This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301, 异硫氰酸荧光素共轭标签
目录 :
16-202A
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
异硫氰酸荧光素
抗原修饰 :
磷酸化
克隆名称 :
JBW301
反应物种 :
人类, 小鼠
应用 :
免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
文章摘录数: 109
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:500; 图 s5
Ding D, Liu J, Dong K, Melnick A, Latham K, Chen C. Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis. Nucleic Acids Res. 2019;47:2594-2608 pubmed 出版商
  • 免疫细胞化学; 小鼠
Ghazaryan S, Sy C, Hu T, An X, Mohandas N, Fu H, et al. Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation. Mol Cell Biol. 2014;34:2833-47 pubmed 出版商
Chernikova S, Nguyen R, Truong J, Mello S, Stafford J, Hay M, et al. Dynamin impacts homology-directed repair and breast cancer response to chemotherapy. J Clin Invest. 2018;128:5307-5321 pubmed 出版商
Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, et al. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Development. 2018;145: pubmed 出版商
Shi B, Xue J, Zhou J, Kasowitz S, Zhang Y, Liang G, et al. MORC2B is essential for meiotic progression and fertility. PLoS Genet. 2018;14:e1007175 pubmed 出版商
Li Z, Wang H, Wang Y, Murnane J, Dynan W. Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells. Radiat Res. 2014;182:573-9 pubmed 出版商
Ishiguro K, Lin Z, Penketh P, Shyam K, Zhu R, Baumann R, et al. Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochem Pharmacol. 2014;91:312-22 pubmed 出版商
Drutovic D, Chripkova M, Pilatova M, Kruzliak P, Perjesi P, Sarissky M, et al. Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells. Tumour Biol. 2014;35:9967-75 pubmed 出版商
Znojek P, Willmore E, Curtin N. Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase. Br J Cancer. 2014;111:1319-26 pubmed 出版商
Manguan García C, Pintado Berninches L, Carrillo J, Machado Pinilla R, Sastre L, Perez Quilis C, et al. Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. PLoS ONE. 2014;9:e101424 pubmed 出版商
Samuni Y, Wink D, Krishna M, Mitchell J, Goldstein S. Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide. Free Radic Biol Med. 2014;73:291-8 pubmed 出版商
Patterson M, Sutton R, Forrest I, Sharrock R, Lane M, Kaufmann A, et al. Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples. Br J Cancer. 2014;111:94-100 pubmed 出版商
Shahar O, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, et al. A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair. Nucleic Acids Res. 2014;42:5689-701 pubmed 出版商
Chang H, Wang H, Chen C, Hung T, Hou M, Yuan S, et al. 5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells. Molecules. 2014;19:3149-59 pubmed 出版商
Bokobza S, Jiang Y, Weber A, Devery A, Ryan A. Short-course treatment with gefitinib enhances curative potential of radiation therapy in a mouse model of human non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;88:947-54 pubmed 出版商
Ramaekers C, van den Beucken T, Bristow R, Chiu R, Durocher D, Wouters B. RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage. PLoS ONE. 2014;9:e89997 pubmed 出版商
Petrova N, Velichko A, Kantidze O, Razin S. Heat shock-induced dissociation of TRF2 from telomeres does not initiate a telomere-dependent DNA damage response. Cell Biol Int. 2014;38:675-81 pubmed 出版商
Islam M, Thomas S, Murty V, Sedoris K, Miller D. c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA. J Biol Chem. 2014;289:8521-31 pubmed 出版商
Ferlazzo M, Sonzogni L, Granzotto A, Bodgi L, Lartin O, Devic C, et al. Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates. Mol Neurobiol. 2014;49:1200-11 pubmed 出版商
Vitale N, Kisslinger A, Paladino S, Procaccini C, Matarese G, Pierantoni G, et al. Resveratrol couples apoptosis with autophagy in UVB-irradiated HaCaT cells. PLoS ONE. 2013;8:e80728 pubmed 出版商
Di Francesco A, De Pittà C, Moret F, Barbieri V, Celotti L, Mognato M. The DNA-damage response to ?-radiation is affected by miR-27a in A549 cells. Int J Mol Sci. 2013;14:17881-96 pubmed 出版商
