge S. Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proc Natl Acad Sci U S A. 2014;111:18631-6 pubmed 出版商

Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, et al. HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015;7:78-101 pubmed 出版商

Gabriel D, Roedl D, Gordon L, Djabali K. Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. Aging Cell. 2015;14:78-91 pubmed 出版商

Chen Y, Wei M, Wang C, Lee H, Pan S, Gao M, et al. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. Cancer Lett. 2015;357:582-90 pubmed 出版商

Zhou Z, Patel M, Ng N, Hsieh M, Orth A, Walker J, et al. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. BMC Cancer. 2014;14:944 pubmed 出版商

Averbeck N, Ringel O, Herrlitz M, Jakob B, Durante M, Taucher Scholz G. DNA end resection is needed for the repair of complex lesions in G1-phase human cells. Cell Cycle. 2014;13:2509-16 pubmed 出版商

Brownlow N, Pike T, Zicha D, Collinson L, Parker P. Mitotic catenation is monitored and resolved by a PKCε-regulated pathway. Nat Commun. 2014;5:5685 pubmed 出版商

Bruhn C, Kroll T, Wang Z. Systematic characterization of cell cycle phase-dependent protein dynamics and pathway activities by high-content microscopy-assisted cell cycle phenotyping. Genomics Proteomics Bioinformatics. 2014;12:255-65 pubmed 出版商

Cho S, Cho M, Kim J, Kaeberlein M, Lee S, Suh Y. Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. Oncotarget. 2015;6:43-55 pubmed

Moutaoufik M, El Fatimy R, Nassour H, Gareau C, Lang J, Tanguay R, et al. UVC-induced stress granules in mammalian cells. PLoS ONE. 2014;9:e112742 pubmed 出版商

Waters C, Saldivar J, Amin Z, Schrock M, Huebner K. FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis. Oncotarget. 2015;6:3409-19 pubmed

Alagpulinsa D, Ayyadevara S, SHMOOKLER REIS R. A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Front Oncol. 2014;4:289 pubmed 出版商

Lehoux M, Fradet Turcotte A, Archambault J. Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response. Methods Mol Biol. 2015;1249:67-80 pubmed 出版商

Vanhoutteghem A, Messiaen S, Hervé F, Delhomme B, Moison D, Petit J, et al. The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014;141:4298-310 pubmed 出版商

Kodaira S, Konishi T, Kobayashi A, Maeda T, Ahmad T, Yang G, et al. Co-visualization of DNA damage and ion traversals in live mammalian cells using a fluorescent nuclear track detector. J Radiat Res. 2015;56:360-5 pubmed 出版商

Li Z, Mon H, Mitsunobu H, Zhu L, Xu J, Lee J, et al. Dynamics of polycomb proteins-mediated histone modifications during UV irradiation-induced DNA damage. Insect Biochem Mol Biol. 2014;55:9-18 pubmed 出版商

Harada A, Matsuzaki K, Takeiri A, Mishima M. The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens. Mutat Res Genet Toxicol Environ Mutagen. 2014;771:23-9 pubmed 出版商

Yousefzadeh M, Wyatt D, Takata K, Mu Y, Hensley S, Tomida J, et al. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 2014;10:e1004654 pubmed 出版商

Kononenko A, Bansal R, Lee N, Grimes B, Masumoto H, Earnshaw W, et al. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. 2014;42: pubmed 出版商

Yaglom J, McFarland C, Mirny L, Sherman M. Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. Oncotarget. 2014;5:8367-78 pubmed

Quimbaya M, Raspé E, Denecker G, De Craene B, Roelandt R, Declercq W, et al. Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability. Neoplasia. 2014;16:694-709 pubmed 出版商

Kerr M, Scott H, Groselj B, Stratford M, Karaszi K, Sharma N, et al. Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer. Clin Cancer Res. 2014;20:5435-45 pubmed 出版商

Smith S, Petrova A, Madden M, Wang H, Pan Y, Warren M, et al. A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response. Nucleic Acids Res. 2014;42:11517-27 pubmed 出版商

Chan Y, West S. Spatial control of the GEN1 Holliday junction resolvase ensures genome stability. Nat Commun. 2014;5:4844 pubmed 出版商

Passaro C, Volpe M, Botta G, Scamardella E, Perruolo G, Gillespie D, et al. PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma. Mol Oncol. 2015;9:78-92 pubmed 出版商

Gole B, Baumann C, Mian E, Ireno C, Wiesmuller L. Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress. Oncogene. 2015;34:3391-401 pubmed 出版商

Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed 出版商

Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed 出版商

Flach J, Bakker S, Mohrin M, Conroy P, Pietras E, Reynaud D, et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. 2014;512:198-202 pubmed 出版商

Larsen D, Hari F, Clapperton J, Gwerder M, Gutsche K, Altmeyer M, et al. The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nat Cell Biol. 2014;16:792-803 pubmed 出版商

Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging (Albany NY). 2014;6:496-510 pubmed

Smith C, Matheson T, Trombly D, Sun X, Campeau E, Han X, et al. A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Mol Biol Cell. 2014;25:2866-81 pubmed 出版商

Carlessi L, Fusar Poli E, Bechi G, Mantegazza M, Pascucci B, Narciso L, et al. Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency. Cell Death Dis. 2014;5:e1342 pubmed 出版商

Simhadri S, Peterson S, Patel D, Huo Y, Cai H, Bowman Colin C, et al. Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice. J Biol Chem. 2014;289:24617-29 pubmed 出版商

Lin B, Gupta D, Heinen C. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. J Biol Chem. 2014;289:24314-24 pubmed 出版商

Manguan García C, Pintado Berninches L, Carrillo J, Machado Pinilla R, Sastre L, Perez Quilis C, et al. Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. PLoS ONE. 2014;9:e101424 pubmed 出版商

Piazzolla D, Palla A, Pantoja C, Canamero M, de Castro I, Ortega S, et al. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun. 2014;5:4226 pubmed 出版商

Adeyemi R, Pintel D. The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice. J Virol. 2014;88:10189-99 pubmed 出版商

Kim C, Pasparakis M. Epidermal p65/NF-?B signalling is essential for skin carcinogenesis. EMBO Mol Med. 2014;6:970-83 pubmed 出版商

Gao C, Bourke E, Scobie M, Famme M, Koolmeister T, Helleday T, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014;4:5372 pubmed 出版商

Mamouni K, Cristini A, Guirouilh Barbat J, Monferran S, Lemarie A, Faye J, et al. RhoB promotes ?H2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol. 2014;34:3144-55 pubmed 出版商

FitzGerald J, Murillo L, O Brien G, O Connell E, O Connor A, Wu K, et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS ONE. 2014;9:e98891 pubmed 出版商

Verver D, Langedijk N, Jordan P, Repping S, Hamer G. The SMC5/6 complex is involved in crucial processes during human spermatogenesis. Biol Reprod. 2014;91:22 pubmed 出版商

Jain V, Hassan P, Das B. Radiation-induced conformational changes in chromatin structure in resting human peripheral blood mononuclear cells. Int J Radiat Biol. 2014;90:1143-51 pubmed 出版商

Carvalho S, Vítor A, Sridhara S, Martins F, Raposo A, Desterro J, et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. elife. 2014;3:e02482 pubmed 出版商

Sarbajna S, Davies D, West S. Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. Genes Dev. 2014;28:1124-36 pubmed 出版商

Winters T, McNicoll F, Jessberger R. Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion. EMBO J. 2014;33:1256-70 pubmed 出版商

Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed 出版商

Vidi P, Liu J, Salles D, Jayaraman S, Dorfman G, Gray M, et al. NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks. Nucleic Acids Res. 2014;42:6365-79 pubmed 出版商

Savage K, Gorski J, Barros E, Irwin G, Manti L, Powell A, et al. Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability. Mol Cell. 2014;54:445-59 pubmed 出版商

Hu B, Li S, Zhang X, Zheng X. HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acids Res. 2014;42:5582-93 pubmed 出版商

FAYZULLINA S, Martin L. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PLoS ONE. 2014;9:e93329 pubmed 出版商

Gaysinskaya V, Soh I, van der Heijden G, Bortvin A. Optimized flow cytometry isolation of murine spermatocytes. Cytometry A. 2014;85:556-65 pubmed 出版商

Stimpson K, Sullivan L, Kuo M, Sullivan B. Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. PLoS ONE. 2014;9:e92432 pubmed 出版商

Clynes D, Jelinska C, Xella B, Ayyub H, Taylor S, Mitson M, et al. ATRX dysfunction induces replication defects in primary mouse cells. PLoS ONE. 2014;9:e92915 pubmed 出版商

Wojdyla L, Stone A, Sethakorn N, Uppada S, Devito J, Bissonnette M, et al. T-oligo as an anticancer agent in colorectal cancer. Biochem Biophys Res Commun. 2014;446:596-601 pubmed 出版商

Bokobza S, Jiang Y, Weber A, Devery A, Ryan A. Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;88:947-54 pubmed 出版商

Storm M, Kumpfmueller B, Bone H, Buchholz M, Sanchez Ripoll Y, Chaudhuri J, et al. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE. 2014;9:e89821 pubmed 出版商

Morales J, Richard P, Rommel A, Fattah F, Motea E, Patidar P, et al. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res. 2014;42:4996-5006 pubmed 出版商

Murakami Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris J, Ichikawa H, et al. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle. 2014;13:1115-31 pubmed 出版商

Douthwright S, Sluder G. Link between DNA damage and centriole disengagement/reduplication in untransformed human cells. J Cell Physiol. 2014;229:1427-36 pubmed 出版商

Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sörensen Zender I, et al. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS ONE. 2014;9:e88071 pubmed 出版商

Aslanian A, Yates J, Hunter T. Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. DNA Repair (Amst). 2014;15:29-38 pubmed 出版商

Laget S, Miotto B, Chin H, Esteve P, Roberts R, Pradhan S, et al. MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress. Epigenetics. 2014;9:546-56 pubmed 出版商

Kim S, Park E, Joo H, Shen Y, Hong S, Kim C, et al. RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress. Cancer Lett. 2014;346:249-56 pubmed 出版商

Belanger F, Rajotte V, Drobetsky E. A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts. PLoS ONE. 2014;9:e85294 pubmed 出版商

Adeyemi R, Pintel D. Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells. PLoS Pathog. 2014;10:e1003891 pubmed 出版商

O Sullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014;21:167-74 pubmed 出版商

Maroschik B, Gürtler A, Kramer A, Rößler U, Gomolka M, Hornhardt S, et al. Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines. Radiat Oncol. 2014;9:15 pubmed 出版商

Schröder Heurich B, Wieland B, Lavin M, Schindler D, Dork T. Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB J. 2014;28:1331-41 pubmed 出版商

Shibata A, Moiani D, Arvai A, Perry J, Harding S, Genois M, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014;53:7-18 pubmed 出版商

Ferlazzo M, Sonzogni L, Granzotto A, Bodgi L, Lartin O, Devic C, et al. Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates. Mol Neurobiol. 2014;49:1200-11 pubmed 出版商

Hall W, Petrova A, Colbert L, Hardy C, Fisher S, Saka B, et al. Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer. Oncogene. 2014;33:5450-6 pubmed 出版商

Frame F, Pellacani D, Collins A, Simms M, Mann V, Jones G, et al. HDAC inhibitor confers radiosensitivity to prostate stem-like cells. Br J Cancer. 2013;109:3023-33 pubmed 出版商

Bana E, Sibille E, Valente S, Cerella C, Chaimbault P, Kirsch G, et al. A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. Mol Carcinog. 2015;54:229-41 pubmed 出版商

Hu L, Filippakis H, Huang H, Yen T, Gjoerup O. Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen. J Virol. 2013;87:13179-92 pubmed 出版商

Maselli J, Hales B, Robaire B. The effects of chemotherapy with bleomycin, etoposide, and cis-platinum (BEP) on rat sperm chromatin remodeling, fecundity and testicular gene expression in the progeny. Biol Reprod. 2013;89:85 pubmed 出版商

Chen Y, Kamili A, Hardy J, Groblewski G, Khanna K, Byrne J. Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle. 2013;12:3083-97 pubmed 出版商

Okumura L, Lesch B, Page D. The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. PLoS ONE. 2013;8:e66062 pubmed 出版商

Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed 出版商

Gómez Herreros F, Romero Granados R, Zeng Z, Alvarez Quilón A, Quintero C, Ju L, et al. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet. 2013;9:e1003226 pubmed 出版商

Trakala M, Fernández Miranda G, Perez de Castro I, Heeschen C, Malumbres M. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Cell Cycle. 2013;12:1030-41 pubmed 出版商

Wilson Robles H, Daly M, Pfent C, Sheppard S. Identification and evaluation of putative tumour-initiating cells in canine malignant melanoma cell lines. Vet Comp Oncol. 2015;13:60-9 pubmed 出版商

Rass E, Chandramouly G, Zha S, Alt F, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem. 2013;288:7086-95 pubmed 出版商

