产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
NeuN Antibody, clone A60
目录 :
MAB377
规格 :
500微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A60
反应物种 :
Styela clava, 豚鼠, African green monkey, smaller spotted dogfish, white-toothed pygmy shrew, Gekkonidae, zebra finch, axolotl, Chinese softshell turtle, Atlantic canary, black ferret, jirds, 人类, 小鼠, 大鼠, , , , , 家羊, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 其他, 免疫印迹基因敲除验证, 免疫细胞化学基因敲除验证
更多信息或购买 :
文章摘录数: 2593
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 1:1000; 图 3a
Yagura K, Ohtaki H, Tsumuraya T, Sato A, Miyamoto K, Kawada N, et al. The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury. PLoS ONE. 2020;15:e0230080 pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 1c
Rambousek L, Gschwind T, Lafourcade C, Paterna J, Dib L, Fritschy J, et al. Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor. Sci Rep. 2020;10:3760 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 6g
Kielkowski P, Buchsbaum I, Kirsch V, Bach N, Drukker M, Cappello S, et al. FICD activity and AMPylation remodelling modulate human neurogenesis. Nat Commun. 2020;11:517 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:750; 图 1c
Evonuk K, Doyle R, Moseley C, Thornell I, Adler K, Bingaman A, et al. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Sci Adv. 2020;6:eaax5936 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 3b
Libner C, Salapa H, Hutchinson C, Lee S, Levin M. Antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1 contribute to neuronal cell loss in an animal model of multiple sclerosis. J Comp Neurol. 2020;528:1704-1724 pubmed 出版商
  • 免疫组化; 小鼠; 0.5 ug/ml; 图 1f
Whyland K, Slusarczyk A, Bickford M. GABAergic cell types in the superficial layers of the mouse superior colliculus. J Comp Neurol. 2020;528:308-320 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:500; 图 1b
Harde E, Nicholson L, Furones Cuadrado B, Bissen D, Wigge S, Urban S, et al. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. elife. 2019;8: pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 图 s9c
Sun A, Yuan Q, Fukuda M, Yu W, Yan H, Lim G, et al. Potassium channel dysfunction in human neuronal models of Angelman syndrome. Science. 2019;366:1486-1492 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s3b
Ercan Herbst E, Ehrig J, Schöndorf D, Behrendt A, Klaus B, Gomez Ramos B, et al. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta Neuropathol Commun. 2019;7:192 pubmed 出版商
  • 免疫组化; 大鼠; 1:100; 图 6d
McCann M, Fisher K, Ahloy Dallaire J, Darian Smith C. Somatosensory corticospinal tract axons sprout within the cervical cord following a dorsal root/dorsal column spinal injury in the rat. J Comp Neurol. 2019;: pubmed 出版商
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Willett R, Bayin N, Lee A, Krishnamurthy A, Wojcinski A, Lao Z, et al. Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth. elife. 2019;8: pubmed 出版商
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Faraco G, Hochrainer K, Segarra S, Schaeffer S, Santisteban M, Menon A, et al. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019;: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000; 图 7h
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Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, et al. MRGPRX4 is a bile acid receptor for human cholestatic itch. elife. 2019;8: pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 4s1a
Holt L, Hernandez R, Pacheco N, Torres Ceja B, Hossain M, Olsen M. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1. elife. 2019;8: pubmed 出版商
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Tomassoni Ardori F, Fulgenzi G, Becker J, Barrick C, Palko M, Kuhn S, et al. Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels. elife. 2019;8: pubmed 出版商
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Rossaert E, Pollari E, Jaspers T, Van Helleputte L, Jarpe M, Van Damme P, et al. Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model. Acta Neuropathol Commun. 2019;7:107 pubmed 出版商
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Zhang H, Sathyamurthy A, Liu F, Li L, Zhang L, Dong Z, et al. Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice. elife. 2019;8: pubmed 出版商
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Ghosh A, Torraville S, Mukherjee B, Walling S, Martin G, Harley C, et al. An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development. Alzheimers Res Ther. 2019;11:59 pubmed 出版商
