Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

抗体

Tau Antibody, clone Tau 12

MAB2241

100微克

单克隆

小鼠

未共轭

Tau 12

神经科学

Anti-Tau Antibody, clone Tau 12

抗体

单克隆抗体

P10636

小鼠

Tau

Tau 12

纯化

IgG1κ

Anti-Tau Antibody, clone Tau 12

人类

Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.

G protein beta1/gamma2 subunit-interacting factor 1;Neurofibrillary tangle protein ;Paired helical filament-tau ;microtubule-associated protein tau ;microtubule-associated protein tau, isoform 4

KLH conjugated synthetic linear peptide.

Cat. # MAB2241 recognizes the N-terminus region of Tau.

100微克

西方墨点法

Stable for 1 year at 2-8ºC from date of receipt.