Lin R, Ho C, Liu L, Lyu Y. Topoisomerase II? deficiency enhances camptothecin-induced apoptosis. J Biol Chem. 2013;288:7182-92 pubmed 出版商

Zimmermann M, Lottersberger F, Buonomo S, Sfeir A, de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science. 2013;339:700-4 pubmed 出版商

Maute R, Schneider C, Sumazin P, Holmes A, Califano A, Basso K, et al. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci U S A. 2013;110:1404-9 pubmed 出版商

Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS ONE. 2012;7:e52810 pubmed 出版商

Wu L, Shao L, Li M, Zheng J, Wang J, Feng W, et al. BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks. Radiat Res. 2013;179:160-70 pubmed 出版商

Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, et al. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Mol Cell Biol. 2013;33:845-57 pubmed 出版商

Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. Nucleic Acids Res. 2013;41:900-11 pubmed 出版商

Culver Cochran A, Chadwick B. The WSTF-ISWI chromatin remodeling complex transiently associates with the human inactive X chromosome during late S-phase prior to BRCA1 and γ-H2AX. PLoS ONE. 2012;7:e50023 pubmed 出版商

Blakemore L, Boes C, Cordell R, Manson M. Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage. Carcinogenesis. 2013;34:351-60 pubmed 出版商

Conradt L, Henrich A, Wirth M, Reichert M, Lesina M, Algül H, et al. Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. Int J Cancer. 2013;132:2248-57 pubmed 出版商

Solarczyk K, Zarebski M, Dobrucki J. Inducing local DNA damage by visible light to study chromatin repair. DNA Repair (Amst). 2012;11:996-1002 pubmed 出版商

Gallagher S, Kofman A, Huszar J, Dannenberg J, Depinho R, Braun R, et al. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Dev Biol. 2013;373:83-94 pubmed 出版商

Schwab K, Smith G, Dressler G. Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol. 2013;373:64-71 pubmed 出版商

Coffey K, Blackburn T, Cook S, Golding B, Griffin R, Hardcastle I, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS ONE. 2012;7:e45539 pubmed 出版商

Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, et al. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012;40:11363-79 pubmed 出版商

Qiao H, Chen J, Reynolds A, Hoog C, PADDY M, Hunter N. Interplay between synaptonemal complex, homologous recombination, and centromeres during mammalian meiosis. PLoS Genet. 2012;8:e1002790 pubmed 出版商

Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed 出版商

Valdez B, Nieto Y, Murray D, Li Y, Wang G, Champlin R, et al. Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines. Exp Hematol. 2012;40:800-10 pubmed 出版商

Dolezalova D, Mraz M, Bárta T, Plevova K, Vinarsky V, Holubcová Z, et al. MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells. Stem Cells. 2012;30:1362-72 pubmed 出版商

McDonel P, Demmers J, Tan D, Watt F, Hendrich B. Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012;363:62-73 pubmed 出版商

Singh K, Shukla P, Quan A, Desjardins J, Lovren F, Pan Y, et al. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem. 2012;287:6604-14 pubmed 出版商

Janssen A, van der Burg M, Szuhai K, Kops G, Medema R. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science. 2011;333:1895-8 pubmed 出版商

Sims J, Wade P. Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. Mol Biol Cell. 2011;22:3094-102 pubmed 出版商

Cotta Ramusino C, McDonald E, Hurov K, Sowa M, Harper J, Elledge S. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science. 2011;332:1313-7 pubmed 出版商

Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011;39:5356-68 pubmed 出版商

Stoepker C, Hain K, Schuster B, Hilhorst Hofstee Y, Rooimans M, Steltenpool J, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-41 pubmed 出版商

Mao F, Sidorova J, Lauper J, Emond M, Monnat R. The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage. Cancer Res. 2010;70:6548-55 pubmed 出版商

Sakasai R, Teraoka H, Takagi M, Tibbetts R. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010;285:15201-8 pubmed 出版商

Tjeertes J, Miller K, Jackson S. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J. 2009;28:1878-89 pubmed 出版商

Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed 出版商

Potts P, Yu H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol. 2007;14:581-90 pubmed

Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed

Basile V, Mantovani R, Imbriano C. DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. J Biol Chem. 2006;281:2347-57 pubmed

Bi X, Slater D, Ohmori H, Vaziri C. DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. J Biol Chem. 2005;280:22343-55 pubmed

Abe H, Alavattam K, Hu Y, Pang Q, Andreassen P, Hegde R, et al. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Curr Biol. 2019;: pubmed 出版商

Kang M, Kim J, Ryu E, Ha N, Hwang S, Kim B, et al. PCNA Unloading Is Negatively Regulated by BET Proteins. Cell Rep. 2019;29:4632-4645.e5 pubmed 出版商

Fifield B, Qemo I, Kirou E, Cardiff R, Porter L. The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis. Breast Cancer Res. 2019;21:140 pubmed 出版商

Crochemore C, Fernandez Molina C, Montagne B, Salles A, Ricchetti M. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nat Commun. 2019;10:5576 pubmed 出版商

Santos Barriopedro I, Li Y, Bahl S, Seto E. HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1. Genes Cancer. 2019;10:119-133 pubmed 出版商

Marcozzi S, Rossi V, Salvatore G, Di Rella F, De Felici M, Klinger F. Distinct effects of epirubicin, cisplatin and cyclophosphamide on ovarian somatic cells of prepuberal ovaries. Aging (Albany NY). 2019;11:10532-10556 pubmed 出版商

Li P, Meng Y, Wang Y, Li J, Lam M, Wang L, et al. Nuclear localization of Desmoplakin and its involvement in telomere maintenance. Int J Biol Sci. 2019;15:2350-2362 pubmed 出版商

Masamsetti V, Low R, Mak K, O Connor A, Riffkin C, Lamm N, et al. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nat Commun. 2019;10:4224 pubmed 出版商

Wang Y, Pandey R, York A, Mallela J, Nichols W, Hu Y, et al. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nat Commun. 2019;10:4143 pubmed 出版商

Panier S, Maric M, Hewitt G, Mason Osann E, Gali H, Dai A, et al. SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance. Mol Cell. 2019;76:27-43.e11 pubmed 出版商

Parvin S, Ramírez Labrada A, Aumann S, Lu X, Weich N, Santiago G, et al. LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Cancer Cell. 2019;36:237-249.e6 pubmed 出版商

Fons N, Sundaram R, Breuer G, Peng S, McLean R, Kalathil A, et al. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun. 2019;10:3790 pubmed 出版商

Swartz S, McKay L, Su K, Bury L, Padeganeh A, Maddox P, et al. Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential. Dev Cell. 2019;51:35-48.e7 pubmed 出版商

Chatzifrangkeskou M, Pefani D, Eyres M, Vendrell I, Fischer R, Panková D, et al. RASSF1A is required for the maintenance of nuclear actin levels. EMBO J. 2019;38:e101168 pubmed 出版商

Kim D, Camacho C, Nagari A, Malladi V, Challa S, Kraus W. Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Mol Cell. 2019;: pubmed 出版商

Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, et al. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nat Commun. 2019;10:3329 pubmed 出版商

Kochan J, van den Belt M, von der Lippe J, Desclos E, Steurer B, Hoebe R, et al. Ultra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage. Nucleic Acids Res. 2019;47:e100 pubmed 出版商

Gross K, Zhou W, Breindel J, Ouyang J, Jin D, Sokol E, et al. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019;28:394-407.e6 pubmed 出版商

Borghesan M, Fafián Labora J, Eleftheriadou O, Carpintero Fernández P, Pàez Ribes M, Vizcay Barrena G, et al. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep. 2019;27:3956-3971.e6 pubmed 出版商

Ahn J, Cho M, Sohn S, Lee J. Inhibition of PP2A activity by H2O2 during mitosis disrupts nuclear envelope reassembly and alters nuclear shape. Exp Mol Med. 2019;51:64 pubmed 出版商

Marshall A, Roes M, Passos D, DeWeerd M, Chaikovsky A, Sage J, et al. RB1 deletion in RB-pathway disrupted cells results in DNA damage and cancer progression. Mol Cell Biol. 2019;: pubmed 出版商

Velichko A, Petrova N, Luzhin A, Strelkova O, Ovsyannikova N, Kireev I, et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription. Nucleic Acids Res. 2019;: pubmed 出版商

Wallace H, Rana V, Nguyen H, Bosco G. Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability. J Cell Physiol. 2019;: pubmed 出版商

Kounatidou E, Nakjang S, McCracken S, Dehm S, Robson C, Jones D, et al. A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities. Nucleic Acids Res. 2019;47:5634-5647 pubmed 出版商

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, et al. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019;177:622-638.e22 pubmed 出版商

Macleod G, Bozek D, Rajakulendran N, Monteiro V, Ahmadi M, Steinhart Z, et al. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. Cell Rep. 2019;27:971-986.e9 pubmed 出版商

Wu D, Pepowski B, Takahashi S, Kron S. A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence. BMC Genomics. 2019;20:290 pubmed 出版商

Lou J, Scipioni L, Wright B, Bartolec T, Zhang J, Masamsetti V, et al. Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response. Proc Natl Acad Sci U S A. 2019;116:7323-7332 pubmed 出版商

Leimbacher P, Jones S, Shorrocks A, De Marco Zompit M, Day M, Blaauwendraad J, et al. MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis. Mol Cell. 2019;74:571-583.e8 pubmed 出版商

Carbajosa S, Pansa M, Paviolo N, Castellaro A, Andino D, Nigra A, et al. Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction. Clin Cancer Res. 2019;: pubmed 出版商

Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019;10:1224 pubmed 出版商

Moeglin E, Desplancq D, Conic S, Oulad Abdelghani M, Stoessel A, Chiper M, et al. Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress. Cancers (Basel). 2019;11: pubmed 出版商

Hu C, Tien S, Hsieh P, Jeng Y, Chang M, Chang Y, et al. High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. Cell Metab. 2019;29:1334-1349.e10 pubmed 出版商

Dehghan Harati M, Rodemann H, Toulany M. Nanog Signaling Mediates Radioresistance in ALDH-Positive Breast Cancer Cells. Int J Mol Sci. 2019;20: pubmed 出版商

Ly P, Brunner S, Shoshani O, Kim D, Lan W, Pyntikova T, et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019;51:705-715 pubmed 出版商

Salvador Moreno N, Liu J, Haas K, Parker L, Chakraborty C, Kron S, et al. The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic Acids Res. 2019;47:2703-2715 pubmed 出版商

Wang Y, Yang J, Wild A, Wu W, Shah R, Danussi C, et al. G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma. Nat Commun. 2019;10:943 pubmed 出版商

Alfano L, Caporaso A, Altieri A, Dell Aquila M, Landi C, Bini L, et al. Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Nucleic Acids Res. 2019;47:4068-4085 pubmed 出版商

Wang Z, Gong Y, Peng B, Shi R, Fan D, Zhao H, et al. MRE11 UFMylation promotes ATM activation. Nucleic Acids Res. 2019;47:4124-4135 pubmed 出版商

Kim H, Chang J, Iyer S, Han L, Campisi J, Manolagas S, et al. Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice. Aging Cell. 2019;18:e12923 pubmed 出版商

Burrage L, Reynolds J, Baratang N, Phillips J, Wegner J, McFarquhar A, et al. Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Am J Hum Genet. 2019;104:422-438 pubmed 出版商

Villafañez F, García I, Carbajosa S, Pansa M, Mansilla S, Llorens M, et al. AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress. Oncogene. 2019;38:4310-4324 pubmed 出版商

Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, et al. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment. Nucleic Acids Res. 2019;47:3365-3382 pubmed 出版商

Mengwasser K, Adeyemi R, Leng Y, Choi M, Clairmont C, D Andrea A, et al. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019;73:885-899.e6 pubmed 出版商

Owusu M, Bannauer P, Ferreira da Silva J, Mourikis T, Jones A, Májek P, et al. Mapping the Human Kinome in Response to DNA Damage. Cell Rep. 2019;26:555-563.e6 pubmed 出版商

Fine A, Ball R, Fujiwara Y, Handel M, Carter G. Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis. Mol Biol Cell. 2019;30:717-728 pubmed 出版商

Alameda J, Ramirez A, Garcia Fernandez R, Navarro M, Page A, Segovia J, et al. Premature aging and cancer development in transgenic mice lacking functional CYLD. Aging (Albany NY). 2019;11:127-159 pubmed 出版商

Donnio L, Lagarou A, Sueur G, Mari P, Giglia Mari G. CSB-Dependent Cyclin-Dependent Kinase 9 Degradation and RNA Polymerase II Phosphorylation during Transcription-Coupled Repair. Mol Cell Biol. 2019;39: pubmed 出版商

Champion L, Pawar S, Luithle N, Ungricht R, Kutay U. Dissociation of membrane-chromatin contacts is required for proper chromosome segregation in mitosis. Mol Biol Cell. 2019;30:427-440 pubmed 出版商

Dworak N, Mąkosa D, Chatterjee M, Jividen K, Yang C, Snow C, et al. A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling. Aging Cell. 2019;18:e12851 pubmed 出版商

