Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

IP3受体抗体

07-1210

100微克

多克隆

domestic rabbit

未共轭

Cell Signaling

抗IP3受体抗体

抗体

多克隆抗体

Q14643

兔

IP3受体

纯化

IgG

抗IP3受体抗体

牛;人类;小鼠;猪;兔;大鼠;狗

The InsP3 (inositol 1,4,5-trisphosphate) Receptor family are intracellular Ca2+ channels activated by the second messenger InsP3. There are at least three types of receptor, with distinct tissue-specific expression profiles and subcellular localizations; it is thought that the exact subtype profile conveys precise Ca2+ release responses. Release of Ca2+ from intracellular stores is the trigger for many cellular responses, including muscle contraction. Receptor activity is subject to feedback regulation by Ca2+ concentration, as high cytosolic Ca2+ concentrations shut down the channel. Ca2+ release is augmented by phosphorylation of the Receptor by PKA and PKG.

Inositol 1,4,5-Trisphosphate Receptor

Synthetic peptide (KDSTEYTGPESYV) corresponding to the C-terminus of human IP3 Receptor type 1.

Reacts with the C-terminal cytoplasmic domain of IP3 receptors Type 1, 2, and 3. IP3 receptors have been shown to play an important role in the regulation of Ca2+ release from internal storage sites during cell activation. AB1622 reacts with IP3 receptor (MW approx. 260 kDa) isolated from a variety of cell types (e.g. lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscle, cardiac muscle and brain tissues).

100微克

免疫印迹;免疫荧光;免疫组化(石蜡);酶联免疫吸附测定;免疫沉淀;放射免疫分析法

Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.