Vavrova J, Zarybnicka L, Lukasova E, Rezacova M, Novotna E, Sinkorova Z, et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys. 2013;52:471-9 pubmed 出版商
Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, et al. Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid. 2014;24:502-10 pubmed 出版商
Wells C, Bhaskara S, Stengel K, Zhao Y, Sirbu B, Chagot B, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS ONE. 2013;8:e68915 pubmed 出版商
Bee L, Fabris S, Cherubini R, Mognato M, Celotti L. The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression. PLoS ONE. 2013;8:e69061 pubmed 出版商
Streppel M, Pai S, Campbell N, Hu C, Yabuuchi S, Canto M, et al. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Clin Cancer Res. 2013;19:4067-78 pubmed 出版商
Millet P, Granotier C, Etienne O, Boussin F. Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. Int J Oncol. 2013;43:375-82 pubmed 出版商
Li Z, Hudson F, Wang H, Wang Y, Bian Z, Murnane J, et al. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013;180:17-24 pubmed 出版商
Ryu S, Kawamura R, Naka R, Silberberg Y, Nakamura N, Nakamura C. Nanoneedle insertion into the cell nucleus does not induce double-strand breaks in chromosomal DNA. J Biosci Bioeng. 2013;116:391-6 pubmed 出版商
Muller I, Merk B, Voss K, Averbeck N, Jakob B, Durante M, et al. Species conserved DNA damage response at the inactive human X chromosome. Mutat Res. 2013;756:30-6 pubmed 出版商
Sorokina S, Markova E, Gursky J, Dobrovodsky J, Belyaev I. Relative biological efficiency of protons at low and therapeutic doses in induction of 53BP1/?H2AX foci in lymphocytes from umbilical cord blood. Int J Radiat Biol. 2013;89:716-23 pubmed 出版商
Lu X, Parvathaneni S, Hara T, Lal A, Sharma S. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer. 2013;12:29 pubmed 出版商
Berchtold C, Coughlin A, Kasper Z, Thibeault S. Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction. Laryngoscope. 2013;123:2228-36 pubmed 出版商
Jha H, Upadhyay S, A J Prasad M, Lu J, Cai Q, Saha A, et al. H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. J Virol. 2013;87:5255-69 pubmed 出版商
Fischer B, Wong J, Degan S, Kummarapurugu A, Zheng S, Haridass P, et al. Increased expression of senescence markers in cystic fibrosis airways. Am J Physiol Lung Cell Mol Physiol. 2013;304:L394-400 pubmed 出版商
Konishi T, Oikawa M, Suya N, Ishikawa T, Maeda T, Kobayashi A, et al. SPICE-NIRS microbeam: a focused vertical system for proton irradiation of a single cell for radiobiological research. J Radiat Res. 2013;54:736-47 pubmed 出版商
Montenegro M, Sáez Ayala M, Piñero Madrona A, Cabezas Herrera J, Rodriguez Lopez J. Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation. PLoS ONE. 2012;7:e52231 pubmed 出版商
Subramanian C, Hada M, Opipari A, Castle V, Kwok R. CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma. Mol Cancer Res. 2013;11:173-81 pubmed 出版商
Xiao Y, Wang J, Song H, Zou P, Zhou D, Liu L. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence. Leuk Res. 2013;37:333-40 pubmed 出版商
Tsai Y, Yeh C, Tzen K, Ho P, Tuan T, Pu Y, et al. Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma. Eur J Cancer. 2013;49:1458-66 pubmed 出版商
Conradt L, Henrich A, Wirth M, Reichert M, Lesina M, Algül H, et al. Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. Int J Cancer. 2013;132:2248-57 pubmed 出版商
Solarczyk K, Zarebski M, Dobrucki J. Inducing local DNA damage by visible light to study chromatin repair. DNA Repair (Amst). 2012;11:996-1002 pubmed 出版商
Gallagher S, Kofman A, Huszar J, Dannenberg J, Depinho R, Braun R, et al. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Dev Biol. 2013;373:83-94 pubmed 出版商
Coffey K, Blackburn T, Cook S, Golding B, Griffin R, Hardcastle I, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS ONE. 2012;7:e45539 pubmed 出版商
