This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
乙酰组蛋白H4(Lys16)抗体
目录 :
07-329
规格 :
100微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, brewer's yeast
应用 :
免疫印迹, 免疫细胞化学, 染色质免疫沉淀 , 免疫组化-自由浮动切片, ChIP-Seq
文章摘录数: 36
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 s3a
Ryu K, Nandu T, Kim J, Challa S, DeBerardinis R, Kraus W. Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis. Science. 2018;360: pubmed 出版商
  • 免疫印迹; 人类; 图 s2a
Utani K, Fu H, Jang S, Marks A, Smith O, Zhang Y, et al. Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability. Nucleic Acids Res. 2017;45:7807-7824 pubmed 出版商
  • 免疫印迹; 小鼠
Raciti G, Spinelli R, Desiderio A, Longo M, Parrillo L, Nigro C, et al. Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity. Sci Rep. 2017;7:43526 pubmed 出版商
  • 免疫印迹; 人类; 图 7d
Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed 出版商
  • 免疫印迹; brewer's yeast; 图 s1d
Desfossés Baron K, Hammond Martel I, Simoneau A, Sellam A, Roberts S, Wurtele H. Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae. Sci Rep. 2016;6:36013 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3b
  • 免疫印迹; 人类; 图 3a
  • ChIP-Seq; 小鼠; 图 s2d
  • 免疫细胞化学; 小鼠; 图 3b
  • 免疫印迹; 小鼠; 图 3a
Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, et al. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Res. 2017;45:672-684 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 8
  • 免疫印迹; 小鼠; 图 8a
Liu Y, Wang T, Zhang R, Fu W, Wang X, Wang F, et al. Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016;213:2473-2488 pubmed
  • 染色质免疫沉淀 ; 人类; 图 s4d
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu W, et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016;538:118-122 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2
Kim J, Yu J, Abdulkadir S, Chakravarti D. KAT8 Regulates Androgen Signaling in Prostate Cancer Cells. Mol Endocrinol. 2016;30:925-36 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Penterling C, Drexler G, Böhland C, Stamp R, Wilke C, Braselmann H, et al. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS ONE. 2016;11:e0156599 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s3
Brasa S, Mueller A, Jacquemont S, Hahne F, Rozenberg I, Peters T, et al. Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome. Clin Epigenetics. 2016;8:15 pubmed 出版商
  • 染色质免疫沉淀 ; brewer's yeast; 图 1f
McCann T, Guo Y, McDonald W, Tansey W. Antagonistic roles for the ubiquitin ligase Asr1 and the ubiquitin-specific protease Ubp3 in subtelomeric gene silencing. Proc Natl Acad Sci U S A. 2016;113:1309-14 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 图 2
  • 免疫印迹; 小鼠; 图 1
Sheikh B, Bechtel Walz W, Lucci J, Karpiuk O, Hild I, Hartleben B, et al. MOF maintains transcriptional programs regulating cellular stress response. Oncogene. 2016;35:2698-710 pubmed 出版商
Bonnefont J, Tiberi L, van den Ameele J, Potier D, Gaber Z, Lin X, et al. Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways. Neuron. 2019;103:1096-1108.e4 pubmed 出版商
Huang H, Kong W, Jean M, Fiches G, Zhou D, Hayashi T, et al. A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG). Nucleic Acids Res. 2019;: pubmed 出版商
Urdinguio R, Lopez V, Bayon G, Díaz de la Guardia R, Sierra M, García Toraño E, et al. Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment. Nucleic Acids Res. 2019;47:5016-5037 pubmed 出版商
Huai W, Liu X, Wang C, Zhang Y, Chen X, Chen X, et al. KAT8 selectively inhibits antiviral immunity by acetylating IRF3. J Exp Med. 2019;216:772-785 pubmed 出版商
Bian C, Zhang C, Luo T, Vyas A, Chen S, Liu C, et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nat Commun. 2019;10:693 pubmed 出版商
