This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
APP A4 Antibody, a.a. 66-81 (NT), Prediluted, clone 22C11
目录 :
IHCR1002-6
规格 :
6毫升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
22C11

同一抗体克隆可从以下厂商购到:
反应物种 :
仓鼠, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
文章摘录数: 214
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2a
Visconte C, Canino J, Guidetti G, Zarà M, Seppi C, Abubaker A, et al. Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation. Cell Signal. 2018;52:95-102 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Xu S, Nigam S, Brodin L. Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein. Neurodegener Dis. 2018;18:26-37 pubmed 出版商
  • 免疫印迹; 大鼠; 1:10,000; 图 1b
Ji C, Steimle B, Bailey D, Kosman D. The Ferroxidase Hephaestin But Not Amyloid Precursor Protein is Required for Ferroportin-Supported Iron Efflux in Primary Hippocampal Neurons. Cell Mol Neurobiol. 2018;38:941-954 pubmed 出版商
  • 免疫印迹; 人类; 图 4e
Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s7e
Sterky F, Trotter J, Lee S, Recktenwald C, Du X, Zhou B, et al. Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand. Proc Natl Acad Sci U S A. 2017;114:E1253-E1262 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1m
Michailidou I, Naessens D, Hametner S, Guldenaar W, Kooi E, Geurts J, et al. Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis. Glia. 2017;65:264-277 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:2000; 图 3g
Kramann N, Menken L, Hayardeny L, Hanisch U, Bruck W. Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling. Neurol Neuroimmunol Neuroinflamm. 2016;3:e233 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed 出版商
  • 免疫印迹; 大鼠; 图 8
Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M. An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid ? Precursor Protein Signaling. J Biol Chem. 2016;291:12282-93 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
  • 免疫印迹; 小鼠; 1:1000; 图 3
Xu G, Ran Y, Fromholt S, Fu C, Yachnis A, Golde T, et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015;3:72 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3c
Bonnemaison M, Bäck N, Duffy M, Ralle M, Mains R, Eipper B. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem. 2015;290:21264-79 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2f
Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, et al. Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology. Sci Rep. 2015;5:12059 pubmed 出版商
  • 免疫沉淀; 人类; 图 1b
Cuddy L, Seah C, Pasternak S, Rylett R. Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. J Neurochem. 2015;134:769-82 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 7
Jadhav S, Katina S, Kovac A, Kazmerova Z, Novak M, Zilka N. Truncated tau deregulates synaptic markers in rat model for human tauopathy. Front Cell Neurosci. 2015;9:24 pubmed 出版商
  • 免疫沉淀; 人类; 图 1b
  • 免疫印迹; 人类; 图 1b
Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido T, et al. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015;7:175-89 pubmed 出版商
  • 免疫印迹; 小鼠
Lin T, Shih Y, Chen S, Lien C, Chang C, Huang T, et al. Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice. Neurobiol Learn Mem. 2015;118:189-97 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:1000
  • 免疫印迹; 人类; 1:1000
Guo L, Alekseev O, Li Y, Song Y, Dunaief J. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res. 2014;129:31-7 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100
Joshi G, Gan K, Johnson D, Johnson J. Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664-79 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed 出版商
  • 免疫印迹; 仓鼠
Kosicek M, Wunderlich P, Walter J, Hecimovic S. GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells. Biochem Biophys Res Commun. 2014;450:160-5 pubmed 出版商
  • 免疫印迹; 人类
Almenar Queralt A, Kim S, Benner C, Herrera C, Kang D, Garcia Bassets I, et al. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013;288:35222-36 pubmed 出版商
  • 免疫细胞化学; 小鼠
Muresan V, Villegas C, Ladescu Muresan Z. Functional interaction between amyloid-? precursor protein and peripherin neurofilaments: a shared pathway leading to Alzheimer's disease and amyotrophic lateral sclerosis?. Neurodegener Dis. 2014;13:122-5 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Beyer A, von Einem B, Schwanzar D, Keller I, Hellrung A, Thal D, et al. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-? precursor protein. Neurobiol Aging. 2012;33:732-43 pubmed 出版商
Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al. Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ. Alzheimers Res Ther. 2019;11:97 pubmed 出版商
Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed 出版商
Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed 出版商
Grant M, Shapiro S, Ashe K, Liu P, Zahs K. A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 2019;21:6 pubmed 出版商
Dinamarca M, Raveh A, Schneider A, Fritzius T, Früh S, Rem P, et al. Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun. 2019;10:1331 pubmed 出版商
Jarosz Griffiths H, Corbett N, Rowland H, Fisher K, Jones A, Baron J, et al. Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers. J Biol Chem. 2019;294:7085-7097 pubmed 出版商
Chen X, Kordich J, Williams E, Levine N, Cole Strauss A, Marshall L, et al. Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2019;116:5765-5774 pubmed 出版商
Tsatsanis A, Dickens S, Kwok J, Wong B, Duce J. Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis. Neurochem Res. 2019;44:1367-1374 pubmed 出版商
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, et al. Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 2019;7:14 pubmed 出版商
Jordão M, Sankowski R, Brendecke S, Sagar -, Locatelli G, Tai Y, et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019;363: pubmed 出版商
Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed 出版商
Evans C, Thomas R, Freeman T, Hvoslef Eide M, Good M, Kidd E. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiol Aging. 2019;75:136-149 pubmed 出版商
Coronel R, Lachgar M, Bernabeu Zornoza A, Palmer C, Domínguez Alvaro M, Revilla A, et al. Neuronal and Glial Differentiation of Human Neural Stem Cells Is Regulated by Amyloid Precursor Protein (APP) Levels. Mol Neurobiol. 2019;56:1248-1261 pubmed 出版商
Tsang J, Lee M, Chan T, Li J, Ni Y, Shao Y, et al. Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer. EBioMedicine. 2018;38:89-99 pubmed 出版商
Scilabra S, Pigoni M, Pravatá V, Schätzl T, Müller S, Troeberg L, et al. Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. Sci Rep. 2018;8:14697 pubmed 出版商
Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al. Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 2018;99:1155-1169.e9 pubmed 出版商
Paschkowsky S, Recinto S, Young J, Bondar A, Munter L. Membrane cholesterol as regulator of human rhomboid protease RHBDL4. J Biol Chem. 2018;293:15556-15568 pubmed 出版商
Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, et al. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun. 2018;9:2892 pubmed 出版商
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, et al. BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS ONE. 2018;13:e0200344 pubmed 出版商
Fong L, Yang M, Dos Santos Chaves R, Reyna S, Langness V, Woodruff G, et al. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes. J Biol Chem. 2018;293:11341-11357 pubmed 出版商
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, et al. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nat Commun. 2018;9:2036 pubmed 出版商
Ruiz Riquelme A, Lau H, Stuart E, Goczi A, Wang Z, Schmitt Ulms G, et al. Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression. Acta Neuropathol Commun. 2018;6:26 pubmed 出版商
Williamson R, Laulagnier K, Miranda A, Fernandez M, Wolfe M, Sadoul R, et al. Disruption of amyloid precursor protein ubiquitination selectively increases amyloid ? (A?) 40 levels via presenilin 2-mediated cleavage. J Biol Chem. 2017;292:19873-19889 pubmed 出版商
Colvin B, Rogers V, Kulas J, Ridgway E, Amtashar F, Combs C, et al. The conformational epitope for a new A?42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. J Neurochem. 2017;143:736-749 pubmed 出版商
Mast N, Saadane A, Valencia Olvera A, Constans J, Maxfield E, Arakawa H, et al. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. 2017;123:465-476 pubmed 出版商
Schultz V, van der Meer F, Wrzos C, Scheidt U, Bahn E, Stadelmann C, et al. Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination. Glia. 2017;65:1350-1360 pubmed 出版商
Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, et al. Amyloid ? production is regulated by ?2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor. J Biol Chem. 2017;292:10153-10168 pubmed 出版商
Klementieva O, Willén K, Martinsson I, Israelsson B, Engdahl A, Cladera J, et al. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP. Nat Commun. 2017;8:14726 pubmed 出版商
Lukas D, Yogev N, Kel J, Regen T, Mufazalov I, Tang Y, et al. TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A. 2017;114:E1480-E1489 pubmed 出版商
Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed 出版商
Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed 出版商
Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, et al. Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Sci Rep. 2016;6:34505 pubmed 出版商
Thomas R, Henson A, Gerrish A, Jones L, Williams J, Kidd E. Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease. BMC Neurosci. 2016;17:50 pubmed 出版商
Triaca V, Sposato V, Bolasco G, Ciotti M, Pelicci P, Bruni A, et al. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging Cell. 2016;15:661-72 pubmed 出版商
Kuhn P, Colombo A, Schusser B, Dreymueller D, Wetzel S, Schepers U, et al. Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. elife. 2016;5: pubmed 出版商
Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed 出版商
Ossola B, Zhao C, Compston A, Pluchino S, Franklin R, Spillantini M. Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation. Glia. 2016;64:457-71 pubmed 出版商
von Einem B, Wahler A, Schips T, Serrano Pozo A, Proepper C, Boeckers T, et al. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). PLoS ONE. 2015;10:e0129047 pubmed 出版商
Liu P, Paulson J, Forster C, Shapiro S, Ashe K, Zahs K. Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS ONE. 2015;10:e0126317 pubmed 出版商
Cheng J, Craft R, Yu G, Ho K, Wang X, Mohan G, et al. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PLoS ONE. 2014;9:e115765 pubmed 出版商
Vorobyeva A, Lee R, Miller S, Longen C, Sharoni M, Kandelwal P, et al. Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation. J Biol Chem. 2014;289:33258-74 pubmed 出版商
Fernandez M, Klutkowski J, Freret T, Wolfe M. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. J Biol Chem. 2014;289:31043-52 pubmed 出版商
Mosser S, Alattia J, Dimitrov M, Matz A, Pascual J, Schneider B, et al. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Hum Mol Genet. 2015;24:371-82 pubmed 出版商
Weitz T, Gate D, Rezai Zadeh K, Town T. MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. Am J Pathol. 2014;184:2855-61 pubmed 出版商
Sutinen E, Korolainen M, Häyrinen J, Alafuzoff I, Petratos S, Salminen A, et al. Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells. Front Cell Neurosci. 2014;8:214 pubmed 出版商
Jung C, Uhm K, Horike H, Kim M, Misumi S, Ishida A, et al. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase. J Alzheimers Dis. 2015;43:1215-28 pubmed 出版商
Brunn A, Mihelcic M, Carstov M, Hummel L, Geier F, Schmidt A, et al. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol. 2014;184:2627-40 pubmed 出版商
Lin Y, Wang J, Wang K, Liao J, Cheng I. Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid-? production. J Neurochem. 2014;131:407-12 pubmed 出版商
Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, et al. Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J Neuroinflammation. 2014;11:124 pubmed 出版商
Chasseigneaux S, Clamagirand C, Huguet L, Gorisse Hussonnois L, Rose C, Allinquant B. Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A. BMC Neurosci. 2014;15:82 pubmed 出版商
Walberer M, Jantzen S, Backes H, Rueger M, Keuters M, Neumaier B, et al. In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats. Brain Res. 2014;1581:80-8 pubmed 出版商
Kukreja L, Kujoth G, Prolla T, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2014;9:16 pubmed 出版商
Lin L, Yang S, Chu J, Wang L, Ning L, Zhang T, et al. Region-specific expression of tau, amyloid-? protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. J Alzheimers Dis. 2014;41:1149-63 pubmed 出版商
Sullivan S, Dillon G, Sullivan J, Ho A. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid ? generation. J Biol Chem. 2014;289:15374-83 pubmed 出版商
Trazzi S, Fuchs C, De Franceschi M, Mitrugno V, Bartesaghi R, Ciani E. APP-dependent alteration of GSK3? activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2014;67:24-36 pubmed 出版商