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Hill S, Blaeser A, Coley A, Xie Y, Shepard K, Harwell C, et al. Sonic hedgehog signaling in astrocytes mediates cell-type-specific synaptic organization. elife. 2019;8: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 8a
Tulloch A, Teo S, Carvajal B, Tessier Lavigne M, Jaworski A. Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3Cre mouse. J Comp Neurol. 2019;527:2948-2972 pubmed 出版商
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Libard S, Alafuzoff I. Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease. Acta Neuropathol Commun. 2019;7:3 pubmed 出版商
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Kobayakawa K, Ohkawa Y, Yoshizaki S, Tamaru T, Saito T, Kijima K, et al. Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. Sci Adv. 2019;5:eaav5086 pubmed 出版商
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Hattori R, Danskin B, Babic Z, Mlynaryk N, Komiyama T. Area-Specificity and Plasticity of History-Dependent Value Coding During Learning. Cell. 2019;177:1858-1872.e15 pubmed 出版商
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Norwood J, Zhang Q, CARD D, Craine A, Ryan T, Drew P. Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate. elife. 2019;8: pubmed 出版商
  • 免疫组化; 小鼠; 图 5i
Alim I, Caulfield J, Chen Y, Swarup V, Geschwind D, Ivanova E, et al. Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019;177:1262-1279.e25 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 s3d
Nagai J, Rajbhandari A, Gangwani M, Hachisuka A, Coppola G, Masmanidis S, et al. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell. 2019;177:1280-1292.e20 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 5s1d
Jang M, Gould E, Xu J, Kim E, Kim J. Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem. elife. 2019;8: pubmed 出版商
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Yang J, Vitery M, Chen J, Osei Owusu J, Chu J, Qiu Z. Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke. Neuron. 2019;102:813-827.e6 pubmed 出版商
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Guan S, Wang J, Gu X, Zhao Y, Hou R, Fan H, et al. Elastocapillary self-assembled neurotassels for stable neural activity recordings. Sci Adv. 2019;5:eaav2842 pubmed 出版商
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Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567:535-539 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 1c
Riedemann S, Sutor B, Bergami M, Riedemann T. Gad1-promotor-driven GFP expression in non-GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line. J Comp Neurol. 2019;: pubmed 出版商
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Rotoli D, Morales M, Maeso M, Avila J, Pérez Rodríguez N, Mobasheri A, et al. IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment. J Histochem Cytochem. 2019;67:481-494 pubmed 出版商
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Rosenzweig N, Dvir Szternfeld R, Tsitsou Kampeli A, Keren Shaul H, Ben Yehuda H, Weill Raynal P, et al. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model. Nat Commun. 2019;10:465 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 图 4c
Andrew R, de Rossi P, Nguyen P, Kowalski H, Recupero A, Guerbette T, et al. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem. 2019;294:4477-4487 pubmed 出版商
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Li H, Pullmann D, Cho J, Eid M, Jhou T. Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing. elife. 2019;8: pubmed 出版商
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Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed 出版商
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Shin M, Kitazawa A, Yoshinaga S, Hayashi K, Hirata Y, Dehay C, et al. Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex. J Comp Neurol. 2019;527:1577-1597 pubmed 出版商
  • 免疫组化-冰冻切片; African green monkey; 1:100; 图 5g
Falcone C, Wolf Ochoa M, Amina S, Hong T, Vakilzadeh G, Hopkins W, et al. Cortical interlaminar astrocytes across the therian mammal radiation. J Comp Neurol. 2019;527:1654-1674 pubmed 出版商
  • 免疫组化-冰冻切片; 豚鼠; 1:1000; 图 1ei
Olthof B, Gartside S, Rees A. Puncta of Neuronal Nitric Oxide Synthase (nNOS) Mediate NMDA Receptor Signaling in the Auditory Midbrain. J Neurosci. 2019;39:876-887 pubmed 出版商
  • 免疫细胞化学; 小鼠; 5 mg/ml; 图 7c
Odagaki K, Kameda H, Hayashi T, Sakurai M. Mediolateral and dorsoventral projection patterns of cutaneous afferents within transverse planes of the mouse spinal dorsal horn. J Comp Neurol. 2019;527:972-984 pubmed 出版商
