产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Tau Mouse mAb (TAU-5)
目录 :
577801-100微克
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫沉淀, immunohistochemistry - free floating section, 免疫组化基因敲除验证
更多信息或购买 :
文章摘录数: 6
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 2c
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed 出版商
  • 免疫组化基因敲除验证; 人类; 图 2
  • immunohistochemistry - free floating section; 人类; 图 2
  • 免疫印迹; 人类; 图 1
Fernández Nogales M, Santos Galindo M, Merchán Rubira J, Hoozemans J, Rábano A, Ferrer I, et al. Tau-positive nuclear indentations in P301S tauopathy mice. Brain Pathol. 2017;27:314-322 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a
  • 免疫印迹; 人类; 1:1000; 图 8
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 1
Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, et al. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016;15:914-23 pubmed 出版商
  • 免疫印迹; 兔; 1:1000; 图 3
Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5e
Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, et al. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc Natl Acad Sci U S A. 2015;112:E4465-74 pubmed 出版商
产品信息
目录代码 :
577801-100微克
类别 :
抗体
亚类别 :
神经科学
产品名称 :
Anti-Tau Mouse mAb (TAU-5)
产品类型 :
抗体
克隆性 :
单克隆
基因编号 :
4137 (Hu), 17762 (Ms), 29477 (Rt)
宿主名称 :
M
克隆 :
TAU-5
共轭标签 :
纯化
抗体亚型 :
IgG
产品描述 :
Anti-Tau Mouse mAb (TAU-5)
交叉活性 :
人类, 小鼠, 大鼠, 羊
背景 :
Tau is a neuronal microtubule-associated protein found predominantly in axons. Tau promotes tubulin polymerization and stabilizes microtubules, and it links certain signaling pathways to the cytoskeleton. Hyperphosphorylated tau is the major component of paired helical filaments, the building block of neurofibrillary lesions in Alzheimer’s disease. Hyperphosphorylation impairs the microtubule-binding function of tau, resulting in the destabilization of microtubules, and ultimately leading to degeneration of the affected neurons.
别名 :
DDPAC, FLJ31424, FTDP-17, MAPTL, MSTD, Mtapt, MTBT1, MTBT2, PHF TAU, PPND, pTau, RNPTAU, TAU, Tau 3r, Tau-1, TAU-FACTOR, Tau40, TAU4R, microtubule-associated protein tau
免疫原 :
纯化牛微管相关蛋白
特异性 :
Recognizes the ~45-68 kDa phosphorylated and unphosphorylated forms of tau.
包装尺寸 :
100微克
用途 :
IH, 免疫印迹, 免疫沉淀, IH(P)
储存 :
Following initial thaw, aliquot and freeze (-70°C). Do not store diluted antibody without carrier protein if the concentration is 50 ug/ml. Avoid repeated freeze-thaw.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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