Arango D, Parihar A, Villamena F, Wang L, Freitas M, Grotewold E, et al. Apigenin induces DNA damage through the PKC?-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochem Pharmacol. 2012;84:1571-80 pubmed 出版商
Li Y, Xiong H, Yang D. Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells. Chin J Cancer. 2012;31:364-72 pubmed 出版商
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed 出版商
Xiao Y, Zou P, Wang J, Song H, Zou J, Liu L. Lower phosphorylation of p38 MAPK blocks the oxidative stress-induced senescence in myeloid leukemic CD34(+)CD38 (-) cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:328-333 pubmed 出版商
Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, Nakagawa K, et al. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer Res. 2012;72:2901-11 pubmed 出版商
Duxin J, Moore H, Sidorova J, Karanja K, Honaker Y, Dao B, et al. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem. 2012;287:21980-91 pubmed 出版商
Thiemann M, Oertel S, Ehemann V, Weichert W, Stenzinger A, Bischof M, et al. In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model. Radiat Oncol. 2012;7:52 pubmed 出版商
Sergent J, Paget V, Chevillard S. Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line. Ann Occup Hyg. 2012;56:622-30 pubmed 出版商
Sultana R, McNeill D, Abbotts R, Mohammed M, Zdzienicka M, Qutob H, et al. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer. 2012;131:2433-44 pubmed 出版商
Brzozowska K, Pinkawa M, Eble M, Müller W, Wojcik A, Kriehuber R, et al. In vivo versus in vitro individual radiosensitivity analysed in healthy donors and in prostate cancer patients with and without severe side effects after radiotherapy. Int J Radiat Biol. 2012;88:405-13 pubmed 出版商
Runge R, Hiemann R, Wendisch M, Kasten Pisula U, Storch K, Zophel K, et al. Fully automated interpretation of ionizing radiation-induced ?H2AX foci by the novel pattern recognition system AKLIDES®. Int J Radiat Biol. 2012;88:439-47 pubmed 出版商
Algire C, Moiseeva O, Deschênes Simard X, Amrein L, Petruccelli L, Birman E, et al. Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila). 2012;5:536-43 pubmed 出版商
Spagnolo L, Barbeau J, Curtin N, Morris E, Pearl L. Visualization of a DNA-PK/PARP1 complex. Nucleic Acids Res. 2012;40:4168-77 pubmed 出版商
Ting H, Yasmin Karim S, Yan S, Hsu J, Lin T, Zeng W, et al. A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer Res. 2012;72:958-68 pubmed 出版商
Moraes M, de Andrade A, Carvalho H, Guecheva T, Agnoletto M, Henriques J, et al. Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions. Cancer Lett. 2012;314:108-18 pubmed 出版商
Lin R, Zhou N, Lyu Y, Tsai Y, Lu C, Kerrigan J, et al. Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase II?. J Biol Chem. 2011;286:33591-600 pubmed 出版商
Bridges K, Hirai H, Buser C, Brooks C, Liu H, Buchholz T, et al. MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res. 2011;17:5638-48 pubmed 出版商
Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Kehlbach R, Rodemann H. Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. Radiother Oncol. 2011;99:317-22 pubmed 出版商
Di Giacomo F, Granotier C, Barroca V, Laurent D, Boussin F, Lewandowski D, et al. Tritium contamination of hematopoietic stem cells alters long-term hematopoietic reconstitution. Int J Radiat Biol. 2011;87:556-70 pubmed 出版商
Castillo P, Bogliolo M, Surralles J. Coordinated action of the Fanconi anemia and ataxia telangiectasia pathways in response to oxidative damage. DNA Repair (Amst). 2011;10:518-25 pubmed 出版商
Pazhanisamy S, Li H, Wang Y, Batinic Haberle I, Zhou D. NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. Mutagenesis. 2011;26:431-5 pubmed 出版商
Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011;39:5356-68 pubmed 出版商
Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z. Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer. 2011;129:2720-31 pubmed 出版商
