产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Kindlin-2 Antibody, clone 3A3
目录 :
MAB2617
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3A3
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫印迹基因敲除验证, 免疫组化基因敲除验证
更多信息或购买 :
默克密理博中国 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 免疫组化基因敲除验证; 小鼠; 图 5e
  • 免疫组化-石蜡切片; 小鼠; 图 5e
  • 免疫细胞化学; 大鼠; 1:200; 图 3e
  • 免疫印迹; 大鼠; 图 1c
Qi L, Chi X, Zhang X, Feng X, Chu W, Zhang S, et al. Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell Death Dis. 2019;10:890 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 e2e
El Brolosy M, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, et al. Genetic compensation triggered by mutant mRNA degradation. Nature. 2019;: pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 8B
  • 免疫细胞化学; 人类; 1:200; 图 5E
  • 免疫印迹; 人类; 1:1000; 图 2A
Wei X, Wang X, Zhan J, Chen Y, Fang W, Zhang L, et al. Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation. J Cell Biol. 2017;216:1455-1471 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1d
Bharadwaj M, Strohmeyer N, Colo G, Helenius J, Beerenwinkel N, Schiller H, et al. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun. 2017;8:14348 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 3a
Zeng F, Xie Y, Liao L, Li L, Chen B, Xie J, et al. Biological characterization of three immortalized esophageal epithelial cell lines. Mol Med Rep. 2016;14:4802-4810 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 1
  • 免疫细胞化学; 小鼠; 1:500; 图 3
Theodosiou M, Widmaier M, Böttcher R, Rognoni E, Veelders M, Bharadwaj M, et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. elife. 2016;5:e10130 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400; 图 4
Austen K, Ringer P, Mehlich A, Chrostek Grashoff A, Kluger C, Klingner C, et al. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol. 2015;17:1597-606 pubmed 出版商
  • 免疫沉淀; 大鼠
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠
Qi L, Yu Y, Chi X, Xu W, Lu D, Song Y, et al. Kindlin-2 interacts with α-actinin-2 and β1 integrin to maintain the integrity of the Z-disc in cardiac muscles. FEBS Lett. 2015;589:2155-62 pubmed 出版商
  • 免疫印迹; 小鼠; 图 9
Yazlovitskaya E, Tseng H, Viquez O, Tu T, Mernaugh G, McKee K, et al. Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell. 2015;26:1857-74 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5a
Artym V, Swatkoski S, Matsumoto K, Campbell C, Petrie R, Dimitriadis E, et al. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol. 2015;208:331-50 pubmed 出版商
Kawamura E, Hamilton G, Miskiewicz E, MacPhee D. Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion. BMC Dev Biol. 2018;18:19 pubmed 出版商
Mana G, Clapero F, Panieri E, Panero V, Böttcher R, Tseng H, et al. PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat Commun. 2016;7:13546 pubmed 出版商
Yang M, Du J, Lu D, Ren C, Shen H, Qiao J, et al. Increased expression of kindlin 2 in luteinized granulosa cells correlates with androgen receptor level in patients with polycystic ovary syndrome having hyperandrogenemia. Reprod Sci. 2014;21:696-703 pubmed 出版商
产品信息
目录代码 :
MAB2617
亚类别 :
Cell Structure
产品名称 :
Anti-Kindlin-2 Antibody, clone 3A3
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
Q96AC1
宿主名称 :
小鼠
抗原 :
Kindlin-2
克隆 :
3A3
共轭标签 :
纯化
抗体亚型 :
IgG1κ
产品描述 :
Anti-Kindlin-2 Antibody, clone 3A3
交叉活性 :
人类;小鼠;大鼠;牛
背景 :
The Kindlin family is a group of focal adhesion proteins that have become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. The isoform Kindlin-2 specifically participates in the recruitment of migfilin protein to focal adhesion sites for cell-ECM interactions, coordinates the manufacture of actin and modifications to cell shape. It is also actively involved in connecting ECM adhesion sites and the actin cytoskeleton (Shi, 2007). Kindlin-2 is pervasively expressed throughout tissue.
别名 :
Mitogen-inducible gene 2 protein;Pleckstrin homology domain-containing family C member 1;fermitin family homolog 2;kindlin 2;mitogen inducible gene 2 protein
免疫原 :
GST-tagged recombinant protein corresponding to human Kindlin-2.
特异性 :
The antibody recognizes Kindlin-2.
包装尺寸 :
100微克
用途 :
免疫印迹;免疫细胞化学
储存 :
收到之日起在2-8℃稳定1年
更多信息或购买 :
默克密理博中国 产品网页
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
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  • • Developmental Biology
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  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.