产品简要
公司名称 :
默克密理博中国
其他品牌 :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
产品类型 :
抗体
产品名称 :
Anti-Hypoxia Inducible Factor 1 α Antibody, clone H1α67
目录 :
MAB5382
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
H1alpha67
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, EMSA, 染色质免疫沉淀
更多信息或购买 :
文章摘录数: 21
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; scFv; 图 7
Ivanina A, Nesmelova I, Leamy L, Sokolov E, Sokolova I. Intermittent hypoxia leads to functional reorganization of mitochondria and affects cellular bioenergetics in marine molluscs. J Exp Biol. 2016;219:1659-74 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠
  • 免疫印迹; 大鼠; 1:1000; 图  5
Formisano L, Guida N, Valsecchi V, Cantile M, Cuomo O, Vinciguerra A, et al. Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism. J Neurosci. 2015;35:7332-48 pubmed 出版商
Owen J, McEwan C, Nesbitt H, Bovornchutichai P, Averre R, Borden M, et al. Reducing Tumour Hypoxia via Oral Administration of Oxygen Nanobubbles. PLoS ONE. 2016;11:e0168088 pubmed 出版商
de Wit R, Mujić Delić A, van Senten J, Fraile Ramos A, Siderius M, Smit M. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget. 2016;7:67966-67985 pubmed 出版商
Seino H, Ono S, Miura H, Morohashi S, Wu Y, Tsushima F, et al. Hypoxia is important in F?18 FDG accumulation in thecoma?fibroma tumors on F?18 FDG PET/CT scans. Mol Med Rep. 2016;13:3821-7 pubmed 出版商
Micucci C, Matacchione G, Valli D, Orciari S, Catalano A. HIF2α is involved in the expansion of CXCR4-positive cancer stem-like cells in renal cell carcinoma. Br J Cancer. 2015;113:1178-85 pubmed 出版商
To C, Farnsworth R, Vail M, Chheang C, Gargett C, Murone C, et al. Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth. PLoS ONE. 2014;9:e112106 pubmed 出版商
Dong M, Fan X, Chen Z, Wang T, Li X, Chen J, et al. Aberrant expression of enhancer of zeste homologue 2, correlated with HIF-1?, refines relapse risk and predicts poor outcome for breast cancer. Oncol Rep. 2014;32:1101-7 pubmed 出版商
Dong M, Wan X, Yuan Z, Wei L, Fan X, Wang T, et al. Low expression of Beclin 1 and elevated expression of HIF-1? refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer. Med Oncol. 2013;30:355 pubmed 出版商
Xu X, Lv Y, Gu W, Tang L, Wei J, Zhang L, et al. Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR. Respir Res. 2013;14:20 pubmed 出版商
Wu X, Chen J, Cao Q, Dong M, Lin Q, Fan X, et al. Beclin 1 activation enhances chemosensitivity and predicts a favorable outcome for primary duodenal adenocarcinoma. Tumour Biol. 2013;34:713-22 pubmed 出版商
Shi Q, Yang P, Xu X, Chen X, Qi C, Zhang J, et al. Neuroprotection of neurotrophin-3 against focal cerebral ischemia/reperfusion injury is regulated by hypoxia-responsive element in rats. Neuroscience. 2012;222:1-9 pubmed 出版商
Wan X, Zhao Y, Fan X, Cai H, Zhang Y, Chen M, et al. Molecular prognostic prediction for locally advanced nasopharyngeal carcinoma by support vector machine integrated approach. PLoS ONE. 2012;7:e31989 pubmed 出版商
Lakemeier S, Schofer M, Foltz L, Schmid R, Efe T, Rohlfs J, et al. Expression of hypoxia-inducible factor-1?, vascular endothelial growth factor, and matrix metalloproteinases 1, 3, and 9 in hypertrophied ligamentum flavum. J Spinal Disord Tech. 2013;26:400-6 pubmed 出版商
