产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Tau Antibody, a.a. 210-241, clone Tau-5
目录 :
MAB361
规格 :
100微升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
Tau-5
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 70
出版应用/物种/样品/稀释参考文献
  • 免疫细胞化学; 人类; 图 5
  • 免疫印迹; 人类; 图 4a
Wu X, Kosaraju J, Tam K. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3? activity in SH-SY5Y cells. Eur J Pharm Sci. 2017;110:101-108 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 4b
Augé E, Cabezón I, Pelegri C, Vilaplana J. New perspectives on corpora amylacea in the human brain. Sci Rep. 2017;7:41807 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2500; 图 4a
He X, Li Z, Rizak J, Wu S, Wang Z, He R, et al. Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells. Front Neurosci. 2016;10:598 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5c
Wang A, Jensen E, Rexach J, Vinters H, Hsieh Wilson L. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:15120-15125 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 6
Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
Polanco J, Scicluna B, Hill A, Götz J. Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner. J Biol Chem. 2016;291:12445-66 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Patzke C, Acuna C, Giam L, Wernig M, Südhof T. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. J Exp Med. 2016;213:499-515 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 1
  • 免疫印迹; 人类; 1:2000; 图 1
Gurdziel K, Vogt K, Walton K, Schneider G, Gumucio D. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016;245:614-26 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Watamura N, Toba J, Yoshii A, Nikkuni M, Ohshima T. Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment. J Neurosci Res. 2016;94:15-26 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:500
Zajkowski T, Nieznanska H, Nieznanski K. Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta. 2015;1853:2228-39 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000
  • 免疫沉淀; 小鼠; 1:1000
Pei L, Wang S, Jin H, Bi L, Wei N, Yan H, et al. A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cereb Cortex. 2015;25:4559-71 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Sabogal Guáqueta A, Muñoz Manco J, Ramírez Pineda J, Lamprea Rodriguez M, Osorio E, Cardona Gómez G. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-45 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Manich G, del Valle J, Cabezón I, Camins A, Pallas M, Pelegri C, et al. Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice. Age (Dordr). 2014;36:151-65 pubmed 出版商
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed 出版商
Shang X, Wang Q, Liu X, Yao X, Cao F, Wang Q, et al. Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats. Neurosci Lett. 2015;584:230-5 pubmed 出版商
Oyanagi K, Negishi T, Tashiro T. Action of thyroxine on the survival and neurite maintenance of cerebellar granule neurons in culture. J Neurosci Res. 2015;93:592-603 pubmed 出版商
Wang D, Hui Y, Peng Y, Tang L, Jin J, He R, et al. Overexpression of heme oxygenase 1 causes cognitive decline and affects pathways for tauopathy in mice. J Alzheimers Dis. 2015;43:519-34 pubmed 出版商
Lv Q, Lan W, Sun W, Ye R, Fan X, Ma M, et al. Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats. J Neurol Sci. 2014;345:48-55 pubmed 出版商
Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed 出版商
Xia Y, Liu R, Chen R, Tian Q, Zeng K, Hu J, et al. Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. J Alzheimers Dis. 2014;42:1029-39 pubmed 出版商
Rao M, McBrayer M, Campbell J, Kumar A, Hashim A, Sershen H, et al. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. J Neurosci. 2014;34:9222-34 pubmed 出版商
Saito R, Kaneko M, Kitamura Y, Takata K, Kawada K, Okuma Y, et al. Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. PLoS ONE. 2014;9:e94576 pubmed 出版商
Liu X, Wang Z, Xia Y, Yu G, Zeng K, Luo H, et al. Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis. 2014;40:419-27 pubmed 出版商
Kimura T, Whitcomb D, Jo J, Regan P, Piers T, Heo S, et al. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130144 pubmed 出版商
Dong D, Zhang Y, Yang W, Wang Qin R, Xu A, Ruan Y. Hyperphosphorylation of tau protein in the ipsilateral thalamus after focal cortical infarction in rats. Brain Res. 2014;1543:280-9 pubmed 出版商
Lu Y, He H, Zhou J, Miao J, Lu J, He Y, et al. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. J Alzheimers Dis. 2013;37:551-63 pubmed 出版商
Hong X, Bu L, Wang Y, Xu J, Wu J, Huang Y, et al. Increases in the risk of cognitive impairment and alterations of cerebral ?-amyloid metabolism in mouse model of heart failure. PLoS ONE. 2013;8:e63829 pubmed 出版商
Basurto Islas G, Grundke Iqbal I, Tung Y, Liu F, Iqbal K. Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease. J Biol Chem. 2013;288:17495-507 pubmed 出版商
Lu J, Miao J, Su T, Liu Y, He R. Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo. Biochim Biophys Acta. 2013;1830:4102-16 pubmed 出版商
Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed 出版商
Oaks A, Frankfurt M, Finkelstein D, Sidhu A. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013;8:e60378 pubmed 出版商
Lee S, Zhang W, Ravi M, Weschenfelder M, Bastmeyer M, Levine J. Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition. J Neurosci. 2013;33:2541-54 pubmed 出版商
Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, et al. Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiol Aging. 2013;34:1748-58 pubmed 出版商
King M, Anderson N, Guernsey L, Jolivalt C. Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res. 2013;91:506-14 pubmed 出版商
Holth J, Bomben V, Reed J, Inoue T, Younkin L, Younkin S, et al. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013;33:1651-9 pubmed 出版商
