This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
肌动蛋白抗体, 克隆C4
目录 :
MAB1501
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C4

同一抗体克隆可从以下厂商购到:
反应物种 :
空肠弯曲杆菌, 仓鼠, root, marine lamprey, redtail notho, African green monkey, 人类, 小鼠, 大鼠, pigs , fruit fly , domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
文章摘录数: 1116
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 s2a
Viol L, Hata S, Pastor Peidro A, Neuner A, Murke F, Wuchter P, et al. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020;219: pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:4000; 图 3a
Liu C, Stevens S, Teliska L, Stankewich M, Mohler P, Hund T, et al. Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Zoi I, Karamouzis M, Xingi E, Sarantis P, Thomaidou D, Lembessis P, et al. Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas. Breast Cancer Res. 2019;21:132 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 6s1b
Cho C, Wang Y, Smallwood P, Williams J, Nathans J. Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5k
A M, Fung T, Kettenbach A, Chakrabarti R, Higgs H. A complex containing lysine-acetylated actin inhibits the formin INF2. Nat Cell Biol. 2019;21:592-602 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 3b
Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed 出版商
  • 免疫印迹; root; 图 5b
Ashok A, Karmakar S, Chandel R, Ravikumar R, Dalal S, Kong Q, et al. Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission. Exp Eye Res. 2018;175:1-13 pubmed 出版商
  • 免疫沉淀; 人类; 图 3a
  • 免疫印迹; 人类; 图 1b
Vélez P, Ocaranza Sánchez R, López Otero D, Grigorian Shamagian L, Rosa I, Guitián E, et al. Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches. Sci Rep. 2016;6:39603 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Lee J, Chiang K, Feng T, Chen Y, Chuang S, Tsui K, et al. The Iron Chelator, Dp44mT, Effectively Inhibits Human Oral Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo. Int J Mol Sci. 2016;17: pubmed 出版商
  • 免疫印迹; 大鼠; 1:10,000; 图 1
Pan B, Huang X, Deng C. Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep. 2016;6:30040 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Huang C, Lee C, Lin H, Chang J. Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Sci Rep. 2016;6:29256 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 4
Tuncbag N, Milani P, Pokorny J, Johnson H, Sio T, Dalin S, et al. Network Modeling Identifies Patient-specific Pathways in Glioblastoma. Sci Rep. 2016;6:28668 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 4
Lange S, Gehmlich K, Lun A, Blondelle J, Hooper C, Dalton N, et al. MLP and CARP are linked to chronic PKC? signalling in dilated cardiomyopathy. Nat Commun. 2016;7:12120 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 2
Baksi S, Tripathi A, Singh N. Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. Free Radic Biol Med. 2016;97:292-306 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Tsai K, Leung C, Lo Y, Chen T, Chan W, Yu S, et al. Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer. Sci Rep. 2016;6:28176 pubmed 出版商
  • 免疫印迹; 空肠弯曲杆菌; 1:2000; 图 4
Faber E, Gripp E, Maurischat S, Kaspers B, Tedin K, Menz S, et al. Novel Immunomodulatory Flagellin-Like Protein FlaC in Campylobacter jejuni and Other Campylobacterales. mSphere. 2016;1: pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Bosch C, Muhaisen A, Pujadas L, Soriano E, MARTINEZ A. Reelin Exerts Structural, Biochemical and Transcriptional Regulation Over Presynaptic and Postsynaptic Elements in the Adult Hippocampus. Front Cell Neurosci. 2016;10:138 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Gilson T, Blanchette P, Ballmann M, Papp T, Pénzes J, BenkÅ‘ M, et al. Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of Adenoviruses. J Virol. 2016;90:7350-7367 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Lin K, Cheng S, Tsai S, Tsai J, Lin C, Cheung C. Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Onco Targets Ther. 2016;9:2601-13 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Hsu C, Hsu C, Hsueh C, Wang C, Wu Y, Wu C, et al. Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma. Mol Cell Proteomics. 2016;15:2396-410 pubmed 出版商
  • 免疫印迹; 人类; 1:4000; 图 9
Rosiak K, Smolarz M, Stec W, Peciak J, Grzela D, Winiecka Klimek M, et al. IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis. PLoS ONE. 2016;11:e0154726 pubmed 出版商
  • 免疫印迹; 大鼠; 图 1
  • 免疫印迹; 小鼠; 图 1
Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Novaira H, Graceli J, Capellino S, Schoeffield A, Hoffman G, Wolfe A, et al. Development and Characterization of Novel Rat Anti-mER? Sera. Endocrinology. 2016;157:2844-52 pubmed 出版商
  • 免疫印迹; 人类; 图 5
