This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Actin Antibody, near a.a. 50-70, clone C4
目录 :
MAB1501R
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
C4

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠, 大鼠, fruit fly
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
文章摘录数: 355
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 s6b
Wegmann S, Bennett R, Delorme L, Robbins A, Hu M, McKenzie D, et al. Experimental evidence for the age dependence of tau protein spread in the brain. Sci Adv. 2019;5:eaaw6404 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2b
Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, et al. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun. 2019;10:1567 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 1f
Zhu C, Li B, Frontzek K, Liu Y, Aguzzi A. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. J Exp Med. 2019;216:743-756 pubmed 出版商
  • 免疫印迹; 人类; 图 5A
Celiku O, Tandle A, Chung J, Hewitt S, Camphausen K, Shankavaram U. Computational analysis of the mesenchymal signature landscape in gliomas. BMC Med Genomics. 2017;10:13 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7f
Schatton D, Pla Martín D, Marx M, Hansen H, Mourier A, Nemazanyy I, et al. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017;216:675-693 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed 出版商
  • 免疫印迹; 人类; 图 s1
Hjerpe R, Bett J, Keuss M, Solovyova A, McWilliams T, Johnson C, et al. UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. Cell. 2016;166:935-949 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Bosch C, Muhaisen A, Pujadas L, Soriano E, MARTINEZ A. Reelin Exerts Structural, Biochemical and Transcriptional Regulation Over Presynaptic and Postsynaptic Elements in the Adult Hippocampus. Front Cell Neurosci. 2016;10:138 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, et al. Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9. Sci Rep. 2016;6:27354 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Gilson T, Blanchette P, Ballmann M, Papp T, Pénzes J, BenkÅ‘ M, et al. Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of Adenoviruses. J Virol. 2016;90:7350-7367 pubmed 出版商
  • 免疫印迹; 小鼠; 1:20,000; 图 1
Kool M, van de Bree J, Bodde H, Elgersma Y, van Woerden G. The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion. Sci Rep. 2016;6:26989 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 3
Mabb A, Simon J, KING I, Lee H, An L, Philpot B, et al. Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS ONE. 2016;11:e0156439 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s5
Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed 出版商
  • 免疫印迹; fruit fly ; 1:5000; 图 1
Mao Y, Tamura T, Yuki Y, Abe D, Tamada Y, Imoto S, et al. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. Cell Death Dis. 2016;7:e2207 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Nivon M, Fort L, Muller P, Richet E, Simon S, Guey B, et al. NF?B is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation. Mol Biol Cell. 2016;27:1712-27 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Beaumatin F, El Dhaybi M, Lasserre J, Salin B, Moyer M, Verdier M, et al. N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro. Oncotarget. 2016;7:17129-43 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Cho C, Lee K, Chen W, Wang C, Chang Y, Huang H, et al. MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer. Oncotarget. 2016;7:14586-604 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Le Pen J, Maillet L, Sarosiek K, Vuillier C, Gautier F, Montessuit S, et al. Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Cell Death Dis. 2016;7:e2083 pubmed 出版商
  • 免疫印迹; 小鼠; 1:50,000; 图 7
  • 免疫印迹; 人类; 1:50,000; 图 1
Tokuda E, Brännström T, Andersen P, Marklund S. Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase. Acta Neuropathol Commun. 2016;4:6 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 3
Allaire J, Roy S, Ouellet C, Lemieux Ã, Jones C, Paquet M, et al. Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. Int J Cancer. 2016;138:2700-12 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb J, et al. Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget. 2016;7:6088-104 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Pajoohesh Ganji A, Pal Ghosh S, Tadvalkar G, Stepp M. K14 + compound niches are present on the mouse cornea early after birth and expand after debridement wounds. Dev Dyn. 2016;245:132-43 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, et al. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J Cell Sci. 2015;128:4453-61 pubmed 出版商