Wang C, Wang G, Feng X, Shepherd P, Zhang J, Tang M, et al. Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene. 2019;38:2451-2463 pubmed 出版商

Zheng S, Kusnadi A, Choi J, Vuong B, Rhodes D, Chaudhuri J. NME proteins regulate class switch recombination. FEBS Lett. 2019;593:80-87 pubmed 出版商

Okamoto K, Ohishi T, Kuroiwa M, Iemura S, Natsume T, Seimiya H. MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs. Oncotarget. 2018;9:35844-35855 pubmed 出版商

Poetsch A, Boulton S, Luscombe N. Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis. Genome Biol. 2018;19:215 pubmed 出版商

Arnandis T, Monteiro P, Adams S, Bridgeman V, Rajeeve V, Gadaleta E, et al. Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell. 2018;47:409-424.e9 pubmed 出版商

Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan Wong S, Dhir S, et al. Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence. Mol Cell. 2018;72:970-984.e7 pubmed 出版商

Baek H, Kim S, Choi E, Kim J, Shin D, Park E, et al. Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation. Int J Biol Sci. 2018;14:1755-1768 pubmed 出版商

. 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) : Washington, D.C., USA. 7-11 November 2018. J Immunother Cancer. 2018;6:114 pubmed 出版商

Barikbin R, Berkhout L, Bolik J, Schmidt Arras D, Ernst T, Ittrich H, et al. Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2-/- mice. Sci Rep. 2018;8:16238 pubmed 出版商

Jones G, Rooney C, Griffin N, Roudier M, Young L, Garcia Trinidad A, et al. pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. Br J Cancer. 2018;119:1233-1243 pubmed 出版商

Bhatia V, Valdés Sánchez L, Rodríguez Martínez D, Bhattacharya S. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Res. 2018;7:1233 pubmed 出版商

Piquet S, Le Parc F, Bai S, Chevallier O, Adam S, Polo S. The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage. Mol Cell. 2018;72:888-901.e7 pubmed 出版商

López Erauskin J, Tadokoro T, Baughn M, Myers B, McAlonis Downes M, Chillon Marinas C, et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018;100:816-830.e7 pubmed 出版商

Gao Y, Kardos J, Yang Y, Tamir T, Mutter Rottmayer E, Weissman B, et al. The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells. Sci Rep. 2018;8:15304 pubmed 出版商

Ferrara Romeo I, Martinez P, Blasco M. Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice. PLoS ONE. 2018;13:e0204909 pubmed 出版商

Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018;9:4115 pubmed 出版商

Vattulainen Collanus S, Southwood M, Yang X, Moore S, Ghatpande P, Morrell N, et al. Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells. Commun Biol. 2018;1:149 pubmed 出版商

Velagapudi S, Costales M, Vummidi B, Nakai Y, Angelbello A, Tran T, et al. Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs. Cell Chem Biol. 2018;25:1086-1094.e7 pubmed 出版商

Albers E, Sbroggiò M, Pladevall Morera D, Bizard A, Avram A, Gonzalez P, et al. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell Rep. 2018;24:3274-3284 pubmed 出版商

. Essential Role of BRCA2 in Ovarian Development and Function. N Engl J Med. 2018;379:1042-1049 pubmed 出版商

Findlay S, Heath J, Luo V, Malina A, Morin T, Coulombe Y, et al. SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice. EMBO J. 2018;37: pubmed 出版商

Fu Y, Long M, Wisitpitthaya S, Inayat H, Pierpont T, Elsaid I, et al. Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3. Nat Chem Biol. 2018;14:943-954 pubmed 出版商

Zagnoli Vieira G, Bruni F, Thompson K, He L, Walker S, de Brouwer A, et al. Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23). Neurol Genet. 2018;4:e262 pubmed 出版商

L honoré A, Commere P, Negroni E, Pallafacchina G, Friguet B, Drouin J, et al. The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration. elife. 2018;7: pubmed 出版商

Kratz K, de Lange T. Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b. J Biol Chem. 2018;293:14384-14392 pubmed 出版商

Yue Z, Gao R, Gao C, Liu S, Zhao X, Xing T, et al. The prognostic potential of coilin in association with p27 expression in pediatric acute lymphoblastic leukemia for disease relapse. Cancer Cell Int. 2018;18:106 pubmed 出版商

Manzo S, Hartono S, Sanz L, Marinello J, De Biasi S, Cossarizza A, et al. DNA Topoisomerase I differentially modulates R-loops across the human genome. Genome Biol. 2018;19:100 pubmed 出版商

Stellavato A, Pirozzi A, Donato S, Scognamiglio I, Reale S, Di Pardo A, et al. Positive Effects against UV-A Induced Damage and Oxidative Stress on an In Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals. Biomed Res Int. 2018;2018:8481243 pubmed 出版商

Van Ly D, Low R, Frölich S, Bartolec T, Kafer G, Pickett H, et al. Telomere Loop Dynamics in Chromosome End Protection. Mol Cell. 2018;71:510-525.e6 pubmed 出版商

Feng X, Hsu S, Bhattacharjee A, Wang Y, Diao J, Price C. CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. Nat Commun. 2018;9:2827 pubmed 出版商

Luczak M, Zhitkovich A. Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks. Toxicol Appl Pharmacol. 2018;355:238-246 pubmed 出版商

Georgilis A, Klotz S, Hanley C, Herranz N, Weirich B, Morancho B, et al. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell. 2018;34:85-102.e9 pubmed 出版商

Miyamoto Y, Whiley P, Goh H, Wong C, Higgins G, Tachibana T, et al. The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress. Biol Open. 2018;7: pubmed 出版商

Andrews A, McCartney H, Errington T, D Andrea A, Macara I. A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links. Nat Commun. 2018;9:2592 pubmed 出版商

Dandoulaki M, Petsalaki E, Sumpton D, Zanivan S, Zachos G. Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis. J Cell Biol. 2018;217:3071-3089 pubmed 出版商

Blaudin de Thé F, Rekaik H, Peze Heidsieck E, Massiani Beaudoin O, Joshi R, Fuchs J, et al. Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression. EMBO J. 2018;37: pubmed 出版商

Higgs M, Sato K, Reynolds J, Begum S, Bayley R, Goula A, et al. Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2. Mol Cell. 2018;71:25-41.e6 pubmed 出版商

Bernal A, Moltó Abad M, Dominguez D, Tusell L. Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells. Oncotarget. 2018;9:27151-27170 pubmed 出版商

Pefani D, Tognoli M, Pirincci Ercan D, Gorgoulis V, O Neill E. MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B. EMBO J. 2018;37: pubmed 出版商

Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César Razquin A, et al. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun. 2018;9:1983 pubmed 出版商

Bellelli R, Borel V, Logan C, Svendsen J, Cox D, Nye E, et al. Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell. 2018;70:707-721.e7 pubmed 出版商

Ho T, Sitz J, Shen Q, Leblanc Lacroix A, Campos E, Borozan I, et al. A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. J Virol. 2018;92: pubmed 出版商

Koh S, Wallez Y, Dunlop C, Bernaldo de Quirós Fernández S, Bapiro T, Richards F, et al. Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine. Cancer Res. 2018;78:3054-3066 pubmed 出版商

Bowling S, Di Gregorio A, Sancho M, Pozzi S, Aarts M, Signore M, et al. P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development. Nat Commun. 2018;9:1763 pubmed 出版商

Rehman I, Basu S, Das S, Bhattacharjee S, Ghosh A, Pommier Y, et al. PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes. Nucleic Acids Res. 2018;46:5601-5617 pubmed 出版商

Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, et al. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018;37:4385-4397 pubmed 出版商

Balmus G, Larrieu D, Barros A, Collins C, Abrudan M, Demir M, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9:1700 pubmed 出版商

Miettinen T, Peltier J, Hartlova A, Gierlinski M, Jansen V, Trost M, et al. Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib. EMBO J. 2018;37: pubmed 出版商

Luo M, Bao Z, Xu F, Wang X, Li F, Li W, et al. Unrepaired DNA damage in macrophages causes elevation of particulate matter- induced airway inflammatory response. Aging (Albany NY). 2018;10:549-560 pubmed 出版商

Tang Z, Yang J, Wang X, Zeng M, Wang J, Wang A, et al. Active DNA end processing in micronuclei of ovarian cancer cells. BMC Cancer. 2018;18:426 pubmed 出版商

Taschner M, Lorentzen A, Mourão A, Collins T, Freke G, Moulding D, et al. Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis. elife. 2018;7: pubmed 出版商

La Torre M, Merigliano C, Burla R, Mottini C, Zanetti G, Del Giudice S, et al. Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. Aging Cell. 2018;:e12730 pubmed 出版商

Varghese J, Schmale I, Mickelsen D, Hansen M, Newlands S, Benoit D, et al. Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection. J Dent Res. 2018;97:1252-1259 pubmed 出版商

Cho S, Abbas A, Irianto J, Ivanovska I, Xia Y, Tewari M, et al. Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. Nucleus. 2018;9:230-245 pubmed 出版商

Barbieri D, Elvira Matelot E, Pelinski Y, Genève L, de Laval B, Yogarajah G, et al. Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response. J Exp Med. 2018;215:1463-1480 pubmed 出版商

Fu J, Huang D, Yuan F, Xie N, Li Q, Sun X, et al. TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage-induced activation of NF-κB. J Biol Chem. 2018;293:7268-7280 pubmed 出版商

Jan S, Jongejan A, Korver C, van Daalen S, van Pelt A, Repping S, et al. Distinct prophase arrest mechanisms in human male meiosis. Development. 2018;145: pubmed 出版商

Sun C, Yin J, Fang Y, Chen J, Jeong K, Chen X, et al. BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell. 2018;33:401-416.e8 pubmed 出版商

Li C, Irrazabal T, So C, Berru M, Du L, Lam E, et al. The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining. Nat Commun. 2018;9:1006 pubmed 出版商

Gong H, Zhang Y, Jiang K, Ye S, Chen S, Zhang Q, et al. p73 coordinates with Δ133p53 to promote DNA double-strand break repair. Cell Death Differ. 2018;25:1063-1079 pubmed 出版商

Baranes Bachar K, Levy Barda A, Oehler J, Reid D, Soria Bretones I, Voss T, et al. The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Mol Cell. 2018;69:866-878.e7 pubmed 出版商

Miotto B, Marchal C, Adelmant G, Guinot N, Xie P, Marto J, et al. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Nucleic Acids Res. 2018;46:4392-4404 pubmed 出版商

Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, et al. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018;9:333-350 pubmed 出版商

Tiwari A, Addis Jones O, Chan K. 53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process. Nat Commun. 2018;9:677 pubmed 出版商

Okamoto Y, Iwasaki W, Kugou K, Takahashi K, Oda A, Sato K, et al. Replication stress induces accumulation of FANCD2 at central region of large fragile genes. Nucleic Acids Res. 2018;46:2932-2944 pubmed 出版商

Her J, Ray C, Altshuler J, Zheng H, Bunting S. 53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress. Mol Cell Biol. 2018;38: pubmed 出版商

Iniguez A, Stolte B, Wang E, Conway A, Alexe G, Dharia N, et al. EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. Cancer Cell. 2018;33:202-216.e6 pubmed 出版商

Shi B, Xue J, Zhou J, Kasowitz S, Zhang Y, Liang G, et al. MORC2B is essential for meiotic progression and fertility. PLoS Genet. 2018;14:e1007175 pubmed 出版商

Wang L, Tu Z, Liu C, Liu H, Kaldis P, Chen Z, et al. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis. Cell Death Differ. 2018;25:1174-1188 pubmed 出版商

Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed 出版商

Fischer J, Zubel T, Jander K, Fix J, Trussina I, Gebhard D, et al. PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity. Arch Toxicol. 2018;92:1323-1340 pubmed 出版商

Chakraborty A, Dorsett K, Trummell H, Yang E, Oliver P, Bonner J, et al. ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage. J Biol Chem. 2018;293:984-994 pubmed 出版商

Carey J, Karakas C, Bui T, Chen X, Vijayaraghavan S, Zhao Y, et al. Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer. Cancer Res. 2018;78:742-757 pubmed 出版商

Canny M, Moatti N, Wan L, Fradet Turcotte A, Krasner D, Mateos Gomez P, et al. Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nat Biotechnol. 2018;36:95-102 pubmed 出版商

Grey W, Ivey A, Milne T, Haferlach T, Grimwade D, Uhlmann F, et al. The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability. Biochim Biophys Acta Mol Cell Res. 2018;1865:105-116 pubmed 出版商

Misiak M, Heldt M, Szeligowska M, Mazzini S, Scaglioni L, Grabe G, et al. Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7. Oncotarget. 2017;8:105137-105154 pubmed 出版商

Wang Y, Hariharan A, Bastianello G, Toyama Y, Shivashankar G, Foiani M, et al. DNA damage causes rapid accumulation of phosphoinositides for ATR signaling. Nat Commun. 2017;8:2118 pubmed 出版商

