产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Tau-1 Antibody, prediluted, clone PC1C6
目录 :
IHCR1015-6
规格 :
6毫升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
PC1C6
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 20
出版应用/物种/样品/稀释参考文献
  • 免疫组化-石蜡切片; 狗; 1:1000; 图 4
Spitzbarth I, Lempp C, Kegler K, Ulrich R, Kalkuhl A, Deschl U, et al. Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. Brain Behav. 2016;6:e00472 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 表 1
El Khoury N, Gratuze M, Petry F, Papon M, Julien C, Marcouiller F, et al. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiol Dis. 2016;88:55-65 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:2; 图 4a
Minoura I, Takazaki H, Ayukawa R, Saruta C, Hachikubo Y, Uchimura S, et al. Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin-microtubule interface. Nat Commun. 2016;7:10058 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 表 1,7
Elias P, Spector M. Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor. J Tissue Eng Regen Med. 2015;9:137-50 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:1000; 图 s4
Goyal U, Renvoisé B, Chang J, Blackstone C. Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development. PLoS ONE. 2014;9:e112428 pubmed 出版商
Chang T, Chen C, Lee M, Chang Y, Lu C, Lu S, et al. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. elife. 2017;6: pubmed 出版商
Laurent C, Eddarkaoui S, Derisbourg M, Leboucher A, Demeyer D, Carrier S, et al. Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiol Aging. 2014;35:2079-90 pubmed 出版商
Mejia L, Litterman N, Ikeuchi Y, de la Torre Ubieta L, Bennett E, Zhang C, et al. A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain. J Neurosci. 2013;33:18015-21 pubmed 出版商
Hawkins B, Krishnamurthy S, Castillo Carranza D, Sengupta U, Prough D, Jackson G, et al. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem. 2013;288:17042-50 pubmed 出版商
Cirak Y, Sarsik B, Cakar B, Sen S, Simsir A, Uslu R. Predictive and prognostic values of Tau and BubR1 protein in prostate cancer and their relationship to the Gleason score. Med Oncol. 2013;30:526 pubmed 出版商
Yaka C, Björk P, Schönberg T, Erlandsson A. A novel in vitro injury model based on microcontact printing demonstrates negative effects of hydrogen peroxide on axonal regeneration both in absence and presence of glia. J Neurotrauma. 2013;30:392-402 pubmed 出版商
Magnaudeix A, Wilson C, Page G, Bauvy C, Codogno P, Leveque P, et al. PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging. 2013;34:770-90 pubmed 出版商
Orozco D, Tahirovic S, Rentzsch K, Schwenk B, Haass C, Edbauer D. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO Rep. 2012;13:759-64 pubmed 出版商
An S, Tsai C, Ronecker J, Bayly A, Herzog E. Spatiotemporal distribution of vasoactive intestinal polypeptide receptor 2 in mouse suprachiasmatic nucleus. J Comp Neurol. 2012;520:2730-41 pubmed 出版商
Alvarez G, Aldudo J, Alonso M, Santana S, Valdivieso F. Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells. J Neurosci Res. 2012;90:1020-9 pubmed 出版商
Millet L, Collens M, Perry G, Bashir R. Pattern analysis and spatial distribution of neurons in culture. Integr Biol (Camb). 2011;3:1167-78 pubmed 出版商
Neukirchen D, Bradke F. Cytoplasmic linker proteins regulate neuronal polarization through microtubule and growth cone dynamics. J Neurosci. 2011;31:1528-38 pubmed 出版商
Tahirovic S, Hellal F, Neukirchen D, Hindges R, Garvalov B, FLYNN K, et al. Rac1 regulates neuronal polarization through the WAVE complex. J Neurosci. 2010;30:6930-43 pubmed 出版商
Garvalov B, FLYNN K, Neukirchen D, Meyn L, Teusch N, Wu X, et al. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci. 2007;27:13117-29 pubmed
Togashi H, Miyoshi J, Honda T, Sakisaka T, Takai Y, Takeichi M. Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery. J Cell Biol. 2006;174:141-51 pubmed
产品信息
目录代码 :
IHCR1015-6
亚类别 :
神经科学
产品名称 :
Anti-Tau-1 Antibody, prediluted, clone PC1C6
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P10636
宿主名称 :
小鼠
抗原 :
Tau-1
克隆 :
PC1C6
共轭标签 :
纯化
抗体亚型 :
IgG2a
产品描述 :
Anti-Tau-1 Antibody, prediluted, clone PC1C6
交叉活性 :
牛;人类;大鼠
免疫原 :
纯化变性的牛微管相关蛋白
特异性 :
Cellular and subcellular localization: In situ, anti-tau-1 has a stringent specificity for the axons of neurons. The antibody does not stain the cell bodies or dendrites of neurons, nor does it stain any other cell type (4). However, this in vivo intracellular specificity is not maintained in culture: anti-tau-1 stains the axon, cell bodies, and dendrites of rat hippocampal neurons grown in culture (5). The specificity of anti-tau-1 was originally thought to represent the restricted expression of tau to axons. Later studies revealed that this specificity is dependant on the state of phosphorylation. In dephosphorylated samples (samples treated with alkaline phosphatase) anti-tau-1 stains astrocytes, perineuronal glial cells, and the axons, cell bodies and dendrites of neurons, while in untreated samples, anti-tau-1 stains only axons (6). (The epitope recognized by anti-tau-1 is probably at or near a phosphorylated site.). Anti-tau-1 binds to all known electrophoretic species of tau in human, rat and bovine brain (one-dimensional SDS-PAGE). However there is some unphosphorylated bias with clone PC1C6 as it seem to recognize only dephosphorylated serine sites at 195, 198, 199, and 202 {Szendrei, et al 1993; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi-cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7680727}. Also see Billingsley & Kincaid, 1997 Biochem J 323:577-591 for additional mapping information on PC1C6.
包装尺寸 :
6毫升
用途 :
免疫组化(石蜡)
储存 :
Maintain at 2-8°C. Refer to vial for expiration dating.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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