Li L, Liu Z, Liu J, Tai X, Hu X, Liu X, et al. Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A. Neurobiol Dis. 2013;54:320-8 pubmed 出版商
Marker D, Puccini J, Mockus T, Barbieri J, Lu S, Gelbard H. LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein. J Neuroinflammation. 2012;9:261 pubmed 出版商
Sharma M, Burré J, Sudhof T. Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Sci Transl Med. 2012;4:147ra113 pubmed 出版商
Xiong Y, Jing X, Zhou X, Wang X, Yang Y, Sun X, et al. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013;34:745-56 pubmed 出版商
Larson M, Sherman M, Greimel S, Kuskowski M, Schneider J, Bennett D, et al. Soluble ?-synuclein is a novel modulator of Alzheimer's disease pathophysiology. J Neurosci. 2012;32:10253-66 pubmed 出版商
Rachubinski A, Maclean K, Evans J, Bjugstad K. Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. Exp Gerontol. 2012;47:723-33 pubmed 出版商
Hui L, Chen X, Geiger J. Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons. Life Sci. 2012;91:1159-68 pubmed 出版商
Wills J, Credle J, Oaks A, Duka V, Lee J, Jones J, et al. Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. PLoS ONE. 2012;7:e30745 pubmed 出版商
Alvarez G, Aldudo J, Alonso M, Santana S, Valdivieso F. Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells. J Neurosci Res. 2012;90:1020-9 pubmed 出版商
Li L, Liu J, Yan X, Qin K, Shi M, Lin T, et al. Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro. J Ethnopharmacol. 2011;138:135-41 pubmed 出版商
Koechling T, Khalique H, Sundstrom E, Avila J, Lim F. A culture model for neurite regeneration of human spinal cord neurons. J Neurosci Methods. 2011;201:346-54 pubmed 出版商
Yang X, Yang Y, Liu J, Li G, Yang E. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochem Res. 2012;37:15-22 pubmed 出版商
Kaul T, Credle J, Haggerty T, Oaks A, Masliah E, Sidhu A. Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. BMC Neurosci. 2011;12:79 pubmed 出版商
Grueninger F, Bohrmann B, Christensen K, Graf M, Roth D, Czech C. Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422. Mol Cell Biochem. 2011;357:199-207 pubmed 出版商
Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, et al. JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. J Alzheimers Dis. 2011;26:315-29 pubmed 出版商
Hui Y, Wang D, Li W, Zhang L, Jin J, Ma N, et al. Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation. J Alzheimers Dis. 2011;26:299-313 pubmed 出版商
Haggerty T, Credle J, Rodriguez O, Wills J, Oaks A, Masliah E, et al. Hyperphosphorylated Tau in an ?-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci. 2011;33:1598-610 pubmed 出版商
Wills J, Credle J, Haggerty T, Lee J, Oaks A, Sidhu A. Tauopathic changes in the striatum of A53T ?-synuclein mutant mouse model of Parkinson's disease. PLoS ONE. 2011;6:e17953 pubmed 出版商
Peethumnongsin E, Yang L, Kallhoff Munoz V, Hu L, Takashima A, Pautler R, et al. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010;30:13409-18 pubmed 出版商
Kern D, Maclean K, Jiang H, Synder E, Sladek J, Bjugstad K. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplant. 2011;20:371-9 pubmed 出版商
Blanchard J, Wanka L, Tung Y, Cárdenas Aguayo M, LaFerla F, Iqbal K, et al. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A? and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010;120:605-21 pubmed 出版商
Saito M, Chakraborty G, Hegde M, Ohsie J, Paik S, Vadasz C, et al. Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brain. J Neurochem. 2010;115:168-77 pubmed 出版商
Wills J, Jones J, Haggerty T, Duka V, Joyce J, Sidhu A. Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol. 2010;225:210-8 pubmed 出版商
Saito M, Chakraborty G, Mao R, Paik S, Vadasz C, Saito M. Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain. Neurochem Res. 2010;35:651-9 pubmed 出版商
Kathleen Baxter K, Uittenbogaard M, Yoon J, Chiaramello A. The neurogenic basic helix-loop-helix transcription factor NeuroD6 concomitantly increases mitochondrial mass and regulates cytoskeletal organization in the early stages of neuronal differentiation. ASN Neuro. 2009;1: pubmed 出版商
van Eersel J, Bi M, Ke Y, Hodges J, Xuereb J, Gregory G, et al. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna). 2009;116:1243-51 pubmed 出版商
Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci. 2008;28:6239-49 pubmed 出版商
Davis R, Furukawa R, Fechheimer M. A cell culture model for investigation of Hirano bodies. Acta Neuropathol. 2008;115:205-17 pubmed
Macleod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A. The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron. 2006;52:587-93 pubmed
Ghribi O, Larsen B, Schrag M, Herman M. High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol. 2006;200:460-7 pubmed
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, Santacruz K, et al. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 2005;25:10637-47 pubmed
Vandebroek T, Vanhelmont T, Terwel D, Borghgraef P, Lemaire K, Snauwaert J, et al. Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. Biochemistry. 2005;44:11466-75 pubmed
产品信息
目录代码 :
MAB361
亚类别 :
神经科学
产品名称 :
Anti-Tau Antibody, a.a. 210-241, clone Tau-5
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
P10636
宿主名称 :
小鼠
抗原 :
Tau
克隆 :
Tau-5
共轭标签 :
腹水
抗体亚型 :
IgG1
产品描述 :
Anti-Tau Antibody, a.a. 210-241, clone Tau-5
交叉活性 :
牛;人类;小鼠;大鼠
背景 :
Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.
别名 :
G protein beta1/gamma2 subunit-interacting factor 1;Neurofibrillary tangle protein;Paired helical filament-tau;microtubule-associated protein tau;microtubule-associated protein tau, isoform 4
免疫原 :
Bovine tau
特异性 :
Tau from bovine, rat and human.
包装尺寸 :
100微升
用途 :
免疫组化;免疫印迹
储存 :
Stable for 1 year at -20ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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