产品简要
公司名称 :
Eagle BioSciences
产品类型 :
ELISA/assay
产品名称 :
iLite ADCC Target HER2 (-) Assay Ready Cells
目录 :
BM5016
规格 :
250微升
价格 :
495.00美元
更多信息或购买 :
产品信息
鹰目录号 :
BM5016
描述 :
iLite ADCC Target HER2 (-) Assay Ready Cells
Assay Background :
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism whereby pathogenic cells are lysed by lymphocytes, most often Natural Killer (NK) cells. The mechanism involves binding of antibodies to surface antigens on the pathogen. Crosslinking of these antibodies to NK cells through the binding of the Fc-portion to Fc receptors on the NK cells leads to activation of the NK cell and formation of an immune synapse with the pathogenic cell. The NK cell releases cytotoxic granules containing granzymes and perforin into the synapse, leading to apoptosis of the targeted cell. Breast cancer is the most common cancer in women worldwide, and the second most common cancer overall. Survival rates have improved in the recent years, and stratification of patients into subgroups has vastly improved treatment options for many patients. As an example, patients with HER2 positive breast cancer generally have a poor prognosis, but treatment with trastuzumab, a monoclonal antibody targeting the HER2 receptor, has shown to increase both overall survival and disease free survival when given together with chemotherapy. Trastuzumab’s mechanism of action is mediated in part by inducing ADCC when crosslinking HER2 positive cells with the patient's immune cells. The drug was FDA approved for treatment of breast cancer patients in 1998, and many biosimilars are currently in development.
Assay Principle :
The iLite ADCC Target HER2 (-) Assay Ready Cells can be used together with iLite ADCC Effector (V) and iLite ADCC Target HER2 (+) Assay Ready Cells for the quantification ADCC activity.
产品类型 :
iLite
产品种类 :
检测试剂盒
产品子类型 :
免疫学
规格 :
250微升
Biomarker :
HER2
政府监管状态 :
RUO
Shipping :
干冰
储存 :
-80C
标价 :
495.00美元
更多信息或购买 :
公司信息
Eagle BioSciences
20A NW Blvd., Suite 112
Nashua, NH 03063
INFO@EAGLEBIO.COM
http://www.eaglebio.com
866-411-8023 617-419-2019
公司总部: 美国