Husted R, Lu H, Sigmund R, Stokes J. Oxygen regulation of the epithelial Na channel in the collecting duct. Am J Physiol Renal Physiol. 2011;300:F412-24 pubmed 出版商
Lakemeier S, Reichelt J, Patzer T, Fuchs Winkelmann S, Paletta J, Schofer M. The association between retraction of the torn rotator cuff and increasing expression of hypoxia inducible factor 1? and vascular endothelial growth factor expression: an immunohistological study. BMC Musculoskelet Disord. 2010;11:230 pubmed 出版商
De Gasperi R, Sosa M, Dracheva S, Elder G. Presenilin-1 regulates induction of hypoxia inducible factor-1?: altered activation by a mutation associated with familial Alzheimer's disease. Mol Neurodegener. 2010;5:38 pubmed 出版商
Ferrari D, Nesic O, Perez Polo J. Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced cerebral edema. J Neurosci Res. 2010;88:2056-65 pubmed 出版商
Bianco C, Cotten C, Lonardo E, Strizzi L, Baraty C, Mancino M, et al. Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells. Am J Pathol. 2009;175:2146-58 pubmed 出版商
Kolev Y, Uetake H, Takagi Y, Sugihara K. Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis. Ann Surg Oncol. 2008;15:2336-44 pubmed 出版商
Picchio M, Beck R, Haubner R, Seidl S, Machulla H, Johnson T, et al. Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-Gluco-RGD autoradiography. J Nucl Med. 2008;49:597-605 pubmed 出版商
产品信息
目录代码 :
MAB5382
亚类别 :
Epigenetics & Nuclear Function
产品名称 :
Anti-Hypoxia Inducible Factor 1 α Antibody, clone H1α67
产品类型 :
抗体
克隆性 :
单克隆抗体
基因编号 :
Q16665
宿主名称 :
小鼠
抗原 :
Hypoxia Inducible Factor 1 α
克隆 :
H1alpha67
共轭标签 :
纯化
抗体亚型 :
IgG2b
产品描述 :
Anti-Hypoxia Inducible Factor 1 α Antibody, clone H1α67
交叉活性 :
白鼬;人类;小鼠;大鼠;羊
背景 :
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis, the posttranslational modification by prolyl hydroxylation as a key regulatory event that targets HIF-alpha subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. The transcriptional complex is composed of an alpha-beta heterodimer; HIF-beta being a constitutive nuclear protein that dimerises with oxygen regulated HIF-alpha subunits. In normoxia, 4-hydroxylation of human HIF-alpha at Pro402 or Pro564 by a set of HIF prolyl hydroxylase isoenzymes (PHD 1-3) mediates HIF1-alpha recognition by von Hippel-Lindau ubiquitin ligase complex leading to its proteasomal destruction. In hypoxia (deprivation of oxygen), lack of hydroxylase activity enables HIF-alpha subunits to escape destruction and become transcriptionally active. Thus HIF hydroxylases provide a focus for understanding cellular responses to hypoxia and target for therapeutic manipulation. There are several HIF factors, which include HIF 1-alpha, HIF 1-beta, HIF 2-alpha. HIF 1-alpha is an 812 a.a. protein in rat and 836 a.a. long in mouse and human. A master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. It is ubiquitous in expression as cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
别名 :
HIF-1 alpha; ARNT Interacting Protein; MOP1
免疫原 :
融合蛋白来自氨基酸432-528人的HIF-1alpha
特异性 :
Recognizes Hypoxia inducible factor-1alpha (HIF-1alpha).
包装尺寸 :
100微克
用途 :
电泳迁移率变动分析 ;免疫组化;免疫沉淀;免疫印迹
储存 :
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
更多信息或购买 :
公司信息
默克密理博中国
上海市浦东张江高科技园区晨晖路88号2号楼2楼
asiatechserv@millipore.com
www.millipore.com/china/wwcn/cnhome
400-889-1988
公司总部: 美国
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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