Rodrigues D, Gutierres J, Pliássova A, Oliveira C, Cunha R, Agostinho P. Synaptic and sub-synaptic localization of amyloid-? protein precursor in the rat hippocampus. J Alzheimers Dis. 2014;40:981-92 pubmed 出版商
Del Campo M, Hoozemans J, Dekkers L, Rozemuller A, Korth C, Müller Schiffmann A, et al. BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease. Neurobiol Aging. 2014;35:1596-604 pubmed 出版商
Liu F, Liu T, Kung F. FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines. J Biosci. 2014;39:85-95 pubmed
Atkin G, Hunt J, Minakawa E, Sharkey L, Tipper N, Tennant W, et al. F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing. J Biol Chem. 2014;289:7038-48 pubmed 出版商
Orr M, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014;35:1233-42 pubmed 出版商
Kim J, Yoon J, Kim Y. HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. PLoS ONE. 2013;8:e77972 pubmed 出版商
Shao B, Xia Z, Xie Q, Ge X, Zhang W, Sun J, et al. Meserine, a novel carbamate AChE inhibitor, ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic mice. CNS Neurosci Ther. 2014;20:165-71 pubmed 出版商
Guo Q, Li H, Cole A, Hur J, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS ONE. 2013;8:e80706 pubmed 出版商
Sosa M, De Gasperi R, Paulino A, Pricop P, Shaughness M, Maudlin Jeronimo E, et al. Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury. Acta Neuropathol Commun. 2013;1:51 pubmed 出版商
Notter T, Knuesel I. Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients. Acta Neuropathol Commun. 2013;1:27 pubmed 出版商
Wang W, Mutka A, Zmrzljak U, Rozman D, Tanila H, Gylling H, et al. Amyloid precursor protein ?- and ?-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2. FASEB J. 2014;28:849-60 pubmed 出版商
Lee I, Jung K, Kim I, Park K. Amyloid-? oligomers regulate the properties of human neural stem cells through GSK-3? signaling. Exp Mol Med. 2013;45:e60 pubmed 出版商
Luo Y, Johnsen R, Griffiths L, Needham M, Fabian V, Fletcher S, et al. Primary over-expression of A?PP in muscle does not lead to the development of inclusion body myositis in a new lineage of the MCK-A?PP transgenic mouse. Int J Exp Pathol. 2013;94:418-25 pubmed 出版商
Puzzo D, Loreto C, Giunta S, Musumeci G, Frasca G, Podda M, et al. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiol Aging. 2014;35:520-31 pubmed 出版商
Nelson C, Sheng M. Gpr3 stimulates A? production via interactions with APP and ?-arrestin2. PLoS ONE. 2013;8:e74680 pubmed 出版商
Chua L, Lim M, Wong B. The Kunitz-protease inhibitor domain in amyloid precursor protein reduces cellular mitochondrial enzymes expression and function. Biochem Biophys Res Commun. 2013;437:642-7 pubmed 出版商
Shukla M, Quirion R, Ma W. Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice. Neuroscience. 2013;250:92-101 pubmed 出版商
Urano Y, Ochiai S, Noguchi N. Suppression of amyloid-? production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. FASEB J. 2013;27:4305-15 pubmed 出版商
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Laßek M, Weingarten J, Einsfelder U, Brendel P, Müller U, Volknandt W. Amyloid precursor proteins are constituents of the presynaptic active zone. J Neurochem. 2013;127:48-56 pubmed 出版商
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产品信息
目录代码 :
IHCR1002-6
亚类别 :
神经科学
产品名称 :
Anti-APP A4 Antibody, a.a. 66-81 (NT), Prediluted, clone 22C11
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P05067
宿主名称 :
小鼠
抗原 :
淀粉样蛋白前体A4
克隆 :
22C11
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
Anti-APP A4 Antibody, a.a. 66-81 (NT), Prediluted, clone 22C11
交叉活性 :
Canine;Human;Mouse;Monkey;Pig;Rat;Fish
背景 :
Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer's Disease. The principle component of this extracellular amyloid is beta/A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins are currently under investigation Reacts with pre-A4.
别名 :
淀粉样蛋白前体
免疫原 :
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
特异性 :
The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000). The antibody is known to cross react with APLP2 (Slunt, 1994).
包装尺寸 :
6毫升
用途 :
免疫组化(石蜡)
储存 :
Maintain at 2-8°C. Refer to vial for expiration dating.
公司信息
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