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed 出版商
Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, et al. Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell. 2018;72:250-262.e6 pubmed 出版商
McCarthy A, Deiulio A, Martin E, Upadhyay M, Rangan P. Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in female Drosophila. Mol Biol Cell. 2018;29:2933-2945 pubmed 出版商
Basilicata M, Bruel A, Semplicio G, Valsecchi C, Aktas T, Duffourd Y, et al. De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nat Genet. 2018;50:1442-1451 pubmed 出版商
Valsecchi C, Basilicata M, Semplicio G, Georgiev P, Gutierrez N, Akhtar A. Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nat Commun. 2018;9:3626 pubmed 出版商
de Bruyn Kops A, Burke J, Guthrie C. Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope. Mol Biol Cell. 2018;29:2578-2590 pubmed 出版商
Saavedra F, Rivera C, Rivas E, Merino P, Garrido D, Hernandez S, et al. PP32 and SET/TAF-I? proteins regulate the acetylation of newly synthesized histone H4. Nucleic Acids Res. 2017;45:11700-11710 pubmed 出版商
Fang J, Ianni A, Smolka C, Vakhrusheva O, Nolte H, Kruger M, et al. Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proc Natl Acad Sci U S A. 2017;114:E8352-E8361 pubmed 出版商
Li L, Wang Y. Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair. J Biol Chem. 2017;292:11951-11959 pubmed 出版商
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed 出版商
Feldman S, Wuerffel R, Achour I, Wang L, Carpenter P, Kenter A. 53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination. J Immunol. 2017;198:2434-2444 pubmed 出版商
Klein B, Wang X, Cui G, Yuan C, Botuyan M, Lin K, et al. PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation. Cell Rep. 2016;17:1158-1170 pubmed 出版商
Roth M, Wang Z, Chen W. SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells. Oncotarget. 2016;7:50195-50214 pubmed 出版商
Saredi G, Huang H, Hammond C, Alabert C, Bekker Jensen S, Forne I, et al. H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Nature. 2016;534:714-718 pubmed 出版商
Menendez S, Villaronga M, Rodrigo J, Álvarez Teijeiro S, Urdinguio R, Fraga M, et al. HERG1A potassium channel is the predominant isoform in head and neck squamous cell carcinomas: evidence for regulation by epigenetic mechanisms. Sci Rep. 2016;6:19666 pubmed 出版商
Mandal M, Hamel K, Maienschein Cline M, Tanaka A, Teng G, Tuteja J, et al. Histone reader BRWD1 targets and restricts recombination to the Igk locus. Nat Immunol. 2015;16:1094-103 pubmed 出版商
Hait N, Wise L, Allegood J, O Brien M, Avni D, Reeves T, et al. Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. Nat Neurosci. 2014;17:971-80 pubmed 出版商
产品信息
目录代码 :
07-329
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗乙酰组蛋白H4(Lys16)抗体
产品类型 :
抗体
克隆性 :
多克隆抗体
基因编号 :
P62805
宿主名称 :
抗原 :
乙酰组蛋白H4(Lys16)
共轭标签 :
亲和纯化
抗体亚型 :
IgG
产品描述 :
抗乙酰组蛋白H4(Lys16)抗体
交叉活性 :
Human;Vertebrates;Yeast ( S. cerevisiae )
背景 :
Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Acetylation of histone H4 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs).
别名 :
H4K16Ac;Histone H4 (acetyl K16);H4 histone family, member A;histone 1, H4a;histone cluster 1, H4a
免疫原 :
Ovalbumin-conjugated, synthetic peptide (…GAAcKRH …) in which AcK corresponds to residue 16 of yeast histone H4.
特异性 :
Histone H4 acetylated on lysine 16, but not histone H4 containing a lysine 16 to arginine substitution.
包装尺寸 :
100微升
用途 :
Western Blotting;Multiplexing;Peptide Inhibition Assay;Dot Blot;ChIP-seq;Chromatin Immunoprecipitation (ChIP)
储存 :
Stable for 1 year at 2-8° C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.