  • 免疫印迹; 小鼠; 图 6
Kumar A, Chalamalasetty R, Kennedy M, Thomas S, Inala S, Garriock R, et al. Zfp703 Is a Wnt/?-Catenin Feedback Suppressor Targeting the ?-Catenin/Tcf1 Complex. Mol Cell Biol. 2016;36:1793-802 pubmed 出版商
  • 免疫印迹; 人类; 图 6
  • 免疫印迹; 小鼠; 图 1
Nagashima H, Okuyama Y, Hayashi T, Ishii N, So T. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. J Immunol. 2016;196:4082-9 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Nivon M, Fort L, Muller P, Richet E, Simon S, Guey B, et al. NF?B is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation. Mol Biol Cell. 2016;27:1712-27 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4
Carrió E, Magli A, Muñoz M, Peinado M, Perlingeiro R, Suelves M. Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation. BMC Biol. 2016;14:30 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Lee J, Kuo C, Tsai S, Cheng S, Chen S, Chan H, et al. Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Front Pharmacol. 2016;7:81 pubmed 出版商
  • 免疫印迹; 大鼠; 1:10,000; 图 2
Pan B, Huang X, Deng C. Aripiprazole and Haloperidol Activate GSK3?-Dependent Signalling Pathway Differentially in Various Brain Regions of Rats. Int J Mol Sci. 2016;17:459 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Margaryan N, Gilgur A, Seftor E, Purnell C, Arva N, Gosain A, et al. Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi. Int J Mol Sci. 2016;17:418 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Ruf M, Moch H, Schraml P. PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma. Int J Cancer. 2016;139:396-403 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Keuss M, Thomas Y, Mcarthur R, Wood N, Knebel A, Kurz T. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016;129:1441-54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3e
Stine R, Shapira S, Lim H, Ishibashi J, Harms M, Won K, et al. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Mol Metab. 2016;5:57-65 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Tai D, Liu Y, Hsu W, Ma Y, Cheng S, Liu S, et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016;7:10552 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 3
Lyons M, Chen L, Deng J, Finn C, Pfenning A, Sabhlok A, et al. The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain. J Neurochem. 2016;137:164-76 pubmed 出版商
  • 免疫印迹; 人类; 1:20,000; 图 4b
Walter D, Hoffmann S, Komseli E, Rappsilber J, Gorgoulis V, Sørensen C. SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication. Nat Commun. 2016;7:10530 pubmed 出版商
  • 免疫印迹; 仓鼠; 1:5000; 图 5
  • 免疫印迹; 大鼠; 1:5000; 图 4
Krishnan B. Amygdala-Hippocampal Phospholipase D (PLD) Signaling As Novel Mechanism of Cocaine-Environment Maladaptive Conditioned Responses. Int J Neuropsychopharmacol. 2016;: pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kuo C, Li X, Stark J, Shih H, Ann D. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016;15:787-98 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Zhang Q, Wan M, Shi J, Horita D, Miller L, Kute T, et al. Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. J Mol Cell Biol. 2016;8:232-43 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, et al. A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development. J Biol Chem. 2016;291:5817-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 2
Eckharter C, Junker N, Winter L, Fischer I, Fogli B, Kistner S, et al. Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR. Front Cell Neurosci. 2015;9:454 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Dinh C, Szabo A, Yu Y, Camer D, Wang H, Huang X. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Ittig S, Schmutz C, Kasper C, Amstutz M, Schmidt A, Sauteur L, et al. A bacterial type III secretion-based protein delivery tool for broad applications in cell biology. J Cell Biol. 2015;211:913-31 pubmed 出版商
  • 免疫印迹; 人类
Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, et al. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. 2015;527:389-93 pubmed 出版商
  • 免疫印迹; 人类
Strizzi L, Sandomenico A, Margaryan N, Focà A, Sanguigno L, Bodenstine T, et al. Effects of a novel Nodal-targeting monoclonal antibody in melanoma. Oncotarget. 2015;6:34071-86 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Fidaleo M, Svetoni F, Volpe E, Miñana B, Caporossi D, Paronetto M. Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. Oncotarget. 2015;6:31740-57 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Choulaki C, Papadaki G, Repa A, Kampouraki E, Kambas K, Ritis K, et al. Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis. Arthritis Res Ther. 2015;17:257 pubmed 出版商
  • 免疫印迹; 人类
