产品简要
公司名称 :
Enzo Life Sciences
其他品牌 :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
产品类型 :
ELISA/assay
产品名称 :
[pThr202/Tyr204]Erk1/2酶联免疫吸附试剂盒
目录 :
ADI-900-098A-0001
规格 :
96 wells
更多信息或购买 :
Enzo Life Sciences 产品网页
文章摘录数: 6
参考文献
Kim J, Ma T. Autocrine fibroblast growth factor 2-mediated interactions between human mesenchymal stem cells and the extracellular matrix under varying oxygen tension. J Cell Biochem. 2013;114:716-27 pubmed 出版商
Arita N, Pelaez D, Cheung H. Activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) is needed for the TGF?-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2011;405:564-9 pubmed 出版商
Fuqua C, Akomeah R, Price J, Adunyah S. Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes. Cytokine. 2008;44:101-7 pubmed 出版商
Chernyavsky A, Arredondo J, Karlsson E, Wessler I, Grando S. The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J Biol Chem. 2005;280:39220-8 pubmed
Bottone F, Moon Y, Alston Mills B, Eling T. Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. J Pharmacol Exp Ther. 2005;315:668-77 pubmed
Mahapatra N, Mahata M, O Connor D, Mahata S. Secretin activation of chromogranin A gene transcription. Identification of the signaling pathways in cis and in trans. J Biol Chem. 2003;278:19986-94 pubmed
产品信息
产品编号 :
ADI-900-098A
目录代码 :
ADI-900-098A-0001
产品名称 :
[pThr202/Tyr204]Erk1/2酶联免疫吸附试剂盒
产品类型 :
Kit
规格 :
96 wells
Pubmed号列表 :
23060043, 21262199, 18707899, 16150734, 16079301, 12646581
产品描述 :
The [pThr202/Tyr204]Erk1/2 EIA kit is a complete assay for the quantitative determination of phosphorylated Erk1/2 using colorimetric detection read at 450 nm. The Extracellular regulated kinases, Erk-1 and Erk-2, both play a critical role in cellular proliferation. These extracellular kinases, are known to reside downstream of the Mitogen activated protein kinase/Extracellular protein kinases referred to as MEK. Both MEK-1 and MEK-2 phosphorylate and activate Erk on the conserved TEY motif within the activation loop of the kinase.
物种活性 :
人类, 小鼠, 大鼠
背景 :
The mitogen-activated protein kinase (MAPK) pathway exists in all eukaryotes. It consists of several subgroups including ERK 1/2 (extracellular signal-regulated kinase), JNK and p38 kinases. These kinases regulate and control fundamental cellular processes including proliferation, apoptosis, survival and differentiation. They are activated by diverse stimuli including cytokines, growth factors, irradiation, changes in osmolarity, heat and shear stress. MAP kinases are characterized by their requirement for dual phosphorylation for full activation. ERK1 (44kDa) and ERK2 (42kDa) kinases are characterized by their requirement for dual phosphorylation at a conserved T-E-Y motif. The literature contains numerous and extensive reviews on MAP kinase.
别名 :
MAPK2/3, 地图激酶2/3
用途 :
For the measurement of [pThr202/Tyr204]Erk1/2 in cell lysates of human, mouse, and rat origin.
应用摘要 :
ELISA, Colorimetric detection
更多信息或购买 :
Enzo Life Sciences 产品网页
公司信息
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
techserv-usa@enzolifesciences.com
https://www.enzolifesciences.com
1-800-942-0430
公司总部: 美国
自2007年始，Enzo Life Sciences先后合并ALEXIS Biochemicals、BIOMOL International等公司，为生命科学研究各个领域提供更全面的试剂产品。比如，肿瘤、细胞死亡、表观遗传、基因组学、免疫学、神经科学、信号转导及泛素和蛋白酶体等领域研究，都可以在Enzo Life Sciences中找到相应抗体、酶、蛋白、小分子抑制剂、产品文库及检测kit等产品。