Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

磷酸甘油醛脱氢酶抗体

AB2302

100微克

多克隆

鸡

未共轭

代谢

抗磷酸甘油醛脱氢酶抗体

抗体

多克隆抗体

P04406

鸡

磷酸甘油醛脱氢酶

亲和纯化

抗磷酸甘油醛脱氢酶抗体

人类;小鼠;大鼠;马;狗

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an ubiquitous glycolytic enzyme present in reasonably high levels in almost all tissues. As a 'house-keeping' enzyme, it catalyzes the synthesis of 1,3-biphosphoglycerate, a "high energy" intermediate used for the synthesis of ATP. Besides its cytoplasmic action in metabolism it is also involved in the initial stages of apoptosis or oxidative stress response where GAPDH is translocated to the nucleus. Such actions may reflect the role of GAPDH in DNA repair or as one nuclear carrier for apoptotic molecules. GAPDH has also been found to bind specifically to proteins implicated in the pathogenesis of a variety of neurodegenerative disorders including the beta-amyloid precursor protein and the huntingtin protein where decreased function of GAPDH is associated with Alzheimer's and Huntington's disease fibroblasts. GAPDH has also been identified as a potential target for nitric oxide (NO)-mediated cellular toxicity. The complete and functional enzyme is a tetramer with each of four identical subunits occupying the vertex of a tetrahedron. Binding domains also include one principally interacting with NAD+ and another interacting with glyceraldehyde 3-phosphate (GAP).

glyceraldehyde 3-phosphate dehydrogenase;aging-associated gene 9 protein;glyceraldehyde-3-phosphate dehydrogenase

KLH-conjugated linear peptide corresponding to the WARS interacting region of human GAPDH.

这抗体识别磷酸甘油醛脱氢酶

100微克

西方墨点法

收到之日起在2-8℃稳定1年