Sirohi K, Kumari A, Radha V, Swarup G. A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. PLoS ONE. 2015;10:e0138289 pubmed 出版商
  • 免疫印迹; fruit fly ; 1:10,000; 图 s3i
Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed 出版商
  • 免疫印迹; 人类; 图 6f
Selleck E, Orchard R, Lassen K, Beatty W, Xavier R, Levine B, et al. A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells. MBio. 2015;6:e01157-15 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 1
Choudhury S, Liu Y, Clark A, Pang I. Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death. Mol Neurodegener. 2015;10:40 pubmed 出版商
  • 免疫印迹; domestic rabbit; 1:5000; 图 2
Varela A, Piperi C, Sigala F, Agrogiannis G, Davos C, Andri M, et al. Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity. Sci Rep. 2015;5:13461 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Popugaeva E, Pchitskaya E, Speshilova A, Alexandrov S, Zhang H, Vlasova O, et al. STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity. Mol Neurodegener. 2015;10:37 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 2b
Levi M, Hasky N, Stemmer S, Shalgi R, Ben Aharon I. Anti-Müllerian Hormone Is a Marker for Chemotherapy-Induced Testicular Toxicity. Endocrinology. 2015;156:3818-27 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed 出版商
  • 免疫印迹; 大鼠; 图 5
Chesser A, Ganeshan V, Yang J, Johnson G. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci. 2016;19:21-31 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000; 图 2e
Chen K, Tsai M, Wu C, Jou M, Wei I, Huang C. AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role. Front Behav Neurosci. 2015;9:162 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 1
Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, et al. Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res. 2015;59:308-20 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5
Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Hu G, McQuiston T, Bernard A, Park Y, Qiu J, Vural A, et al. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. Nat Cell Biol. 2015;17:930-942 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Gagnon J, Daou S, Zamorano N, Iannantuono N, Hammond Martel I, Mashtalir N, et al. Undetectable histone O-GlcNAcylation in mammalian cells. Epigenetics. 2015;10:677-91 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Yan R, Zhang Y, Cai D, Liu Y, Cuconati A, Guo H. Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes. PLoS ONE. 2015;10:e0129889 pubmed 出版商
  • 免疫印迹; 小鼠
Dinh C, Szabo A, Yu Y, Camer D, Zhang Q, Wang H, et al. Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet. Nutrients. 2015;7:4705-23 pubmed 出版商
  • 免疫印迹; 小鼠; 1:700
Gulino R, Parenti R, Gulisano M. Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease. Biomed Res Int. 2015;2015:654637 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Cui W, Sun M, Galeva N, Williams T, Azuma Y, Staudinger J. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes. Drug Metab Dispos. 2015;43:1316-25 pubmed 出版商
  • 免疫印迹; 人类
Neo S, Itahana Y, Alagu J, Kitagawa M, Guo A, Lee S, et al. TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification. Mol Cell Biol. 2015;35:2851-63 pubmed 出版商
  • 免疫印迹; 人类; 图 4
O Callaghan K, Palagano E, Butini S, Campiani G, Williams D, Zisterer D, et al. Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines. Mol Med Rep. 2015;12:3748-3754 pubmed 出版商
  • 免疫印迹; 人类; 图 s7
Webb B, Forouhar F, Szu F, Seetharaman J, Tong L, Barber D. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. 2015;523:111-4 pubmed 出版商
  • 免疫印迹; 大鼠
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, De Strooper B, et al. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Rep. 2015;11:1176-83 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 6
Ketema M, Secades P, Kreft M, Nahidiazar L, Janssen H, Jalink K, et al. The rod domain is not essential for the function of plectin in maintaining tissue integrity. Mol Biol Cell. 2015;26:2402-17 pubmed 出版商
  • 免疫印迹; 人类; 表 s3
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Goldstein M, Kastan M. Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res. 2015;75:2699-707 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 2
Hung T, Li Y, Tseng C, Lan Y, Hsu S, Chen Y, et al. Knockdown of c-MET induced apoptosis in ABCB1-overexpressed multidrug-resistance cancer cell lines. Cancer Gene Ther. 2015;22:262-70 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 2
Alkhateeb A, Buckett P, Gardeck A, Kim J, Byrne S, Fraenkel P, et al. The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro. Am J Physiol Gastrointest Liver Physiol. 2015;308:G1019-26 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 2
