产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Nitrated Tau (Tyr29) Antibody, clone Tau-nY29
目录 :
MAB2244
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
Tau-nY29
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 1
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠
  • 免疫印迹基因敲除验证; 人类; 1:500; 表 1
  • 免疫细胞化学; 人类; 1:50; 表 2
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed 出版商
产品信息
目录代码 :
MAB2244
亚类别 :
神经科学
产品名称 :
Anti-Nitrated Tau (Tyr29) Antibody, clone Tau-nY29
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P10636
宿主名称 :
小鼠
抗原 :
Nitrated Tau (Tyr29)
克隆 :
Tau-nY29
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-Nitrated Tau (Tyr29) Antibody, clone Tau-nY29
交叉活性 :
人类
背景 :
Microtubule Associated Proteins, or MAPs, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, Iand II. Type II MAP includes MAP2, MAP4, and tau and is found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.
别名 :
G protein beta1/gamma2 subunit-interacting factor 1;Neurofibrillary tangle protein ;Paired helical filament-tau ;microtubule-associated protein tau ;microtubule-associated protein tau, isoform 4
免疫原 :
KLH conjugated synthetic linear peptide corresponding to the amino acids surrounding and including nitrated Tyr29 of human Tau.
特异性 :
Recognizes nitrated Tau (Tyr29).
包装尺寸 :
100微克
用途 :
免疫印迹;免疫组化
储存 :
Stable for 1 year at 2-8ºC from date of receipt.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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