Ye W, Blain S. Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage. Apoptosis. 2011;16:449-59 pubmed 出版商
Zhang Y, Regairaz M, Seiler J, Agama K, Doroshow J, Pommier Y. Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res. 2011;39:3607-20 pubmed 出版商
Zhang K, Wu J, Wu X, Wang X, Wang Y, Zhou N, et al. p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest. Mol Cancer Ther. 2011;10:269-78 pubmed 出版商
Hill J, Tansavatdi K, Lockett K, Allen G, Takita C, Pollack A, et al. Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk. Cancer Manag Res. 2009;1:39-48 pubmed
Rothkamm K, Burdak Rothkamm S. Ionizing radiation-induced DNA strand breaks and ?-H2AX?-H2AX foci in cells exposed to nitric oxide. Methods Mol Biol. 2011;704:17-25 pubmed 出版商
Elliott S, Crawford C, Mulligan E, Summerfield G, Newton P, Wallis J, et al. Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia. Br J Haematol. 2011;152:61-71 pubmed 出版商
Nykky J, Tuusa J, Kirjavainen S, Vuento M, Gilbert L. Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine. Int J Nanomedicine. 2010;5:417-28 pubmed
Landsverk H, Mora Bermúdez F, Landsverk O, Hasvold G, Naderi S, Bakke O, et al. The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Rep. 2010;11:868-75 pubmed 出版商
Kuck D, Caulfield T, Lyko F, Medina Franco J. Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. Mol Cancer Ther. 2010;9:3015-23 pubmed 出版商
Audebert M, Riu A, Jacques C, Hillenweck A, Jamin E, Zalko D, et al. Use of the ?H2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines. Toxicol Lett. 2010;199:182-92 pubmed 出版商
Nelson A, Holt J. Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage. Radiat Res. 2010;174:1-13 pubmed 出版商
Ye W, Blain S. S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons. Brain. 2010;133:2295-312 pubmed 出版商
Carlessi L, Buscemi G, Fontanella E, Delia D. A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage. Biochim Biophys Acta. 2010;1803:1213-23 pubmed 出版商
Mukhopadhyay A, Elattar A, Cerbinskaite A, Wilkinson S, Drew Y, Kyle S, et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin Cancer Res. 2010;16:2344-51 pubmed 出版商
Le O, Rodier F, Fontaine F, Coppe J, Campisi J, DeGregori J, et al. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 2010;9:398-409 pubmed 出版商
Mitchell J, Choudhuri R, Fabre K, Sowers A, Citrin D, Zabludoff S, et al. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Clin Cancer Res. 2010;16:2076-84 pubmed 出版商
Soule B, Simone N, DeGraff W, Choudhuri R, Cook J, Mitchell J. Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. Radiat Oncol. 2010;5:8 pubmed 出版商
Glauser D, Seyffert M, Strasser R, Franchini M, Laimbacher A, Dresch C, et al. Inhibition of herpes simplex virus type 1 replication by adeno-associated virus rep proteins depends on their combined DNA-binding and ATPase/helicase activities. J Virol. 2010;84:3808-24 pubmed 出版商
Belzile J, Richard J, Rougeau N, Xiao Y, Cohen E. HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest. J Virol. 2010;84:3320-30 pubmed 出版商
Pospelova T, Demidenko Z, Bukreeva E, Pospelov V, Gudkov A, Blagosklonny M. Pseudo-DNA damage response in senescent cells. Cell Cycle. 2009;8:4112-8 pubmed
Wang Y, Liu L, Pazhanisamy S, Li H, Meng A, Zhou D. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med. 2010;48:348-56 pubmed 出版商
Bauerschmidt C, Arrichiello C, Burdak Rothkamm S, Woodcock M, Hill M, Stevens D, et al. Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin. Nucleic Acids Res. 2010;38:477-87 pubmed 出版商
Wilson P, Nham P, Urbin S, Hinz J, Jones I, Thompson L. Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. Mutat Res. 2010;683:91-7 pubmed 出版商
Ciccia A, Bredemeyer A, Sowa M, Terret M, Jallepalli P, Harper J, et al. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 2009;23:2415-25 pubmed 出版商