Dilsizoglu Senol A, Tagliafierro L, Huguet L, Gorisse Hussonnois L, Chasseigneaux S, Allinquant B. PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons. BMC Neurosci. 2015;16:10 pubmed 出版商
  • 免疫印迹; 人类
Fukumoto M, Kurisu S, Yamada T, Takenawa T. α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation. PLoS ONE. 2015;10:e0120616 pubmed 出版商
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Malchenko S, Sredni S, Hashimoto H, Kasai A, Nagayasu K, Xie J, et al. A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. PLoS ONE. 2015;10:e0121707 pubmed 出版商
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Leslie P, Ke H, Zhang Y. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. J Biol Chem. 2015;290:12941-50 pubmed 出版商
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Bilal M, Zhang E, Dinkel B, Hardy D, Yankee T, Houtman J. GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. Cell Signal. 2015;27:841-50 pubmed 出版商
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Huang P, Hung S, Pao C, Wang T. N-(1-pyrenyl) maleimide induces bak oligomerization and mitochondrial dysfunction in Jurkat Cells. Biomed Res Int. 2015;2015:798489 pubmed 出版商
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Gomez Bougie P, Halliez M, Maïga S, Godon C, Kervoëlen C, Pellat Deceunynck C, et al. Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups. Cancer Biol Ther. 2015;16:60-5 pubmed 出版商
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Sontag J, Wasek B, Taleski G, Smith J, Arning E, Sontag E, et al. Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Front Aging Neurosci. 2014;6:214 pubmed 出版商
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Gargalionis A, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. Int J Cancer. 2015;136:1515-27 pubmed 出版商
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Burman J, Itsara L, Kayser E, Suthammarak W, Wang A, Kaeberlein M, et al. A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis Model Mech. 2014;7:1165-74 pubmed 出版商
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Legrand N, Araud T, Conne B, Kuijpers O, Jaquier Gubler P, Curran J. An AUG codon conserved for protein function rather than translational initiation: the story of the protein sElk1. PLoS ONE. 2014;9:e102890 pubmed 出版商
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Yamamoto J, Hagiwara Y, Chiba K, Isobe T, Narita T, Handa H, et al. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat Commun. 2014;5:4263 pubmed 出版商
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Chuderland D, Ben Ami I, Friedler S, Hasky N, Ninio Many L, Goldberg K, et al. Hormonal regulation of pigment epithelium-derived factor (PEDF) expression in the endometrium. Mol Cell Endocrinol. 2014;390:85-92 pubmed 出版商
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Nikitczuk J, Patil S, Matikainen Ankney B, Scarpa J, Shapiro M, Benson D, et al. N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus. 2014;24:943-962 pubmed 出版商
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Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed 出版商
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Yeh Y, Chen C, Huang P, Hsu C, Wu C, Wang T. Proteomic analyses of genes regulated by heterogeneous nuclear ribonucleoproteins A/B in Jurkat cells. Proteomics. 2014;14:1357-66 pubmed 出版商
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Cheng C, Lin J, Su S, Tang N, Kao S, Hsieh C. Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemi. BMC Complement Altern Med. 2014;14:92 pubmed 出版商
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Guezguez A, Paré F, Benoit Y, Basora N, Beaulieu J. Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res. 2014;322:355-64 pubmed 出版商
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Mizunoya W, Iwamoto Y, Sato Y, Tatsumi R, Ikeuchi Y. Cold exposure increases slow-type myosin heavy chain 1 (MyHC1) composition of soleus muscle in rats. Anim Sci J. 2014;85:293-304 pubmed 出版商
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Almenar Queralt A, Kim S, Benner C, Herrera C, Kang D, Garcia Bassets I, et al. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013;288:35222-36 pubmed 出版商
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Bobinet M, Vignard V, Florenceau L, Lang F, Labarriere N, Moreau Aubry A. Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation. PLoS ONE. 2013;8:e75421 pubmed 出版商
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Wittchen E, Nishimura E, McCloskey M, Wang H, Quilliam L, Chrzanowska Wodnicka M, et al. Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. PLoS ONE. 2013;8:e73070 pubmed 出版商
