产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Tau (T22), oligomeric
目录 :
ABN454
规格 :
100微升
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 中和反应, 免疫沉淀
更多信息或购买 :
文章摘录数: 5
出版应用/物种/样品/稀释参考文献
  • 免疫组化; 小鼠; 图 1d
Merezhko M, Brunello C, Yan X, Vihinen H, Jokitalo E, Uronen R, et al. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018;25:2027-2035.e4 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 1:1000; 图 2h
Takeda S, Wegmann S, Cho H, DeVos S, Commins C, Roe A, et al. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015;6:8490 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4
Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, et al. Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes. J Neuropathol Exp Neurol. 2015;74:873-88 pubmed 出版商
Wang Y, Hall R, Lee M, Kamgar Parsi A, Bi X, Baudry M. The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Sci Rep. 2017;7:11771 pubmed 出版商
Stancu I, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, et al. Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta Neuropathol. 2015;129:875-94 pubmed 出版商
产品信息
目录代码 :
ABN454
亚类别 :
神经科学
产品名称 :
Anti-Tau (T22), oligomeric
产品类型 :
抗体
克隆性 :
多克隆抗体
基因编号 :
P10636
宿主名称 :
抗原 :
MAPT
共轭标签 :
血清
纯化方法 :
Unpurified
产品描述 :
Anti-Tau (T22), oligomeric
交叉活性 :
人类, 小鼠, 大鼠
背景 :
In Alzheimer's disease (AD) pathology, accumulation of the microtubule-associated protein tau takes place primarily in the neurons. Tau accumulates in both the somatodendritic and axonal domains of neurons. Tau also accumulates in the soma as neurofibrillary tangles (NFTs). Cell death and synaptic lesions occur independently of NFT formation, and research indicates that NFT formation alone is insufficient for neurodegeneration. This suggests that soluble tau aggregates may be the most toxic and pathologically significant tau species. Tau oligomers are neurotoxic when applied extracellularly to cultured neuronal cells tau oligomers (but not fibrils) induce neurodegeneration and synaptic and mitochondrial dysfunction in vivo. Moreover using a new Tau oligomer specific antibody, Tau (T22), researchers were able to use tau oligomers as a reliable biomarker to differentiate patients with AD from age-matched controls. Tau (T22) should further allow researchers to begin to analyze the relation between tau aggregation, amyloid, and disease progression.
别名 :
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Oligomeric Tau
免疫原 :
Tau oligomers corresponding to human oligomeric Tau (T22).
包装尺寸 :
100微升
用途 :
Western Blotting, Dot Blot, Immunohistochemistry, Immunocytochemistry, Neutralizing, Immunoprecipitation
储存 :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
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