  • 免疫印迹; fruit fly ; 1:10,000; 图 s3i
Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed 出版商
  • 免疫印迹; 人类; 图 6f
Selleck E, Orchard R, Lassen K, Beatty W, Xavier R, Levine B, et al. A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells. MBio. 2015;6:e01157-15 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s8
Fu Y, Cruz Monserrate Z, Helen Lin H, Chung Y, Ji B, Lin S, et al. Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype. Sci Rep. 2015;5:13347 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed 出版商
  • 免疫细胞化学; 人类; 1:700; 图 5
  • 免疫印迹; 人类; 1:500; 图 1
Maugeri G, D Amico A, Magro G, Salvatorelli L, Barbagallo G, Saccone S, et al. Expression profile of parkin isoforms in human gliomas. Int J Oncol. 2015;47:1282-92 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:250; 图 1b
  • 免疫印迹; 大鼠; 1:500; 图 5f
Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, et al. Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc Natl Acad Sci U S A. 2015;112:E4465-74 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Hamazaki J, Hirayama S, Murata S. Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet. 2015;11:e1005401 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 5
Cho M, Park J, Choi H, Park M, Won H, Park Y, et al. DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nat Commun. 2015;6:7821 pubmed 出版商
  • 免疫印迹; 人类; 图 3
  • 免疫印迹; 小鼠; 图 3
Dombernowsky S, Samsøe Petersen J, Petersen C, Instrell R, Hedegaard A, Thomas L, et al. The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. Nat Commun. 2015;6:7518 pubmed 出版商
  • 免疫印迹; 人类
Neo S, Itahana Y, Alagu J, Kitagawa M, Guo A, Lee S, et al. TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification. Mol Cell Biol. 2015;35:2851-63 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
Zarkoob H, Bodduluri S, Ponnaluri S, Selby J, Sander E. Substrate Stiffness Affects Human Keratinocyte Colony Formation. Cell Mol Bioeng. 2015;8:32-50 pubmed
  • 免疫细胞化学; 小鼠; 图 6
Ketema M, Secades P, Kreft M, Nahidiazar L, Janssen H, Jalink K, et al. The rod domain is not essential for the function of plectin in maintaining tissue integrity. Mol Biol Cell. 2015;26:2402-17 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Landais I, Pelton C, Streblow D, DeFilippis V, McWeeney S, Nelson J. Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway. PLoS Pathog. 2015;11:e1004881 pubmed 出版商
  • 免疫印迹; 人类; 表 s3
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Goldstein M, Kastan M. Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res. 2015;75:2699-707 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
  • 免疫印迹; 小鼠; 图 4g
Wang L, Jirka G, Rosenberg P, Buckley A, Gomez J, Fields T, et al. Gq signaling causes glomerular injury by activating TRPC6. J Clin Invest. 2015;125:1913-26 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Wang D, Chadha G, Feygin A, Ivanov A. F-actin binding protein, anillin, regulates integrity of intercellular junctions in human epithelial cells. Cell Mol Life Sci. 2015;72:3185-3200 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 s7
Xu G, Chapman J, Brandsma I, Yuan J, Mistrik M, Bouwman P, et al. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015;521:541-544 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Staudacher J, Naarmann de Vries I, Ujvari S, Klinger B, Kasim M, Benko E, et al. Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum. Nucleic Acids Res. 2015;43:3219-36 pubmed 出版商
  • 免疫印迹; 小鼠; 1:20000
Leirós M, Alonso E, Rateb M, Houssen W, Ebel R, Jaspars M, et al. Gracilins: Spongionella-derived promising compounds for Alzheimer disease. Neuropharmacology. 2015;93:285-93 pubmed 出版商
  • 免疫细胞化学; 人类; 1:700; 图 4
D Amico A, Maugeri G, Magro G, Salvatorelli L, Drago F, D Agata V. Expression pattern of parkin isoforms in lung adenocarcinomas. Tumour Biol. 2015;36:5133-41 pubmed 出版商
  • 免疫印迹; 人类
Loganzo F, Tan X, Sung M, Jin G, Myers J, Melamud E, et al. Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments. Mol Cancer Ther. 2015;14:952-63 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Bilal M, Zhang E, Dinkel B, Hardy D, Yankee T, Houtman J. GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. Cell Signal. 2015;27:841-50 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 4
