Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

抗体

PEN2多克隆抗体

ADI-905-736-100

100微克

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

ADI-905-736-100

PEN2多克隆抗体

兔

多克隆

抗体

100微克

人类, 小鼠, 大鼠

PEN2, in addition to nicastrin, presenilin, and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is thought to be required for the generation of neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimers disease. Gamma- secretase will cleave the amyloid precursor protein (APP) within the intramembrane region, resulting in either the nontoxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site).

γ-secretase subunit PEN-2, Presenilin enhancer protein 2

Synthetic peptide corresponding to the sequence near the N-terminus of human PEN2.

液体。 在PBS含0.02% 叠氮化钠

免疫组化, 免疫印迹

+4°C