Onyango D, Lee G, Stark J. PRPF8 is important for BRCA1-mediated homologous recombination. Oncotarget. 2017;8:93319-93337 pubmed 出版商

Guo X, Bai Y, Zhao M, Zhou M, Shen Q, Yun C, et al. Acetylation of 53BP1 dictates the DNA double strand break repair pathway. Nucleic Acids Res. 2017;: pubmed 出版商

Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, et al. Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nat Cell Biol. 2017;19:1400-1411 pubmed 出版商

Hromas R, Kim H, Sidhu G, Williamson E, Jaiswal A, Totterdale T, et al. The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells. Breast Cancer Res. 2017;19:122 pubmed 出版商

Gong J, Huang M, Wang F, Ma X, Liu H, Tu Y, et al. RBM45 competes with HDAC1 for binding to FUS in response to DNA damage. Nucleic Acids Res. 2017;45:12862-12876 pubmed 出版商

Vohhodina J, Barros E, Savage A, Liberante F, Manti L, Bankhead P, et al. The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export. Nucleic Acids Res. 2017;45:12816-12833 pubmed 出版商

Méndez Pertuz M, Martinez P, Blanco Aparicio C, Gómez Casero E, Belen García A, Martinez Torrecuadrada J, et al. Modulation of telomere protection by the PI3K/AKT pathway. Nat Commun. 2017;8:1278 pubmed 出版商

Fouquin A, Guirouilh Barbat J, Lopez B, Hall J, Amor Gueret M, Pennaneach V. PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection. Nucleic Acids Res. 2017;45:12325-12339 pubmed 出版商

Parisis N, Krasinska L, Harker B, Urbach S, Rossignol M, Camasses A, et al. Initiation of DNA replication requires actin dynamics and formin activity. EMBO J. 2017;36:3212-3231 pubmed 出版商

Bencherit D, Remy S, Le Vern Y, Vychodil T, Bertzbach L, Kaufer B, et al. Induction of DNA Damages upon Marek's Disease Virus Infection: Implication in Viral Replication and Pathogenesis. J Virol. 2017;91: pubmed 出版商

Schuhwerk H, Bruhn C, Siniuk K, Min W, Erener S, Grigaravicius P, et al. Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo. Nucleic Acids Res. 2017;45:11174-11192 pubmed 出版商

Moruno Manchon J, Koellhoffer E, Gopakumar J, Hambarde S, Kim N, McCullough L, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9:1957-1970 pubmed 出版商

Mochizuki A, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, et al. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. Mol Cell Biol. 2017;37: pubmed 出版商

Chang C, Kuo C, Ito T, Su Y, Jiang S, Chiu M, et al. CK1? ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation. Proc Natl Acad Sci U S A. 2017;114:E8035-E8044 pubmed 出版商

Hollingworth R, Horniblow R, Forrest C, Stewart G, Grand R. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017;91: pubmed 出版商

Vidi P, Anderson K, Chen H, Anderson R, Salvador Moreno N, Mora D, et al. Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children. Mutat Res. 2017;822:27-33 pubmed 出版商

Sapio R, Nezdyur A, Krevetski M, Anikin L, Manna V, Minkovsky N, et al. Inhibition of post-transcriptional steps in ribosome biogenesis confers cytoprotection against chemotherapeutic agents in a p53-dependent manner. Sci Rep. 2017;7:9041 pubmed 出版商

Simón Carrasco L, Grana O, Salmón M, Jacob H, Gutierrez A, Jiménez G, et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017;31:1456-1468 pubmed 出版商

Horton S, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford Rogers R, et al. Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nat Cell Biol. 2017;19:1093-1104 pubmed 出版商

Daniloski Z, Smith S. Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells. Cancer Res. 2017;77:5530-5542 pubmed 出版商

Avgousti D, Della Fera A, Otter C, Herrmann C, Pancholi N, Weitzman M. Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome. J Virol. 2017;91: pubmed 出版商

Nieto P, Ambrogio C, Esteban Burgos L, Gomez Lopez G, Blasco M, Yao Z, et al. A Braf kinase-inactive mutant induces lung adenocarcinoma. Nature. 2017;548:239-243 pubmed 出版商

Betts J, Moradi Marjaneh M, Al Ejeh F, Lim Y, Shi W, Sivakumaran H, et al. Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage. Am J Hum Genet. 2017;101:255-266 pubmed 出版商

Min J, Wright W, Shay J. Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Mol Cell Biol. 2017;37: pubmed 出版商

Mackenzie K, Carroll P, Martin C, Murina O, Fluteau A, Simpson D, et al. cGAS surveillance of micronuclei links genome instability to innate immunity. Nature. 2017;548:461-465 pubmed 出版商

Walker C, Herranz Martin S, Karyka E, Liao C, Lewis K, Elsayed W, et al. C9orf72 expansion disrupts ATM-mediated chromosomal break repair. Nat Neurosci. 2017;20:1225-1235 pubmed 出版商

Sivanand S, Rhoades S, Jiang Q, Lee J, Benci J, Zhang J, et al. Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell. 2017;67:252-265.e6 pubmed 出版商

Pan X, Drosopoulos W, Sethi L, Madireddy A, Schildkraut C, Zhang D. FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres. Proc Natl Acad Sci U S A. 2017;114:E5940-E5949 pubmed 出版商

Chu H, Cifuentes Rojas C, Kesner B, Aeby E, Lee H, Wei C, et al. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell. 2017;170:86-101.e16 pubmed 出版商

Zarei M, Lal S, Parker S, Nevler A, Vaziri Gohar A, Dukleska K, et al. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. Cancer Res. 2017;77:4460-4471 pubmed 出版商

Liu L, He J, Wei X, Wan G, Lao Y, Xu W, et al. MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability. Oncogene. 2017;36:5874-5884 pubmed 出版商

Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, et al. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. 2017;36:2161-2176 pubmed 出版商

Grossman N, Bono D, Dedic N, Kodandaramaiah S, Rudenko A, Suk H, et al. Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. Cell. 2017;169:1029-1041.e16 pubmed 出版商

Gong F, Clouaire T, Aguirrebengoa M, Legube G, Miller K. Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair. J Cell Biol. 2017;216:1959-1974 pubmed 出版商

Li Y, Luo K, Yin Y, Wu C, Deng M, Li L, et al. USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. Nat Commun. 2017;8:15752 pubmed 出版商

Reda A, Albalushi H, Montalvo S, Nurmio M, Sahin Z, Hou M, et al. Knock-Out Serum Replacement and Melatonin Effects on Germ Cell Differentiation in Murine Testicular Explant Cultures. Ann Biomed Eng. 2017;45:1783-1794 pubmed 出版商

Day T, Layer J, Cleary J, Guha S, Stevenson K, Tivey T, et al. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun. 2017;8:15110 pubmed 出版商

Latella L, Dall Agnese A, Boscolo F, Nardoni C, Cosentino M, Lahm A, et al. DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation. Genes Dev. 2017;31:648-659 pubmed 出版商

Kim H, Chang J, Shao L, Han L, Iyer S, Manolagas S, et al. DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age. Aging Cell. 2017;16:693-703 pubmed 出版商

Gasset Rosa F, Chillon Marinas C, Goginashvili A, Atwal R, Artates J, Tabet R, et al. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. 2017;94:48-57.e4 pubmed 出版商

Berton S, Cusan M, Segatto I, Citron F, D Andrea S, Benevol S, et al. Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells. Sci Rep. 2017;7:595 pubmed 出版商

Bhattacharya S, Srinivasan K, Abdisalaam S, Su F, Raj P, Dozmorov I, et al. RAD51 interconnects between DNA replication, DNA repair and immunity. Nucleic Acids Res. 2017;45:4590-4605 pubmed 出版商

Han D, Chen Q, Shi J, Zhang F, Yu X. CTCF participates in DNA damage response via poly(ADP-ribosyl)ation. Sci Rep. 2017;7:43530 pubmed 出版商

Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, et al. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS ONE. 2017;12:e0173047 pubmed 出版商

Slator C, Molphy Z, McKee V, Kellett A. Triggering autophagic cell death with a di-manganese(II) developmental therapeutic. Redox Biol. 2017;12:150-161 pubmed 出版商

Qiu Z, Zhang Z, Roschke A, Varga T, Aplan P. Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break. Sci Rep. 2017;7:43156 pubmed 出版商

Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S. NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell. 2017;65:801-817.e4 pubmed 出版商

Hua G, Wang C, Pan Y, Zeng Z, Lee S, Martin M, et al. Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells. Cancer Res. 2017;77:2124-2133 pubmed 出版商

Walter D, Venancio O, Buza E, Tobias J, Deshpande C, Gudiel A, et al. Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma. Cancer Res. 2017;77:1719-1729 pubmed 出版商

Modi P, Balakrishnan K, Yang Q, Wierda W, Keating M, Gandhi V. Idelalisib and bendamustine combination is synergistic and increases DNA damage response in chronic lymphocytic leukemia cells. Oncotarget. 2017;8:16259-16274 pubmed 出版商

Viziteu E, Klein B, Basbous J, Lin Y, Hirtz C, Gourzones C, et al. RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma. Leukemia. 2017;31:2104-2113 pubmed 出版商

Sun L, Nakajima S, Teng Y, Chen H, Yang L, Chen X, et al. WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. Nucleic Acids Res. 2017;45:3844-3859 pubmed 出版商

Biehs R, Steinlage M, Barton O, Juhasz S, Künzel J, Spies J, et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell. 2017;65:671-684.e5 pubmed 出版商

Borsos B, Huliák I, Majoros H, Ujfaludi Z, Gyenis A, Pukler P, et al. Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage. Sci Rep. 2017;7:40960 pubmed 出版商

Reindl J, Girst S, Walsh D, Greubel C, Schwarz B, Siebenwirth C, et al. Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci. Sci Rep. 2017;7:40616 pubmed 出版商

Bijangi Vishehsaraei K, Reza Saadatzadeh M, Wang H, Nguyen A, Kamocka M, Cai W, et al. Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways. J Neurosurg. 2017;127:1219-1230 pubmed 出版商

Atwal M, Lishman E, Austin C, Cowell I. Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy. Mol Pharmacol. 2017;91:49-57 pubmed

Chen Y, Liu H, Zhang H, Sun C, Hu Z, Tian Q, et al. And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance. Nucleic Acids Res. 2017;45:2516-2530 pubmed 出版商

Kramer D, Stark N, Schulz Heddergott R, Erytch N, Edmunds S, Roßmann L, et al. Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells. Cell Death Differ. 2017;24:300-316 pubmed 出版商

Zámborszky J, Szikriszt B, Gervai J, Pipek O, Poti A, Krzystanek M, et al. Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions. Oncogene. 2017;36:746-755 pubmed 出版商

Lohse I, Kumareswaran R, Cao P, Pitcher B, Gallinger S, Bristow R, et al. Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts. PLoS ONE. 2016;11:e0167272 pubmed 出版商

Gabriel D, Gordon L, Djabali K. Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype. PLoS ONE. 2016;11:e0168988 pubmed 出版商

Borodkina A, Shatrova A, Deryabin P, Griukova A, Abushik P, Antonov S, et al. Calcium alterations signal either to senescence or to autophagy induction in stem cells upon oxidative stress. Aging (Albany NY). 2016;8:3400-3418 pubmed 出版商

Lopez Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic Terzic I, Terzic J, et al. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. elife. 2016;5: pubmed 出版商

Rasmussen R, Gajjar M, Tučková L, Jensen K, Maya Mendoza A, Holst C, et al. BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity. Nat Commun. 2016;7:13398 pubmed 出版商

Goh Y, Yan Y, Tan N, Goh S, Li S, Teoh Y, et al. Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex. Sci Rep. 2016;6:36868 pubmed 出版商

Lerner C, Lei W, Sundar I, Rahman I. Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury. Front Pharmacol. 2016;7:391 pubmed

Aredia F, Czaplinski S, Fulda S, Scovassi A. Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage. BMC Cancer. 2016;16:851 pubmed

De Chiara G, Racaniello M, Mollinari C, Marcocci M, Aversa G, Cardinale A, et al. Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons. Front Aging Neurosci. 2016;8:242 pubmed

Petrova N, Luzhin A, Serebrovskaya E, Ryumina A, Velichko A, Razin S, et al. Inducing cellular senescence in vitro by using genetically encoded photosensitizers. Aging (Albany NY). 2016;8:2449-2462 pubmed 出版商

Leidecker O, Bonfiglio J, Colby T, Zhang Q, Atanassov I, Zaja R, et al. Serine is a new target residue for endogenous ADP-ribosylation on histones. Nat Chem Biol. 2016;12:998-1000 pubmed 出版商

Wang Y, Guan H, Xie D, Xie Y, Liu X, Wang Q, et al. Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation. PLoS ONE. 2016;11:e0163896 pubmed 出版商

Nagaria P, Robert C, Park T, Huo J, Zambidis E, Rassool F. High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature. Stem Cells Int. 2016;2016:3826249 pubmed 出版商