Msiska Z, Pacurari M, Mishra A, Leonard S, Castranova V, Vallyathan V. DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential?. Am J Respir Cell Mol Biol. 2010;43:210-9 pubmed 出版商
Cook J, Choudhuri R, DeGraff W, Gamson J, Mitchell J. Halofuginone enhances the radiation sensitivity of human tumor cell lines. Cancer Lett. 2010;289:119-26 pubmed 出版商
Simonnet A, Nehme J, Vaigot P, Barroca V, Leboulch P, Tronik Le Roux D. Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure. Stem Cells. 2009;27:1400-9 pubmed 出版商
Zarebski M, Wiernasz E, Dobrucki J. Recruitment of heterochromatin protein 1 to DNA repair sites. Cytometry A. 2009;75:619-25 pubmed 出版商
Nichols G, Schaack J, Ornelles D. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009;83:5987-98 pubmed 出版商
Golding S, Morgan R, Adams B, Hawkins A, Povirk L, Valerie K. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biol Ther. 2009;8:730-8 pubmed
Carlessi L, De Filippis L, Lecis D, Vescovi A, Delia D. DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. Cell Death Differ. 2009;16:795-806 pubmed 出版商
Parsels L, Morgan M, Tanska D, Parsels J, Palmer B, Booth R, et al. Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. Mol Cancer Ther. 2009;8:45-54 pubmed 出版商
Kasten Pisula U, Menegakis A, Brammer I, Borgmann K, Mansour W, Degenhardt S, et al. The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair. Radiother Oncol. 2009;90:257-64 pubmed 出版商
Perotti C, Liu R, Parusel C, Böcher N, Schultz J, Bork P, et al. Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation. Breast Cancer Res. 2008;10:R94 pubmed 出版商
Eliezer Y, Argaman L, Rhie A, Doherty A, Goldberg M. The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. J Biol Chem. 2009;284:426-35 pubmed 出版商
Enokido Y, Yoshitake A, Ito H, Okazawa H. Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain. Biochem Biophys Res Commun. 2008;376:128-33 pubmed 出版商
Muslimovic A, Ismail I, Gao Y, Hammarsten O. An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells. Nat Protoc. 2008;3:1187-93 pubmed 出版商
Burgess D, Doles J, Zender L, Xue W, Ma B, McCombie W, et al. Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A. 2008;105:9053-8 pubmed 出版商
Vuyyuri S, Hamstra D, Khanna D, Hamilton C, Markwart S, Campbell K, et al. Evaluation of D-methionine as a novel oral radiation protector for prevention of mucositis. Clin Cancer Res. 2008;14:2161-70 pubmed 出版商
Al Ejeh F, Darby J, Brown M. The La autoantigen is a malignancy-associated cell death target that is induced by DNA-damaging drugs. Clin Cancer Res. 2007;13:5509s-5518s pubmed
Kotsopoulos J, Chen Z, Vallis K, Poll A, Ainsworth P, Narod S. DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers. Br J Cancer. 2007;96:118-25 pubmed
Rose J, Reeves K, Likhotvorik R, Hoyt D. Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells. J Pharmacol Exp Ther. 2007;321:318-26 pubmed
产品信息
目录代码 :
16-202A
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301, 异硫氰酸荧光素共轭标签
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P16104
宿主名称 :
小鼠
抗原 :
磷酸化组蛋白H2A.X(Ser139)
克隆 :
克隆JBW301
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
抗磷酸化组蛋白H2A.X(Ser139)抗体, 克隆JBW301, 异硫氰酸荧光素共轭标签
交叉活性 :
人类
背景 :
Histone H2A is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H2A is involved with the structure of the nucleosomes of the 'beads on a string' structure.
别名 :
H2AXS139P;Histone H2A.X (phospho S139);H2A histone family, member X;H2AX histone
免疫原 :
KLH-conjugated, synthetic peptide (CKATQA[pS]QEY) corresponding to amino acids 134-142 of human histone H2A.X. The immunizing sequence has 8 identical amino acids in yeast and mouse. Clone JBW301.
特异性 :
Recognizes Histone H2A.X phosphorylated at Ser139, MW 15 kDa.
包装尺寸 :
100微克
用途 :
流式细胞仪;免疫细胞化学
储存 :
Stable for 1 year at from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
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