This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Huntingtin Protein Antibody, a.a. 181-810, clone 1HU-4C8
目录 :
MAB2166
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1HU-4C8

同一抗体克隆可从以下厂商购到:
反应物种 :
人类, 小鼠, 大鼠
产品信息
目录代码 :
MAB2166
亚类别 :
神经科学
产品名称 :
Anti-Huntingtin Protein Antibody, a.a. 181-810, clone 1HU-4C8
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P42858
宿主名称 :
小鼠
抗原 :
Huntingtin Protein
克隆 :
1HU-4C8
共轭标签 :
腹水
抗体亚型 :
IgG1κ
产品描述 :
Anti-Huntingtin Protein Antibody, a.a. 181-810, clone 1HU-4C8
交叉活性 :
Human;Mouse;Rat;Monkey;Hamster;Rabbit
背景 :
Huntington disease (HD) is a hereditary, progressive, neurodegenerative ailment characterized by personality changes, motor impairment and subcortical dementia. The molecular basis of the disease involves the expansion of the trinucleotide CAG, coding for polyglutamine in the first exon of a chromosome four gene (4p16.3), which normally produces a widely expressed 3136 a.a. (~350 kDa) protein huntingtin with unclear function. The protein is found in the perinuclear region along with microtubules, and in the centrosomal region along with gamma-tubulin. Huntingtin is necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis. In the HD condition, neuronal cells with the mutant form of huntingtin possess intranuclear aggregations of the N-terminal fragment, causing damaging inclusions in perinuclear locations and striatal neuron cell death. Wild-type huntington and anti-huntingtin reduce aggregation and cellular toxicity of the mutant huntingtin form in mammalian cell models of HD. Huntingtin is known to interact with GAPDH, HAP-1, SP1 and TAFII130.
别名 :
Huntingtin;Huntington's Disease Protein;HD Protein
免疫原 :
Huntingtin fragment from a.a. 181 to 810 as a fusion protein.
特异性 :
Huntingtin Protein. No detectable cross reactivity to other proteins by Western blot.
包装尺寸 :
100微升
用途 :
酶联免疫吸附测定;免疫细胞化学;免疫组化(石蜡);免疫沉淀;免疫印迹
储存 :
Stable for 1 year at -20ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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