Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

NR2A抗体, 克隆A12W, 兔单克隆

05-901R

100微升

单克隆

domestic rabbit

未共轭

A12W

神经科学

抗NR2A抗体, 克隆A12W, 兔单克隆

抗体

单克隆抗体

P35436

兔

NR2A

纯化

IgG

抗NR2A抗体, 克隆A12W, 兔单克隆

大鼠;人类;小鼠

NR2 or glutamate receptor, ionotropic, N-methyl D-aspartate 2 (NMDA2; NMDAR2) along with the NR1 subunit forms a heterodimer that make up the NMDA receptor. By alternative splicing there are various isoforms of NR2 classified as NR2A through D. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.

N-methyl D-aspartate receptor subtype 2A;N-methyl-D-aspartate receptor channel, subunit epsilon-1;N-methyl-D-aspartate receptor subunit 2A;NMDA receptor subtype 2A;glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Histidine-tagged recombinant protein corresponding to the C-terminus of mouse NR2A.

This antibody recognizes NR2A at the C-terminus.

100微升

西方墨点法

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.