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Boon J, Clarke E, Kessaris N, Goffinet A, Moln r Z, Hoerder Suabedissen A. Long-range projections from sparse populations of GABAergic neurons in murine subplate. J Comp Neurol. 2019;527:1610-1620 pubmed 出版商
  • 免疫组化; 小鼠; 图 4a
Webster K, Sun M, Crack P, O Brien T, Shultz S, Semple B. Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice. J Comp Neurol. 2019;527:1102-1117 pubmed 出版商
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Kim H, Kim S, Choi J, Han D, Koh S, Kim H, et al. Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory. Neurochem Res. 2019;44:676-682 pubmed 出版商
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Wang M, Tang C, Xing R, Liu X, Han X, Liu Y, et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry. 2018;: pubmed 出版商
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Betlazar C, Harrison Brown M, Middleton R, Banati R, Liu G. Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain. Int J Mol Sci. 2018;19: pubmed 出版商
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Han S, Dennis D, Balakrishnan A, Dixit R, Britz O, Zinyk D, et al. A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis. Development. 2018;145: pubmed 出版商
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Driessen T, Zhao C, Saenz M, Stevenson S, Owada Y, Gammie S. Down-regulation of fatty acid binding protein 7 (Fabp7) is a hallmark of the postpartum brain. J Chem Neuroanat. 2018;92:92-101 pubmed 出版商
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Kaczmarek Hájek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, et al. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. elife. 2018;7: pubmed 出版商
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Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed 出版商
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Castro L, Noelia M, Vidal Jorge M, Sanchez Ortiz D, Gándara D, Martínez Sáez E, et al. Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K+ Channels, Is Overexpressed in Human Posttraumatic Brain Contusions. J Neurotrauma. 2018;: pubmed 出版商
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Nam M, Han K, Lee J, Bae J, An H, Park S, et al. Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes. Exp Neurobiol. 2018;27:120-128 pubmed 出版商
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Kelenis D, Hart E, Edwards Fligner M, Johnson J, Vue T. ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord. Glia. 2018;66:1862-1880 pubmed 出版商
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Gong Z, Zhou Q. Dnmt3a in the dorsal dentate gyrus is a key regulator of fear renewal. Sci Rep. 2018;8:5093 pubmed 出版商
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Qin L, Ma K, Wang Z, Hu Z, Matas E, Wei J, et al. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nat Neurosci. 2018;21:564-575 pubmed 出版商
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Wang S, Ko S, Kim Y, Jo S, Lee S, Jung S, et al. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Exp Mol Med. 2018;50:e455 pubmed 出版商
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Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlen M, et al. Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell. 2018;173:153-165.e22 pubmed 出版商
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Lin Y, Kuo K, Chen S, Huang H. RBFOX3/NeuN is dispensable for visual function. PLoS ONE. 2018;13:e0192355 pubmed 出版商
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Jacko M, Weyn Vanhentenryck S, Smerdon J, Yan R, Feng H, Williams D, et al. Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly. Neuron. 2018;97:853-868.e6 pubmed 出版商
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Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed 出版商
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Bennett R, Robbins A, Hu M, Cao X, Betensky R, Clark T, et al. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proc Natl Acad Sci U S A. 2018;115:E1289-E1298 pubmed 出版商
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He L, Yu K, Lu F, Wang J, Wu L, Zhao C, et al. Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development. J Neurosci. 2018;38:1575-1587 pubmed 出版商
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Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat Carotta S, et al. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018;21:207-217 pubmed 出版商
