This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸化Akt1/PKBα(Ser473)抗体, 克隆11E6
目录 :
05-669
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
11E6

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠, 犬
应用 :
免疫印迹, 免疫细胞化学
文章摘录数: 16
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Stergiou L, Bauer M, Mair W, Bausch Fluck D, Drayman N, Wollscheid B, et al. Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS ONE. 2013;8:e55799 pubmed 出版商
Chen K, Tsai M, Wu C, Jou M, Wei I, Huang C. AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role. Front Behav Neurosci. 2015;9:162 pubmed 出版商
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商
Zhuang Y, Chan D, Haugrud A, Miskimins W. Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo. PLoS ONE. 2014;9:e108444 pubmed 出版商
Dong C, Rovnaghi C, Anand K. Ketamine affects the neurogenesis of rat fetal neural stem progenitor cells via the PI3K/Akt-p27 signaling pathway. Birth Defects Res B Dev Reprod Toxicol. 2014;101:355-63 pubmed 出版商
Chen Y, Lu H, Hsu S, Kuo C, Chang S, Lin J, et al. Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways. Environ Toxicol. 2015;30:74-82 pubmed 出版商
Lu C, Yang J, Chiang J, Hour M, Amagaya S, Lu K, et al. Inhibition of invasion and migration by newly synthesized quinazolinone MJ-29 in human oral cancer CAL 27 cells through suppression of MMP-2/9 expression and combined down-regulation of MAPK and AKT signaling. Anticancer Res. 2012;32:2895-903 pubmed
Jones L, Antonelli J, Masko E, Broadwater G, Lascola C, Fels D, et al. Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. J Appl Physiol (1985). 2012;113:263-72 pubmed 出版商
Biensø R, Ringholm S, Kiilerich K, Aachmann Andersen N, Krogh Madsen R, Guerra B, et al. GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012;61:1090-9 pubmed 出版商
Chen Y, Chen Y, Hsu Y, Chang W, Hsiao C, Min M, et al. Akt1 deficiency modulates reward learning and reward prediction error in mice. Genes Brain Behav. 2012;11:157-69 pubmed 出版商
Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Iwaki R, Uemura Y, et al. Low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells. Stem Cells. 2011;29:1783-91 pubmed 出版商
Pulinilkunnil T, He H, Kong D, Asakura K, Peroni O, Lee A, et al. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011;286:8798-809 pubmed 出版商
Sei Y, Li Z, Song J, Ren Patterson R, Tunbridge E, Iizuka Y, et al. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models. PLoS ONE. 2010;5:e10789 pubmed 出版商
Deng K, Gao Y, Cao Z, Graziani E, Wood A, Doherty P, et al. Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. J Biol Chem. 2010;285:6425-33 pubmed 出版商
Chang M, Chen C, Hsieh C, Lee C, Su Y, Hu Y, et al. Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway. Biochem J. 2009;424:449-58 pubmed 出版商
Sei Y, Ren Patterson R, Li Z, Tunbridge E, Egan M, Kolachana B, et al. Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms. Mol Psychiatry. 2007;12:946-57 pubmed
产品信息
目录代码 :
05-669
亚类别 :
Cell Signaling
产品名称 :
抗磷酸化Akt1/PKBα(Ser473)抗体, 克隆11E6
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P31749
宿主名称 :
小鼠
抗原 :
磷酸化Akt1/PKBα(Ser473)
克隆 :
11E6
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
抗磷酸化Akt1/PKBα(Ser473)抗体, 克隆11E6
交叉活性 :
小鼠;大鼠;人类;狗
背景 :
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKB-β or RacPK-β) and Akt3 (also designated PKB-γ or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the 85 kDa subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity, and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in insulin/IGF-1- stimulated cells by an upstream kinase(s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin. Taken together, this data strongly suggests that the protein signals downstream of the PI kinases.
别名 :
Protein kinase B;RAC-alpha serine/threonine-protein kinase;murine thymoma viral (v-akt) oncogene homolog-1;rac protein kinase alpha;v-akt murine thymoma viral oncogene homolog 1
免疫原 :
KLH conjugated synthetic peptide containing a pSer that corresponds to amino acid residues around phosphoserine 473.
特异性 :
Recognizes phosphorylated Akt1/PKBα at Ser473, Mr 60 kDa. This lot of antibody does not cross-react with Akt1/PKBα dephosphorylated at Ser473.
包装尺寸 :
100微克
用途 :
酶联免疫吸附测定;免疫印迹
储存 :
Stable for 1 year at -20°C from date of receipt. Reconstitute prior to use. Reconstitute with 1 mL H 2 O for 15 min at room temperature. Reconstituted aliquots should be stored frozen at -80°C. Thawed aliquots may be stored at 2-8°C for up to 3 months. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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