产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Glial fibrillary acidic protein δ Antibody
目录 :
AB9598
规格 :
100微升
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片, 免疫组化-冰冻切片, immunohistochemistry - free floating section
更多信息或购买 :
文章摘录数: 6
已发表的文献中的应用方法/种属/稀释度参考文献
  • 免疫组化-冰冻切片; 人类; 1:750
Leonard B, Mastroeni D, Grover A, Liu Q, Yang K, Gao M, et al. Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. J Comp Neurol. 2009;515:269-94 pubmed 出版商
Smith B, Santos M, Marshall M, Cantuti-Castelvetri L, Lopez-Rosas A, Li G, et al. Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease. J Pathol. 2014;232:509-21 pubmed 出版商
Heo D, Kim S, Yang K, Cho Y, Kim K, Yoon D, et al. A histopathological diagnostic marker for human spinal astrocytoma: expression of glial fibrillary acidic protein-δ. J Neurooncol. 2012;108:45-52 pubmed 出版商
Ahn S, Byun K, Kim D, Lee K, Yoo J, Kim S, et al. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS ONE. 2008;3:e3917 pubmed 出版商
McGill T, Cottam B, Lu B, Wang S, Girman S, Tian C, et al. Transplantation of human central nervous system stem cells - neuroprotection in retinal degeneration. Eur J Neurosci. 2012;35:468-77 pubmed 出版商
Galan L, Gómez-Pinedo U, Vela-Souto A, Guerrero-Sola A, Barcia J, Gutierrez A, et al. Subventricular zone in motor neuron disease with frontotemporal dementia. Neurosci Lett. 2011;499:9-13 pubmed 出版商
产品信息
目录代码 :
AB9598
亚类别 :
神经科学
产品名称 :
Anti-Glial fibrillary acidic protein δ Antibody
产品类型 :
抗体
克隆性 :
多克隆抗体
基因编号 :
P14136
宿主名称 :
抗原 :
Glial fibrillary acidic protein δ
共轭标签 :
血清
产品描述 :
Anti-Glial fibrillary acidic protein δ Antibody
交叉活性 :
人类
背景 :
Human Glial Fibrillary Acidic Protein delta (GFAP-delta) is a GFAP protein isoform that is encoded by an alternative splice variant of the GFAP-gene. As a result, GFAP-delta protein differs from the predominant splice form, GFAP-alpha, by its C-terminal protein sequence. GFAP-delta protein is not expressed by all GFAP expressing astrocytes but specifically by a subpopulation located in the subpial zone of the cerebral cortex, the subgranular zone of the hippocampus and, most intensely, by a ribbon of astrocytes following the ependymal layer of the cerebral ventricles. Therefore, at least in the sub ventricular zone (SVZ), GFAP-delta specifically marks the population of astrocytes that contain the neural stem cells in the adult human brain. Interestingly, the SVZ astrocytes actively splice GFAP-delta transcripts, in contrast to astrocytes adjacent to this layer. Data shows that GFAP-delta protein, unlike GFAP-alpha, is not upregulated in astrogliosis. Data indicates a different functional role for GFAP-delta in astrocyte physiology. Transfection studies showed that GFAP-delta protein expression has a negative effect on GFAP filament formation, and therefore could be important for modulating intermediate filament cytoskeletal properties, possibly facilitating astrocyte motility. Further studies on GFAP-delta and the cells that express it are important for gaining insights into its function during differentiation, migration and during health and disease (Roelofs, RF, et al., Glia (2005) 52:289-300.).
别名 :
GFAPdelta
免疫原 :
Synthetic peptide from human GFAP-delta.
特异性 :
Glial Fibrillary Acidic Protein-delta (GFAP-delta). The antibody does not recognize GFAP-alpha protein.
包装尺寸 :
100微升
用途 :
免疫印迹;免疫组化(石蜡)
储存 :
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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