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Ziegler Waldkirch S, d Errico P, Sauer J, Erny D, Savanthrapadian S, Loreth D, et al. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. EMBO J. 2018;37:167-182 pubmed 出版商
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Gasparotto J, Girardi C, Somensi N, Ribeiro C, Moreira J, Michels M, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018;293:226-244 pubmed 出版商
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Ruan C, Liu J, Yang M, Saadipour K, Zeng Y, Liao H, et al. Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP. Exp Neurol. 2018;299:75-85 pubmed 出版商
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Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi J, Gangarossa G, et al. Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity. Neuroscience. 2018;370:130-138 pubmed 出版商
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Claus L, Philippot C, Griemsmann S, Timmermann A, Jabs R, Henneberger C, et al. Barreloid Borders and Neuronal Activity Shape Panglial Gap Junction-Coupled Networks in the Mouse Thalamus. Cereb Cortex. 2018;28:213-222 pubmed 出版商
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Gray J, Rubin T, Kogan J, Marrocco J, Weidmann J, Lindkvist S, et al. Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice. Mol Psychiatry. 2018;23:904-913 pubmed 出版商
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Mohammad H, Marchisella F, Ortega Martinez S, Hollos P, Eerola K, Komulainen E, et al. JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche. Mol Psychiatry. 2018;23:362-374 pubmed 出版商
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Pocratsky A, Burke D, Morehouse J, Beare J, Riegler A, Tsoulfas P, et al. Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation. Nat Commun. 2017;8:1963 pubmed 出版商
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Sousa A, Zhu Y, Raghanti M, Kitchen R, Onorati M, Tebbenkamp A, et al. Molecular and cellular reorganization of neural circuits in the human lineage. Science. 2017;358:1027-1032 pubmed 出版商
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Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed 出版商
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Tseng K, Danilova T, Domanskyi A, Saarma M, Lindahl M, Airavaara M. MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex. Eneuro. 2017;4: pubmed 出版商
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McCarthy G, Bridges C, Blednov Y, Harris R. CNS cell-type localization and LPS response of TLR signaling pathways. F1000Res. 2017;6:1144 pubmed 出版商
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产品信息
目录代码 :
MAB377
亚类别 :
神经科学
产品名称 :
Anti-NeuN Antibody, clone A60
产品类型 :
抗体
克隆性 :
单克隆抗体
宿主名称 :
小鼠
抗原 :
NeuN
克隆 :
A60
共轭标签 :
纯化
抗体亚型 :
IgG1
产品描述 :
Anti-NeuN Antibody, clone A60
交叉活性 :
Avian;Chicken;Ferret;Human;Mouse;Pig;Rat;Salamander
背景 :
NeuN antibody (NEUronal Nuclei; clone A60) specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples (Mullen et al., 1992; Wolf et al., 1996). Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron (Mullen et al., 1992). Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found (Mullen et al., 1992).
别名 :
Neuron-Specific Nuclear Protein;Neuna60;A60
免疫原 :
纯化细胞核来自小鼠大脑
特异性 :
MILLIPORE's exclusive monoclonal antibody to vertebrate neuron-specific nuclear protein called NeuN (or Neuronal Nuclei) reacts with most neuronal cell types throughout the nervous system of mice including cerebellum, cerebral cortex, hippocampus, thalamus, spinal cord and neurons in the peripheral nervous system including dorsal root ganglia, sympathetic chain ganglia and enteric ganglia. Developmentally, immunoreactivity is first observed shortly after neurons have become postmitotic, no staining has been observed in proliferative zones. The immunohistochemical staining is primarily localized in the nucleus of the neurons with lighter staining in the cytoplasm. The few cell types not reactive with MAB377 include Purkinje, mitral and photoreceptor cells. The antibody is an excellent marker for neurons in primary cultures and in retinoic acid-stimulated P19 cells. It is also useful for identifying neurons in transplants.
包装尺寸 :
500微克
用途 :
流式细胞仪;免疫细胞化学;免疫荧光;免疫组化;免疫组化(石蜡);免疫沉淀;免疫印迹
储存 :
Stable for 6 months at 2-8ºC from date of receipt.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
http://www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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