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Zhang X, Meyn M, Smithgall T. c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src. ACS Chem Biol. 2014;9:139-46 pubmed 出版商
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Kubota S, Fukumoto Y, Aoyama K, Ishibashi K, Yuki R, Morinaga T, et al. Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1? (HP1?) with heterochromatin. J Biol Chem. 2013;288:17871-83 pubmed 出版商
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Sogn C, Puchades M, Gundersen V. Rare contacts between synapses and microglial processes containing high levels of Iba1 and actin--a postembedding immunogold study in the healthy rat brain. Eur J Neurosci. 2013;38:2030-40 pubmed 出版商
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Benoit Y, Witherspoon M, Laursen K, Guezguez A, Beauséjour M, Beaulieu J, et al. Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells. Exp Cell Res. 2013;319:1463-70 pubmed 出版商
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Chen M, Huang C, Hsu S, Lin E, Ku C, Lin H, et al. Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation. Evid Based Complement Alternat Med. 2012;2012:580736 pubmed 出版商
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Tomasek J, Haaksma C, Schwartz R, Howard E. Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen. 2013;21:166-76 pubmed 出版商
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Alimova I, Birks D, Harris P, Knipstein J, Venkataraman S, Marquez V, et al. Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells. Neuro Oncol. 2013;15:149-60 pubmed 出版商
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Chen Y, Wu K, Chen C. Methamphetamine reduces human influenza A virus replication. PLoS ONE. 2012;7:e48335 pubmed 出版商
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Martin S, Fernandez Rojo M, Stanley A, Bastiani M, Okano S, Nixon S, et al. Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model. PLoS ONE. 2012;7:e46242 pubmed 出版商
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Fitzgerald A, Benz C, Clark A, Wordinger R. The effects of transforming growth factor-?2 on the expression of follistatin and activin A in normal and glaucomatous human trabecular meshwork cells and tissues. Invest Ophthalmol Vis Sci. 2012;53:7358-69 pubmed 出版商
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产品信息
目录代码 :
MAB1501
亚类别 :
Cell Structure
产品名称 :
抗肌动蛋白抗体, 克隆C4
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P68133
宿主名称 :
小鼠
抗原 :
肌动蛋白
克隆 :
C4
共轭标签 :
腹水
抗体亚型 :
IgG1κ
产品描述 :
抗肌动蛋白抗体, 克隆C4
交叉活性 :
都是
背景 :
Actin is an abundant cytoskeletal protein found in all cells (True, 1990). The protein's 42 kD peptide chain assumes two physical forms: globular actin, which may serve as a cytoplasmic storage pool, and fibrous actin, which, in conjunction with myosin, generates muscle contraction (True, 1990). In non-muscle cells, actin appears to be involved in a variety of functions, such as cell motility, exocytosis, and phagocytosis (True, 1990). Distribution of the six known isoforms of actin - four muscle actins (alpha-skeletal, alpha-vascular smooth, alpha-cardiac, and gamma-enteric smooth) and two cytoplasmic actins (alpha and gamma) is tissue specific (Otey, 1986; Lessard, 1988).
别名 :
MAB1501X;MAB1501R
免疫原 :
Purified chicken gizzard actin (Lessard, 1988).
特异性 :
MAB1501 is a pan-actin antibody that binds to an epitope in a highly conserved region of actin; therefore, this antibody reacts with all six isoforms of vertabrate actin (Lessard, 1988). The epitope recognized by the antibody appears to be located in the N-terminal two thirds of the actin molecule, possibly near amino acids 50-70. Reacts with both globular (G) and fillimentous (F) forms of actin and does not interfere with actin polymerization to form filaments, at a ratio as high as one antibody per two actin monomers. However, this antibody does increase the extent of polymerization when used at a lower ratio of antibody to actin. In addition to labeling myotubes, anti-actin stains myoblasts and fibroblasts (Lessard, 1983). Although clone C4 is prepared as an antibody to chicken gizzard muscles actin, it reacts with actins from all vertebrates, as well as with Dictyostelium discoideum and Physarum polycephalum actins (Lessard, 1988).
包装尺寸 :
100微升
用途 :
酶联免疫吸附测定;免疫细胞化学;免疫荧光;免疫组化;免疫组化(石蜡);免疫印迹
储存 :
Stable at -20°C in undiluted aliquots for up to 12 months from date of receipt. Do not store in a diluted format. Avoid repeated freeze/thaw cycles.
公司信息
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http://www.millipore.com/china/wwcn/cnhome
400-889-1988
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