Naegelen I, Plançon S, Nicot N, Kaoma T, Muller A, Vallar L, et al. An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells. J Leukoc Biol. 2015;97:557-71 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Choi M, Nakamura T, Cho S, Han X, Holland E, Qu J, et al. Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J Neurosci. 2014;34:15123-31 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Ho T, Zollinger D, Chang K, Xu M, Cooper E, Stankewich M, et al. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014;17:1664-72 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Lin H, Lin S, Chung Y, Vonderfecht S, Camden J, Flodby P, et al. Dynamic involvement of ATG5 in cellular stress responses. Cell Death Dis. 2014;5:e1478 pubmed 出版商
  • 免疫印迹; 人类
Legrand N, Araud T, Conne B, Kuijpers O, Jaquier Gubler P, Curran J. An AUG codon conserved for protein function rather than translational initiation: the story of the protein sElk1. PLoS ONE. 2014;9:e102890 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10000
Chasseigneaux S, Clamagirand C, Huguet L, Gorisse Hussonnois L, Rose C, Allinquant B. Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A. BMC Neurosci. 2014;15:82 pubmed 出版商
  • 免疫印迹; 大鼠; 1:10000
Barragán Iglesias P, Pineda Farias J, Cervantes Durán C, Bravo Hernández M, Rocha González H, Murbartián J, et al. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain. 2014;10:29 pubmed 出版商
  • 流式细胞仪; 人类; 1:10000
  • 免疫沉淀; 人类; 1:10000
  • 免疫印迹; 人类; 1:10000
van de Weijer M, Bassik M, Luteijn R, Voorburg C, Lohuis M, Kremmer E, et al. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014;5:3832 pubmed 出版商
  • 免疫印迹; 小鼠
Cooper M, Koleske A. Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. J Comp Neurol. 2014;522:3351-62 pubmed 出版商
  • 免疫印迹; 人类; 1:10000
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, et al. P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. PLoS ONE. 2014;9:e94645 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Chauhan H, Killinger B, Miller C, Moszczynska A. Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum. Int J Mol Sci. 2014;15:5884-906 pubmed 出版商
  • 免疫印迹; 小鼠
Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, et al. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. PLoS ONE. 2014;9:e89763 pubmed 出版商
  • 免疫印迹; 人类
van Gent M, Braem S, de Jong A, Delagic N, Peeters J, Boer I, et al. Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling. PLoS Pathog. 2014;10:e1003960 pubmed 出版商
  • 免疫印迹; fruit fly
Machamer J, Collins S, Lloyd T. The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction. Hum Mol Genet. 2014;23:3810-22 pubmed 出版商
  • 免疫印迹; 人类
Praetorius C, Grill C, Stacey S, Metcalf A, Gorkin D, Robinson K, et al. A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway. Cell. 2013;155:1022-33 pubmed 出版商
  • 免疫印迹; 小鼠; 1:10,000; 图 4
Su J, Gu Y, Pruijn F, Smaill J, Patterson A, Guise C, et al. Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence. J Biol Chem. 2013;288:37138-53 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:500
Milman P, Woulfe J. Novel variant of neuronal intranuclear rodlet immunoreactive for 40 kDa huntingtin associated protein and ubiquitin in the mouse brain. J Comp Neurol. 2013;521:3832-46 pubmed 出版商
  • 免疫印迹; 小鼠
Choi J, Batchu V, Schubert M, Castellani R, Russell J. A novel PGC-1? isoform in brain localizes to mitochondria and associates with PINK1 and VDAC. Biochem Biophys Res Commun. 2013;435:671-7 pubmed 出版商
  • 免疫印迹; 小鼠; 1:6000
Jacobi C, Rudigier L, Scholz H, Kirschner K. Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development. J Biol Chem. 2013;288:18811-24 pubmed 出版商
  • 免疫印迹; 人类
Kubota S, Fukumoto Y, Aoyama K, Ishibashi K, Yuki R, Morinaga T, et al. Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1? (HP1?) with heterochromatin. J Biol Chem. 2013;288:17871-83 pubmed 出版商
Wei Z, Greaney J, Loh W, Homer H. Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry. Nat Commun. 2020;11:3393 pubmed 出版商
Guarascio R, Salih D, Yasvoina M, Edwards F, Cheetham M, van der Spuy J. Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment. Hum Mol Genet. 2020;29:80-96 pubmed 出版商
