This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Tau Antibody, clone EP2456Y, rabbit monoclonal
目录 :
MAB10417
规格 :
100微升
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
克隆名称 :
EP2456Y
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪
文章摘录数: 5
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠; 1:2000; 图 1
  • 免疫印迹; 人类; 1:2000; 图 1
Gurdziel K, Vogt K, Walton K, Schneider G, Gumucio D. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016;245:614-26 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000
Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed 出版商
Kosaraju J, Madhunapantula S, Chinni S, Khatwal R, Dubala A, Muthureddy Nataraj S, et al. Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease. Behav Brain Res. 2014;267:55-65 pubmed 出版商
Kosaraju J, Gali C, Khatwal R, Dubala A, Chinni S, Holsinger R, et al. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology. 2013;72:291-300 pubmed 出版商
Chai X, Dage J, Citron M. Constitutive secretion of tau protein by an unconventional mechanism. Neurobiol Dis. 2012;48:356-66 pubmed 出版商
产品信息
目录代码 :
MAB10417
亚类别 :
神经科学
产品名称 :
Anti-Tau Antibody, clone EP2456Y, rabbit monoclonal
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P10636
宿主名称 :
抗原 :
Tau
克隆 :
EP2456Y
共轭标签 :
Unpurified
抗体亚型 :
IgG
产品描述 :
Anti-Tau Antibody, clone EP2456Y, rabbit monoclonal
交叉活性 :
人类;小鼠;大鼠
背景 :
Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I and II. Type II MAPs include MAP2, MAP4, and tau, and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.
别名 :
G protein beta1/gamma2 subunit-interacting factor 1;Neurofibrillary tangle protein ;Paired helical filament-tau ;microtubule-associated protein tau ;microtubule-associated protein tau, isoform 4
免疫原 :
Phospho-synthetic-peptide corresponding to residues surrounding Ser622 of human Tau 37.
特异性 :
This antibody detects Tau phospholyated and unphospholyated on Ser622.
包装尺寸 :
100微升
用途 :
免疫印迹;免疫细胞化学;流式细胞仪
储存 :
Stable for 1 year at -20ºC from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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