产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
抗HIF-1α抗体
目录 :
ABE279
规格 :
100微克
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
文章摘录数: 2
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:1000
Panneerselvam J, Jin J, Shanker M, Lauderdale J, BATES J, Wang Q, et al. IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. PLoS ONE. 2015;10:e0122439 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Schaffner C, Mwinyi J, Gai Z, Thasler W, Eloranta J, Kullak Ublick G. The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes. Liver Int. 2015;35:1152-61 pubmed 出版商
产品信息
目录代码 :
ABE279
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
抗HIF-1α抗体
产品类型 :
抗体
克隆性 :
多克隆抗体
基因编号 :
Q16665
宿主名称 :
抗原 :
HIF-1α
共轭标签 :
亲和纯化
产品描述 :
抗HIF-1α抗体
交叉活性 :
人类
背景 :
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1), EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1α dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1α independent. EPAS-1 and HIF-3α have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.
别名 :
ARNT interacting protein;ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;HIF-1 alpha;HIF1 alpha;Member of PAS protein 1;hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor);hypoxia-inducible factor 1, alpha subunit;hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor);member of PAS superfamily 1
免疫原 :
KLH-conjugated linear peptide corresponding to human HIF-1α.
包装尺寸 :
100微克
用途 :
西方墨点法
储存 :
收到之日起在2-8℃稳定1年
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
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