This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸化Erk1/2(Thr202/Tyr204, Thr185/Tyr187)抗体, 重组克隆AW39R, 兔单克隆
目录 :
05-797R
规格 :
100微升
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
AW39R
反应物种 :
人类, 小鼠
文章摘录数: 17
参考文献
Pan C, Chen C, Shih C, Wang M, Wang J, Wu C. Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta. Aging (Albany NY). 2019;11:8085-8102 pubmed 出版商
Arcuri L, Novello S, Frassineti M, Mercatelli D, Pisano C, Morella I, et al. Antiparkinsonian and antidyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists. Br J Pharmacol. 2017;: pubmed 出版商
Pahng A, Paulsen R, McGinn M, Edwards K, Edwards S. Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. Neuroscience. 2017;366:1-14 pubmed 出版商
Ferland D, Darios E, Neubig R, Sjögren B, Truong N, Torres R, et al. Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol. 2017;88:30-41 pubmed 出版商
Waters A, Stewart J, Atigadda V, Mroczek Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies. Mol Cancer Ther. 2016;15:911-21 pubmed 出版商
O Sullivan C, Schubart A, Mir A, Dev K. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation. 2016;13:31 pubmed 出版商
Chen K, Tsai M, Wu C, Jou M, Wei I, Huang C. AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role. Front Behav Neurosci. 2015;9:162 pubmed 出版商
Waters A, Stewart J, Atigadda V, Mroczek Musulman E, Muccio D, Grubbs C, et al. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Mol Cancer Ther. 2015;14:1559-69 pubmed 出版商
Rutkowska A, Preuss I, Gessier F, Sailer A, Dev K. EBI2 regulates intracellular signaling and migration in human astrocyte. Glia. 2015;63:341-51 pubmed 出版商
Isham C, Netzel B, Bossou A, Milosevic D, Cradic K, Grebe S, et al. Development and characterization of a differentiated thyroid cancer cell line resistant to VEGFR-targeted kinase inhibitors. J Clin Endocrinol Metab. 2014;99:E936-43 pubmed 出版商
Megison M, Gillory L, Stewart J, Nabers H, Mrozcek Musulman E, Beierle E. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res. 2014;12:514-26 pubmed 出版商
Hayes H, Moss L, Schisler J, Haldeman J, Zhang Z, Rosenberg P, et al. Pdx-1 activates islet ?- and ?-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. Mol Cell Biol. 2013;33:4017-29 pubmed 出版商
García San Frutos M, Fernández Agulló T, Carrascosa J, Horrillo D, Barrús M, Oliveros E, et al. Involvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: effect of caloric restriction. Mech Ageing Dev. 2012;133:489-97 pubmed 出版商
Wu Y, Wang N, Gu L, Yang H, Xia N, Zhang H. The suppressive effect of metabotropic glutamate receptor 5 (mGlu5) inhibition on hepatocarcinogenesis. Biochimie. 2012;94:2366-75 pubmed 出版商
Sun L, Gu L, Wang S, Yuan J, Yang H, Zhu J, et al. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS ONE. 2012;7:e32503 pubmed 出版商
Trachtenberg A, Pushkarsky T, Heine S, Constant S, Brichacek B, Bukrinsky M. The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxis. BMC Res Notes. 2011;4:396 pubmed 出版商
Gangehei L, Ali M, Zhang W, Chen Z, Wakame K, Haidari M. Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation. Phytomedicine. 2010;17:1047-56 pubmed 出版商
产品信息
目录代码 :
05-797R
亚类别 :
Cell Signaling
产品名称 :
抗磷酸化Erk1/2(Thr202/Tyr204, Thr185/Tyr187)抗体, 重组克隆AW39R, 兔单克隆
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P28482;P27361
宿主名称 :
兔
抗原 :
磷酸化Erk1/2(Thr202/Tyr204
克隆 :
AW39R
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
抗磷酸化Erk1/2(Thr202/Tyr204, Thr185/Tyr187)抗体, 重组克隆AW39R, 兔单克隆
交叉活性 :
人类;小鼠;大鼠
背景 :
Erk (Extracellular signal-Related Kinase) is a family of two, highly homologous proteins denoted as Erk1 (p44, MAPK3) and Erk2 (p42, MAPK1) that both function in the same pathway. The two proteins are often referred to collectively as Erk1/2 or p44/p42 MAP kinase. The Erk pathway is considered the classical, canonical MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It is an evolutionarily conserved pathway that controls and is a critical regulator of the growth and survival through the promotion of cell proliferation and the prevention of apoptosis. Erk is involved in the control of many fundamental cellular processes including cell proliferation, survival, differentiation, apoptosis, motility and metabolism. Erk is activated by growth factor stimulation of receptor tyrosine kinases (RTKs), GPCR, and/or integrin stimulation. This activates the Ras-Raf-MEK-Erk pathway that results in the phosphorylation/activation of Erk1/2 (p44/p42) on the TxY motif (Thr202/Tyr204 and Thr185/Tyr187 for Erk1 & Erk2, respectively).
别名 :
Erk1;Erk2;p44-MAPK;p42-MAPK;MAPK2;PRKM2;p41mapk;PRKM1;p44;ERK2;P42MAPK;ERK;p42;MAPK1;ERT1;ERT2;Mitogen-activated protein kinase;MAP Kinase 2;MAP Kianse 1;MAPK
免疫原 :
Phosphorylated peptide corresponding to amino acids surrounding the pTEpY motif in the activation loop of human phospho-Erk1/2, in which the Thr and Tyr residues are phosphorylated
特异性 :
Recognizes Erk 1 & 2 only when dually phosphorylated on its TxY activation motif.
包装尺寸 :
100微升
用途 :
Multiplexing;Western Blotting
储存 :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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