产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Tau phospho Threonine 231 Antibody
目录 :
AB9668
规格 :
100微升
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
文章摘录数: 3
出版应用/物种/样品/稀释参考文献
  • 免疫组化; 小鼠; 1:250; 图 5b
  • 免疫印迹; 小鼠; 1:1000; 图 5c
Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed 出版商
Choi J, Chandrasekaran K, Demarest T, Kristian T, Xu S, Vijaykumar K, et al. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Ann Clin Transl Neurol. 2014;1:589-604 pubmed 出版商
Sagare A, Bell R, Zhao Z, Ma Q, Winkler E, Ramanathan A, et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013;4:2932 pubmed 出版商
产品信息
目录代码 :
AB9668
亚类别 :
神经科学
产品名称 :
Anti-Tau phospho Threonine 231 Antibody
产品类型 :
抗体
克隆性 :
多克隆抗体
基因编号 :
P10636
宿主名称 :
抗原 :
Tau phospho Threonine 231
共轭标签 :
亲和纯化
产品描述 :
Anti-Tau phospho Threonine 231 Antibody
交叉活性 :
人类
背景 :
Tau is a neuronal microtubule-associated protein found predominantly on axons and functions to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylated Tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II (CK2), phosphorylate Tau. Threonine 231 is phosphorylated by GSK-3beta, cdk5 and cdk1 and has been shown to be involved in the pre-tangle process of AD.
免疫原 :
Synthetic peptide of amino acids surrounding the phosphoThreonine 231 site of human Tau.
特异性 :
Tau phosphoThreonine 231. The antibody recognizes Tau pThreonine 231 in samples of recombinant human Tau treated with GSK-3beta for 45 minutes. The reactivity of the antibody is blocked with the pThreonine 231 peptide but not the non-phosphopeptide or a generic phosphoThreonine-containing peptide.
包装尺寸 :
100微升
用途 :
西方墨点法
储存 :
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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