Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

ELISA/assay

骨桥蛋白(啮齿类), 酶联免疫吸附试剂盒

ADI-900-090A

96 wells

ADI-900-090A

骨桥蛋白(啮齿类), 酶联免疫吸附试剂盒

Kit

96 wells

24247243, 24008574, 23427088

The Osteopontin (rodent), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours.

小鼠, 大鼠

Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to be a positive indicator of colon and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

OPN, SPP1, Secreted phosphoprotein 1, Bone sialoprotein 1

For the quantitative determination of mouse and rat osteopontin in culture supernatants, plasma, and urine. Cited sample type includes cerebrospinal fluid.

ELISA, Colorimetric detection

+4°C