产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
抗HIF-1抗体, 羟脯氨酸(Pro402)
目录 :
07-1585
规格 :
100微克
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, , 斑马鱼
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 6
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:1000
Lin A, Abbas S, Kim S, Ortega M, Bouamar H, Escobedo Y, et al. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nat Commun. 2015;6:7768 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Chan M, Atasoylu O, Hodson E, Tumber A, Leung I, Chowdhury R, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS ONE. 2015;10:e0132004 pubmed 出版商
Koukourakis M, Giatromanolaki A, Zois C, Kalamida D, Pouliliou S, Karagounis I, et al. Normal tissue radioprotection by amifostine via Warburg-type effects. Sci Rep. 2016;6:30986 pubmed 出版商
Snell C, Turley H, McIntyre A, Li D, Masiero M, Schofield C, et al. Proline-hydroxylated hypoxia-inducible factor 1? (HIF-1?) upregulation in human tumours. PLoS ONE. 2014;9:e88955 pubmed 出版商
Tian Y, Yeoh K, Lee M, Eriksson T, Kessler B, Kramer H, et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J Biol Chem. 2011;286:13041-51 pubmed 出版商
O Flaherty L, Adam J, Heather L, Zhdanov A, Chung Y, Miranda M, et al. Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum Mol Genet. 2010;19:3844-51 pubmed 出版商
产品信息
目录代码 :
07-1585
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗HIF-1抗体, 羟脯氨酸(Pro402)
产品类型 :
抗体
克隆性 :
多克隆抗体
基因编号 :
Q16665
宿主名称 :
抗原 :
HIF-1-alpha
共轭标签 :
亲和纯化
产品描述 :
抗HIF-1抗体, 羟脯氨酸(Pro402)
交叉活性 :
人类
背景 :
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1), EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with HIF-1β to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1α dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1α independent. EPAS-1 and HIF-3α have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.
别名 :
Hypoxia-inducible factor 1-alpha;HIF-1-alpha;HIF1-alpha;ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;Class E basic helix-loop-helix protein 78;bHLHe78;Member of PAS protein 1;PAS domain-containing protein 8
免疫原 :
KLH-conjugated linear peptide corresponding to the ODD region of human HIF-1-alpha.
特异性 :
This antibody recognizes HIF-1-alpha at the ODD region.
包装尺寸 :
100微克
用途 :
西方墨点法
储存 :
收到之日起在2-8℃稳定1年
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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