Will L, Portegies S, van Schelt J, van Luyk M, Jaarsma D, Hoogenraad C. Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo. Acta Neuropathol Commun. 2019;7:162 pubmed 出版商
Schneider H, Berger E, Dolan B, Martínez Abad B, Arike L, Pelaseyed T, et al. The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochem J. 2019;476:2281-2295 pubmed 出版商
Kenny T, Craig A, Villanueva A, Germain D. Mitohormesis Primes Tumor Invasion and Metastasis. Cell Rep. 2019;27:2292-2303.e6 pubmed 出版商
Ramovs V, Secades P, Song J, Thijssen B, Kreft M, Sonnenberg A. Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo. Breast Cancer Res. 2019;21:63 pubmed 出版商
Slocum E, Craig A, Villanueva A, Germain D. Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2. Breast Cancer Res. 2019;21:56 pubmed 出版商
Murru S, Hess S, Barth E, Almajan E, Schatton D, Hermans S, et al. Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. 2019;67:1526-1541 pubmed 出版商
Tomita T, Hirayama S, Sakurai Y, Ohte Y, Yoshihara H, Saeki Y, et al. Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice. Mol Cell Biol. 2019;39: pubmed 出版商
Beaudry K, Langlois M, Montagne A, Cagnol S, Carrier J, Rivard N. Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis. J Cell Physiol. 2019;234:6731-6745 pubmed 出版商
Cheng C, Qi Y, Wang Y, Chi K, Chung Y, Ouyang C, et al. Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol. 2018;1:178 pubmed 出版商
Liu Y, Sorce S, Nuvolone M, Domange J, Aguzzi A. Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression. Sci Rep. 2018;8:14600 pubmed 出版商
Ogmundsdóttir M, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, et al. A short isoform of ATG7 fails to lipidate LC3/GABARAP. Sci Rep. 2018;8:14391 pubmed 出版商
Rotaru D, van Woerden G, Wallaard I, Elgersma Y. Adult Ube3a Gene Reinstatement Restores the Electrophysiological Deficits of Prefrontal Cortex Layer 5 Neurons in a Mouse Model of Angelman Syndrome. J Neurosci. 2018;38:8011-8030 pubmed 出版商
Chang R, Eriksen J, Edwards R. The dual role of chloride in synaptic vesicle glutamate transport. elife. 2018;7: pubmed 出版商
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产品信息
目录代码 :
MAB1501R
亚类别 :
Cell Structure
产品名称 :
Anti-Actin Antibody, near a.a. 50-70, clone C4
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P68133
宿主名称 :
小鼠
抗原 :
肌动蛋白
克隆 :
C4
共轭标签 :
蛋白质G纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-Actin Antibody, near a.a. 50-70, clone C4
交叉活性 :
都是
背景 :
Actin is an abundant cytoskeletal protein found in all cells (True, 1990). The protein's 42 kD peptide chain assumes two physical forms: globular actin, which may serve as a cytoplasmic storage pool, and fibrous actin, which, in conjunction with myosin, generates muscle contraction (True, 1990). In non-muscle cells, actin appears to be involved in a variety of functions, such as cell motility, exocytosis, and phagocytosis (True, 1990). Distribution of the six known isoforms of actin - four muscle actins (alpha-skeletal, alpha-vascular smooth, alpha-cardiac, and gamma-enteric smooth) and two cytoplasmic actins (alpha and gamma) is tissue specific (Otey, 1986; Lessard, 1988).
别名 :
肌动蛋白, 甲1, 骨骼肌;甲骨骼肌肌动蛋白;MAB1501;MAB1501X;肌动蛋白;平滑肌肌动蛋白;SMA
免疫原 :
Purified chicken gizzard actin (Lessard, 1988).
特异性 :
MAB1501R is a pan-actin antibody that binds to an epitope in a highly conserved region of actin; therefore, this antibody reacts with all six isoforms of vertabrate actin (Lessard, 1988). The epitope recognized by the antibody appears to be located in the N-terminal two thirds of the actin molecule, possibly near amino acids 50-70. Reacts with both globular (G) and fillimentous (F) forms of actin and does not interfere with actin polymerization to form filaments, at a ratio as high as one antibody per two actin monomers. However, this antibody does increase the extent of polymerization when used at a lower ratio of antibody to actin. In addition to labeling myotubes, anti-actin stains myoblasts and fibroblasts (Lessard, 1983). Although clone C4 is prepared as an antibody to chicken gizzard muscles actin, it reacts with actins from all vertebrates, as well as with Dictyostelium discoideum and Physarum polycephalum actins (Lessard, 1988).
包装尺寸 :
100微克
用途 :
酶联免疫吸附测定;免疫细胞化学;免疫组化;免疫组化(石蜡);免疫印迹
储存 :
Stable for 6 months at 2-8°C from date of receipt.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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