Xia N, Cai J, Wang F, Dong B, Liu S, Chen F, et al. SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1. Sci Rep. 2016;6:34099 pubmed 出版商

Moureau S, Luessing J, Harte E, Voisin M, Lowndes N. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol. 2016;6: pubmed

Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, et al. Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016;6:33861 pubmed 出版商

Kanu N, Cerone M, Goh G, Zalmas L, Bartkova J, Dietzen M, et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. Genome Biol. 2016;17:185 pubmed 出版商

Bhide S, Thway K, Lee J, Wong K, Clarke P, Newbold K, et al. Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma. Br J Cancer. 2016;115:825-30 pubmed 出版商

Nieto Soler M, Morgado Palacin I, Lafarga V, Lecona E, Murga M, Callen E, et al. Efficacy of ATR inhibitors as single agents in Ewing sarcoma. Oncotarget. 2016;7:58759-58767 pubmed 出版商

Ball R, Fujiwara Y, Sun F, Hu J, Hibbs M, Handel M, et al. Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes. BMC Genomics. 2016;17:628 pubmed 出版商

Ding X, Ray Chaudhuri A, Callen E, Pang Y, Biswas K, Klarmann K, et al. Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nat Commun. 2016;7:12425 pubmed 出版商

Hartford S, Chittela R, Ding X, Vyas A, MARTIN B, Burkett S, et al. Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2. PLoS Genet. 2016;12:e1006236 pubmed 出版商

Wang Y, Krais J, Bernhardy A, Nicolas E, Cai K, Harrell M, et al. RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. J Clin Invest. 2016;126:3145-57 pubmed 出版商

Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016;12:e1006107 pubmed 出版商

Simon A, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, et al. Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. J Exp Med. 2016;213:1429-40 pubmed 出版商

van der Crabben S, Hennus M, McGregor G, Ritter D, Nagamani S, Wells O, et al. Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. J Clin Invest. 2016;126:2881-92 pubmed 出版商

Noll A, Illuzzi G, Ame J, Dantzer F, Schreiber V. PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency. Cancer Cell Int. 2016;16:53 pubmed 出版商

Saredi G, Huang H, Hammond C, Alabert C, Bekker Jensen S, Forne I, et al. H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Nature. 2016;534:714-718 pubmed 出版商

van Ree J, Nam H, Jeganathan K, Kanakkanthara A, van Deursen J. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016;18:814-21 pubmed 出版商

Mayer M, Kaiser N, Layer P, Frohns F. Cell Cycle Regulation and Apoptotic Responses of the Embryonic Chick Retina by Ionizing Radiation. PLoS ONE. 2016;11:e0155093 pubmed 出版商

Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed 出版商

Lima M, Bouzid H, Soares D, Selle F, Morel C, Galmarini C, et al. Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair. Oncotarget. 2016;7:25885-901 pubmed 出版商

Rai P, He F, Kwang J, Engelward B, Chow V. Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest. Sci Rep. 2016;6:22972 pubmed 出版商

Lecona E, Rodriguez Acebes S, Specks J, López Contreras A, Ruppen I, Murga M, et al. USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 2016;23:270-7 pubmed 出版商

Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala S. Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mol Cell Biol. 2016;36:1354-65 pubmed 出版商

Bassi C, Li Y, Khu K, Mateo F, Baniasadi P, Elia A, et al. The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. Cell Death Differ. 2016;23:1198-208 pubmed 出版商

Yang Y, Poe J, Yang L, Fedoriw A, Desai S, Magnuson T, et al. Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. Nucleic Acids Res. 2016;44:4174-88 pubmed 出版商

Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016;212:399-408 pubmed 出版商

Mollet I, Patel D, Govani F, Giess A, Paschalaki K, Periyasamy M, et al. Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes. PLoS ONE. 2016;11:e0147990 pubmed 出版商

Poletto M, Legrand A, Fletcher S, Dianov G. p53 coordinates base excision repair to prevent genomic instability. Nucleic Acids Res. 2016;44:3165-75 pubmed 出版商

Zambrano S, De Toma I, Piffer A, Bianchi M, Agresti A. NF-κB oscillations translate into functionally related patterns of gene expression. elife. 2016;5:e09100 pubmed 出版商

Zhao D, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges F, et al. SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature. 2016;529:48-53 pubmed 出版商

Ahmed E, Scherthan H, de Rooij D. DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids. Int J Mol Sci. 2015;16:29923-35 pubmed 出版商

Cramer C, Yoon S, Reinsvold M, Joo K, Norris H, Hood R, et al. Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats. PLoS ONE. 2015;10:e0143208 pubmed 出版商

Iuso D, Czernik M, Toschi P, Fidanza A, Zacchini F, Feil R, et al. Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures. Cell Rep. 2015;13:1765-71 pubmed 出版商

Wright D, Marchal C, Hoang K, Ankney J, Nguyen S, Rushing A, et al. Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget. 2016;7:1687-706 pubmed 出版商

Zhang S, Matsunaga S, Lin Y, Sishc B, Shang Z, Sui J, et al. Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection. Oncogene. 2016;35:3909-18 pubmed 出版商

Suberbielle E, Djukic B, Evans M, Kim D, Taneja P, Wang X, et al. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun. 2015;6:8897 pubmed 出版商

Serber D, Runge J, Menon D, Magnuson T. The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis. Biol Reprod. 2016;94:8 pubmed 出版商

Decarpentrie F, Ojarikre O, Mitchell M, Burgoyne P. Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR. Chromosoma. 2016;125:177-88 pubmed 出版商

Djuzenova C, Zimmermann M, Katzer A, Fiedler V, Distel L, Gasser M, et al. A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome. BMC Cancer. 2015;15:856 pubmed 出版商

Perez M, Muñoz Galván S, Jiménez García M, Marín J, Carnero A. Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA. Oncotarget. 2015;6:40557-74 pubmed 出版商

Gill S, Travers J, Pshenichnaya I, Kogera F, Barthorpe S, Mironenko T, et al. Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. PLoS ONE. 2015;10:e0140988 pubmed 出版商

Nicolas E, Arora S, Zhou Y, Serebriiskii I, Andrake M, Handorf E, et al. Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget. 2015;6:39614-33 pubmed 出版商

Kim H, Kim S, Hromas R, Lee S. The SET Domain Is Essential for Metnase Functions in Replication Restart and the 5' End of SS-Overhang Cleavage. PLoS ONE. 2015;10:e0139418 pubmed 出版商

Reiner T, de las Pozas A, Parrondo R, Palenzuela D, Cayuso W, Rai P, et al. Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage. Oncoscience. 2015;2:703-15 pubmed

Lee K, Jeong J, Kim I, Kim K, Ju B. Cyclo(phenylalanine-proline) induces DNA damage in mammalian cells via reactive oxygen species. J Cell Mol Med. 2015;19:2851-64 pubmed 出版商

Lin J, Fallahi Sichani M, Sorger P. Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method. Nat Commun. 2015;6:8390 pubmed 出版商

Hehlgans S, Oppermann J, Reichert S, Fulda S, Rödel C, Rödel F. The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. Radiat Oncol. 2015;10:198 pubmed 出版商

Osipov A, Grekhova A, Pustovalova M, Ozerov I, Eremin P, Vorobyeva N, et al. Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation. Oncotarget. 2015;6:26876-85 pubmed 出版商

Chojnowski A, Ong P, Wong E, Lim J, Mutalif R, Navasankari R, et al. Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. elife. 2015;4: pubmed 出版商

Ruiz S, López Contreras A, Gabut M, Marion R, Gutierrez Martinez P, Bua S, et al. Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nat Commun. 2015;6:8036 pubmed 出版商

He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed 出版商

Mondesert O, Frongia C, Clayton O, Boizeau M, Lobjois V, Ducommun B. Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. PLoS ONE. 2015;10:e0134411 pubmed 出版商

Zauri M, Berridge G, Thézénas M, Pugh K, Goldin R, Kessler B, et al. CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature. 2015;524:114-8 pubmed 出版商

De Melo Bernardo A, Heeren A, van Iperen L, Fernandes M, He N, Anjie S, et al. Meiotic wave adds extra asymmetry to the development of female chicken gonads. Mol Reprod Dev. 2015;82:774-86 pubmed 出版商

Rozacky J, Nemec A, Sweasy J, Kidane D. Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks. Oncotarget. 2015;6:24474-87 pubmed

Virts E, Jankowska A, MacKay C, Glaas M, Wiek C, Kelich S, et al. AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia. Hum Mol Genet. 2015;24:5093-108 pubmed 出版商

Magnussen G, Emilsen E, Giller Fleten K, Engesæter B, Nähse Kumpf V, Fjær R, et al. Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. BMC Cancer. 2015;15:462 pubmed 出版商

Mandriota S, Valentijn L, Lesne L, Betts D, Marino D, Boudal Khoshbeen M, et al. Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget. 2015;6:18558-76 pubmed

Velichko A, Petrova N, Razin S, Kantidze O. Mechanism of heat stress-induced cellular senescence elucidates the exclusive vulnerability of early S-phase cells to mild genotoxic stress. Nucleic Acids Res. 2015;43:6309-20 pubmed 出版商

Kilic Eren M, Kilincli A, Eren Ã. Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS ONE. 2015;10:e0124837 pubmed 出版商

Paget V, Dekali S, Kortulewski T, Grall R, Gamez C, Blazy K, et al. Specific uptake and genotoxicity induced by polystyrene nanobeads with distinct surface chemistry on human lung epithelial cells and macrophages. PLoS ONE. 2015;10:e0123297 pubmed 出版商

Ip L, Poulogiannis G, Viciano F, Sasaki J, Kofuji S, Spanswick V, et al. Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015;6:10548-62 pubmed

Hatano K, Kumar B, Zhang Y, Coulter J, Hedayati M, Mears B, et al. A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation. Nucleic Acids Res. 2015;43:4075-86 pubmed 出版商

Ahmad T, Sundar I, Lerner C, Gerloff J, Tormos A, Yao H, et al. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J. 2015;29:2912-29 pubmed 出版商

Chang F, Chan F, R McGhie J, Udugama M, Mayne L, Collas P, et al. CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. Nucleic Acids Res. 2015;43:2603-14 pubmed 出版商

Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, et al. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle. 2015;14:375-87 pubmed 出版商

Tsao N, Lee M, Zhang W, Cheng Y, Chang Z. The contribution of CMP kinase to the efficiency of DNA repair. Cell Cycle. 2015;14:354-63 pubmed 出版商

Moore Z, Chakrabarti G, Luo X, Ali A, Hu Z, Fattah F, et al. NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone. Cell Death Dis. 2015;6:e1599 pubmed 出版商

Xiong X, Du Z, Wang Y, Feng Z, Fan P, Yan C, et al. 53BP1 promotes microhomology-mediated end-joining in G1-phase cells. Nucleic Acids Res. 2015;43:1659-70 pubmed 出版商

Xu W, Cheng M, Lao Y, Wang X, Wu J, Zhou L, et al. DNA damage and ER stress contribute to oblongifolin C-induced cell killing in Bax/Bak-deficient cells. Biochem Biophys Res Commun. 2015;457:300-6 pubmed 出版商

Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami Tonami Y, Ichikawa H, et al. Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Cancer Sci. 2015;106:237-43 pubmed 出版商

Klement K, Luijsterburg M, Pinder J, Cena C, Del Nero V, Wintersinger C, et al. Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair. J Cell Biol. 2014;207:717-33 pubmed 出版商

Meisenberg C, Gilbert D, Chalmers A, Haley V, Gollins S, Ward S, et al. Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Mol Cancer Ther. 2015;14:575-85 pubmed 出版商

Kempf S, Casciati A, Buratovic S, Janik D, von Toerne C, Ueffing M, et al. The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation. Mol Neurodegener. 2014;9:57 pubmed 出版商

Wit N, Buoninfante O, van den Berk P, Jansen J, Hogenbirk M, de Wind N, et al. Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage. Nucleic Acids Res. 2015;43:282-94 pubmed 出版商

Herrera Moyano E, Moriel Carretero M, Montelone B, Aguilera A. The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes. PLoS Genet. 2014;10:e1004859 pubmed 出版商

Sone K, Piao L, Nakakido M, Ueda K, Jenuwein T, Nakamura Y, et al. Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nat Commun. 2014;5:5691 pubmed 出版商

Oh W, Frost J. Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A. Cell Cycle. 2014;13:2765-72 pubmed 出版商

Chene G, Cayre A, Raoelfils I, Lagarde N, Dauplat J, Penault Llorca F. Morphological and immunohistochemical pattern of tubo-ovarian dysplasia and serous tubal intraepithelial carcinoma. Eur J Obstet Gynecol Reprod Biol. 2014;183:89-95 pubmed 出版商

Kidane D, Murphy D, Sweasy J. Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection. Oncogenesis. 2014;3:e128 pubmed 出版商

Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman Colin C, et al. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014;5:5496 pubmed 出版商

Sjolund A, Nemec A, Paquet N, Prakash A, Sung P, Doublié S, et al. A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. PLoS Genet. 2014;10:e1004753 pubmed 出版商

Zwicker F, Swartman B, Roeder F, Sterzing F, Hauswald H, Thieke C, et al. In vivo measurement of dose distribution in patients' lymphocytes: helical tomotherapy versus step-and-shoot IMRT in prostate cancer. J Radiat Res. 2015;56:239-47 pubmed 出版商

Cui L, Tse K, Zahedi P, Harding S, Zafarana G, Jaffray D, et al. Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells. Radiat Res. 2014;182:475-88 pubmed 出版商

Robertson A, Robertson J, Fusser M, Klungland A. Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Res. 2014;42:13280-93 pubmed 出版商

Morgado Palacin L, Llanos S, Urbano Cuadrado M, Blanco Aparicio C, Megias D, Pastor J, et al. Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway. Carcinogenesis. 2014;35:2822-30 pubmed 出版商

Fumagalli M, Rossiello F, Mondello C, d Adda di Fagagna F. Stable cellular senescence is associated with persistent DDR activation. PLoS ONE. 2014;9:e110969 pubmed 出版商

Slaats G, Ghosh A, Falke L, Le Corre S, Shaltiël I, van de Hoek G, et al. Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition. PLoS Genet. 2014;10:e1004594 pubmed 出版商

Hu Y, Wang C, Huang K, Xia F, Parvin J, Mondal N. Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair. PLoS ONE. 2014;9:e110522 pubmed 出版商

Li Z, Wang H, Wang Y, Murnane J, Dynan W. Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiat Res. 2014;182:573-9 pubmed 出版商

Tang M, Li Y, Zhang X, Deng T, Zhou Z, Ma W, et al. Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage. J Biol Chem. 2014;289:34024-32 pubmed 出版商

Facchini A, Cetrullo S, D Adamo S, Guidotti S, Minguzzi M, Facchini A, et al. Hydroxytyrosol prevents increase of osteoarthritis markers in human chondrocytes treated with hydrogen peroxide or growth-related oncogene α. PLoS ONE. 2014;9:e109724 pubmed 出版商

McQuade C, Al Zaki A, Desai Y, Vido M, Sakhuja T, Cheng Z, et al. A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response. Small. 2015;11:834-43 pubmed 出版商

Jackstadt R, Hermeking H. AP4 is required for mitogen- and c-MYC-induced cell cycle progression. Oncotarget. 2014;5:7316-27 pubmed

Sugahara R, Mon H, Lee J, Shiotsuki T, Kusakabe T. Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells. FEBS Lett. 2014;588:3959-63 pubmed 出版商

Cheng S, Chang Y, Liu C, Lee J, Chan H, Kuo C, et al. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Br J Pharmacol. 2015;172:214-34 pubmed 出版商

Sayin V, Khan O, Pehlivanoglu L, Staffas A, Ibrahim M, Asplund A, et al. Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53. Circ Res. 2014;115:781-9 pubmed 出版商

DeFilippis R, Fordyce C, Patten K, Chang H, Zhao J, Fontenay G, et al. Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Res. 2014;74:5032-5044 pubmed 出版商

Oberbeck N, Langevin F, King G, de Wind N, Crossan G, Patel K. Maternal aldehyde elimination during pregnancy preserves the fetal genome. Mol Cell. 2014;55:807-817 pubmed 出版商

Chan M, Gravel M, Bramoullé A, Bridon G, Avizonis D, Shore G, et al. Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption. Cancer Res. 2014;74:5948-54 pubmed 出版商

Ishiguro K, Lin Z, Penketh P, Shyam K, Zhu R, Baumann R, et al. Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochem Pharmacol. 2014;91:312-22 pubmed 出版商

Scherthan H, Schöfisch K, Dell T, Illner D. Contrasting behavior of heterochromatic and euchromatic chromosome portions and pericentric genome separation in pre-bouquet spermatocytes of hybrid mice. Chromosoma. 2014;123:609-24 pubmed 出版商

Karnak D, Engelke C, Parsels L, Kausar T, Wei D, Robertson J, et al. Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer. Clin Cancer Res. 2014;20:5085-96 pubmed 出版商

Dean R, Fam H, An J, Choi K, Shimizu Y, Jones S, et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014;19:1372-82 pubmed 出版商

Kotov I, Siebring van Olst E, Knobel P, van der Meulen Muileman I, Felley Bosco E, van Beusechem V, et al. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. Mol Oncol. 2014;8:1747-59 pubmed 出版商

Feng F, Speers C, Liu M, Jackson W, Moon D, Rinkinen J, et al. Targeted radiosensitization with PARP1 inhibition: optimization of therapy and identification of biomarkers of response in breast cancer. Breast Cancer Res Treat. 2014;147:81-94 pubmed 出版商

Hill S, Clark A, Silver D, Livingston D. BRCA1 pathway function in basal-like breast cancer cells. Mol Cell Biol. 2014;34:3828-42 pubmed 出版商

Zhao H, Thienpont B, Yesilyurt B, Moisse M, Reumers J, Coenegrachts L, et al. Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks. elife. 2014;3:e02725 pubmed 出版商

Bolcaen J, Descamps B, Deblaere K, Boterberg T, Hallaert G, Van den Broecke C, et al. MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP). J Neurooncol. 2014;120:257-66 pubmed 出版商

Bartkova J, Hoei Hansen C, Krizova K, Hamerlik P, Skakkebæk N, Rajpert De Meyts E, et al. Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment. Mol Oncol. 2014;8:1667-78 pubmed 出版商

Park S, Kang J, Kim S, Kim H, Hong S, Lee Y, et al. Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair. Cell Mol Life Sci. 2015;72:583-596 pubmed 出版商

Jones R, Kotsantis P, Stewart G, Groth P, Petermann E. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine. Mol Cancer Ther. 2014;13:2412-21 pubmed 出版商

Su W, Hsu S, Wu C, Chang S, Lin Y, Yang W, et al. Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma. Oncotarget. 2014;5:6323-37 pubmed

Zeman M, Lin J, Freire R, Cimprich K. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 2014;206:183-97 pubmed 出版商

Drutovic D, Chripkova M, Pilatova M, Kruzliak P, Perjesi P, Sarissky M, et al. Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells. Tumour Biol. 2014;35:9967-75 pubmed 出版商

Znojek P, Willmore E, Curtin N. Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase. Br J Cancer. 2014;111:1319-26 pubmed 出版商

Kilic Eren M, Tabor V. The role of hypoxia inducible factor-1 alpha in bypassing oncogene-induced senescence. PLoS ONE. 2014;9:e101064 pubmed 出版商

Ensminger M, Iloff L, Ebel C, Nikolova T, Kaina B, Lӧbrich M. DNA breaks and chromosomal aberrations arise when replication meets base excision repair. J Cell Biol. 2014;206:29-43 pubmed 出版商

Anderson D, Mirzayans R, Andrais B, Siegbahn E, Fallone B, Warkentin B. Spatial and temporal distribution of ?H2AX fluorescence in human cell cultures following synchrotron-generated X-ray microbeams: lack of correlation between persistent ?H2AX foci and apoptosis. J Synchrotron Radiat. 2014;21:801-10 pubmed 出版商

Bridges K, Toniatti C, Buser C, Liu H, Buchholz T, Meyn R. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014;5:5076-86 pubmed

Glover K, Markell L, Donner E, Han X. Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells. Toxicol Lett. 2014;229:210-9 pubmed 出版商

Cervelli T, Panetta D, Navarra T, Andreassi M, Basta G, Galli A, et al. Effects of single and fractionated low-dose irradiation on vascular endothelial cells. Atherosclerosis. 2014;235:510-8 pubmed 出版商

Trapp Fragnet L, Bencherit D, Chabanne Vautherot D, Le Vern Y, Remy S, Boutet Robinet E, et al. Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells. PLoS ONE. 2014;9:e100004 pubmed 出版商

Cazzalini O, Sommatis S, Tillhon M, Dutto I, Bachi A, Rapp A, et al. CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 2014;42:8433-48 pubmed 出版商

Fattah F, Hara K, Fattah K, Yang C, Wu N, Warrington R, et al. The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability. PLoS Genet. 2014;10:e1004419 pubmed 出版商

Soriani A, Iannitto M, Ricci B, Fionda C, Malgarini G, Morrone S, et al. Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. J Immunol. 2014;193:950-60 pubmed 出版商

Liang H, Esposito A, De S, Ber S, Collin P, Surana U, et al. Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing. Nat Commun. 2014;5:4048 pubmed 出版商

Samuni Y, Wink D, Krishna M, Mitchell J, Goldstein S. Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide. Free Radic Biol Med. 2014;73:291-8 pubmed 出版商

Dinami R, Ercolani C, Petti E, Piazza S, Ciani Y, Sestito R, et al. miR-155 drives telomere fragility in human breast cancer by targeting TRF1. Cancer Res. 2014;74:4145-56 pubmed 出版商

Yang A, Rajeshkumar N, Wang X, Yabuuchi S, Alexander B, Chu G, et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov. 2014;4:905-13 pubmed 出版商

Patterson M, Sutton R, Forrest I, Sharrock R, Lane M, Kaufmann A, et al. Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples. Br J Cancer. 2014;111:94-100 pubmed 出版商

Liou J, Wu Y, Yen W, Tang Y, Kakadiya R, Su T, et al. Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest. Toxicol Appl Pharmacol. 2014;278:249-58 pubmed 出版商

Mason J, Logan H, Budke B, Wu M, Pawlowski M, Weichselbaum R, et al. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014;74:3546-55 pubmed 出版商

Cheung H, Liu X, Canterel Thouennon L, Li L, Edmonson C, Rennert O. Telomerase protects werner syndrome lineage-specific stem cells from premature aging. Stem Cell Reports. 2014;2:534-46 pubmed 出版商

Nikolova T, Dvorak M, Jung F, Adam I, Kramer E, Gerhold Ay A, et al. The ?H2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response. Toxicol Sci. 2014;140:103-17 pubmed 出版商

Mizukami H, Takahashi K, Inaba W, Tsuboi K, Osonoi S, Yoshida T, et al. Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of ?-cell mass in Japanese type 2 diabetic patients. Diabetes Care. 2014;37:1966-74 pubmed 出版商

Singh R, Shankar B, Sainis K. TGF-?1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells. Cell Signal. 2014;26:1604-15 pubmed 出版商

Shahar O, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, et al. A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. Nucleic Acids Res. 2014;42:5689-701 pubmed 出版商

Al Ejeh F, Staudacher A, Smyth D, Darby J, Denoyer D, Tsopelas C, et al. Postchemotherapy and tumor-selective targeting with the La-specific DAB4 monoclonal antibody relates to apoptotic cell clearance. J Nucl Med. 2014;55:772-9 pubmed 出版商

Nemec A, MURPHY D, Donigan K, Sweasy J. The S229L colon tumor-associated variant of DNA polymerase ? induces cellular transformation as a result of decreased polymerization efficiency. J Biol Chem. 2014;289:13708-16 pubmed 出版商

Mohni K, Kavanaugh G, Cortez D. ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency. Cancer Res. 2014;74:2835-45 pubmed 出版商

Chang H, Wang H, Chen C, Hung T, Hou M, Yuan S, et al. 5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells. Molecules. 2014;19:3149-59 pubmed 出版商

Colbert L, Petrova A, Fisher S, Pantazides B, Madden M, Hardy C, et al. CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer. Cancer Res. 2014;74:2677-87 pubmed 出版商

Chua M, Horn S, Somaiah N, Davies S, Gothard L, A Hern R, et al. DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy. Radiat Environ Biophys. 2014;53:355-64 pubmed 出版商

Münch S, Weidtkamp Peters S, Klement K, Grigaravicius P, Monajembashi S, Salomoni P, et al. The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence. Mol Cell Biol. 2014;34:1733-46 pubmed 出版商

Wang Z, Yin H, Lv L, Feng Y, Chen S, Liang J, et al. Unrepaired DNA damage facilitates elimination of uniparental chromosomes in interspecific hybrid cells. Cell Cycle. 2014;13:1345-56 pubmed 出版商

Leung J, Agarwal P, Canny M, Gong F, Robison A, Finkelstein I, et al. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet. 2014;10:e1004178 pubmed 出版商

Ramaekers C, van den Beucken T, Bristow R, Chiu R, Durocher D, Wouters B. RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage. PLoS ONE. 2014;9:e89997 pubmed 出版商

Kim H, Chen Q, Kim S, Nickoloff J, Hromas R, Georgiadis M, et al. The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart. J Biol Chem. 2014;289:10930-8 pubmed 出版商

Hosono Y, Abe T, Higuchi M, Kajii K, Sakuraba S, Tada S, et al. Tipin functions in the protection against topoisomerase I inhibitor. J Biol Chem. 2014;289:11374-84 pubmed 出版商

Alvarez Quilón A, Serrano Benítez A, Lieberman J, Quintero C, Sánchez Gutiérrez D, Escudero L, et al. ATM specifically mediates repair of double-strand breaks with blocked DNA ends. Nat Commun. 2014;5:3347 pubmed 出版商

Köpper F, Binkowski A, Bierwirth C, Dobbelstein M. The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells. Cell Cycle. 2014;13:884-9 pubmed 出版商

Nishida Y, Mizutani N, Inoue M, Omori Y, Tamiya Koizumi K, Takagi A, et al. Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines. Biochim Biophys Acta. 2014;1839:265-74 pubmed 出版商

Bhattacharyya T, Reifová R, Gregorova S, Simecek P, Gergelits V, Mistrik M, et al. X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids. PLoS Genet. 2014;10:e1004088 pubmed 出版商

Iacobazzi D, Mangialardi G, Gubernator M, Hofner M, Wielscher M, Vierlinger K, et al. Increased antioxidant defense mechanism in human adventitia-derived progenitor cells is associated with therapeutic benefit in ischemia. Antioxid Redox Signal. 2014;21:1591-604 pubmed 出版商

Cavalheiro G, Matos Rodrigues G, Gomes A, Rodrigues P, Martins R. c-Myc regulates cell proliferation during lens development. PLoS ONE. 2014;9:e87182 pubmed 出版商

Srivastava N, Shukla S, Yashavarddhan M, Devi M, Tripathi R, Gupta M. Modification of radiation-induced DNA double strand break repair pathways by chemicals extracted from Podophyllum hexandrum: an in vitro study in human blood leukocytes. Environ Mol Mutagen. 2014;55:436-48 pubmed 出版商

Sayin V, Ibrahim M, Larsson E, Nilsson J, Lindahl P, Bergo M. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014;6:221ra15 pubmed 出版商

Petrova N, Velichko A, Kantidze O, Razin S. Heat shock-induced dissociation of TRF2 from telomeres does not initiate a telomere-dependent DNA damage response. Cell Biol Int. 2014;38:675-81 pubmed 出版商

Islam M, Thomas S, Murty V, Sedoris K, Miller D. c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA. J Biol Chem. 2014;289:8521-31 pubmed 出版商

Li Y, Hao H, Tzatzalos E, Lin R, Doh S, Liu L, et al. Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3:172-84 pubmed 出版商

Desai A, Qing Y, Gerson S. Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells. Stem Cells. 2014;32:582-93 pubmed 出版商

Morita A, Tanimoto K, Murakami T, Morinaga T, Hosoi Y. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells. Biochem Biophys Res Commun. 2014;443:1286-90 pubmed 出版商

Quinet A, Vessoni A, Rocha C, Gottifredi V, Biard D, Sarasin A, et al. Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome. DNA Repair (Amst). 2014;14:27-38 pubmed 出版商

Khalaj M, Abbasi A, Yamanishi H, Akiyama K, Wakitani S, Kikuchi S, et al. A missense mutation in Rev7 disrupts formation of Pol?, impairing mouse development and repair of genotoxic agent-induced DNA lesions. J Biol Chem. 2014;289:3811-24 pubmed 出版商

Kim K, Kim D, Park J, Jeon Y, Kim D, Rhee S, et al. Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-I? regulates Ku70-mediated DNA damage response. Cell Mol Life Sci. 2014;71:2731-45 pubmed 出版商

Lan L, Nakajima S, Wei L, Sun L, Hsieh C, Sobol R, et al. Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin. Nucleic Acids Res. 2014;42:2330-45 pubmed 出版商

Vitale N, Kisslinger A, Paladino S, Procaccini C, Matarese G, Pierantoni G, et al. Resveratrol couples apoptosis with autophagy in UVB-irradiated HaCaT cells. PLoS ONE. 2013;8:e80728 pubmed 出版商

Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, et al. Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS Genet. 2013;9:e1003945 pubmed 出版商

Perez de Castro I, Aguirre Portolés C, Fernández Miranda G, Canamero M, Cowley D, van Dyke T, et al. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res. 2013;73:6804-15 pubmed 出版商

Saha J, Wang M, Cucinotta F. Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation. DNA Repair (Amst). 2013;12:1143-51 pubmed 出版商

Bailis J, Gordon M, Gurgel J, Komor A, Barton J, Kirsch I. An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. PLoS ONE. 2013;8:e78726 pubmed 出版商

Sciurano R, Solari A. Ultrastructural and immunofluorescent methods for the study of the XY body as a biomarker. Methods Mol Biol. 2014;1094:137-49 pubmed 出版商

Neumann J, Boerries M, Kohler R, Giaisi M, Krammer P, Busch H, et al. The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer. 2014;134:1991-2002 pubmed 出版商

Cortizas E, Zahn A, Hajjar M, Patenaude A, Di Noia J, Verdun R. Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination. J Immunol. 2013;191:5751-63 pubmed 出版商

Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes A, Yague E, et al. FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene. 2014;33:4144-55 pubmed 出版商

Luo T, Cui S, Bian C, Yu X. Uhrf2 is important for DNA damage response in vascular smooth muscle cells. Biochem Biophys Res Commun. 2013;441:65-70 pubmed 出版商

Secher T, Samba Louaka A, Oswald E, Nougayrede J. Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells. PLoS ONE. 2013;8:e77157 pubmed 出版商

Zhao H, Halicka H, Li J, Biela E, Berniak K, Dobrucki J, et al. DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA. Cytometry A. 2013;83:979-88 pubmed 出版商

Helchowski C, Skow L, Roberts K, Chute C, Canman C. A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci. Cell Cycle. 2013;12:3749-58 pubmed 出版商

Ji G, Ruan W, Liu K, Wang F, Sakellariou D, Chen J, et al. Telomere reprogramming and maintenance in porcine iPS cells. PLoS ONE. 2013;8:e74202 pubmed 出版商

Brozovic A, Vuković L, Polančac D, Arany I, Köberle B, Fritz G, et al. Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells. PLoS ONE. 2013;8:e76397 pubmed 出版商

Wu Y, Deighan C, Miller B, Balasubramanian P, Lustberg M, Zborowski M, et al. Isolation and analysis of rare cells in the blood of cancer patients using a negative depletion methodology. Methods. 2013;64:169-82 pubmed 出版商

Akiyama K, Noguchi J, Hirose M, Kajita S, Katayama K, Khalaj M, et al. A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice. J Biol Chem. 2013;288:31830-41 pubmed 出版商

Vassena L, Giuliani E, Matusali G, Cohen r, Doria M. The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway. J Gen Virol. 2013;94:2664-9 pubmed 出版商

Men N, Kikuchi K, Nakai M, Fukuda A, Tanihara F, Noguchi J, et al. Effect of trehalose on DNA integrity of freeze-dried boar sperm, fertilization, and embryo development after intracytoplasmic sperm injection. Theriogenology. 2013;80:1033-44 pubmed 出版商

Yajima H, Fujisawa H, Nakajima N, Hirakawa H, Jeggo P, Okayasu R, et al. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. DNA Repair (Amst). 2013;12:936-46 pubmed 出版商

Cron K, Zhu K, Kushwaha D, Hsieh G, Merzon D, Rameseder J, et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS ONE. 2013;8:e73710 pubmed 出版商

Xiao Y, Ramiscal J, Kowanetz K, Del Nagro C, Malek S, Evangelista M, et al. Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor. Mol Cancer Ther. 2013;12:2285-95 pubmed 出版商

Storci G, Bertoni S, De Carolis S, Papi A, Nati M, Ceccarelli C, et al. Slug/?-catenin-dependent proinflammatory phenotype in hypoxic breast cancer stem cells. Am J Pathol. 2013;183:1688-1697 pubmed 出版商

Tu W, Li B, Huang B, Wang Y, Liu X, Guan H, et al. ?H2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. FEBS Lett. 2013;587:3437-43 pubmed 出版商

Iwasa H, Kudo T, Maimaiti S, Ikeda M, Maruyama J, Nakagawa K, et al. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. J Biol Chem. 2013;288:30320-9 pubmed 出版商

Di Francesco A, De Pittà C, Moret F, Barbieri V, Celotti L, Mognato M. The DNA-damage response to ?-radiation is affected by miR-27a in A549 cells. Int J Mol Sci. 2013;14:17881-96 pubmed 出版商

Fujii W, Kawasaki K, Sugiura K, Naito K. Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease. Nucleic Acids Res. 2013;41:e187 pubmed 出版商

Yu L, Zhao Y, Quan C, Ji W, Zhu J, Huang Y, et al. Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells. PLoS ONE. 2013;8:e71988 pubmed 出版商

Min J, Tian Y, Xiao Y, Wu L, Li L, Chang S. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Cell Res. 2013;23:1396-413 pubmed 出版商

Zalmas L, Coutts A, Helleday T, La Thangue N. E2F-7 couples DNA damage-dependent transcription with the DNA repair process. Cell Cycle. 2013;12:3037-51 pubmed 出版商

Lawrence M, Ormsby R, Blyth B, Bezak E, England G, Newman M, et al. Lack of high-dose radiation mediated prostate cancer promotion and low-dose radiation adaptive response in the TRAMP mouse model. Radiat Res. 2013;180:376-88 pubmed 出版商

Cornelissen B, Waller A, Able S, Vallis K. Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and ?H2AX. Mol Cancer Ther. 2013;12:2472-82 pubmed 出版商

Forbes M, Paitsel M, Bourland J, Riddle D. Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats. Radiat Res. 2013;180:326-33 pubmed 出版商

Galick H, Kathe S, Liu M, Robey Bond S, Kidane D, Wallace S, et al. Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation. Proc Natl Acad Sci U S A. 2013;110:14314-9 pubmed 出版商

Lai X, Egan L. Suppression of radiation-induced DNA double-strand break repair by MyD88 is accompanied by apoptosis and crypt loss in mouse colon. Oncogenesis. 2013;2:e62 pubmed 出版商

Talluri S, Francis S, Dick F. Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo. PLoS ONE. 2013;8:e72236 pubmed 出版商

Postel Vinay S, Bajrami I, Friboulet L, Elliott R, Fontebasso Y, Dorvault N, et al. A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer. Oncogene. 2013;32:5377-87 pubmed 出版商

Belluti S, Basile V, Benatti P, Ferrari E, Marverti G, Imbriano C. Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-II? by bis-DemethoxyCurcumin in cancer cells. Cell Death Dis. 2013;4:e756 pubmed 出版商

Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, et al. Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid. 2014;24:502-10 pubmed 出版商

Verver D, van Pelt A, Repping S, Hamer G. Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis. Cell Death Dis. 2013;4:e749 pubmed 出版商

Tanoue K, Miller Jenkins L, Durell S, Debnath S, Sakai H, Tagad H, et al. Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity. Biochemistry. 2013;52:5830-43 pubmed 出版商

Britton S, Coates J, Jackson S. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol. 2013;202:579-95 pubmed 出版商

Butin Israeli V, Adam S, Goldman R. Regulation of nucleotide excision repair by nuclear lamin b1. PLoS ONE. 2013;8:e69169 pubmed 出版商

Wells C, Bhaskara S, Stengel K, Zhao Y, Sirbu B, Chagot B, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS ONE. 2013;8:e68915 pubmed 出版商

Bee L, Fabris S, Cherubini R, Mognato M, Celotti L. The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression. PLoS ONE. 2013;8:e69061 pubmed 出版商

Lai Z, Moravcová S, Canitrot Y, Andrzejewski L, Walshe D, Rea S. Msl2 is a novel component of the vertebrate DNA damage response. PLoS ONE. 2013;8:e68549 pubmed 出版商

Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, et al. Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells. Endocr Relat Cancer. 2013;20:633-47 pubmed 出版商

Padberg I, Jansen S, Meyer T. Chlamydia trachomatis inhibits telomeric DNA damage signaling via transient hTERT upregulation. Int J Med Microbiol. 2013;303:463-74 pubmed 出版商

Lin T, Ibrahim W, Peng C, Finegold M, Tsai R. A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration. Hepatology. 2013;58:2176-87 pubmed 出版商

Vasileva A, Hopkins K, Wang X, Weisbach M, Friedman R, Wolgemuth D, et al. The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse. J Cell Sci. 2013;126:3927-38 pubmed 出版商

Del Turco S, Ciofani G, Cappello V, Gemmi M, Cervelli T, Saponaro C, et al. Cytocompatibility evaluation of glycol-chitosan coated boron nitride nanotubes in human endothelial cells. Colloids Surf B Biointerfaces. 2013;111:142-9 pubmed 出版商

Magnussen G, Hellesylt E, Nesland J, Trope C, Flørenes V, Holm R. High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients. BMC Cancer. 2013;13:288 pubmed 出版商

Fradet Turcotte A, Canny M, Escribano Diaz C, Orthwein A, Leung C, Huang H, et al. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 2013;499:50-4 pubmed 出版商

Streppel M, Pai S, Campbell N, Hu C, Yabuuchi S, Canto M, et al. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Clin Cancer Res. 2013;19:4067-78 pubmed 出版商

Somaiah N, Yarnold J, Lagerqvist A, Rothkamm K, Helleday T. Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy. Radiother Oncol. 2013;108:155-61 pubmed 出版商

Young L, McDonald D, Hendzel M. Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following ?-irradiation. J Biol Chem. 2013;288:21376-88 pubmed 出版商

Lindgren A, Karlberg T, Thorsell A, Hesse M, Spjut S, Ekblad T, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 2013;8:1698-703 pubmed 出版商

Floyd S, Pacold M, Huang Q, Clarke S, Lam F, Cannell I, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013;498:246-50 pubmed 出版商

Millet P, Granotier C, Etienne O, Boussin F. Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. Int J Oncol. 2013;43:375-82 pubmed 出版商

Cousin W, Ho M, Desai R, Tham A, Chen R, Kung S, et al. Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage. PLoS ONE. 2013;8:e63528 pubmed 出版商

Montero J, Dutta C, Van Bodegom D, Weinstock D, Letai A. p53 regulates a non-apoptotic death induced by ROS. Cell Death Differ. 2013;20:1465-74 pubmed 出版商

Maire V, Baldeyron C, Richardson M, Tesson B, Vincent Salomon A, Gravier E, et al. TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer. PLoS ONE. 2013;8:e63712 pubmed 出版商

Li Z, Hudson F, Wang H, Wang Y, Bian Z, Murnane J, et al. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013;180:17-24 pubmed 出版商

Li B, Shang Z, Yin J, Xu Q, Liu X, Wang Y, et al. PIG3 functions in DNA damage response through regulating DNA-PKcs homeostasis. Int J Biol Sci. 2013;9:425-34 pubmed 出版商

Ulukaya E, Frame F, Cevatemre B, Pellacani D, Walker H, Mann V, et al. Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells. PLoS ONE. 2013;8:e64278 pubmed 出版商

Mahen R, Hattori H, Lee M, Sharma P, Jeyasekharan A, Venkitaraman A. A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei. PLoS ONE. 2013;8:e61893 pubmed 出版商

Ryu S, Kawamura R, Naka R, Silberberg Y, Nakamura N, Nakamura C. Nanoneedle insertion into the cell nucleus does not induce double-strand breaks in chromosomal DNA. J Biosci Bioeng. 2013;116:391-6 pubmed 出版商

Muller I, Merk B, Voss K, Averbeck N, Jakob B, Durante M, et al. Species conserved DNA damage response at the inactive human X chromosome. Mutat Res. 2013;756:30-6 pubmed 出版商

Kopova I, Bacakova L, Lavrentiev V, Vacik J. Growth and potential damage of human bone-derived cells on fresh and aged fullerene c60 films. Int J Mol Sci. 2013;14:9182-204 pubmed 出版商

Meyer B, Voss K, Tobias F, Jakob B, Durante M, Taucher Scholz G. Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK. Nucleic Acids Res. 2013;41:6109-18 pubmed 出版商

Djuzenova C, Elsner I, Katzer A, Worschech E, Distel L, Flentje M, et al. Radiosensitivity in breast cancer assessed by the histone ?-H2AX and 53BP1 foci. Radiat Oncol. 2013;8:98 pubmed 出版商

Sorokina S, Markova E, Gursky J, Dobrovodsky J, Belyaev I. Relative biological efficiency of protons at low and therapeutic doses in induction of 53BP1/?H2AX foci in lymphocytes from umbilical cord blood. Int J Radiat Biol. 2013;89:716-23 pubmed 出版商

Lu X, Parvathaneni S, Hara T, Lal A, Sharma S. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer. 2013;12:29 pubmed 出版商

Taylor B, Nik Zainal S, Wu Y, Stebbings L, Raine K, Campbell P, et al. DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. elife. 2013;2:e00534 pubmed 出版商

Kim S, Cordeiro M, Serna V, Ebbert K, Butler L, Sinha S, et al. Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network. Cell Death Differ. 2013;20:987-97 pubmed 出版商

Chene G, Tchirkov A, Pierre Eymard E, Dauplat J, Raoelfils I, Cayre A, et al. Early telomere shortening and genomic instability in tubo-ovarian preneoplastic lesions. Clin Cancer Res. 2013;19:2873-82 pubmed 出版商

Anantha R, Alcivar A, Ma J, Cai H, Simhadri S, Ule J, et al. Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination. PLoS ONE. 2013;8:e61368 pubmed 出版商

Bahassi E, Li Y, Wise Draper T, Deng L, Wang J, Darnell C, et al. A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer. Eur J Cancer. 2013;49:2345-55 pubmed 出版商

Saha A, Kappes F, Mundade A, Deutzmann A, Rosmarin D, Legendre M, et al. Intercellular trafficking of the nuclear oncoprotein DEK. Proc Natl Acad Sci U S A. 2013;110:6847-52 pubmed 出版商

Wang L, Wang M, Wang S, Qi T, Guo L, Li J, et al. Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage. PLoS ONE. 2013;8:e60179 pubmed 出版商

Chen D, Chen Y, Forrest D, Bremner R. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ. 2013;20:931-40 pubmed 出版商

Min A, Im S, Yoon Y, Song S, Nam H, Hur H, et al. RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib. Mol Cancer Ther. 2013;12:865-77 pubmed 出版商

Crosetto N, Mitra A, Silva M, Bienko M, Dojer N, Wang Q, et al. Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods. 2013;10:361-5 pubmed 出版商

Berchtold C, Coughlin A, Kasper Z, Thibeault S. Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction. Laryngoscope. 2013;123:2228-36 pubmed 出版商

Jelveh S, Kaspler P, Bhogal N, Mahmood J, Lindsay P, Okunieff P, et al. Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin. Int J Radiat Biol. 2013;89:618-27 pubmed 出版商

Spaapen F, van den Akker G, Caron M, Prickaerts P, Rofel C, Dahlmans V, et al. The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis. PLoS ONE. 2013;8:e58083 pubmed 出版商

Neelsen K, Zanini I, Herrador R, Lopes M. Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J Cell Biol. 2013;200:699-708 pubmed 出版商

Yehezkel S, Shaked R, Sagie S, Berkovitz R, Shachar Bener H, Segev Y, et al. Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts. Front Oncol. 2013;3:35 pubmed 出版商

Jha H, Upadhyay S, A J Prasad M, Lu J, Cai Q, Saha A, et al. H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. J Virol. 2013;87:5255-69 pubmed 出版商

Ma H, Pederson T. The nucleolus stress response is coupled to an ATR-Chk1-mediated G2 arrest. Mol Biol Cell. 2013;24:1334-42 pubmed 出版商

BURRELL R, McClelland S, Endesfelder D, Groth P, Weller M, Shaikh N, et al. Replication stress links structural and numerical cancer chromosomal instability. Nature. 2013;494:492-496 pubmed 出版商

Koyama T, Sun B, Tokunaga K, Tatsumi M, Ishizaka Y. DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition. Retrovirology. 2013;10:21 pubmed 出版商

Gawecka J, Marh J, Ortega M, Yamauchi Y, Ward M, Ward W. Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development. PLoS ONE. 2013;8:e56385 pubmed 出版商

Lawrence M, Blyth B, Ormsby R, Tilley W, Sykes P. False-positive TUNEL staining observed in SV40 based transgenic murine prostate cancer models. Transgenic Res. 2013;22:1037-47 pubmed 出版商

Murdoch B, Owen N, Stevense M, Smith H, Nagaoka S, Hassold T, et al. Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior. PLoS Genet. 2013;9:e1003241 pubmed 出版商

Simões M, Martins C, Ferreira F. Host DNA damage response facilitates African swine fever virus infection. Vet Microbiol. 2013;165:140-7 pubmed 出版商

Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, et al. Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol. 2013;20:347-54 pubmed 出版商

Okamoto K, Bartocci C, Ouzounov I, Diedrich J, Yates J, Denchi E. A two-step mechanism for TRF2-mediated chromosome-end protection. Nature. 2013;494:502-5 pubmed 出版商

Kim B, Serebreni L, Hamdan O, Wang L, Parniani A, Sussan T, et al. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free Radic Biol Med. 2013;60:336-46 pubmed 出版商

Lawrence J, Karpuzoglu E, Vance A, Vandenplas M, Saba C, Turek M, et al. Changes in ?-H2AX expression in irradiated feline sarcoma cells: an indicator of double strand DNA breaks. Res Vet Sci. 2013;94:545-8 pubmed 出版商

Renaud E, Rosselli F. FANC pathway promotes UV-induced stalled replication forks recovery by acting both upstream and downstream Pol? and Rev1. PLoS ONE. 2013;8:e53693 pubmed 出版商

Karan T, Moiseenko V, Gill B, Horwood R, Kyle A, Minchinton A. Radiobiological effects of altering dose rate in filter-free photon beams. Phys Med Biol. 2013;58:1075-82 pubmed 出版商

Hewish M, Martin S, Elliott R, Cunningham D, Lord C, Ashworth A. Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress. Br J Cancer. 2013;108:983-92 pubmed 出版商

Castro Vega L, Jouravleva K, Liu W, Martinez C, Gestraud P, Hupe P, et al. Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis. 2013;34:1173-80 pubmed 出版商

Vera E, Bernardes de Jesus B, Foronda M, Flores J, Blasco M. Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS ONE. 2013;8:e53760 pubmed 出版商

Saker J, Kriegs M, Zenker M, Heldt J, Eke I, Pietzsch H, et al. Inactivation of HNSCC cells by 90Y-labeled cetuximab strictly depends on the number of induced DNA double-strand breaks. J Nucl Med. 2013;54:416-23 pubmed 出版商

Oliver L, Hue E, Séry Q, Lafargue A, Pecqueur C, Paris F, et al. Differentiation-related response to DNA breaks in human mesenchymal stem cells. Stem Cells. 2013;31:800-7 pubmed 出版商

Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed 出版商

Fischer B, Wong J, Degan S, Kummarapurugu A, Zheng S, Haridass P, et al. Increased expression of senescence markers in cystic fibrosis airways. Am J Physiol Lung Cell Mol Physiol. 2013;304:L394-400 pubmed 出版商

Nakamura A. Methods for the assessment of telomere status. Methods Mol Biol. 2013;965:233-42 pubmed 出版商

Yang Y, Durando M, Smith Roe S, Sproul C, Greenwalt A, Kaufmann W, et al. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Res. 2013;41:2296-312 pubmed 出版商

Konishi T, Oikawa M, Suya N, Ishikawa T, Maeda T, Kobayashi A, et al. SPICE-NIRS microbeam: a focused vertical system for proton irradiation of a single cell for radiobiological research. J Radiat Res. 2013;54:736-47 pubmed 出版商

Montenegro M, Sáez Ayala M, Piñero Madrona A, Cabezas Herrera J, Rodriguez Lopez J. Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation. PLoS ONE. 2012;7:e52231 pubmed 出版商

Mannava S, Moparthy K, Wheeler L, Natarajan V, Zucker S, Fink E, et al. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. Am J Pathol. 2013;182:142-51 pubmed 出版商

Ji G, Liu K, Okuka M, Liu N, Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012;13:36 pubmed 出版商

Lopez M, Tollervey J, Krastins B, Garces A, Sarracino D, Prakash A, et al. Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells. Aging (Albany NY). 2012;4:823-42 pubmed

Collins M, Brisset J, Zhang Y, Bednar F, Pierre J, Heist K, et al. Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. PLoS ONE. 2012;7:e49707 pubmed 出版商

Subramanian C, Hada M, Opipari A, Castle V, Kwok R. CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma. Mol Cancer Res. 2013;11:173-81 pubmed 出版商

Dvorakova M, Karafiat V, Pajer P, Kluzáková E, Jarkovska K, Pekova S, et al. DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment. Oncogene. 2013;32:5201-9 pubmed 出版商

de Vries M, Ramos L, Housein Z, de Boer P. Chromatin remodelling initiation during human spermiogenesis. Biol Open. 2012;1:446-57 pubmed 出版商

Nikolaev S, Sotiriou S, Pateras I, Santoni F, Sougioultzis S, Edgren H, et al. A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res. 2012;72:6279-89 pubmed 出版商

Finnon P, Kabacik S, Mackay A, Raffy C, A Hern R, Owen R, et al. Correlation of in vitro lymphocyte radiosensitivity and gene expression with late normal tissue reactions following curative radiotherapy for breast cancer. Radiother Oncol. 2012;105:329-36 pubmed 出版商

Haro K, Sheth A, Scheinberg D. Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells. PLoS ONE. 2012;7:e48841 pubmed 出版商

Tsai Y, Yeh C, Tzen K, Ho P, Tuan T, Pu Y, et al. Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma. Eur J Cancer. 2013;49:1458-66 pubmed 出版商

Fan X, Liu Y, Heilman S, Chen J. Human papillomavirus E7 induces rereplication in response to DNA damage. J Virol. 2013;87:1200-10 pubmed 出版商

Yüce O, West S. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol. 2013;33:406-17 pubmed 出版商

Yamtich J, Nemec A, Keh A, Sweasy J. A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. PLoS Genet. 2012;8:e1003052 pubmed 出版商

Sun X, Cohen P. Studying recombination in mouse oocytes. Methods Mol Biol. 2013;957:1-18 pubmed 出版商